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FeCo-N encapsuled in nitrogen-doped carbon nanotubes as bifunctional electrocatalysts with a high stability for zinc air batteries

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Rare Metals 2023年第5期42卷 1526-1534页

作者： xiao-Gang wu Rui wang Fei Ma xiao-li liu Da-li Jia Hong-Cen Yang Yan-Peng liu zhi-xia wang Han-zhen zheng Ya-Nan Zhang Juan Hou Juan-Juan Huang Shang-Long Peng School of Materials and Energy Lanzhou UniversityLanzhou730000China School of Physical Science and Technology Lanzhou UniversityLanzhou730000China School of Science/Key Laboratory of Ecophysics and Department of Physics Shihezi UniversityShihezi832003China

For zinc air batteries,a non-noble metal-based electrocatalyst with a high performance and stability in oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)is imperative in ***,a catalyst based on FeCo-N encapsuled in nitrogen-doped carbon nanotubes has been prepared,which provides an implementable method to design controlled structures with excellent bifunction al electrocatalytic *** adjusting the molar ratio of two metals,the synthesized FeCo-N-C catalyst delivers a competitive ORR and OER performance compared with commercial Pt/C and IrO_(2),performing a low overvoltage gap between ORR(E_(1/2))and OER(E_(j=10))of 0.8 ***,as a promising cathode in zinc air battery,the FeCo-N-C catalyst possesses an affirmative stability of over 100 h and large power density(129 mW·cm^(-2)).This work demonstrates that FeCo-N-C is one of the most promising catalysts for zinc air batteries and provides a possibility for exploration of batteries with high stability by adjusting the molar ratio of metals in the catalysts.

关键词： Iron Cobalt N-doped carbon Oxygen reduction reaction(ORR) Oxygen evolution reaction(OER) Zinc air battery(ZAB)

Timing and approaches in congenital cataract surgery:a four-year,two-layer randomized controlled trial

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1835-1843页

作者： Hao-Tian lin Er-Ping Long Jing-Jing Chen zhen-zhen liu Zhuo-ling lin Qian-Zhong Cao xia-Yin Zhang xiao-Hang wu Qi-Wei wang Duo-Ru lin xiao-Yan li Jin-Chao liu li-xia Luo Bo Qu Wei-Rong Chen Yi-zhi liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Ya-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM：To compare visual prognoses and postoperative adverse events of congenital cataract surgery performed at different times and using different surgical ***：In this prospective,randomized controlled trial,we recruited congenital cataract patients aged 3 mo or younger before cataract ***-one eligible patients were randomly assigned to two groups according to surgical timing：a 3-month-old group and a 6-month-old *** eye underwent one of three randomly assigned surgical procedures,as follows：surgery A,lens aspiration（I/A）;surgery B,lens aspiration with posterior continuous curvilinear capsulorhexis（I/A＋PCCC）;and surgery C,lens aspiration with posterior continuous curvilinear capsulorhexis and anterior vitrectomy（I/A＋PCCC＋A-Vit）.The long-term best-corrected visual acuity（BCVA） and the incidence of complications in the different groups were compared and ***：A total of 57 participants（114 eyes） with a mean follow-up period of 48.7 mo were included in the final *** overall log MAR BCVA in the 6-month-old group was better than that in the 3-month-old group（0.81±0.28 vs 0.96±0.30;P=0.02）.The overall log MAR BCVA scores in the surgery B group were lower than the scores in the A and C groups（A：0.80±0.29,B：1.02±0.28,and C：0.84±0.28;P=0.007）.A multivariate linear regression revealed no significant relationships between the incidence of complications and long-term ***：It might be safer and more beneficial for bilateral total congenital cataract patients to undergosurgery at 6 mo of age than 3 ***,with rigorous follow-up and timely intervention,the postoperative complications in these patients are treatable and do not compromise visual outcomes.

