Screening and immune infiltration analysis of ferroptosis-related genes in pancreatic cancer with predictions for traditional Chinese medicine treatments

作     者：Meng-Ru Yang Ying Zhang Jing-Bai Li Xin-Ru Shen Zi-Yue Pi Zhi-Dong Liu 

作者机构：School of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation TechniqueTianjin University of Traditional Chinese MedicineTianjin 301617China 

出 版 物：《Natural Therapy Advances》 

年 卷 期：2024年第7卷第3期

页      面：1-13页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Modern Traditional Chinese Medicine Haihe Laboratory science and technology project(22HHZYSS00005)and the National Administration of Traditional Chinese Medicine Young Qihuang Scholar Project 

主　　题：pancreatic cancer ferroptosis immune infiltration bioinformatics traditional Chinese medicine prediction 

摘      要：Background:This study aims to explore the involvement of ferroptosis-related genes and pathogenesis in pancreatic cancer and predict potential therapeutic interventions using Traditional Chinese Medicine(TCM).Methods:We utilized gene expression datasets,ferroptosis upregulated genes and applied machine learning algorithms,including LASSO and SVM-RFE,to identify key ferroptosis-related genes in pancreatic *** Gene Ontology,Kyoto Encyclopedia of Genes and Genomes,and Disease Ontology enrichment analysis,immune infiltration analysis and correlation analysis between immune infiltrating cells and characteristic genes on differentially expressed genes using the R software *** potential traditional Chinese medicine for targeted ferroptosis gene therapy for pancreatic cancer through Coremine and Herb ***:Seventeen feature genes were identified,with significant implications for immune cell infiltration in pancreatic *** results of immune cell infiltration analysis showed that B cells naive,B cells memory,T cells regulatory,and M0 macrophages were significantly upregulated in pancreatic cancer patients;Mast cells resting were significantly *** herbal medicines such as ginkgo,turmeric,ginseng,Codonopsis pilosula,Zedoary turmeric,deer tendons,senna leaves,Guanmu Tong,Huangqi,and Banzhilian are potential drugs for targeted ferroptosis gene therapy for pancreatic ***:TIMP1 emerged as a key gene,with several TCM herbs predicted to modulate its expression,offering new avenues for treatment.