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Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-Bin Cai Xuan Wu Yin-Bing Tang Jin-Yan Wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang zhong-Hai guan Jie-Ni Xiong Wan-Xin Peng Jin-Hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

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基于Cu(Ⅰ)配合物的OLEDs发光材料研究进展

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应用化学 2024年第6期41卷 783-799页

作者：王冠中宋世平彭红珍张瑜诸颖陈静中国科学院上海应用物理研究所上海201800 上海大学理学院材料生物学研究所上海200444 中国科学院上海高等研究院上海同步辐射光源上海201210 中国科学院大学北京100049

由于有机材料丰富的发光特性,有机发光二极管(OLEDs)在平面显示器和照明中的应用获得了广泛的关注。传统的有机发光二极管发光层材料主要为有机小分子或贵金属配合物,其中贵金属配合物,如铂(Ⅱ)和铱(Ⅲ),存在热稳定性较差、载流子传输... 详细信息

由于有机材料丰富的发光特性,有机发光二极管(OLEDs)在平面显示器和照明中的应用获得了广泛的关注。传统的有机发光二极管发光层材料主要为有机小分子或贵金属配合物,其中贵金属配合物,如铂(Ⅱ)和铱(Ⅲ),存在热稳定性较差、载流子传输能力有限、获取难度大、性能受限和材料价格高昂等问题,严重限制了其应用和发展。Cu(Ⅰ)配合物具有优异的发光特性、发射可调性和相对较低的成本,为开发金属配合物发光材料提供了新的途径。本文总结了基于Cu(Ⅰ)配合物的OLEDs发光材料的研究进展,探讨了改变配位原子类型和配体结构调节Cu(Ⅰ)配合物电致发光的策略,对Cu(Ⅰ)配合物OLEDs发光材料的发展前景予以展望。

关键词： Cu(Ⅰ)配合物有机发光二极管电致发光

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The Effect of Platinum on Stability of the B_2O_3/TiO_2-ZrO_2 Catalyst for Beckmann Rearrangement of Cyclohexanone Oxime

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Chinese Chemical Letters 2006年第8期17卷 1025-1028页

作者： Dong Sen MAO guan zhong LU Research Institute Applied Catalysis Department of Chemical Engineering Shanghai Institute of Technology Shanghai 200235

The addition of platinum over the B2O3/TiO2-ZrO2 remarkably enhanced its catalytic stability in the vapor phase Beckmann rearrangement of cyclohexanone oxime under the carder gas of H2. The content of coke deposited on catalyst surface was decreased from 1.92% over the B2O3/TiO2-ZrO2 to 1.14% over the platinum promoted B2O3/TiO2-ZrO2 after reaction of six hours. This result indicates that the platinum added on the B2O3/TiO2-ZrO2 catalyst plays an important role in reducing the coke formation on the catalyst surface.

关键词： Cyclohexanone oxime vapor-phase Beckmann rearrangement ε-caprolactam B2O3/TiO2-ZrO2 catalyst platinum.

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阻塞性睡眠呼吸暂停低通气综合征患儿颌骨发育异常情况及其影响因素、对策分析

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中国实用医药 2024年第12期19卷 51-54页

作者：钟冠忠吴莉黄翠仪黄斌唐智南方医科大学顺德医院附属杏坛医院耳鼻咽喉科 528325

目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿颌骨发育异常情况及其影响因素和对策。方法98例OSAHS患儿,根据是否发生颌骨发育异常分为观察组(49例)和对照组(49例)。所有患儿均以医用数字化X线摄影术(DR)行头影测量和颌骨DR影像... 详细信息

目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿颌骨发育异常情况及其影响因素和对策。方法98例OSAHS患儿,根据是否发生颌骨发育异常分为观察组(49例)和对照组(49例)。所有患儿均以医用数字化X线摄影术(DR)行头影测量和颌骨DR影像测量:X线头影测量后气道间隙(PAS),反映上颌突度的SNA角和反映下颌突度的SNB角,上颌骨宽度以及下颌骨长度、宽度、高度。比较两组患儿颌面部测量指标,分析患儿SNA、SNB、PAS与呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO_(2))的相关性。结果两组患儿上颌骨宽度、下颌骨长度、下颌骨宽度、下颌骨高度比较,无统计学差异(P>0.05)。与对照组患儿SNA(81.31±2.52)°、SNB(82.53±2.34)°、PAS(6.35±2.12)mm相比,观察组患儿的(82.34±2.45)°、(83.83±3.17)°、(11.13±2.35)mm更高,差异有统计学意义(P<0.05)。将独立样本t检验中差异有统计学意义的项目分别与AHI、LSaO_(2)做相关性分析,结果发现,SNA与AHI呈负相关,SNA与LSaO_(2)以及SNB、PAS与AHI、LSaO_(2)均呈正相关,SNB、PAS与LSaO_(2)呈负相关(P<0.05)。结论对于OSAHS患儿SNA、SNB、PAS水平均与AHI、LSaO_(2)显著相关,在一定程度上影响儿童早期颌骨发育,应及时发现,及时干预。

