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Treatment of Alzheimer's disease with small-molecule photosensitizers

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Chinese Chemical Letters 2023年第5期34卷 132-142页

作者： Yefei Jiang zhiyong zeng Jianhua Yao Ying Guan Peipei Jia Xiaoli Zhao Lin Xu Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Joint Institute of Tobacco and Health Yunnan Academy of Tobacco ScienceKunming 650024China Wuhu Hospital Affiliated to East China Normal University(The Second People's Hospital of Wuhu) Wuhu 241001China

Alzheimer's disease is a neurodegenerative disease that signals for excessβ-amyloid(Aβ)*** people have made great attempts to control the aggregation of Aβ,no effective medications have been produced *** to its excellent temporal and spatial selectivity,photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ,with some *** enhance the research and application of photodynamic therapy in Alzheimer's disease,this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.

关键词： Alzheimer’s disease Photosensitizer Aβaggregation PDT

Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats

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Bio-Design and Manufacturing 2021年第4期4卷 902-911页

作者： zhiyong zeng Guohua Jiang Tianqi Liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China

Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

关键词： Microneedles Metformin Transdermal delivery Biodegradable Gelatin Hypoglycemic effect

基于机器学习算法构建浸润性肺腺癌预后预测模型

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中国胸心血管外科临床杂志 2025年第1期32卷 80-86页

作者：崔严奇杨鲸蓉倪琳连铎煌叶仕新廖毅张锦灿曾志勇福建医科大学福总临床医学院联勤保障部队第九〇〇医院心胸外科联勤保障部队第九〇〇医院普外科

目的确定肺腺癌（lung adenocarcinoma,LUAD）预后生物学标志物，并据此建立LUAD预后的预测模型。方法从UCSC数据库获取癌症基因组图谱（TCGA）LUAD基因表达量和临床病理数据，把纳入的数据进行综合生物信息学分析，包括差异表达基因... 详细信息

目的确定肺腺癌（lung adenocarcinoma,LUAD）预后生物学标志物，并据此建立LUAD预后的预测模型。方法从UCSC数据库获取癌症基因组图谱（TCGA）LUAD基因表达量和临床病理数据，把纳入的数据进行综合生物信息学分析，包括差异表达基因（differentially expressed genes,DEGs）筛选、基因本体（GO）功能富集分析、京都基因与基因组百科全书（KEGG）分析和基因集富集分析（GSEA）。采用Cox分析和最小绝对值收缩和选择算子（least absolute shrinkage and selection operator,LASSO）回归分析构建基因组的风险评估预测模型，并采用列线图预测患者1年、2年、3年、5年和10年生存率。绘制Kaplan-Meier生存曲线、受试者工作特征（receiver operating characteristic,ROC）曲线和时间依赖性ROC曲线评价模型的预测能力。在验证组中校验模型。结果浸润性LUAD患者不同级别病理亚型间DEGs富集分析结果显示，280个DEGs主要参与细胞色素P450相关物质代谢、自然杀伤细胞介导的免疫反应、抗原的呈递和酶活性调节等生物学过程，与肿瘤的发生、发展密切相关。构建5个基因（MELTF、MAGEA1、FGF19、DKK4、C14ORF105）组成的风险预测模型，Cox分析和LASSO回归显示，模型的ROC曲线下面积（area under the curve,AUC）值为0.675，时间依赖性ROC曲线1年、3年、5年AUC值分别为0.893、0.713、0.632，表明该预测风险模型具有良好的敏感性和特异性。在验证组中，校准曲线和一致性指数（C指数）也表明构建的列线图预测性能较好。结论 5个基因组成的预测模型可作为LUAD患者生存率实用和可靠的预测工具，这可能有助于制定个体化治疗的临床决策，为患者预后预测提供一种新方法。

关键词：浸润性肺腺癌机器学习生物标志物风险评估模型列线图

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Construction of FRET-based metallacycles with efficient photosensitization efficiency and photocatalytic activity

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Chinese Chemical Letters 2023年第1期34卷 304-309页

作者： Peipei Jia Yixiong Hu zhiyong zeng Yute Wang Bo Song Yanrong Jiang Haitao Sun Ming Wang Wenwei Qiu Lin Xu Shanghai Key Laboratory of Green Chemistry and Chemical Processes Shanghai Frontiers Science Center of Molecule Intelligent SynthesesShanghai Engineering Research Center of Molecular Therapeutics and New Drug DevelopmentSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Institute of Eco-Chongming Shanghai 202162China

The fabrication of highly effective photosensitizers has received considerable attention because of their attractive functions and applications in the fields of photodynamic therapy, photosynthesis, photocatalysis, etc. Thus, it is highly desirable to develop a new approach to enhance photosensitization ***, through coordination-driven self-assembly, a series of metallacycles with efficient fluorescence resonance energy transfer(FRET) were effectively constructed, which displayed higher photosensitization efficiency and photocatalytic activity than their model metallacycles without FRET due to broadband absorption and singlet energy transfer from the energy acceptor to the energy donor. Moreover, iodization of fluorophores induced a significant enhancement of the photosensitization efficiency and photocatalytic activity of the metallacycles. This research provides an efficient strategy for improving photosensitization efficiency and a promising platform for the preparation of effective photosensitizers and photocatalysts.

