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A fundamental theorem for eco-environmental surface modelling and its applications

science china Earth sciences 2020年第8期63卷 1092-1112页

作者： Tianxiang YUE Na ZHAO Yu liu Yifu WANG Bin ZHANG Zhengping DU Zemeng fan Wenjiao SHI Chuanfa chen Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA hongsheng HUANG Yimin LU Qing WANG chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi liu Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin fan Saibo LI Yang YANG John PWILSON State Key L aboratory of Resources and Environment Information System Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China College of Land Resources and Environment Jiangxi Agricultural UniversityNanchang 330045China College of Geomatics Shandong University of Science and TechnologyQingdao 266590China College of Forestry Beijing Forestry UniversityBeijing 100083China School of Land and Resources China West Normal UniversityNanchong 637002China College of Geographical Information and Tourism Chuzhou UniversityChuzhou 239000China institutes of science and Development Chinese Academy of SciencesBeijing 100190China department of Information engineering Shandong University of Science and TechnologyTai'an 271019China College of Resources Sichuan Agricultural UniversityChengdu 611130China College of Geography and Tourism Qufu Normal UniversityRizhao 276828China Aerospace Information Research institute Chinese Academy of SciencesBeijing 100101China School of Geographical science Southwest UniversityChongqing 400715China National Disaster Reduction Center of china Ministry of Emergency ManagementBeijing 100721China department for Population Data China Population and Development Research CenterBeijing 100081China department for Industrial Standard China Standardization AdministrationBeijing 100088China The Academy of Digital china Fuzhou UniversityFuzhou 350002China National institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China School of Information engineering China University of GeoscienceBeijing 100083China Qian Xuesen Laboratory of Space technology Beijing 100094China College of Architecture and Urban Planning Chongqing Jiaotong UniversityChongqing 400074China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing

We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM.

关键词： HASM FTEEM Spatial upscaling Spatial downscaling Spatial interpolation Data fusion Model-data assimilation Model coupling

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COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors

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Signal Transduction and Targeted Therapy 2022年第1期7卷 270-281页

作者： Xi He chenshu liu Jiangyun Peng Zilun Li fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen chen Sifan chen Chunliang Lei Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhouChina Division of Vascular Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina National-Guangdong Joint engineering Laboratory for Diagnosis and Treatment of Vascular Diseases The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Medical Research Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina department of Obstetrics and Gynecology Guangzhou Women and Children Medical CenterGuangzhou Medical UniversityGuangzhouChina institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina department of Immunology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Guangzhou Center for Disease control and Prevention GuangzhouChina Wuhan Metware Biotechnology Co. LtdWuhanChina department of Biomedical sciences New York Institute of TechnologyCollege of Osteopathic MedicineOld WestburyNYUSA Max Planck institute for Heart and Lung Research and Cardiopulmonary institute(CPI) Bad NauheimGermany department of Molecular Diagnostics Sun Yat-sen Cancer CenterSun Yat-sen UniversityGuangzhouChina School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenChina State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhouChina The Sixth Affiliated Hospital of Sun Yat-sen University GuangzhouChina department of Endocrinology Sun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Guangzhou Regenerative Medicine and Health-Guangdong Laboratory(GRMH-GDL) Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina Key Laboratory of Regenerative Biology of the Chinese Academy of

Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear *** this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie *** nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid ***,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin *** together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications.

关键词： metabolism mechanism resistance

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我国煤矿开采工作面顶板灾害及防治技术研究现状

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采矿与岩层控制工程学报 2024年第5期6卷 13-38页

作者：徐刚张震张春会范志忠卢振龙黄志增陆闯薛吉胜王传朋陈法兵李岩刘前进李正杰孙晓东蔺星宇马镕山天地科技股份有限公司开采设计事业部北京100013 中煤科工开采研究院有限公司北京100013 河北科技大学建筑工程学院河北石家庄050018 辽宁工程技术大学力学与工程学院辽宁阜新123000

从岩层控制理论、监测预警技术及装备、矿压规律及数据分析、防控手段等方面系统地阐述了当前我国煤矿开采工作面顶板灾害方面的研究现状。当前工作面顶板灾害依然是制约我国煤矿安全生产的重要因素,近两年来无论是顶板灾害起数还是伤... 详细信息

