检索结果-南通市图书馆

Enhanced Bioenergy Transformation by Metal-Free Electrozyme-Based Mitochondrion Nanoarchitectonics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第7期5卷 1644-1652页

作者： Tonghui Wang Jinbo Fei zhenzhen dong Xia Xu Weiguang dong Junbai Li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

Herein,we couple a synthetic electrozyme in a supramolecule-assembled nanoarchitecture to achieve enhanced bioenergy transformation by mimicking mitochondrial oxidative phosphorylation.Different from the natural counterpart,the metal-free electrozyme is a semiconducting polymer deposited on an electrode.The wellmatched electrocatalytic property of the electrozyme permits oxidization of reduced nicotinamide adenine dinucleotide(NADH)to release protons under a much lower electric potential.As a consequence,the generated proton gradient drives rotary catalysis of adenosine 5′-triphosphate(ATP)synthase reconstituted in a lipid membrane to produce ATP.Remarkably,electrochemical bioenergy conversion of NADH to ATP is accomplished with much higher efficiency in such a bio-like system compared with the natural mitochondria.This work integrates synthetic and natural catalytic chemistry to facilitate enhanced bioenergy transformation,thereby greatly improving prospects in ATP-fueled bioapplications.

关键词： molecular assembly bioenergy nanozyme biocatalysis nanoarchitectonics

Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第8期11卷 2789-2800页

作者： JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi zhenzhen dong Yan Li CaiQi Wang School of ChemicalScience University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Engineering Beihang UniversityBeijing 100083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China

Biomedical magnesium is an ideal material for hard tissue repair and replacement.However,its rapid degradation and infection after implantation significantly hindersclinical applications.To overcome these two critical drawbacks,we describe an integrated strategybased on the changes in pH and Mg^(2+)triggered by magnesiumdegradation.This system can simultaneously offer anticorrosion and antibacterial activity.First,nanoengineered peptide-grafted hyperbranched polymers(NPGHPs)with excellent antibacterial activity were introduced to sodium alginate(SA)to construct a sensitive NPGHPs/SA hydrogel.The swelling degree,responsiveness,and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg^(2+)with controllable antimicrobial properties.Furthermore,an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition layer.The alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate,thus exhibiting superior corrosion resistance.Antibacterial testing shows that the material can effectively fight against bacteria,while hemolytic and cytotoxicity testing suggest that it is highly biocompatible.Thus,this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium,thereby providing broader prospects for the use of magnesium.

关键词： Biomedical magnesium Anticorrosion Antibacterial Intelligent Nanoengineered peptide-grafted hyperbranched polymers

Rh(Ⅲ)-Catalyzed Diverse C-H Functionalization of Iminopyridinium Ylides

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第9期39卷 2489-2494页

作者： zhenzhen dong Pengfei Li Xingwei Li Bingxian Liu NMPA Key Laboratory for Research and Evaluation of Innovative Drug Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China

Divergent synthesis of useful skeletons has been realized via rhodium(Ⅲ)-catalyzed C-H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents.Isocoumarins and isoquinolones were obtained via cleavage of the C-N or N-N bond in the ylidic di recti ng group,while fluorinated alkenes were delivered with the di recti ng group in tact.The reactions occurred with wide substrate scopes and good efficiency under redox-neutral and air-tolerant conditions.Representative products exhibit solid-state fluoresce nt property and bioactivity of in hibiti on toward huma n cancer cells.

关键词： C-H functionalization Iminopyridinium ylide Diverse transformation Redox-neutral Ylidic directing group

薄鞘高包覆涤纶/棉包芯纱的结构控制及其工艺

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纺织学报 2024年第6期45卷 46-52页

作者：李文雅周剑廖昙倩董真真西安工程大学纺织科学与工程学院陕西西安710048

为探究高包覆包芯纱的临界包覆率实现不露芯的包覆效果,采用低比例棉纤维包覆7.78 tex涤纶低弹丝制备出高包覆率包芯纱,且截面接近理想结构的涤纶/棉包芯纱,并进一步探讨外包棉纤维的临界比例,以及纱线结构与包覆率、棉与涤纶比例之间... 详细信息

