Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats

作     者：Zhiyong Zeng Guohua Jiang Tianqi Liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi Zhiyong Zeng;Guohua Jiang;Tianqi Liu;Gao Song;Yanfang Sun;Xueya Zhang;Yanting Jing;Mingjia Feng;Yufei Shi

作者机构：School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Institute of Smart Biomedical MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第4期

页      面：902-911页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 0817[工学-化学工程与技术] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0836[工学-生物工程] 0811[工学-控制科学与工程] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.51873194) the Natural Science Foundation of Zhejiang Province,China(No.LY18E030006) 

主　　题：Microneedles Metformin Transdermal delivery Biodegradable Gelatin Hypoglycemic effect 

摘      要：Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.