从岩层控制理论、监测预警技术及装备、矿压规律及数据分析、防控手段等方面系统地阐述了当前我国煤矿开采工作面顶板灾害方面的研究现状。当前工作面顶板灾害依然是制约我国煤矿安全生产的重要因素,近两年来无论是顶板灾害起数还是伤亡人数,均呈明显上升的趋势,顶板灾害防控依然严峻。在矿压基础理论研究方面,国内科研人员相继提出了“砌体梁”、“传递岩梁”、“组合悬臂梁–铰接岩梁”、“切落体”和“分区支撑理论”等力学结构模型,明确了不同岩层赋存条件下顶板灾害致灾机理;在顶板灾害监测预警方面,我国煤矿已经开始摆脱传统单一的近场矿压监测,逐步向工作面近、远场顶板状态联合实时监测、动态感知、协同预警发展,实现矿压监测系统监测近场支架工作阻力、顶板下沉量、煤体应力等,微震监测系统监测工作面远场上覆岩层顶板断裂位置和能量大小;在矿压规律及数据分析方面,总结了浅埋深、坚硬顶板、非坚硬顶板不同围岩赋存状态下工作面矿压规律,明确了各条件下支架工作阻力的增阻特性;在顶板灾害防治方面,针对不同围岩赋存条件下易发生的顶板灾害类型,形成了相对应的顶板灾害防治技术,针对矿压显现较强烈,容易发生顶板灾害的坚硬顶板矿井,通过顶板深孔爆破、浅孔水力压裂、井下定向区域水力压裂、地面水力压裂等技术,有效地预防了顶板灾害的发生。总体而言,我国工作面顶板灾害防控理论及技术体系仍在不断完善,随着新技术的不断发展和智能化矿井的建设,顶板灾害的智能预警及联动防控将获得更大的发展。

关键词：顶板灾害致灾机理监测预警矿压特征灾害防治

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A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

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National science Review 2022年第8期9卷 100-109页

作者： Zhi chen Jingfeng Li Tianzhong Li Taojian fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar A.Al-hartomy Swelm Wageh Abdullah G.Al-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang Shenzhen engineering Laboratory of Phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics science and technology of Ministry of Education 3. Shenzhen institute of Translational Medicine 4. department of Otolaryngology Shenzhen Second People’s Hospital 5. the First Affiliated Hospital 6. Institute of Microscale Optoelectronics Shenzhen University 7. Shenzhen International Institute for Biomedical Research 8. Shenzhen Han’s Tech Limited Company 9. Shenzhen Metasensing Tech Limited Company department of Physics Faculty of Science King Abdulaziz University Research Center for Advanced Materials science (RCAMS) King Khalid University department of Chemistry College of Science King Khalid University Zhongmin (Shenzhen) Intelligent Ecology Co.Ltd Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University department of Laboratory Medicine Shenzhen Children’s Hospital Optoelectronics Research Center School of Science Minzu University of China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Research Unit of Adaptive Evolution and control of Emerging Viruses Chinese Academy of Medical Sciences institute of Pathogenic Organism Shenzhen Center for Disease Control and Prevention Respiratory department Shenzhen Children’s Hospital institute of Pediatrics Shenzhen Children’s Hospital

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-Co V-2 variants,including Omicron, are required to be identified as soon as the samples are identified as ‘positive’.Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance(SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat(CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification,within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-Co V-2, and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron) and BA.1(a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in china, identified by the Centers for Disease control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.

关键词： surface plasmon resonance CRISPR SARS-CoV-2 Omicron variant

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Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet

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science Bulletin 2017年第24期62卷 1628-1630页

