N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones

作     者：Jie Lv Yingling Nong Kai Chen Qingyun Wang Jiamiao Jin Tingting Li Zhichao Jin Yonggui Robin Chi Jie Lv;Yingling Nong;Kai Chen;Qingyun Wang;Jiamiao Jin;Tingting Li;Zhichao Jin;Yonggui Robin Chi

作者机构：State Key Laboratory Breeding Base of Green Pesticide and Agricultural BioengineeringKey Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of EducationGuizhou UniversityGuiyang 550025China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第1期

页      面：357-361页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support from the National Natural Science Foundation of China(Nos.21772029,32172459,21961006,22001173) The 10 Talent Plan(Shicengci)of Guizhou Province(No.5649) the Science and Technology Department of Guizhou Province(Nos.1020,Qiankehejichu-ZKKey033) the Program of Introducing Talents of Discipline to Universities of China(111 Program,No.D20023)at Guizhou University Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[No.Qianjiaohe KY(2020)004] the Guizhou Province First-Class Disciplines Project(No.GNYL(2017)008) Guizhou University(China) 

主　　题：N-Heterocyclic carbene Organocatalysis C-Acylation reaction Animoenone synthesis 

摘      要：An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone ***β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild *** reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.