Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium

作     者：JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang JianLiang Zhao;HanRui Cui;ZeYu Gao;YanZe Bi;ZhenZhen Dong;Yan Li;CaiQi Wang

作者机构：School of ChemicalScienceUniversity of Chinese Academy of SciencesBeijing100049China School of Materials Science and EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Centre for Biomedical EngineeringBeihang UniversityBeijing 100191China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2023年第11卷第8期

页      面：2789-2800页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(no.51671179,51971014) the Excellent teacher ability improvement project(E1E40308) 

主　　题：Biomedical magnesium Anticorrosion Antibacterial Intelligent Nanoengineered peptide-grafted hyperbranched polymers 

摘      要：Biomedical magnesium is an ideal material for hard tissue repair and ***,its rapid degradation and infection after implantation significantly hindersclinical *** overcome these two critical drawbacks,we describe an integrated strategybased on the changes in pH and Mg^(2+)triggered by *** system can simultaneously offer anticorrosion and antibacterial ***,nanoengineered peptide-grafted hyperbranched polymers(NPGHPs)with excellent antibacterial activity were introduced to sodium alginate(SA)to construct a sensitive NPGHPs/SA *** swelling degree,responsiveness,and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg^(2+)with controllable antimicrobial ***,an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition *** alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate,thus exhibiting superior corrosion *** testing shows that the material can effectively fight against bacteria,while hemolytic and cytotoxicity testing suggest that it is highly ***,this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium,thereby providing broader prospects for the use of magnesium.