作者： Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie fang Zhang hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe fan chen Yang Zhong Ministry of Education Key Laboratory for Biodiversity science and Ecological engineering School of Life Sciences Fudan University Shanghai 200433 China Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China institute of Biodiversity science and Geobiology College of Sciences Tibet University Lhasa 850000 China institute of Forest Inventory Planning and Research of Tibet Autonomous Region Lhasa 850010 China Three Gorges Center for Food and Drug control Yichang 443005 China institute of Mathematical Statistics Midori-cho 10-3 Tachikawa Tokyo 190-8562 Japan Tibet Museum of Natural science Lhasa 850000 China h Department of Bioengineering University of Illinois at Urbana-Champaign Champaign IL 61801 USA department of Bioengineering University of Illinois at Urbana-Champaign Champaign IL 61801 USA School of Computer science Fudan University Shanghai 200433 China School of Urban Rail Transportation Soochow University Suzhou 215131 China institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China School of Life sciences Peking University Beijing 100871 China School of Life sciences Yunnan University Kunming 650091 China department of Genetics Evolution and Environment University College London Darwin Building Cower Street London WCIE 6BT United Kingdom department of Zoology University of Oxford Tinbergen Building South Parks Road Oxford OX1 3PS United Kingdom institute of Biomedical and Environmental science & technology Department of Life Sdences University of Bedfordshire Park Square Luton LU1 3JU United Kingdom Shanghai Center for Bioinformation technology Shanghai 201203 China

Arabidopsis thaliana（A, thaliana） has long been a model species for dicotyledon study, and was the first flowering plant to get its genome completed sequenced . Although most wild A. thaliana are collected in Europe, several studies have found a rapid A. thaliaria west-east expansion from Central Asia . The Qinghai-Tibet Plateau （QTP） is close to Central Asia and known for its high altitude, unique environments and biodiversity . However, no wild-type A. thaliana had been either discovered or sequenced from QTP. Studies on the A. thaliana populations collected under 2000 m asl have shown that the adaptive variations associated with climate and altitudinal gradients .

关键词： Discovery a high-altitude ecotype ancient lineage of Arabidopsis thaliana from Tibet

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基于微服务的飞行管理系统仿真:体系与方法

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清华大学学报（自然科学版） 2020年第7期60卷 589-596页

作者：李清樊一萍李大川蒋欣刘恩钰陈甲清华大学自动化系北京100084 南方科技大学计算机科学与工程系深圳518055 中国商用飞机有限责任公司北京民用飞机技术研究中心北京102211

飞行管理系统(flight management system,FMS)是基于轨迹运行的下一代空管体系的核心,也是一个典型的大型多专业复杂产品系统。解决大规模复杂产品研发周期长、成本高、专业多、跨度大的问题,需要灵活、可扩展的分布式仿真系统来支持产... 详细信息

飞行管理系统(flight management system,FMS)是基于轨迹运行的下一代空管体系的核心,也是一个典型的大型多专业复杂产品系统。解决大规模复杂产品研发周期长、成本高、专业多、跨度大的问题,需要灵活、可扩展的分布式仿真系统来支持产品设计、测试、验证、评估。该文设计了基于面向服务的架构(service-oriented architecture,SOA)、云计算与微服务概念和技术的仿真系统框架,开发了仿真单元服务封装、仿真编排和仿真过程建模与控制等关键技术,并搭建了面向多专业协同开发的FMS仿真平台。提供以服务形式封装的仿真微服务单元,根据系统框架和任务要求的不同,编排不同的仿真过程和仿真架构,仿真组件通过代理访问封装的单元服务。工程应用结果表明:该架构能够满足复杂产品开发的灵活性、扩展性和可复用性要求。

关键词：微服务云计算面向服务的架构飞行管理系统协同仿真

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Chemical looping based ammonia production--A promising pathway for production of the noncarbon fuel

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science Bulletin 2022年第20期67卷 2124-2138,M0004页

作者： Qinghua Lai Tianyi Cai Shik Chi Edman Tsang Xia chen Runping Ye Zhenghe Xu Morris D.Argyle Dong Ding Yongmei chen Jianji Wang Armistead G.Russell Ye Wu Jian liu Maohong fan College of engineering and Applied science University of WyomingLaramie WY 82071USA School of Energy and Power engineering Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Wolfson Catalysis Department of ChemistryUniversity of OxfordOxford Ox13QRUK College of Chemistry and Chemical engineering Ocean University of ChinaQingdao 266100China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China department of Materials science and engineering Southern University of Science and TechnologyShenzhen 518055China department of Chemical and Materials engineering University of AlbertaEdmonton Alberta T6G1H9Canada department of Chemical engineering Brigham Young UniversityProvo UT 84602USA Idaho National Laboratory Idaho Falls ID83415USA College of Chemistry Beijing University of Chemical TechnologyBejing 100029China School of Chemistry and Environmental science Henan Normal UniversityXinxiang 453007China School of Civil and Environmental engineering Georgia Institute of TechnologyAtlanta GA 30332USA MIIT Key Laboratory of Thermal control of Electronic Equipment School of Power EngineeringNanjing University of Science&TechnologyNanjing 210094China DICP-Surrey Joint Centre for Future Materials Department of Chemical and Process Engineeringand Advanced Technology InstituteUniversity of SurreyGuilford Surrey GU27XH UK