关键词： Self-assembly Metallacycle FRET Photosensitization Photocatalytic

A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte

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Microsystems & Nanoengineering 2022年第3期8卷 185-198页

作者： Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu zhiyong zeng Depeng Wang Tianxing Wang Ning Hu Diming Zhang Department of Obstetrics and Gynecology Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguan 523058China Research Center for Inelligent Sensing Systems Zhejiang LaboratoryHangzhou 311100China Research Center for Humanoid Sensing Zhejiang LaboratoryHangzhou 311100China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China E-Link Care Meditech Co. LtdHangzhou 310011China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemitryZhejiang UniversityHangzhou 310058China

Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental *** arrays record the electrical potential of cells in a minimally invasive and highthroughput ***,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single *** this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar *** pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously *** intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular *** to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication *** NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation.

关键词： arrays potential record

Fabrication of Transparent Hydrophilous Nanosized TiO2 Films via Layer-by-Layer Self-Assembly

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Fabrication of Transparent Hydrophilous Nanosized TiO2 Films...

第二届海峡两岸功能材料科技与产业峰会（2015）

作者： zeng zhiyong SHI Ying YUAN Sujun XIE Jianjun School of Materials Science and Engineering Shanghai University

Thetransparentnanosized TiO film was fabricated by a layer-by-layerassembly method starting from the highlydispersed anataseoppositely charged TiO nanoparticles without using *** positively charged TiO nanoparticles(ca.7 nm) and negatively charged TiOnanoparticles(ca.5 nm) were synthesized by a subsequentlyhydrothermal process. Thezeta-potential of the oppositely TiO nanoparticles depending on the p H of the TiO sol was discussed. Field-emission scanning electron microscopy,UV-vis transmittance spectra and Contact angle measurement were employed to characterize TiO *** the treatment of 500 ℃for 2hrs,the nano-structured TiO film showeda water contact angle ofbelow10°andthe relative transmittance to quartz glass of over 90%.

关键词： Nanosize layer-by-layer self-assembly Titanium dioxide hydrophilicity

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酸化条件对海泡石调湿性能的影响

同济大学学报（自然科学版） 2008年第12期36卷 1674-1678页

作者：蒋正武曾志勇同济大学先进土木工程材料教育部重点实验室上海200092

研究了酸化浓度、温度与时间等条件对海泡石在恒温密闭空间内调湿性能的影响．利用X射线衍射仪、扫描电子显微镜和比表面积仪等测试了处理前后的海泡石的微观结构并分析了其与调湿性能的关系．结果表明，酸化条件对海泡石在密闭空间内... 详细信息

研究了酸化浓度、温度与时间等条件对海泡石在恒温密闭空间内调湿性能的影响．利用X射线衍射仪、扫描电子显微镜和比表面积仪等测试了处理前后的海泡石的微观结构并分析了其与调湿性能的关系．结果表明，酸化条件对海泡石在密闭空间内的调湿性能有明显的影响，酸化处理后的海泡石纤维变细变短，层间和孔道中的碳酸盐被溶解，孔道被疏通．试验获得的最佳酸化条件为用1．2mol·L^-1的盐酸在95℃下处理6h．经最佳酸化处理后，海泡石的5～10nm的微孔体积增大，累积孔容积增大，比表面积略有下降．

关键词：空气湿度调湿海泡石密闭空间酸化孔结构

电流品质优化的容错型三相四开关逆变器载波调制算法

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电力自动化设备 2017年第5期37卷 40-47页

作者：朱翀曾志勇赵荣祥浙江大学电气工程学院浙江杭州310027 国家电力电子应用技术工程研究中心浙江杭州310027

在深入分析四开关逆变器运行原理的基础上,提出一种基于载波调制的三相四开关逆变器简化算法,无需扇区选择、三角函数运算等复杂计算过程,只需对参考电压进行简单的四则运算,即可获得四扇区统一的调制波表达式。采用所提出的调制策略,... 详细信息

在深入分析四开关逆变器运行原理的基础上,提出一种基于载波调制的三相四开关逆变器简化算法,无需扇区选择、三角函数运算等复杂计算过程,只需对参考电压进行简单的四则运算,即可获得四扇区统一的调制波表达式。采用所提出的调制策略,可对逆变器中性点电压波动进行补偿,有效抑制了输出电流畸变。同时,对2种不同零矢量合成方案进行比较,以电流纹波有效值作为评估标准,推导出其在时域中的解析表达形式,最终确定输出电流性能更优良的调制方式。实验结果验证了所提出的调制算法的正确性和有效性。

关键词：容错型四开关逆变器载波调制中性点电压波动补偿电流纹波零矢量合成逆变器

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多钒酸铵静态热分解制备粉状五氧化二钒

无机盐工业 2005年第8期37卷 20-22页

作者：曾志勇攀枝花学院生物与化学工程系四川攀枝花617000

分析了多钒酸铵(APV)热分解的动力学模型。在实验室条件下,通过APV静态热解制备了粉状五氧化二钒,研究了静态中温条件下氨的脱除、钒的价态变化,以及硫、硅、钾、钠等主要杂质在产物中的含量与温度及时间的关系。结果表明,较佳的反应条... 详细信息

分析了多钒酸铵(APV)热分解的动力学模型。在实验室条件下,通过APV静态热解制备了粉状五氧化二钒,研究了静态中温条件下氨的脱除、钒的价态变化,以及硫、硅、钾、钠等主要杂质在产物中的含量与温度及时间的关系。结果表明,较佳的反应条件为:分解温度(640±5)℃,时间30min,即可获得分析纯的产品。

关键词：多钒酸铵静态中温分解脱氨补充氧化