Ultrasound-guided in vivo porcine liver ablation with nanosecond pulsed electric fields

作     者：Jun-Jie Huang Rong-Wei Ma Da-Zhi Li Sheng-Yong Yin Zhen Liu Lin Zhou Ke-Ping Yan Shu-Sen Zheng Jun-Jie Huang;Rong-Wei Ma;Da-Zhi Li;Sheng-Yong Yin;Zhen Liu;Lin Zhou;Ke-Ping Yan;Shu-Sen Zheng

作者机构：Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ TransplantationThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Industrial Ecology and EnvironmentCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310028China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2022年第21卷第5期

页      面：503-507页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(81971768 and 82172681) 

主　　题：homeostasis ablation pulsed 

摘      要：To the Editor:In recent decades,local ablative therapies have evolved considerably and played an increasingly important role in the treatment of inoperable *** modalities are mainly based on thermal ablation to destroy targeted lesions,such as radiofrequency ablation[1].The clinical application of pulsed electric fields[2]is emerging as an innovative and promising technique for tumor ablation,which does not depend on heat energy and preserves surrounding tissues adjacent to tumors[3].Highvoltage ultrashort electric pulses compromise the integrity of the plasma membrane and destroy intracellular *** pulsed electric fields(nsPEFs),with a strength of several tens of kV/cm and a nanosecond duration,have attracted much attention and been extensively studied in cancer ablation[4,5].