Ammonia, primarily made with Haber-Bosch process developed in 1909 and winning two Nobel prizes, is a promising noncarbon fuel for preventing global warming of 1.5 °C above pre-industrial levels. However,the undesired characteristics of the process, including high carbon footprint, necessitate alternative ammonia synthesis methods, and among them is chemical looping ammonia production(CLAP) that uses nitrogen carrier materials and operates at atmospheric pressure with high product selectivity and energy efficiency. To date, neither a systematic review nor a perspective in nitrogen carriers and CLAP has been reported in the critical area. Thus, this work not only assesses the previous results of CLAP but also provides perspectives towards the future of CLAP. It classifies, characterizes, and holistically analyzes the fundamentally different CLAP pathways and discusses the ways of further improving the CLAP performance with the assistance of plasma technology and artificial intelligence(AI).

关键词： Ammonia synthesis Chemical looping Nitrogen carrier Renewable fuels Energy carrier

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Promoting thermodynamic and kinetic stabilities of FA-based perovskite by in-situ bilayer structure

Promoting thermodynamic and kinetic stabilities of FA-based ...

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第八届新型太阳能材料科学与技术学术研讨会

作者： Alex fan Xu Na liu fanlong Xie Tinglu Song Yue Ma Pengxiang Zhang Yang Bai Yujing Li Qi chen Gu Xu Experimental Center of Advanced Materials School of Materials Science and EngineeringBeijing Institute of Technology department of Materials science and engineering McMaster University

The commonly employed formamidinium(FA)-containing perovskite solar cells(PSCs) exhibit severe phase instability problem, thereby limiting their commercial applications. Here, both phase stability and energy efficiency of FA-based PSCs were improved by treating the perovskite surface with pyrrolidinium hydroiodide(PyI) salts, resulting in 1 D perovskite structure(PyPbI3), stacked on the original 3 D perovskite. By employing in-situ XRD measurements, we revealed that the temperature-dependent phase transition activation barrier was enhanced after forming 1 D/3 D structure, resulting in a prolonged transition time by 30-40 folds. From the first-principle calculations, we found the thermodynamic energy difference between two phases reduced from-0.16 to-0.04 eV after the stacking of 1 D PyPbI3, offering additional lifetime improvement. Moreover, the champion 1 D/3 D bilayer PSC exhibits a boosted power conversion efficiency of 19.62%, versus 18.21% of the control. Such 1 D/3 D bilayer structure may be employed in PSCs to enhance their phase stability and photovoltaic performance.

关键词： 1D/3D bilayer phase stability activation barrier thermodynamic FA-based perovskite

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Standard:Human intestinal organoids

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Cell Regeneration 2023年第1期12卷 199-203页