为探究高包覆包芯纱的临界包覆率实现不露芯的包覆效果,采用低比例棉纤维包覆7.78 tex涤纶低弹丝制备出高包覆率包芯纱,且截面接近理想结构的涤纶/棉包芯纱,并进一步探讨外包棉纤维的临界比例,以及纱线结构与包覆率、棉与涤纶比例之间的关系。实验以5%为梯度不断减少外包棉纤维含量共纺制8组包芯纱,并通过数码显微系统表征纱线包覆率、截面结构等特点。结果表明:当外包棉纤维比例为53%时,包芯纱包覆率还保持在87.5%,此后包芯纱包覆率低于85%出现大面积露芯;随着外包棉纤维含量梯度化减少,包芯纱包覆率降幅呈三段变化,由开始的0.3%变化为4%,最后在52%的比例时降幅突增为9.4%。不同比例涤纶与棉纺制的包芯纱截面偏心度平均变化范围为8.8%~11.2%,实现了包芯纱结构的稳定控制。

关键词：涤纶/棉包芯纱包覆率纱线结构纺纱工艺偏心度混纺比

在线全文

学校读者我要写书评

暂无评论

针织物图案变化与精准纺纱工艺的关系模型

毛纺科技 2024年第3期52卷 51-55页

作者：董真真李文雅孟天玉梁建行任学勤西安工程大学纺织科学与工程学院陕西西安710048

为进一步确定基于一根结构可控的自固结子线经过织造可直接在织物上形成精准图案的尺寸变化与纺纱工艺之间的关系,以织物尺寸不变、图案等比例放大为研究要点,分析随着图案大小变化时各纱线段长度以及纺纱时间的变化规律,最终建立图案... 详细信息

为进一步确定基于一根结构可控的自固结子线经过织造可直接在织物上形成精准图案的尺寸变化与纺纱工艺之间的关系,以织物尺寸不变、图案等比例放大为研究要点,分析随着图案大小变化时各纱线段长度以及纺纱时间的变化规律,最终建立图案放大倍数与精准纺纱工艺的关系模型。以基础图案为基准,2个矩形图案间距不变,分别将矩形横向放大2倍和3倍。经过纺纱织造后分析可得:图案放大倍数(a)与循环纱长L呈(L)=1.65a+67.17的线性关系;各结构段长度及纺纱时间也呈现线性规律变化;所得精准纺纱工艺计算模型可快速确定各纱线段长度及运行时间,为织物图案尺寸变化后相对应的精准纺纱工艺参数预测提供了依据,减少试织次数和成本,提高制备效率。

关键词：精准图案图案放大循环纱长纺纱工艺

在线全文

学校读者我要写书评

暂无评论

摩擦组元对铜基摩擦材料性能影响的研究进展

粉末冶金工业 2024年第2期34卷 107-115页

作者：吴深司屈钒蒋爱云董珍珍刘建秀张倩郑州轻工业大学机电工程学院河南郑州450002 黄河科技学院工学部河南郑州450006 武汉文理学院机电与建筑工程学院湖北武汉430345

制动系统是高速列车安全运行的关键核心部件,铜基粉末冶金摩擦材料具有组织均匀、高耐磨、高硬度和摩擦因数稳定的特点,能充分发挥基体材料、摩擦组元及润滑组元各自的优点以及它们之间的协同作用,成为高速列车制动闸片的首选材料。随... 详细信息

制动系统是高速列车安全运行的关键核心部件,铜基粉末冶金摩擦材料具有组织均匀、高耐磨、高硬度和摩擦因数稳定的特点,能充分发挥基体材料、摩擦组元及润滑组元各自的优点以及它们之间的协同作用,成为高速列车制动闸片的首选材料。随着列车行驶速度的不断提高,摩擦制动产生的温度越来越高对摩擦材料的高温稳定性和抗氧化性提出了更高的要求。因此,主要论述了铜基粉末冶金摩擦材料中摩擦组元的种类及添加方式对材料组织结构和摩擦性能的影响,对摩擦组元与基体的结合效果和摩擦磨损机制等方面进行了总结和评述,对铜基粉末冶金摩擦材料的未来发展趋势进行了展望。