关键词：阻塞性睡眠呼吸暂停低通气综合征颌骨发育异常影响因素对策

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Poly(GMA/MA/MBAA)Copolymer Beads:a Highly Efficient Support Immobilizing Penicillin G Acylase

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Chinese Chemical Letters 2006年第1期17卷 129-132页

作者： Ping XUE guan zhong LU Wan Yi LIU Key Laboratory of Energy Source and Chemical Engineering Ningxia University Yinchuan 750021 Research Institute of Industrial Catalysis East China University of Science and Technology Shanghai 200237

The hydrophilic, macroporous and beaded ternary copolymer of glycidyl methacrylate （GMA）/methacrylamide（MA）/N,N＇-methylene-bis（acrylamide）（MBAA）was synthesized using the industrial agents by inverse suspension polymerization. The apparent activity of the immobilized penicillin G acylase reached 1096 IU/g for hydrolysis penicillin G on the beads with diameter of 0.11-0.13 ram, and it changed hardly after 50 cycles. It can be expected to be a good potential in industrial application,

关键词： Poly(GMA/MA/MBAA) copolymer beads penicillin G acylase immobilization,inverse suspension polymerization.

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马堃教授以肾虚血瘀论治子宫肌瘤所致不孕病案举隅

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中国中药杂志 2024年第8期49卷 2037-2041页

作者：马堃李佳妮钟观兰张涵马林纳孙立华中国中医科学院西苑医院北京100091 天津中医药大学天津301617

子宫肌瘤是影响育龄期女性不孕的常见因素,通过整理马堃教授临床诊治子宫肌瘤所致不孕症的案例,探讨其治疗子宫肌瘤导致不孕症的理论依据及组方原则。肾藏精,主生殖,肾虚是导致不孕症的基本病机,无论是肾气、肾精不足或肾阴阳失调均可... 详细信息

子宫肌瘤是影响育龄期女性不孕的常见因素,通过整理马堃教授临床诊治子宫肌瘤所致不孕症的案例,探讨其治疗子宫肌瘤导致不孕症的理论依据及组方原则。肾藏精,主生殖,肾虚是导致不孕症的基本病机,无论是肾气、肾精不足或肾阴阳失调均可导致气血运行不畅,久滞成瘀,而血瘀是贯穿始终的重要因素,女子以血为用,气血之根在于肾,故马堃教授认为肾虚血瘀是子宫肌瘤所致不孕症的关键病机。马堃教授以补肾活血法为原则治疗子宫肌瘤所致不孕,根据月经周期气血变化规律和卵泡生长过程,辨证施治,行经期胞宫正开,正值经血下泄之时,以滋肾阴活血为主促进卵泡发育;经后期在此基础上化瘀消癥散结,攻补并行;经间期重阴则阳时,则以补肾活血为法,促进阴阳转化,卵子得以顺利排出;经前期以温肾阳为主,促进孕卵着床,兼以疏肝理气,行气消滞,补中有行,随症加减,临床效果显著,供广大同仁参考。

关键词：子宫肌瘤不孕症肾虚血瘀补肾活血

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Synthesis and Crystal Structure of 2-tert-Butyl-5-(4-tert-butylbenzylthio)-4-chloropyridazin-3(2H)-one

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Chemical Research in Chinese Universities 2006年第6期22卷 763-764页

作者： XU Liang-zhong YU guan-ping XU zhong-jie ZHANG Gong-sheng ZHAI Zhi-wei College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

