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N-Heterocyclic carbene-catalyzed enantioselective(dynamic) kinetic resolutions and desymmetrizations

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Science China Chemistry 2024年第2期67卷 482-511页

作者： Yi Zhang Hui Cai Xiuhai Gan zhichao jin National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang550025China

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions,dynamic kinetic resolutions,and desymmetrization reactions are systematically *** content is organized according to the activation modes involved i... 详细信息

关键词： N-heterocyclic carbene kinetic resolution dynamic kinetic resolution desymmetrization organocatalysis

Carbene-catalyzed activation of cyclopropylcarbaldehydes for mannich reaction andδ-lactam formation:remote enantioselecitvity control and dynamic kinetic asymmetric transformation

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Science China Chemistry 2021年第6期64卷 985-990页

作者： Jie Lv Jun Xu Xuling Pan zhichao jin Yonggui Robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

An N-heterocyclic carbene(NHC)-catalyzed enantioselective Mannich reaction of the remoteγ-carbon of cyclopropylcarbaldehydes is disclosed for the first ***-and enantiomerically enriched multicyclicδ-lactam compound is afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asymmetric transformation(DYKAT)*** chiral functional molecules can be afforded from the lactam products through simple protocols with retentions of the optical purities.

关键词： N-heterocyclic carbene organocatalysis dynamic kinetic asymmetric transformation 1-cyclopropylcarbaldehydes asymmetric reactions

N-Heterocyclic Carbene Organocatalysis: Activation Modes and Typical Reactive Intermediates

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Chinese Journal of Chemistry 2020年第10期38卷 1167-1202页

作者： Xingkuan Chen Hongling Wang zhichao jin Yonggui Robin Chi Department of Chemistry Jinan UniversityGuangzhouGuangdong 510632China Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinisry of EducationGuizhou UniversityHuaxi DistrictGuiyangGuizhou 550025China Division of Chemistry&Biological Chemistr School of Physical&Mathematical SciencesNanyang Technological UniversitySingopore 637371Singapore

N-Heterocyclic carbene(NHC)organocatalysis has been developed as an important approach in modern organic *** activation modes within NHC organocatalysis have been established with countless transformations being realized in both efficient and selective *** would like to provide an overview on the key progresses achieved within this field in the past two *** numerous excellent reviews have been documented within this area,we will mainly focus on the scientific development of this research field based on the basic reaction modes and typical reaction intermediates.

关键词： synthesis. catalysis Heterocyclic

Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

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Research 2024年第3期2024卷 715-721页

作者： Yuanlin Cai Ya Lv Liangzhen Shu zhichao jin Yonggui Robin Chi Tingting Li National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore.

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

关键词： chemistry aldehydes chiral

N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones

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Chinese Chemical Letters 2023年第1期34卷 357-361页

作者： Jie Lv Yingling Nong Kai Chen Qingyun Wang Jiamiao jin Tingting Li zhichao jin Yonggui Robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of EducationGuizhou UniversityGuiyang 550025China

An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone ***β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild *** reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.

关键词： N-Heterocyclic carbene Organocatalysis C-Acylation reaction Animoenone synthesis

Research progress on the synthesis of phenylurea derived plant growth regulators

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Advanced Agrochem

Advanced Agrochem 2024年第2期3卷 143-150页

作者： Dongmei Chen Tianhui Liao Wenjun Ye zhichao jin Shichao Ren National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang550025China

Plant growth regulators(PGRs)are chemical substances that imitate the functions of phytohormones to enhance the crop yield and the harvest ***-derived plant growth regulators are known for their excellent efﬁcacy in promoting fruit growth,particularly in kiwifruit,grapes,and *** derivatives represent one class of the highly efﬁcient and versatile ***ﬁcally,forchlorfenuron(CPPU,N-(2-chloro-4-pyridinyl)-N0-phenylurea)exhibits similar growth-regulating efﬁcacy to cytokinins and has a signiﬁcant impact on the plant growth and the crop *** a result,there is growing interest in exploring the incorporation of various phenylurea moieties into agrochemicals to enhance their regulatory properties on *** review aims to provide a comprehensive overview on representative synthetic approaches for phenylurea derived ***,we provide our perspective on the future development in this active researchﬁeld.

