检索结果-南通市图书馆

Screening and immune infiltration analysis of ferroptosis-related genes in pancreatic cancer with predictions for traditional Chinese medicine treatments

引用

Natural Therapy Advances 2024年第3期7卷 1-13页

作者： Meng-Ru Yang Ying Zhang Jing-Bai Li Xin-Ru Shen Zi-Yue Pi zhi-dong liu School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Tianjin University of Traditional Chinese MedicineTianjin 301617China

Background:This study aims to explore the involvement of ferroptosis-related genes and pathogenesis in pancreatic cancer and predict potential therapeutic interventions using Traditional Chinese Medicine(TCM).Methods:We utilized gene expression datasets,ferroptosis upregulated genes and applied machine learning algorithms,including LASSO and SVM-RFE,to identify key ferroptosis-related genes in pancreatic *** Gene Ontology,Kyoto Encyclopedia of Genes and Genomes,and Disease Ontology enrichment analysis,immune infiltration analysis and correlation analysis between immune infiltrating cells and characteristic genes on differentially expressed genes using the R software *** potential traditional Chinese medicine for targeted ferroptosis gene therapy for pancreatic cancer through Coremine and Herb ***:Seventeen feature genes were identified,with significant implications for immune cell infiltration in pancreatic *** results of immune cell infiltration analysis showed that B cells naive,B cells memory,T cells regulatory,and M0 macrophages were significantly upregulated in pancreatic cancer patients;Mast cells resting were significantly *** herbal medicines such as ginkgo,turmeric,ginseng,Codonopsis pilosula,Zedoary turmeric,deer tendons,senna leaves,Guanmu Tong,Huangqi,and Banzhilian are potential drugs for targeted ferroptosis gene therapy for pancreatic ***:TIMP1 emerged as a key gene,with several TCM herbs predicted to modulate its expression,offering new avenues for treatment.

关键词： pancreatic cancer ferroptosis immune infiltration bioinformatics traditional Chinese medicine prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1-[2-(2-Methoxyphenylthio) benzyl]-4-arylpiperazines derivatives:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

引用

Chinese Chemical Letters 2008年第1期19卷 37-39页

作者： Xin Wang dong zhi liu Ai Jun Li School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Pharmaceutical Science and technology Tianjin University Tianjin 300072 China

A series of 1-[2-（2-methoxyphenylthio） benzyl]-4-arylpiperazines derivatives was designed and synthesized based on 5-HT1A/ SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/5-HTT activities. 2007 Ai Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Antidepressants 5-HT1A/5-HTT Serotonin transporter 5-HT1A receptor Diphenylsulfide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

引用

Chinese Chemical Letters 2008年第1期19卷 40-42页

作者： Xin Wang dong zhi liu Ai Jun Li School of Chemical Engineering and Technology Ttanjin University 7ianjin 300072 China School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China

A series of 1-（N-（2-（2-methoxyphenylthio）benzyl）-N-methylamino-3-aryloxypropan-2-ols derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/ 5-HTT activities. 2007 Ai Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： 5-HT1A/SSRI Serotonin transporter 5-HT1A receptor Diphenylsulfide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Facile Synthesis of Five-membered Phosphoroheterocycles Bearing N-P-N and S-P-N Moieties

引用

Chinese Chemical Letters 2001年第12期12卷 1065-1068页

作者： Sheng Lou DENG dong zhi liu Ru Yu CHEN School of Chemical Engineering Tianjin UniversityTianjin 300072 Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

New reactions of Lawesson reagent (LR) with alpha -hydroxy (amino)nitriles have been studied. The experimental results showed that the five-membered phosphoroheterocycles 2 and 4 bearing N-P-N or S-P-N moiety could be... 详细信息

关键词： new reactions Lawesson reagent nitriles phosphoroheterocycle mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of Slow Light Periodic Signals Considering the Distortion in EDF

引用

Chinese Physics Letters 2014年第3期31卷 82-85页

作者： WANG WU Chong-Qing WANG zhi liu Guo-dong liu Lan-Lan SUN Zhen-Chao Institute of Optical Information and Key Lab of Luminescence and Optical Information Technology Beijing Jiaotong University Beijing 100044

