检索结果-南通市图书馆

SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 41-49页

作者： Qi-Jun Zhang da-zhi li Bing-Yi lin Lei Geng Zhe Yang Shu-Seng Zheng Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

Background:Accumulating data have suggested that long non-coding RNAs(lncRNAs)play important roles in regulating tumor cell *** study was designed to investigate the role of SNHG16 in hep-atocellular carcinoma(HCC).Methods:SNHG16 expression was detected with real-time polymerase chain reaction(PCR).The cut-offvalue of SNHG16 for tumor-free survival(TFS)was determined with receiver operating characteristic curve *** interfering RNA was used to inhibit the expression of SNHG16 in HCC cell *** biologic behavior of HCC cell was determined with cell viability assay and Transwell assay in *** potential predictive value of SNHG16 on prognosis was analyzed by Kaplan-Meier curves and Cox proportional hazards regression ***:SNHG16 expression was upregulated in tumor tissues and HCC cell *** expression of SNHG16 was associated with tumor recurrence and poor prognosis after *** analysis revealed that SNHG16 was an independent prognostic factor for poor recurrence-free ***,inhibition of SNHG16 in HepG2,Hep3B,and BEL-7402 cells significantly reduced cell invasiveness and *** analyses indicated that the ECM-receptor interaction pathway was remarkably activated by ***:SNHG16 might be a promising biomarker for predicting tumor recurrence in HCC patients after surgery and a potential therapeutic target for HCC.

关键词： Hepatocellular carcinoma SNHG16 ECM-receptor interaction pathway Long non-coding RNA

Ternary B3S2H3, B3S2H3-, and B3S2H32- clusters: Boron sulfur hydride analogues of cyclopentadiene

在线全文

学校读者我要写书评

暂无评论

Ternary B3S2H3, B3S2H3-, and B3S2H32- clusters: Boron sulfur...

Ultrasound-guided in vivo porcine liver ablation with nanosecond pulsed electric fields

第七届全国物理无机化学学术会议

作者： da-zhi li ling Pei Department of Chemical Engineering Binzhou University

Inorganic analogues of hydrocarbons are of current interest in chemistry.A number of recent studies show that there exist analogous relationships between boron-based clusters and the planar hydrocarbons[1-4].Here,we p...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 503-507页

作者： Jun-Jie Huang Rong-Wei Ma da-zhi li Sheng-Yong Yin Zhen liu lin Zhou Ke-Ping Yan Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Industrial Ecology and Environment College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310028China

To the Editor:In recent decades,local ablative therapies have evolved considerably and played an increasingly important role in the treatment of inoperable *** modalities are mainly based on thermal ablation to destroy targeted lesions,such as radiofrequency ablation[1].The clinical application of pulsed electric fields[2]is emerging as an innovative and promising technique for tumor ablation,which does not depend on heat energy and preserves surrounding tissues adjacent to tumors[3].Highvoltage ultrashort electric pulses compromise the integrity of the plasma membrane and destroy intracellular *** pulsed electric fields(nsPEFs),with a strength of several tens of kV/cm and a nanosecond duration,have attracted much attention and been extensively studied in cancer ablation[4,5].

关键词： homeostasis ablation pulsed

COSINE:A web server for clonal and subclonal structure inference and evolution in cancer genomics

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2022年第1期43卷 75-77页

作者： Xi-Guo Yuan Yuan Zhao Yang Guo lin-Mei Ge Wei liu Shi-Yu Wen Qi li Zhang-Bo Wan Pei-Na Zheng Tao Guo zhi-da li Martin Peifer Yu-Peng Cun School of Computer Science and Technology Xidian UniversityXi'anShaanxi 710071China iFlora Bioinformatics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunan 650201China Yuxi Rongjian Information Technology Co. Ltd.YuxiYunan 653100China Center for Molecular Medicine Cologne(CMMC) University of CologneCologne 50931Germany Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China

Cancer cell genomes originate from single-cell mutation with sequential clonal and subclonal expansion of somatic mutation acquisition during pathogenesis,thus exhibiting a darwinian evolutionary process(Gerstung et al.,2020;Nik-Zainal et al.,2012).Through next-generation sequencing of tumor tissue,this evolutionary process can be characterized by statistical modelling,which can identify the clonal state,somatic mutation order,and evolutionary process(Gerstung et al.,2020;Mcgranahan&Swanton,2017).Inference of clonal and subclonal structure from bulk or single-cell tumor genomic sequencing data has a huge impact on studying cancer *** state and mutation order can provide detailed insight into tumor origin and future *** the past decade,various methods for subclonal reconstruction using bulk tumor sequencing data have been ***,these methods had different programming languages and data input formats,which limited their use and ***,we established a web server for Clonal and Subclonal Structure Inference and Evolution(COSINE)of cancer genomic data,which incorporated twelve popular subclonal reconstruction *** deconstructed each method to provide a detailed workflow of single processing steps with a user-friendly *** the best of our knowledge,this is the first web server providing online subclonal inference based on the integration of most popular subclonal reconstruction *** is freely accessible at ***.