The title compound, 2-ten-butyl-6 （4-ten -butylbenzylthio） -4-chloropyridazin-3 （ 2H ） -one, was synthesized from 1 -ten-butylhydrazine, （ Z ） -2,3 -dichloro-3 -formylacrylic acid and （ 4 -tert -butylphenyl ） methanethiol in several steps. It crystallized in an orthorhombic space group Pnma with Mr = 364. 93 （ C19H25 ClN2OS）, a = 1. 0091 （2） nm, b = 0.7076（2） nm, c=2. 8103（5） nm, V=2.0066（6） nm^3, Z=4, Dc =1. 192 g/cm^3, F（000） =765, μ=0.301 mm , final R1 = 0. 0665, and wR = 0. 1913 for 1927 unique reflections. Inter- and intramolecular hydrogen bond C-H…O interactions stabilize the structure.

关键词： Pyridaben Synthesis Crystal structure

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Design and Implementation of On-Line Hot Topic Discovery Model

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 21-26页

作者： YE Hui-min CHENG Wei DAI guan-zhong School of Automatic Control Northwestern Polyteehnieal University Xi＇an 710072 Shaanxi China Institute of Artificial Intelligence Beijing City University Beijing 100083 China

Internet has become a major medium for infomation transmission, how to detect hot topic on web, track the event development and forecast emergency is important to many fields, particularly to some government departments. On the basis of the researches in the field of topic detection and tracking, we propose a model for hot topic discovery that will pick out hot topics by automatically detecting, clustering and weighting topics on the websites within a time period. Based on the idea of stock index, we also introduce a topic index approach in following the growth of topics, which is useful to analyze and forecast the development of topics on web.

关键词： topic tracking stock index hot topic topic weight

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Imputation of Mean of Ratios for Missing Data and Its Application to PPSWR Sampling

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Acta Mathematica Sinica,English Series 2010年第5期26卷 863-874页

作者： Guo Hua ZOU Ying Fu LI Rong ZHU zhong guan Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 P. R. China Department of Mathematical Sciences University of Houston-Clear Lake Houston TX 77058-1098 USA Department of Mathematical Sciences Indiana University South Bend South Bend IN 46634-7111 USA

In practical survey sampling, nonresponse phenomenon is unavoidable. How to impute missing data is an important problem. There are several imputation methods in the literature. In this paper, the imputation method of the mean of ratios for missing data under uniform response is applied to the estimation of a finite population mean when the PPSWR sampling is used. The imputed estimator is valid under the corresponding response mechanism regardless of the model as well as under the ratio model regardless of the response mechanism. The approximately unbiased jackknife variance estimator is also presented. All of these results are extended to the case of non-uniform response. Simulation studies show the good performance of the proposed estimators.

关键词： imputation item nonresponse jackknife variance estimator non-uniform response PP-SWR sampling

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Which Is Safer,Chinese Medicine or Western Medicine?Comparative Analysis Based on Chinese Spontaneous Reporting Database

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Chinese Journal of Integrative Medicine 2022年第2期28卷 138-144页

作者： WEI Jian-xiang LU Zhi-qiang FENG guan-zhong ZHU Yun-xia School of Management Nanjing University of Posts and TelecommunicationsNanjing(210003)China School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing(210003)China

Objective:To compare the safety differences between Chinese medicine(CM)and Western medicine(WM)based on Chinese Spontaneous Reporting Database(CSRD).Methods:Reports of adverse events(AEs)caused by CM and WM in the CSRD between 2010 and 2011 were *** following assessment indicators were constructed:the proportion of serious AEs(PSE),the average number of AEs(ANA),and the coverage rate of AEs(CRA).Further comparisons were also conducted,including the drugs with the most reported serious AEs,the AEs with the biggest report number,and the 5 serious AEs of interest(including death,anaphylactic shock,coma,dyspnea and abnormal liver function).Results:The PSE,ANA and CRA of WM were 1.09,8.23 and 2.35 times higher than those of CM,*** top 10 drugs with the most serious AEs were mainly injections for CM and antibiotics for *** AEs with the most reports were rash,pruritus,nausea,dizziness and vomiting for both CM and *** proportions of CM and WM in anaphylactic shock and coma were *** abnormal liver function and death,the proportions of WM were 5.47 and 3.00 times higher than those of CM,***:Based on CSRD,CM was safer than WM at the average level from the perspective of adverse drug reactions.

关键词： Chinese medicine Western medicine data analysis adverse drug reaction drug safety

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