Based on the fundamental harmonic phase delay, a new definition of fundamental harmonic fractional delay （FHFD） is proposed to evaluate slow light with the consideration of signal distortion, to eliminate the dependence on the choice of the reference point. By solving the rate equation of erbium-doped fiber （EDF）, it is shown that the slow light always accompanies the signal distortion when the periodic signal propagates in EDF, and FHFD depends on the signal distortion, as well as the average input power, the modulation depth and the length of EDF. The results of simulations and experiments indicate that the definition of FHFD is reasonable and effective to evaluate the slow light of periodic signals.

关键词： FIBERS RESEARCH SEMICONDUCTOR doping ERBIUM SLOW light PHYSICS research

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure

引用

Chinese Chemical Letters 2005年第12期16卷 1593-1596页

作者： Ji Cheng CHU dong zhi liu Hong Sheng GUO Kang ZHAO School of Chemical Engineering and Technology Tianjin University Tianjin 300072 Medical College Chinese People＇s Armed Police Force Tianjin 300071 College of Pharmaceutical and Biotechnology Tianjin UniversityTianjin 300072

Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different subs... 详细信息

关键词： N-Alkoxyamides bis(trifluoroacetoxy)iodobenzene intramolecular cyclization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

引用

Chinese Chemical Letters 2008年第3期19卷 295-298页

作者： Xue Dan Wu dong zhi liu Ai Jun Li Xue Qin Zhou School of Chemical Engineering and Technology lianjin University lianjin 300072 China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018 China

The design, synthesis and biological evaluation of N-（2-（2-methoxyphenylthio） benzyl）-2-aryloxyethyl amines with dual 5-HT1A/SSR/activities are reported. Compound 8e displays the best dual activities and is a prom... 详细信息

关键词： Antidepressants 5-HT1A/5-HTT 5-HT1A receptor Diphenylsulfide Aryloxyethylamines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives:Synthesis and evaluation for dual 5-HT1A/SSRI activities

引用

Chinese Chemical Letters 2008年第4期19卷 412-414页

作者： Ai Jun Li Xiao Hua Zhang Xue Qin Zhou dong zhi liu School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China

A series of 3-（4-arylpiperazin-1-yl）-1-（benzo[b]thiophen-3-yl）-2-methylpropanol derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design *** synthesized compounds were evaluated for their dual 5... 详细信息

关键词： Antidepressants Arylpiperazines 5-HT1A/SSRI 5-HT transporter 5-HT1A receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arylpiperazine derivatives of diphenylsulfide:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

引用

Chinese Chemical Letters 2008年第3期19卷 291-294页

作者： Xue Dan Wu dong zhi liu Ai Jun Li Xue Qin Zhou School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology. Shijiazhuang 050018 China

The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5- HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5- HT1A affinity, Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.

关键词： Antidepressants 5-HT1A/SSRI Arylpiperazines 5-HT1A receptor Diphenylsulfide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular model of neuronal atrophy induced by DYNC111 deficiency reveals protective roles of RAS-RAF-MEK signaling

引用

Protein & Cell 2016年第9期7卷 638-650页

作者： zhi-dong liu Su Zhang Jian-Jin Hao Tao-Rong Xie Jian-Sheng Kang Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200231 China University of Chinese Academy of Sciences Beijing 100049 China

Neuronal atrophy is a common pathological feature occurred in aging and neurodegenerative diseases. A variety of abnormalities including motor protein mal- function and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known about the intracallular signaling pathways that can pro- tect against or delay this pathogenic process. Here, we show that the DYNClll deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. With this cellular model, we are able to find that activation of *** signaling protects against neuronal atrophy induced by DYNClll deficiency, which relies on MEK-dependent autophagy in neuron. Moreover, we further reveal that BRAF also protects against neuronal atrophy induced by mitochondrial impairment. These findings demon- strate protective roles of the RAS-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention.

关键词： RAS-RAF-MEK pathway atrophy dyneinintermediate chain mitochondria hippocampal neuron,autophagy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：