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Spatiotemporal expression of inducible nitric oxide synthase and cyclooxygenase 2 in the spinal cord during early stage sciatic nerve crush injury

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Neural Regeneration Research 2010年第10期5卷 747-751页

作者： Qiben Wang Linfeng Zheng Yinggui Xie Qinghong Huang He Huang zhicheng zeng Song Wu Department of Human Anatomy XiangNan University Chenzhou 423000 Hunan Province China Department of Radiology Shanghai First People's Hospital Medical College Shanghai Jiaotong University Shanghai 200080 China Department of Orthopaedics Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China Department of Human Anatomy and Neurobiology Xiangya School of Medicine Central South University Changsha 410013 Hunan Province China

BACKGROUND： Previous studies have shown that inducible nitric oxide synthase （iNOS） and cyclooxygenase 2 （COX-2） participate in inflammatory immune responses and neuropathic pain following peripheral nerve injury. However, few reports have addressed time-dependent expression of iNOS and COX-2 following peripheral nerve injury. OBJECTIVE： To investigate spatiotemporal expression of iNOS and COX-2 during early stage sciatic nerve crush injury.DESIGN, TIME AND SETTING： The randomized, controlled, animal experiment was performed at the Laboratory of Applied Anatomy, Department of Human Anatomy and Neurobiology, Central South University, China from September 2006 to September 2007.MATERIALS： Mouse anti-rat iNOS monoclonal antibody and goat anti-rat COX-2 monoclonal antibody （Transduction Laboratory, USA）, as well as biotinylated rabbit anti-mouse lgG and biotinylated rabbit anti-goat IgG （Santa Cruz Biotechnology, USA） were used in the present study.METHODS： A total of 48 healthy, adult, Sprague Dawley rats were randomly assigned to three groups. In the model group （n = 32）, crush injury to the right sciatic nerve was established using an artery clamp. The model group was further assigned to four subgroups according to survival time （6,12, 24, and 72 hours）, respectively （n = 8）. Sham surgery （n = 8） and normal control （n = 8） groups were also established.MAIN OUTCOME MEASURES： iNOS and COX-2 expression was detected in the L4-6 spinal cord with immunohistochemistry. Gray values of iNOS- and COX-2-postive cells in the anterior horn and posterior horn of spinal cord, as well as quantification of iNOS- and COX-2-positive cells in the anterior horn of spinal cord, were measured.RESULTS： iNOS and COX-2 expression gradually increased in the anterior horn and posterior horn of the spinal cord on the damaged side over time from 6 hours following sciatic nerve injury （P〈0.05） and peaked at 72 hours. Simultaneously, the number of iNOS- and COX-2-positive cells similarly increased in the anterior horn of spinal cord on the damag

关键词： inducible nitric oxide synthase cyclooxygenase 2 sciatic nerve spinal cord peripheral nerve injury neural regeneration

Alteration of P2X3 expression in dorsal root ganglia after sciatic nerve ligation

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Neural Regeneration Research 2007年第4期2卷 198-202页

作者： Guoxing Zhou Lesi Xie Qiben Wang Qingping Yu Xiaofu Liu Qiumei Liu Wei Peng zhicheng zeng Department of Morphology Hunan Traditional Chinese Medical College Zhuzhou 412012 Hunan Province China Department of Human Anatomy and Neurobiology Xiangya Medical College Central South University Changsha 410013 Hunan Province China Department of Human Anatomy Xiangnan College Chenzhou 423000 Hunan Province China

