COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors
作者机构：Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Division of Vascular SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular DiseasesThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Department of Obstetrics and GynecologyGuangzhou Women and Children Medical CenterGuangzhou Medical UniversityGuangzhouChina Institute of Human VirologyKey Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Department of ImmunologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Guangzhou Center for Disease Control and PreventionGuangzhouChina Wuhan Metware Biotechnology Co.LtdWuhanChina Department of Biomedical SciencesNew York Institute of TechnologyCollege of Osteopathic MedicineOld WestburyNYUSA Max Planck Institute for Heart and Lung Research and Cardiopulmonary Institute(CPI)Bad NauheimGermany Department of Molecular DiagnosticsSun Yat-sen Cancer CenterSun Yat-sen UniversityGuangzhouChina School of Public Health(Shenzhen)Sun Yat-sen UniversityShenzhenChina State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhouChina The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of EndocrinologySun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Guangzhou Regenerative Medicine and Health-Guangdong Laboratory(GRMH-GDL)Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第1期
页 面：270-281页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was supported by the joint emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology of China,Guangdong Science and Technology Department and Guangzhou Municipal Science and Technology Bureau(2020B111108001) Guangdong Science and Technology Department(2020B121206001&2020B1212030004) The funders had no role in study design,data collection and analysis,or preparation of the manuscript
主 题：metabolism mechanism resistance
摘 要：Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear *** this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie *** nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid ***,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin *** together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications.
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