关键词： Plant growth regulators Synthesis Phenylurea derivatives Cytokinin

Asymmetric construction of axial and planar chirality with N-heterocyclic carbene(NHC) organocatalysis

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Science China Chemistry 2024年

作者： Meng Zhang Xiaoqun Yang Xiaolin Peng Xiangyang Li zhichao jin State Key Laboratory of Green Pesticide Guizhou University

N-heterocyclic carbene(NHC) organocatalytic reactions that have been developed for asymmetric construction of axial and planar chirality are systematically summarized and discussed in this review. The challenges and limitations inherent to this highly reactive research field are highlighted towards the end of the review. Additionally, based on our understanding of the current advancements in NHC organocatalysis, we propose potential future directions for further exploration.

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医学研究中的系统综述与meta分析

上海预防医学 2023年第7期35卷 724-727页

作者：金志超海军军医大学军队卫生统计学教研室上海200433

为方便广大医学科研人员开展系统综述和meta分析,以教程性质的综述文体对系统综述和meta分析的相关概念、具体步骤和相关要点进行梳理,特别是对文献检索、研究风险偏倚评价、效应量的选择、效应量合并以及发表偏倚的检验和校正等问题进... 详细信息

为方便广大医学科研人员开展系统综述和meta分析,以教程性质的综述文体对系统综述和meta分析的相关概念、具体步骤和相关要点进行梳理,特别是对文献检索、研究风险偏倚评价、效应量的选择、效应量合并以及发表偏倚的检验和校正等问题进行详细说明,并对方法的实现提供了软件和文献的参考,最后对论文的撰写要求进行简要的介绍。

关键词：医学研究系统综述 meta分析研究流程统计方法

Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2252-2267页

作者： Shuzhen Chen Yaping Dong Xinming Qi Qiqi Cao Tao Luo Zhaofang Bai Huisi He Zhecai Fan Lingyan Xu Guozhen Xing Chunyu Wang zhichao jin Zhixuan Li Lei Chen Yishan Zhong Jiao Wang Jia Ge Xiaohe Xiao Xiuwu Bian Wen Wen jin Ren Hongyang Wang National Center for Liver Cancer Second Military Medical UniversityShanghai 200438China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Center for Drug Safety Evaluation and Research State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Fudan University Shanghai Cancer Center Shanghai 200032China The Graduate School of Fujian Medical University Fuzhou 350122China Institute of Pathology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Key Laboratory of Tumor Immunopathology Ministry of Education of ChinaChongqing 400038China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Health Statistics Faculty of Medical ServiceSecond Military Medical UniversityShanghai 200438China

Aristolochic acids(AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I(AAI) reacts with DNA to form covalent aristolactam(AL)-DNA adducts,leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether AAs exposure was the main cause of liver cancer in the context of HBV infection in China's Mainland. Totally 1256 liver cancer samples were randomly retrieved from 3 medical centers and a refined bioanalytical method was used to detect AAI-DNA adducts. 5.10% of these samples could be identified as AAI positive exposure. Whole genome sequencing suggested 8.41% of 107 liver cancer patients exhibited the dominant AA mutational signature, indicating a relatively low overall AAI exposure rate. In animal models, long-term administration of AAI barely increased liver tumorigenesis in adult mice, opposite from its tumor-inducing role when subjected to infant mice. Furthermore, AAI induced dose-dependent accumulation of AA-DNA adduct in target organs in adult mice, with the most detected in kidney instead of liver. Taken together, our data indicate that AA exposure was not the major threat of liver cancer in adulthood.

关键词： Aristolochic acids(AAs) Mutational signature AA-DNA adduct Hepatocellular carcinoma(HCC) Liver tumorigenesis Hepatitis B virus(HBV) Risk factors Tumor prevention