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Ectopic pregnancy and failed oocyte retrieval during in vitro fertilization stimulation:Two case reports

World Journal of Clinical Cases 2022年第28期10卷 10310-10316页

作者： Wen-Jie Zhou Bu-Fang Xu zhi-hong niu Department of Obstetrics and Gynecology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

BACKGROUND Due to a slight rise in beta-human chorionic(β-h CG)levels that are undetectable,and vaginal bleeding that is similar to regular menstruation,ectopic pregnancy(EP)that occurs during the expected menstrual cycle prior to ovulation induction as part of in vitro fertilization(IVF)is likely to be *** present two cases of unexpected EP and emphasize the importance of theβ-h CG assay when an unexplained increase in progesterone is present prior to the triggering of ovulation during controlled ovarian stimulation(COS).CASE SUMMARY A 26-year-old woman with primary infertility and a 31-year-old woman with secondary *** patients sought IVF treatment due to fallopian tube obstruction and underwent COS using the gonadotropin-releasing-hormone(Gn RH)-antagonist *** the late stage of COS,progesterone levels in both patients significantly increased,and luteinizing hormone levels decreased,followed by oocyte retrieval failure.A right salpingectomy was performed and tubal ectopic pregnancy was diagnosed by pathology in the first patient,and the second patients was diagnosed with a suspected EP abortion because herβ-h CG levels declined to 12.5 m IU/m *** full recovery for 2 mo,the first patient entered a new IVF treatment cycle with a Gn RH-antagonist regimen and successfully achieved eight oocytes and three viable *** 6 mo,the second patient received another COS treatment with a progestin-primed ovarian stimulation protocol and successfully achieved nine oocytes and five viable ***β-h CG levels in the initial and midterm phases of COS must be considered in patients with unusual hormone dynamics.

关键词： Infertility Ectopic pregnancy In vitro fertilization Ovarian induction Case report

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Microstructural adjustments and mechanical properties of a cold-rolled biomedical near β-Ti alloy sheet

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Rare Metals 2018年第10期37卷 846-851页

作者： Xi-Qun Ma hong-zhi niu Zhen-Tao Yu Sen Yu Chang Wang Northwest Institute for Nonferrous Metal Research Xi'an 710016 China School of Materials Science and Engineering Northeastern University Shenyang 110819 China

In this study, microstructural adjustments and mechanical properties of a cold-rolled near β-type alloy Ti-25Nb-3Zr-3Mo-2Sn （wt%） sheet were investigated. Microstructures and phase transformation products strongly depended on aging temperatures. Solution treatments within single β-phase field removed the stress-induced at martensites and produced a few new lath-shaped ones, but metastable β phase still dominated. This is exactly the reason why current alloy exhibits the lowest modulus （54 GPa） and best elongation to fracture （39 %）, but the worst yield strength of only 340 MPa, at solutiontreated state. A fairly large number of ellipsoidal ω phase nanoparticles precipitated throughout parent β phase during aging at 380℃. These ω nanoparticles possess remarkable strengthening effect, but deteriorate ductility seriously. A novel post-aging process was proposed to remove brittle ω phase. By contrast, aging at 450 ℃ resulted in sufficient precipitation of fine needle-like α phase. This brought about the best combination of high yield strength （770 MPa） and moderate elastic modulus （75 GPa） and good elongation （15 %） for biomedical implants.

关键词： Near β-Ti alloy Microstructures Phase transformation Mechanical properties

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Sperm DNA fragmentation in Chinese couples with unexplained recurrent pregnancy loss

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Asian Journal of Andrology 2020年第3期22卷 296-301页

作者： Xiao-Bin Zhu Qian Chen Wei-Min Fan zhi-hong niu Bu-Fang Xu Ai-Jun Zhang Reproductive Medical Center of Ruijin Hospital Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China

We aimed to study the association between sperm DNA fragmentation and recurrent pregnancy loss(RPL)in the Chinese population via a retrospective observational study of Chinese couples who had experienced RPL between May 2013 and August *** study population included 461 men from couples with RPL and 411 men from a control group(couples with clinical pregnancy via in v/tro fertiIization owing to female causes).Routine semen analysis,sperm chromatin analysis,and microscopic(high-power)morphological analysis were performed using semen *** samples were assessed for volume,sperm count,and *** sperm DNA fragmentation index(DFI)was calculated,and the median DFI was *** were categorized as having normal(37.8%;DFI<15.0%),moderate(33.6%;15.0%

关键词： DNA fragmentation index recurrent pregnancy loss sperm chromatin structure assay

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Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF

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Asian Journal of Andrology 2011年第6期13卷 862-866页

作者： zhi-hong niu Hui-Juan Shi Hui-Qin Zhang Ai-Jun Zhang Yi-Juan Sun Yun Feng IVF Unit Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Shanghai Institute of Planned Parenthood Research Shanghai 200032 China

The aim of this study was to investigate whether the sperm chromatin structure assay （SCSA） results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitrofertilization （IVF）. A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index （DFI） subgroups and high DNA stainability （HDS） subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF.