关键词： pediatric cataract surgery postoperativecomplications long-term visual function

lipoprotein(a)and Benefit of PCSK9 Inhibition in Emergency Complex Higher-risk and Indicated Patients

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Current Medical Science 2023年第6期43卷 1206-1212页

作者： zhi-li JIN Tao HE li PENG xiao-yan wu Di FAN Ming CHEN Yong-zhen FAN Yuan-lin GUO zhi-bing LU Hai-rong wang Department of Cardiovascular Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Institute of Myocardial Injury and Repair Wuhan UniversityWuhan430071China Cardio-Metabolic Medicine Center Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100037China

Objective There is a large population of patients classified as complex higher-risk and indicated patients(CHIPs)in China with a poor *** treatment of these patients is complex and challenging,especially when acute cardiac events occur,such as acute coronary syndrome(ACS)or heart *** and some mechanical circulatory support(MCS)therapeutic devices can provide stable hemodynamic support for CHIPs-percutaneous coronary intervention(PCI).LDL-C is an important pathogenic factor in atherosclerosis,and the target of blood lipid *** studies have revealed that lipoprotein(a)[Lp(a)],which is formed when a covalent bond between apolipoprotein(a)and apolipoprotein B-100 is made,produces an LDL-like *** particle is an independent risk factor for the development of atherosclerosis,and is closely correlated to stent thrombosis and ***,this requires active ***9 inhibitors have been used in lipid-lowering treatment,and preventing *** present study explores the efficacy of PCSK9 inhibitors in CHIPs-ACS,and the association between the change in Lp(a)and survival after 2 years of *** The present real-world,prospective control study enrolled 321 CHIPs-ACS who underwent emergency PCI from August 2019 to November 2020,and these patients were followed up for 2 *** patients were divided into two groups:PCSK9 group(n=161)given the combined PCSK9 inhibitor(140 mg of evolocumab every 2 weeks)and statins-based therapy,and SOC group(n=160)treated with statin-based lipid-lowering therapy ***,the change in lipid index was measured,and the cardiovascular(CV)event recurrence rate was evaluated after one month and 2 ***,the contribution of serum lipid parameters,especially the Lp(a)alteration,in patients with earlier initiation of the PCSK9 inhibitor to the CV outcome was *** The LDL-C level was significantly reduced in both groups:52.3%in the PCSK

关键词： PCSK9 inhibitor complex higher-risk and indicated patients lipoprotein(a)level low-density lipoprotein cholesterol level 2-year cardiovascular event rate

Rectifying characteristics and solar-blind photoresponse in β-Ga2O3/ZnO heterojunctions

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Chinese Physics B 2019年第8期28卷 403-407页

作者： xiao-Fei Ma Yuan-Qi Huang Yu-Song zhi xia wang Pei-Gang li zhen-Ping wu Wei-Hua Tang State Key Laboratory of Information Photonics and Optical Communications & School of Science Beijing University of Posts and Telecommunications

Heterojunctions composed ofβ-Ga2 O3 and ZnO films are fabricated on sapphire substrates by using the laser molecular beam epitaxy *** heterojunction possesses excellent rectifying characteristics with an asymmetry ratio over *** solar-blind photoresponse effect is also observed in the formed *** photodetector exhibits a self-powered behavior with a fast response speed(rise time and decay time are 0.035 s and 0.032 s respectively)at zero *** obtained high performance can be related to the built-in field driven photogenerated electron-hole separation.

关键词： Ga2O3 solar blind photodetector heterojunction self-powered

High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1600-1614页

作者： lin-lin zheng Ya-Ru wang zhen-Rong liu zhi-Hao wang Chang-Cheng Tao Yong-Gang xiao Kai Zhang An-Ke wu Hai-Yang li Jian-Xiong wu Ting xiao Wei-Qi Rong Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Hernia Surgery Liaocheng Dongcangfu People's HospitalLiaocheng 252000Shandong ProvinceChina The Second Ward of Hepatobiliary Surgery Qianxinan People's HospitalXingyi 562400Guizhou ProvinceChina Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300000China