BACKGROUND： The expressions of P2X3 receptor in dorsal root ganglia （DRG） after different peripheral nerve injuries are diverse. It indicates the different roles of P2X3 in different models-caused neuropathologic pains. OBJECTIVE： To observe the expressions of P2X3 in corresponding DRG after sciatic nerve ligation in rots. DESIGN： Controlled observation experiment. SETTING： Department of Morphology, Hunan Traditional Chinese Medical College; Department of Human Anatomy and Neurobiology, Xiangya Medical College, Central South University. MATERIALS： Thirty-five healthy adult SD rots of clean grade an d either gender, weighing （ 200 ± 20 ） g, were involved. According to the random digits table, the involved rats were randomized into 3 groups： normal group （n =5）, sham-operated group （n =5） and experimental group （n =25）. The experimental group were subdivided into 3, 7, 14, 21, 28 days groups according to different surviving time after operation, 5 rots at each time point. Polyclonal rabbit anti-P2X3 antibody （ABCAM company）; biotinylated goat anti-rabbit IgG （Zhongshanjingqiao Biotechnical Co., Ltd., Beijing）; Motic fluorescence microscope （Motic, Germany）. METHODS： The experiments were carried out in the Department of Human Anatomy and Neurobiology, Xiangya Medical College, Central South University from June to December 2006. ① Rats of experimental group were created into models by ligation of right sciatic nerve according to the method of Seltzer et al. Left sciatic nerve was used as self-control. As for rats in the sham-operated group, ligation of sciatic nerve was omitted, but other procedures were the same as those in the experimental group. Rats of normal group were untouched, ② Rats of the normal group and sham-operated group survived for 14 days separately, and those of experimental group survived for corresponding time. After being deeply anesthetized by intraperitoneal injection of over-dose sodium pentobarbital, the rots of experimental group were transcardially perfused. L4- 6 corresponding DRG

关键词： sciatic nerve ligation ganglia neuralgia

Valorization of Camellia oleifera oil processing byproducts to value-added chemicals and biobased materials: A critical review

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Green Energy & Environment 2024年第1期9卷 28-53页

作者： Xudong Liu Yiying Wu Yang Gao zhicheng Jiang Zicheng Zhao Wenquan zeng Mingyu Xie Sisi Liu Rukuan Liu Yan Chao Suli Nie Aihua Zhang Changzhu Li Zhihong Xiao State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha410004China Key Laboratory of State Forestry and Grassland Administration on Utilization Science for Southern Woody Oil Resource Hunan Academy of ForestryChangsha410004China Hunan Provincial Key Laboratory of Oils and Fats Molecular Structure and Function Changsha410004China State Key Laboratory of Separation Membranes and Membrane Processes College of ChemistryTiangong UniversityTianjin300387China College of Biomass Science and Engineering Sichuan UniversityChengdu610065China College of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan411105China

The C.oleifera oil processing industry generates large amounts of solid wastes,including C.oleifera shell(COS)and C.oleifera cake(COC).Distinct from generally acknowledged lignocellulosic biomass(corn stover,bamboo,birch,etc.),Camellia wastes contain diverse bioactive substances in addition to the abundant lignocellulosic components,and thus,the bioreﬁnery utilization of C.oleifera processing byproducts involves complicated processing technologies.This reviewﬁrst summarizes various technologies for extracting and converting the main components in C.oleifera oil processing byproducts into value-added chemicals and biobased materials,as well as their potential applications.Microwave,ultrasound,and Soxhlet extractions are compared for the extraction of functional bioactive components(tannin,ﬂavonoid,saponin,etc.),while solvothermal conversion and pyrolysis are discussed for the conversion of lignocellulosic components into value-added chemicals.The application areas of these chemicals according to their properties are introduced in detail,including utilizing antioxidant and anti-in-ﬂammatory properties of the bioactive substances for the speciﬁc application,as well as drop-in chemicals for the substitution of unrenewable fossil fuel-derived products.In addition to chemical production,biochar fabricated from COS and its applications in theﬁelds of adsorption,supercapacitor,soil remediation and wood composites are comprehensively reviewed and discussed.Finally,based on the compositions and structural characteristics of C.oleifera byproducts,the development of full-component valorization strategies and the expansion of the appli-cationﬁelds are proposed.

关键词： Camellia oleifera shell Camellia oleifera cake Value-added chemicals Bioactive components Biobased materials

构建生命共同体:“两个和解”思想的当代生动实践

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江汉大学学报（社会科学版） 2022年第3期39卷 54-65,125,126页

作者：曾志诚商丘师范学院马克思主义学院河南商丘476000

马克思恩格斯的“两个和解”思想是关于人类本身、人与自然之间和解关系建构及至实现和谐共生发展的科学指南。新时代构建生命共同体的发展理念是对“两个和解”思想的继承与发展,是对“人与自然和谐共生”的具体坚持,是对“生态环境与... 详细信息