关键词：铜基粉末冶金摩擦组元磨损量磨损机制摩擦因数

替格瑞洛与氯吡格雷分别联合阿司匹林治疗冠心病不稳定型心绞痛的疗效比较

在线全文

学校读者我要写书评

暂无评论

中外医疗 2024年第4期43卷 115-118页

作者：董珍珍孙中奇徐寒锡苏州市吴中人民医院心内科江苏苏州215128

目的探讨替格瑞洛与氯吡格雷分别联合阿司匹林治疗冠状动脉粥样硬化性心脏病(简称冠心病)不稳定型心绞痛的效果差异。方法方便选取2019年6月-2022年6月苏州市吴中人民医院收治的102例冠心病不稳定型心绞痛患者为研究对象,以不同治疗方... 详细信息

目的探讨替格瑞洛与氯吡格雷分别联合阿司匹林治疗冠状动脉粥样硬化性心脏病(简称冠心病)不稳定型心绞痛的效果差异。方法方便选取2019年6月-2022年6月苏州市吴中人民医院收治的102例冠心病不稳定型心绞痛患者为研究对象,以不同治疗方法分为两组。对照组(n=50)行氯吡格雷与阿司匹林联合治疗,观察组(n=52)行替格瑞洛与阿司匹林联合治疗,比较两组的疗效。结果观察组总疗效率较对照组的高(96.15%vs 80.00%),差异有统计学意义(χ^(2)=6.408,P0.05)。结论对冠心病不稳定型心绞痛患者,在阿司匹林治疗基础上联合替格瑞洛较氯吡格雷的疗效更为可靠,更利于患者心绞痛症状与炎症反应的改善,能降低患者心血管不良反应发生率,且不增加出血风险。

关键词：替格瑞洛氯吡格雷阿司匹林冠心病不稳定型心绞痛疗效

Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第2期7卷 166-178页

作者： Xuecui Yin Lin dong Xiaohan Wang zhenzhen Qin Yuying Ma Xiaofei Ke Ya Li Qingde Wang Yang Mi Quanjun Lyu Xia Xu Pengyuan Zheng Youcai Tang Department of Internal Medicine the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Pediatrics the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Clinical Nutrition the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education of ChinaCo-innovation Center of Henan Province for New drug R&D and Preclinical SafetySchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pediatrics GastroenterologyHenan Key Laboratory of Rehabilitation MedicineHenan Joint International Research Laboratory of Chronic Liver Injury and Henan Provincial Outstanding Overseas Scientists Chronic Liver Injury Studiothe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Background:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases globally.Hepatic stellate cells(HSCs)are the major effector cells of liver fibrosis.HSCs contain abundant lipid droplets(LDs)in their cytoplasm during quiescence.Perilipin 5(PLIN 5)is a LD surface-associated protein that plays a crucial role in lipid homeostasis.However,little is known about the role of PLIN 5 in HSC activation.Methods:PLIN 5 was overexpressed in HSCs of Sprague–Dawley rats by lentivirus transfection.At the same time,PLIN 5 gene knockout mice were constructed and fed with a high-fat diet(HFD)for 20 weeks to study the role of PLIN 5 in NAFLD.The corresponding reagent kits were used to measure TG,GSH,Caspase 3 activity,ATP level,and mitochondrial DNA copy number.Metabolomic analysis of mice liver tissue metabolism was performed based on UPLC-MS/MS.AMPK,mitochondrial function,cell proliferation,and apoptosis-related genes and proteins were detected by western blotting and qPCR.Results:Overexpression of PLIN 5 in activated HSCs led to a decrease in ATP levels in mitochondria,inhibition of cell proliferation,and a significant increase in cell apoptosis through AMPK activation.In addition,compared with the HFD-fed C57BL/6J mice,PLIN 5 knockout mice fed with HFD showed reduced liver fat deposition,decreased LD abundance and size,and reduced liver fibrosis.Conclusion:These findings highlight the unique regulatory role of PLIN 5 in HSCs and the role of PLIN 5 in the fibrosis process of NAFLD.

关键词： AMPK apoptosis hepatic stellate cell liver fibrosis perilipin 5

The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li zhenzhen Liang Yinling Wei Jing dong Hongyan Wen Lingli Guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

关键词：