BACKGROUND Spindle and kinetochore-associated complex subunit 3(SKA3)is a malignancyassociated gene that plays a critical role in the regulation of chromosome separation and cell ***,the molecular mechanism through which SKA3 regulates tumor cell proliferation in hepatocellular carcinoma(HCC)has not been fully *** To investigate the molecular mechanisms underlying the role of SKA3 in *** SKA3 expression,clinicopathological,and survival analyses were performed using multiple public database platforms,and the results were verified by Western blot and immunohistochemistry staining using collected clinical *** enrichment analyses were performed to evaluate the biological functions and molecular mechanisms of SKA3 in ***,the Tumor Immune Estimation Resource and single-sample Gene Set Enrichment Analysis(ssGSEA)algorithms were utilized to investigate the abundance of tumor-infiltrating immune cells in *** response to chemotherapeutic drugs was evaluated by the R package“pRRophetic”.RESULTS We found that upregulated SKA3 expression was significantly correlated with poor prognosis in patients with *** Cox regression analysis indicated that SKA3 was an independent risk factor for *** revealed that SKA3 expression may facilitate proliferation and migratory processes by regulating the cell cycle and DNA ***,patients with high SKA3 expression had significantly decreased ratios of CD8+T cells,natural killer cells,and dendritic *** sensitivity analysis showed that the high SKA3 group was more sensitive to sorafenib,sunitinib,paclitaxel,doxorubicin,gemcitabine,and *** High SKA3 expression led to poor prognosis in patients with HCC by enhancing HCC proliferation and repressing immune cell infiltration surrounding ***3 may be used as a biomarker for poor prognosis and as a therapeutic target in HCC.

关键词： Spindle and kinetochore-associated protein 3 Hepatocellular carcinoma Prognosis Immune infiltration cells

Function-oriented design:A novel strategy for advanced biomedical materials

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Journal of Materials Science & Technology 2023年第14期145卷 197-209页

作者： zhiyu Zhou Wentao wang Jianmin wang Hongshui wang Yi xia Wei Zhang Yuxiao Lai xiao lin Yongcan Huang Xuenong Zou Martin J.Stoddart zhen li Wei Tian Shaoyu liu Xinbao wu Manman Gao Junhong li Lei Yang Dafu Chen Department of Orthopaedic Surgery the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Center for Health Science and Engineering School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Centre for Translational Medicine Research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518063China Orthopedic Institute and Department of Orthopedics the First Affiliated HospitalSoochow UniversitySuzhou 215000China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518034China AO Research Institute Davos Davos7270Switzerland h Laboratory of Bone Tissue EngineeringBeijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China Department of Sport Medicine Institute of Translational Medicinethe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518025China Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhen 518060China The Department of Orthopaedics and Trauma the Affiliated Hospital of Yunnan UniversityYunnan UniversityKunming 650091China

It has always been a dream to construct tissues and even organs for transplantation to replace those with defects caused by diseases or *** engineering is another milestone in the developmental history of life science after cellular and molecular ***,despite decades of rapid de-velopment,tissue-engineered biomaterials have not been widely used *** constructed by physical and chemical methods have lots of difficulty in precisely mimicking the macroscopic and mi-croscopic structures of human *** ultimate way to build organoid tissue for regeneration is to enable the cells to take the initiative and build suitable *** on the thoughts of tissue engi-neering,organoid technology holds great potential as a research tool for a wide range of fields,including developmental biology,disease pathology,cell biology,precision medicine,and drug toxicity and efficacy *** technology also holds tremendous potential for regenerative medicine,as organoids present the possibility for autologous and allogeneic cell therapy through the replacement of damaged or dis-eased tissues with organoid-propagated tissue or stem cell *** this review work,we briefly outlook the development history of organoid technology,summarize the current bottlenecks and the un-derlying reasons,and propose the unified term“function-oriented design in tissue engineering”,a new topic that may provide a solution to overcome these bottlenecks.