关键词： embryo fertilization in-vitro fertilization sperm chromatin structure assay

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Value of Evaluating Ovarian Response According to Basal FSH/LH Ratio

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Journal of Reproduction and Contraception 2006年第1期17卷 29-34页

作者： zhi-hong niu Lan XIA Yao WANG Reproductive Center of Shanghai RuiJin Hospital Shanghai Jiaotong University Shanghai 200025 China

Objective To analyze the value of evaluating ovarian response to gonadotrophin stimulation according to patients basal FSH / LH ratio. Methods A total of 134 patients undergoing IVF-ET or ICSI were enrolled using short protocol. We studied their age, basal FSH, bFSH/LH ratio and some indexes which can represent ovarian response. Statistical evaluation was performed using logistic regression analysis and ROC curve to determine odds ratios（OR） and FSH/LH cutoffs. Results Among the patients whose bFSH were less than 8 IU/L, three odds ratios between the ovarian response index and their age, bFSH, bFSH/LH were no significant difference and bFSH/LH cutoff was 3.7. But among the patients those bFSH ≥ 8 IU/L, there were differences among the three OR and bFSH/LH cutoff was 3.3. The highest OR was between bFSH/LH ratio and ovarian response indexes, while the lowest was between bFSH and those indexes . Conclusions Among the patients who has lower ovary reserve （bFSH ≥8 IU/L）, the ratio of bFSH/LH has superior value to age and basal FSH on evaluating ovarian response.

关键词： FSH LH ovary response

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An Impact of Suspected Peritubal Adhesions by Hysterosalpingography on Outcomes of Intrauterine Insemination

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Journal of Reproduction and Contraception 2013年第3期24卷 173-180页

作者： Dan-dan WU zhi-hong niu Ai-jun ZHANG Rui-huan GU Yun FENG Center of Reproductive Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Objective To assess the fertility prospect of women with suspected peritubal adhesions diagnosed by hysterosalpingography （HSG） treated with intrauterine insemination （IUI）. Methods The study group consisted of 93 patients diagnosed as bilateral suspected peritubal adhesions by HSG, and 175 patients with no tubal pathology were classified as control group. A total of 496 cycles of lUI were finished in 268 infertile women. Results There were no differences in basic clinical parameters between the two groups. Cumulative pregnancy rates after two cycles of lUI were 19.4%for the study group, and 34.3%for the control. Cumulative pregnancy rate in the women with abnormal contrast media loculation was significantly lower than that in women of the control （7.4% vs 34.3%, P=0.037）. The cumulative pregnancy rates were similar between the women with abnormal tubal contour and the normal ones （36. 7% vs 34.3%, P=0.800）. Conclusion Suspected peritubal adhesions in HSG were worthy more attention, since the outcome of lUI in women with loculation of contrast material, combined with or without abnormal tubal contour resulted in a significantly lower pregnancy rate than the normal ones. IUI should be delayed before tubal patency was confirmed during these patients.

关键词： hysterosalpingography peritubal adhesion ovulation induction intrauterine insemination

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In-vitro Developmental Potential of Single Blastomeres Derived from Day 3 Discarded Human Embryos

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Journal of Reproduction and Contraception 2010年第1期21卷 1-8页

作者： Dong-mei JI Yi-juan SUN Ai-jun ZHANG Xiao-wei LU zhi-hong niu Yun FENG Reproductive Medical Center Ruijin Hospital Shanghai Jiao Tong University of Medicine Shanghai 200025 China

Objective To investigate whether isolated blastomeres of discarded human embryos could develop into blastocysts cultured in vitro without zona pellucida. Methods Total discarded 60 embryos, which were not suitable for transplanting or freezing, were collected from 21 patients. Of 60 embryos, 10, 8, 24, 12, and 4 embryos were at 2-, 3-, 4-, 5- and 6-cell stage, respectively. These embryos were split by 0.5% protease combined with mechanical method. The resulting single blastomere was cultured individually, evaluated daily and counted blastocyst development. Pluripotency of inner cell mass （ICM） of the blastocyst was analyzed by the expression of alkaline phosphatase（AKP）. Results A total of 229 single blastomeres were isolated from 60 embryos. Defining the day when the embryos were split as the first day （d 1）. The majority of the blastomere- derived embryos followed the normal pattern of development with compaction on d 3 and cavitationon d 4 and developed into small blastocysts on d 5. Rates of division, compaction, cavity and expansion of single blastomeres from 4-cell embryos were higher than those in other groups （P 〈O.05）, and AKP was expressed in ICM. Conclusion Some of the blastomeres from discarded human embryo are flexible and able to develop into blastocysts, the potential was related to their donor embryos closely. They seem to follow development pattern of their donor embryos. The blastomere- derived blastocysts have smaller size and fewer cells compared with regular in vitro cultured human embryos. However, AKP expression showed ICM cells with pluripotency. We believe that the value of single blastomere of discarded embryos will be further confirmed in the future.