马克思恩格斯的“两个和解”思想是关于人类本身、人与自然之间和解关系建构及至实现和谐共生发展的科学指南。新时代构建生命共同体的发展理念是对“两个和解”思想的继承与发展,是对“人与自然和谐共生”的具体坚持,是对“生态环境与生产力发展”辩证关系的科学诠释,是推动全球生态治理和建设全球生态文明的中国方案。以构建生命共同体为视角深化“两个和解”思想的研究,对于在全球化背景下发展具有中国特色和世界意义的命运共同体建设具有重要的战略意蕴。

关键词： “两个和解”思想构建生命共同体和谐共生

基于预测恒定车头时距策略的自适应巡航控制研究

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汽车工程学报 2023年第5期13卷 695-704页

作者：周春国曾志成毛锦西安理工大学机械与精密仪器工程学院西安710048

为了进一步提高车辆跟车过程中的跟踪性、安全性、舒适性和燃油经济性,针对已有间距策略表现过于保守或反应过于激烈等不足之处,提出了一种预测恒定车头时距策略。该策略考虑了相对加速度,建立了一种预测型期望车间距模型,进而应用于模... 详细信息

为了进一步提高车辆跟车过程中的跟踪性、安全性、舒适性和燃油经济性,针对已有间距策略表现过于保守或反应过于激烈等不足之处,提出了一种预测恒定车头时距策略。该策略考虑了相对加速度,建立了一种预测型期望车间距模型,进而应用于模型预测控制的多目标自适应巡航控制系统中,能进一步提高模型预测控制对多个控制目标的综合协调能力。搭建上层控制器、下层PID控制器、油门制动切换、逆纵向动力学模型。在多工况下仿真,通过建立性能评判指标对多目标进行量化分析。结果表明,所提出的间距策略在保证安全性的前提下,提升了自适应巡航控制系统的综合性能。在不同驾驶风格的车头时距下,跟踪性、舒适性和燃油经济性均有良好表现。

关键词：间距策略模型预测控制多目标自适应巡航控制驾驶员风格

新颖性寻求对创造性行为表现的影响:语义网络的中介作用

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心理科学 2022年第5期45卷 1037-1044页

作者：曾芷橙陈雪梅刘英芝梁正赵庆柏于全磊华中师范大学心理学院武汉430079

研究采用物品多用途任务、中文复合远距离联想任务和汉语双字词词对相关性判断任务,考察新颖性寻求特质水平对创造性表现的影响,探明语义网络在其中的作用。结果发现:高新颖性寻求个体在物品多用途任务中有更高的新颖性得分,而在中文复... 详细信息

研究采用物品多用途任务、中文复合远距离联想任务和汉语双字词词对相关性判断任务,考察新颖性寻求特质水平对创造性表现的影响,探明语义网络在其中的作用。结果发现:高新颖性寻求个体在物品多用途任务中有更高的新颖性得分,而在中文复合远距离联想任务中与低新颖性寻求个体表现一致;在低相关词对判断时,高新颖性寻求个体反应时更短;低相关词对的判断反应时在新颖性寻求对创造性行为表现的影响中起部分中介作用。结果预示,新颖性寻求特质有利于个体建构形成能快速激活远距离信息的语义网络,进而促进创造性行为表现。

关键词：新颖性寻求语义网络创造性行为表现语义激活速度

考虑交叉饱和效应的变角度方波电压注入永磁同步电机无位置传感器控制

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电工技术学报 2020年第22期35卷 4678-4687页

作者：吴春陈科南余荣魏春曾志成浙江工业大学信息工程学院杭州310023 杭州士兰微电子股份有限公司杭州310012

针对常规估计d轴方波电压注入位置估计方法,受磁场交叉饱和效应影响而导致转子位置估计误差的问题,提出一种考虑磁场交叉饱和效应补偿的变角度方波电压注入永磁同步电机(PMSM)无位置传感器控制策略。该方法首先定义注入电压同步旋转坐标... 详细信息