作者： Yalong Wang Hanqing Lin Lianzheng Zhao fan hong Jie Hao Zhen Zhang Weiqi Sheng Linhong Song Chu‑Xia Deng Bing Zhao Jiani Cao Lei Wang liu Wang Lingmin Liang Wenli Kelly chen Chunping Yu Zhijian Sun Yingying Yang Changlin Wang Yong Zhang Qiyuan Li Ka Li Aijin Ma Tongbiao Zhao Guoqiang Hua Ye-Guang chen The State Key Laboratory of Membrane Biology Tsinghua‑Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Guangzhou Laboratory Guangzhou 510005China Guangzhou institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Guangzhou Hua Yi Regeneration technology Co. LtdHuangpu DistrictGuangzhou 510700China D1Med technology(Shanghai)Inc Shanghai 201802China State Key Laboratory of Stem Cell and Reproductive Biology Institute for Stem Cell and RegenerationInstitute of ZoologyNational Stem Cell Resource CenterChinese Academy of SciencesBeijing 100101China Beijing institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of sciences Beijing 100049China institute of Clinical science Zhongshan HospitalFudan UniversityShanghai 200433China department of Radiation Oncology and Cancer institute Fudan University Shanghai Cancer Center Fudan UniversityShanghai 200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Key Laboratory of Radiation Oncology Shanghai 200032China department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Sichuan Academy of Medical sciences&Sichuan Provincial People’s Hospital Chengdu 610072China Cancer Centre Faculty of Health SciencesUniversity of MacaoMacao 999078SARChina State Key Laboratory of Genetic engineering School of Life SciencesFudan UniversityShanghai 200438China china Innovation Center of Roche Li Shi Zhen RoadPudongShanghai 201203China Eli Lilly and Company PudongShanghai 201203China K2 Oncology Co. LtdKeChuang StreetBeijing 100176China Qilu Pharmaceutical Co. LtdJinan 250104China china National institute of Standardization Beijing 100191China Chinese Society for Stem Cell Research Shanghai 200032China HHLIFE Co. IncShenzhen 518040China china National GeneBank Shenzhen 518000China Beijing technology and Business University Beijing 100048China School of Bas

Organoids have attracted great interest for disease modelling,drug discovery and development,and tissue growth and homeostasis ***,lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.“Human intestinal organoids”is the first guideline on human intestinal organoids in china,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell *** standard specifies terms and definitions,technical requirements,test methods,inspection rules for human intestinal organoids,which is applicable to quality control during the process of manufacturing and testing of human intestinal *** was originally released by the Chinese Society for Cell Biology on 24 September *** hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.

关键词： Human jointly branch

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西南典型区域夏季大气含氧挥发性有机化合物来源解析

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环境科学 2021年第6期42卷 2648-2658页

作者：陈木兰王赛男陈天舒朱波彭超周佳维车汉雄黄汝辉杨复沫刘合凡谭钦文韩丽陈军辉陆克定陈阳中国科学院重庆绿色智能技术研究院大气环境研究中心重庆400714 中国科学院大学重庆学院资源与环境学院重庆400714 中国科学院大学资源与环境学院北京101400 山东大学环境研究院青岛266237 北京大学深圳研究生院环境与能源学院城市人居环境科学与技术重点实验室深圳518055 四川大学建筑与环境学院成都610065 成都市环境保护科学研究院成都610031 四川省生态环境科学研究部成都610041 北京大学环境科学与工程学院北京100871

含氧挥发性有机物(OVOCs)是大气光化学过程中的重要中间产物,是臭氧的重要来源之一.利用质子转移反应飞行时间质谱仪(PTR-TOF-MS)在成都平原对OVOCs进行观测,探讨其日变化特征、光化学反应活性、臭氧生成潜势和来源.结果表明,10个VOCs[... 详细信息

含氧挥发性有机物(OVOCs)是大气光化学过程中的重要中间产物,是臭氧的重要来源之一.利用质子转移反应飞行时间质谱仪(PTR-TOF-MS)在成都平原对OVOCs进行观测,探讨其日变化特征、光化学反应活性、臭氧生成潜势和来源.结果表明,10个VOCs[乙醛、丙酮、异戊二烯、甲基乙基酮(methyl ethyl ketone,MEK)、甲基乙烯基甲酮(methyl vinyl ketone,MVK)、甲基丙烯醛(methacrolein,MACR)、苯、甲苯、苯乙烯、C8芳香烃和C9芳香烃]总浓度(体积分数)为(10.97±4.69)×10^(-9),OVOCs为(8.54±3.44)×10^(-9),芳香烃为(1.53±0.93)×10^(-9),生物源VOCs为(0.90±0.32)×10^(-9);光化学活性和臭氧生成潜势均排名前三的物种为:异戊二烯、乙醛和C8芳香烃;3个OVOCs物种(乙醛、丙酮和MEK)主要来源于本地生物源和人为二次源,且丙酮有较强的区域背景值,说明该地区的污染受到较为显著的区域传输的影响.本研究可加深对西南地区臭氧的区域形成机制的认识,为科学管控臭氧污染提供依据.

关键词：含氧挥发性有机物(OVOCs) 质子转移反应飞行时间质谱仪(PTR-TOF-MS) 臭氧生成潜势光化学年龄参数法来源分析

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