关键词： discarded embryo single blastomere in-vitro development

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A THEORY OF C-Si SEGREGATION IN Fe-C-Si ALLOYS(Ⅰ)

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Chinese Science Bulletin 1989年第2期34卷 100-105页

作者：刘志林牛洪军金灿风王斌 Jilin University of Technology Changckun Central Iron and Steel Resenrch Institute Beijing

Ⅰ. HYPOTHESES OF C-Si SEGREGATIONAccording to the inhomogeneous theory of solid solution, the distribution of solute atoms would be in the state of a short range order if the bond between atoms (AB) of different kinds is stronger than that between atoms (AA) or (BB) of the same kind. This leads to the hypotheses about Fe-C-Si austenite as follows:

关键词： segresation Fe-C-Si alloy bainite bainitic ferrite residual austenite.

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种植窗期宫腔液单核细胞趋化蛋白(MCP)-1预测冻融胚胎移植妊娠结局

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生殖与避孕 2015年第3期35卷 154-158,171页

作者：叶瑶牛志宏谷瑞环冯云上海交通大学医学院附属瑞金医院生殖医学中心上海200025

目的:探讨体外受精-冻融胚胎移植(IVF-FET)周期种植窗期宫腔液和血清生物因子表达谱与胚胎植入的关系。方法:收集87例患者行FET前的血清及宫腔液,根据妊娠结局分为妊娠组和非妊娠组,分析患者血清和宫腔液中27种调节因子的表达谱。结果:... 详细信息

目的:探讨体外受精-冻融胚胎移植(IVF-FET)周期种植窗期宫腔液和血清生物因子表达谱与胚胎植入的关系。方法:收集87例患者行FET前的血清及宫腔液,根据妊娠结局分为妊娠组和非妊娠组,分析患者血清和宫腔液中27种调节因子的表达谱。结果:宫腔液中妊娠组单核细胞趋化蛋白-1(MCP-1)表达水平低于非妊娠组(11.67±23.68 ng/L vs 17.02±33.67 ng/L),差异有统计学意义(P0.05)。结论:种植窗期宫腔液MCP-1可预测FET妊娠结局,且其表达水平与妊娠结局呈负相关。

关键词：体外受精-胚胎移植(IVF-ET) 冻融胚胎移植(FET) 反复种植失败(RIF) 临床妊娠率

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子宫内膜轻创对着床相关因子及IVF妊娠结局影响的研究

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生殖与避孕 2007年第7期27卷 454-462页

作者：王瑶冯云牛志宏黄晓燕张爱军上海交通大学医学院附属瑞金医院妇产科生殖医学中心上海200025

目的:探讨子宫内膜轻创术对提高子宫内膜容受性的价值及分子机理。方法:对120例不孕症患者行IVF140周期,随机分为行子宫内膜搔刮轻创术组60例(A组)及对照组60例(B组),采用内膜微活检的方法,在扫描电镜下观察胞饮突,免疫组化定位及半定... 详细信息

目的:探讨子宫内膜轻创术对提高子宫内膜容受性的价值及分子机理。方法:对120例不孕症患者行IVF140周期,随机分为行子宫内膜搔刮轻创术组60例(A组)及对照组60例(B组),采用内膜微活检的方法,在扫描电镜下观察胞饮突,免疫组化定位及半定量检测白血病抑制因子(LIF)、骨桥蛋白(OPN)。再将对照组未孕患者中的20例行轻创术(B2组),重复IVF,并进行相关因子测定。结果:A组和B组相关因子分别为:胞饮突丰富占63.33%和36.67%、LIF6.07±1.33和4.94±2.26、OPN6.36±1.49和5.28±2.06、单胚种植率27.8%和14.3%,组间比较差异均有统计学意义(P<0.05)。B2组行轻创术前后比,分别为:胞饮突丰富10%vs50%,LIF4.50±0.82vs6.33±1.25,OPN5.06±0.98vs6.83±1.46,轻创术前后差异均有统计学意义(P<0.05)。按妊娠与否分组后,妊娠组(n=62)与非妊娠组(n=78)相关因子分别为:胞饮突丰富54.84%和25.64%,LIF6.94±1.03和4.24±1.84,OPN7.31±0.85和4.52±1.65,差异有统计学意义(P<0.05),且LIF与OPN间呈正相关。结论:胞饮突、LIF、OPN是子宫内膜着床期重要的相关因子,它们的高表达与子宫内膜容受性紧密相关。而轻创术可增强3者的表达,从而提高胚胎种植率,改善IVF妊娠结局。

关键词：轻创术胞饮突(pinopode) 白血病抑制因子(LIF) 骨桥蛋白(OPN) 妊娠结局

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