New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives:Synthesis and evaluation for dual 5-HT1A/SSRI activities

作     者：Ai Jun Li Xiao Hua Zhang Xue Qin Zhou Dong Zhi Liu 

作者机构：School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China College of Chemical and Pharmaceutical EngineeringHebei University of Science and TechnologyShijiazhuang 050018China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第4期

页      面：412-414页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.20576094) 

主　　题：Antidepressants Arylpiperazines 5-HT1A/SSRI 5-HT transporter 5-HT1A receptor 

摘      要：A series of 3-（4-arylpiperazin-1-yl）-1-（benzo[b]thiophen-3-yl）-2-methylpropanol derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design *** synthesized compounds were evaluated for their dual 5-HT1A/5-HTT activities.