关键词： Biomaterial Organoid Tissue engineering Function-oriented design

Direct reuse of liFePO_(4)cathode materials from spent lithium-ion batteries:Extracting li from brine

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Chinese Chemical Letters 2023年第6期34卷 556-562页

作者： Miao Du Jin-zhi Guo Shuo-Hang zheng Yan liu Jia-lin Yang Kai-Yang Zhang zhen-Yi Gu xiao-Tong wang Xing-Long wu Faculty of Chemistry Northeast Normal UniversityChangchun 130024China MOE Key Laboratory for UV light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China

Due to the serious imbalance between demand and supply of lithium,lithium extraction from brine has become a research *** the demand for power lithium-ion batteries(liBs)increased rapidly,a large number of spent liFePO_(4)power batteries have been scrapped and entered the recycling ***,a novel and efficient strategy is proposed to extract lithium from brine by directly reusing spent liFePO_(4)powder without any *** electrochemical test results show that spent liFePO_(4)electrode has appropriate lithium capacity(14.62 mg_(li)/g_(liFePO_(4))),excellent separation performance(α_(li-Na)=210.5)and low energy consumption(0.768 Wh/g_(li))in electrochemical lithium extraction from simulated *** work not only provides a novel idea for lithium extraction from brine,but also develops an effective strategy for recycling spent *** concept of from waste to wealth is of great significance to the development of recycling the spent batteries.

关键词： Spent lithium-ion batteries Reuse liFePO_(4) lithium extraction Brine

TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice

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Neuroscience Bulletin 2021年第4期37卷 550-562页

作者： lin-xia Zhao Ming Jiang Xue-Qiang Bai De-li Cao xiao-Bo wu Jing Zhang Jian-Shuang Guo Tong-Tong Chen Juan wang Hao wu Yong-Jing Gao zhi-Jun Zhang Department of Human Anatomy School of MedicineNantong UniversityNantong 226001China Institute of Pain Medicine Institute of Nautical MedicineNantong UniversityNantong 226019China Department of Otolaryngology Head Neck Surgery The Affiliated Hospital of Nantong UniversityNantong 226001China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

Trigeminal neuropathic pain(TNP)is a significant health problem but the involved mechanism has not been completely ***-like receptors(TLRs)have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic ***,we show that TLR8 was persistently increased in the trigeminal ganglion(TG)neurons in model of TNP induced by partial infraorbital nerve ligation(pIONL).In addition,deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia,reduced the activation of ERK and p38-MAPK,and decreased the expression of pro-inflammatory cytokines in the ***,intra-TG injection of the TLR8 agonist VTX-2337 induced pain ***-2337 also increased the intracellular Ca^(2+)concentration,induced the activation of ERK and p38,and increased the expression of pro-inflammatory cytokines in the *** data indicate that TLR8 contributes to the maintenance of TNP through increasing MAPK-mediated *** TLR8 signaling may be effective for the treatment of TNP.

关键词： TLR8 ERK p38 Pro-inflammatory cytokine Trigeminal ganglion Trigeminal neuropathic pain Mouse

Prostatic tissue ectopia in the rectum

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Chinese Medical Journal 2010年第22期123卷 3372-3374页

作者： wu Xin-lin SHI lin ZHAO li-zhen wang Jing-yuan DONG Pei-de xia Yang-zhi Department of General Surgery the First Affiliated Hospital of Inner Mongolia Medical College Huhhot Inner Mongolia 010059 China Department of Pathology the First Affiliated Hospital of Inner Mongolia Medical College Huhhot Inner Mongolia 010059 China

Areview of the literature on ectopic prostatic tissue reveals about 200 reports dating back to as early as 1894. The presence of prostate tissue outside the genitourinary system is extremely rare. It is usually incidentally found in surgical pathology and autopsy. Including the present case, there are only 16 cases of ectopic prostatic tissue outside the genitourinary system reported.

关键词： prostate ectopia rectum immunohistochemistry