针对常规估计d轴方波电压注入位置估计方法,受磁场交叉饱和效应影响而导致转子位置估计误差的问题,提出一种考虑磁场交叉饱和效应补偿的变角度方波电压注入永磁同步电机(PMSM)无位置传感器控制策略。该方法首先定义注入电压同步旋转坐标系fg,并在f轴上注入方波电压。f轴与估计d轴之间夹角即为注入角,且该注入角随着磁场交叉饱和效应不同而实时改变。再计算g轴差分电流并用于位置估计,由于方波电压注入角的改变,g轴差分电流中将不再包含交叉饱和效应相关信息,从而可实现准确的位置估计。最后将该文所提变角度方波注入方法与常规估计d轴方波电压注入方法进行实验对比,实验结果表明,所提方法在不同负载转矩、不同转速等工况下,位置估计误差始终维持在零附近,动态响应快,且方便实现。

关键词：永磁同步电机方波电压注入磁场交叉饱和效应无位置传感器控制

中药汤剂口服联合玻璃体内注射曲安奈德治疗非增生性糖尿病视网膜病变弥漫性黄斑水肿30例临床观察

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中医杂志 2015年第11期56卷 937-940页

作者：曾志成彭清华桂阳县第一人民医院湖南中医药大学第一附属医院

目的观察益气养阴、活血利水中药汤剂口服联合曲安奈德玻璃体内注射治疗非增生性糖尿病视网膜病变弥漫性黄斑水肿的疗效及安全性。方法将60例(92眼)非增生性糖尿病视网膜病变弥漫性黄斑水肿患者随机分为治疗组(30例,47眼)和对照组(30例... 详细信息

目的观察益气养阴、活血利水中药汤剂口服联合曲安奈德玻璃体内注射治疗非增生性糖尿病视网膜病变弥漫性黄斑水肿的疗效及安全性。方法将60例(92眼)非增生性糖尿病视网膜病变弥漫性黄斑水肿患者随机分为治疗组(30例,47眼)和对照组(30例,45眼)。两组患者于治疗第1天均行患眼玻璃体内注射曲安奈德4 mg。治疗组同时予以益气养阴活血利水中药汤剂口服,每日1剂,服药3个月。观察治疗前和注射后3、6个月患眼视力、视网膜厚度及黄斑区渗漏情况。注射后第1、3、7天及3、6个月分别测量眼压、眼前节、眼后节。结果注射后3、6个月,治疗组临床疗效有效率分别为89.36%和87.23%,对照组分别为73.33%和62.22%,治疗组临床有效率优于对照组(P<0.05或P<0.01)。治疗组注射后3、6个月视力、视网膜厚度均较治疗前显著改善,且显著优于对照组(P<0.05或P<0.01)。治疗组未见明显不良反应,对照组1例患者6个月时发现晶状体后囊下呈锅底样混浊,严重影响视力。结论益气养阴、活血利水中药汤剂口服联合玻璃体内注射曲安奈德治疗非增生性糖尿病视网膜病变弥漫性黄斑水肿,能够明显提高患者的视功能,减轻视网膜水肿和黄斑区渗漏,疗效稳定,安全性良好。

关键词：糖尿病视网膜病变弥漫性黄斑水肿益气养阴活血利水曲安奈德玻璃体内注射

面向自智光网络的数字孪生技术研究及示范应用

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信息通信技术与政策 2023年第10期49卷 54-61页

作者：匡立伟曾至诚韵湘邹菲烽火通信科技股份有限公司武汉430074 武汉邮电科学研究院武汉430073

信息通信技术处于加速融合、系统创新和智能引领的重大变革期,基于数字孪生技术构建具备自配置、自优化、自修复能力的自智光网络,实现光网络规划、建设、维护、优化、运营全生命周期智能化、自动化已经成为研究热点。全面分析数字孪生... 详细信息

信息通信技术处于加速融合、系统创新和智能引领的重大变革期,基于数字孪生技术构建具备自配置、自优化、自修复能力的自智光网络,实现光网络规划、建设、维护、优化、运营全生命周期智能化、自动化已经成为研究热点。全面分析数字孪生技术国内外研究现状,提出新型自智光通信网络体系架构,设计基于高维空间的光网数据量化表示模型,构建完备的数字孪生仿真建模运算集合,并针对当前光网络运维挑战梳理出三类数字孪生应用场景;利用光网传输质量评估和自动优化案例阐述数字孪生技术的应用效果,并对数字孪生技术进行总结与展望。

关键词：光传送网络智慧光网络数字孪生仿真建模