关键词： .net server COSINE

From planar B4O5 with B2O2 core to B4O5- with B3O3 core: influence of the extra electron on the structure

在线全文

学校读者我要写书评

暂无评论

From planar B4O5 with B2O2 core to B4O5- with B3O3 core: inf...

An Improved Model for Bending of Thin Viscoelastic Plate on Elastic Foundation

中国化学会第八届全国物理无机化学学术会议

作者： Bing Yang Hui Wang ling Pei Ming-zhi Song da-zhi li College of Chemistry and Chemical Engineering Binzhou University

Considerable attention has been paid to boron oxide, due primarily to their novel structures and chemical bonding, and to their role in mechanistic understanding of the highly-energetic combustion processes of boron and boranes at the molecular level. In this work, global structural searches and B3 LYP and CCSD(T) calculations are used to probe the structures and chemical bonding of oxygen-rich boron oxide clusters BO and BO,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Natural Science 2009年第2期1卷 120-123页

作者： zhi-da li Ting-Qing Yang Wen-Bo Luo 不详

An improved model for bending of thin viscoe-lastic plate resting on Winkler foundation is presented. The thin plate is linear viscoelastic and subjected to normal distributed loading, the effect of normal stress along the plate thickness on the deflection and internal forces is taken into account. The basic equations for internal forces and stress distribution are derived based on the general viscoelastic theory under small deformation condition. The reduced equations for elastic case are given as well. It is shown that the proposed model reveals a larger flex-ural rigidity compared to that in classic models, in which the normal stress along the plate thickness is neglected.

关键词： Thin Viscoelastic Plate Deformable Foundation Flexural Rigidity Winkler Foundation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中空液滴碰撞水平壁面数值分析

物理学报 2017年第1期66卷 235-244页

作者：郑志伟李大树仇性启崔运静中国石油大学(华东)化学工程学院青岛266580 中海油研究总院北京100028 中国石油大学(华东)机电工程学院青岛266580

采用耦合水平集-体积分数法并综合考虑传热及接触热阻作用建立了中空液滴碰撞水平壁面数值模型,并验证了模型的可靠性.通过分析计算结果,获得了中空液滴与实心液滴撞壁的动力学特征差异,揭示了中空液滴撞壁流动传热机理和中心射流形成机... 详细信息

采用耦合水平集-体积分数法并综合考虑传热及接触热阻作用建立了中空液滴碰撞水平壁面数值模型,并验证了模型的可靠性.通过分析计算结果,获得了中空液滴与实心液滴撞壁的动力学特征差异,揭示了中空液滴撞壁流动传热机理和中心射流形成机制,探索了碰撞速度和壁面浸润性对中空液滴撞壁动力学和传热特性的影响.研究表明:中空液滴撞壁后中心射流特征明显,并伴随有射流收缩和液壳破碎等现象.中空液滴内部压力梯度是液滴铺展、中心射流产生和发展的主要原因;撞壁过程中中心射流表面温度分布较为均匀,破碎液壳表面温度分布波动较大.碰撞速度与中空液滴撞壁最大铺展系数的相关性较小,但其对无量纲射流长度和壁面平均热流密度的影响较大;壁面浸润性与中空液滴撞壁后期铺展系数的相关性较大,但其对无量纲射流长度和壁面平均热流密度的影响较小.

关键词：中空液滴液滴撞壁中心射流

Planar Tricyclic B8O80/- Clusters:Boron Oxide Analogs of s-Indacene C12H8

在线全文

学校读者我要写书评

暂无评论

Planar Tricyclic B8O80/- Clusters:Boron Oxide Analogs of s-I...

Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

第十三届全国量子化学会议

作者： da-zhi li lin-Yan Feng li-Juan Zhang Wen-Juan Tian Qiu-Hong Xu Hua-Jin Zhai Si-Dian li College of Chemistry and Chemical Engineering Binzhou University Nanocluster Laboratory Institute of Molecular ScienceShanxi University

Boron-containing heterocyclic clusters possess unique bonding characteristics. Some skeleton materials with boron-containing heterocycles as building units have potential application in gas adsorption, selective catalysis and optics.[1-2]The s-indacene CH with C symmetry can be described as a limit system between the classes of aromatic and antiaromatic molecules due to its unique structural and magnetic properties.[3] Inspired by the principle of isoelectronic species, we design planar tricyclic BOmolecules with D symmetries. Interestingly, D BO(A) and D BO.(B) are the global minima of the systems based upon global structural searches and B LYP and CCSD(T) calculations. The D structures feature tricyclic system(5+6+5), which consists two BOfive-membered rings fused together via two bridging O atoms and terminated by two BO groups. Bonding analyses show that the closed-shell BO cluster possesses 12 delocalized π electrons, closely analogous to the bonding pattern of the s-indacene CH.

关键词： Boron oxide analog polycyclic aromatic hydrocarbons

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia li Wenwu liu Shiji da lingbin Kong Fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management