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Impact of the next-generation sequencing data depth on various biological result inferences

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Science China(Life Sciences) 2013年第2期56卷 104-109页

作者： HOU Rui yang zhenxing LI MingHui XIAO HuaSheng National Engineering Center for Biochip at Shanghai

Next-generation sequencing(NGS) technologies have revolutionized the field of genomics and provided unprecedented opportunities for high-throughput analysis at the levels of genomics,transcriptomics and ***,the cost of NGS is still prohibitive for many *** is imperative to address the trade-off between the sequencing depth and *** this review,we will discuss the effects of sequencing depth on the detection of genes,quantification of gene expression and discovering of gene structural *** will provide readers information on choosing appropriate sequencing depth that best meet the needs of their particular project.

关键词： next-generation sequencing depth gene discovery gene expression structure variation next-generation sequencing depth gene discovery gene expression structure variation

Vagus nerve stimulation in cerebral stroke:biological mechanisms,therapeutic modalities,clinical applications,and future directions

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Neural Regeneration Research 2024年第8期19卷 1707-1717页

作者： Li Du Xuan He Xiaoxing Xiong Xu Zhang Zhihong Jian zhenxing yang Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of *** stro ke victims are left with long-term neurological dysfunction,which adversely affects the well-being of the individual and the broader socioeconomic ***,poststroke brain dysfunction is a major and difficult area of *** nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autis m,refractory depression,epilepsy,and Alzheimer’s *** is expected to be a novel therapeutic technique for the treatment of stroke owing to its association with multiple mechanisms such as alte ring neurotransmitters and the plasticity of central neuro *** animal models of acute ischemic stroke,vagus nerve stimulation has been shown to reduce infarct size,reduce post-stroke neurological damage,and improve learning and memory capacity in rats with stroke by reducing the inflammatory response,regulating bloodbrain barrier permeability,and promoting angiogenesis and *** present,vagus nerve stimulation includes both invasive and non-invasive vagus nerve *** studies have found that invasive vagus nerve stimulation combined with rehabilitation therapy is effective in im proving upper limb motor and cognitive abilities in stroke *** clinical studies have shown that non-invasive vagus nerve stimulation,including ear/ce rvical vagus nerve stimulation,can stimulate vagal projections to the central nervous system similarly to invasive vagus nerve stimulation and can have the same *** this paper,we first describe the multiple effects of vagus nerve stimulation in stroke,and then discuss in depth its neuroprotective mechanisms in ischemic *** go on to outline the res ults of the current major clinical applications of invasive and non-invasive vagus nerve ***,we provide a more comprehensive evaluation of the advantages and disadvantages of di

关键词： cerebral stroke neuroplasticity non-invasive vagus nerve stimulation rehabilitation vagus nerve stimulation

Metabolic and proteostatic differences in quiescent and active neural stem cells

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Neural Regeneration Research 2024年第1期19卷 43-48页

作者： Jiacheng Yu Gang Chen Hua Zhu Yi Zhong zhenxing yang Zhihong Jian Xiaoxing Xiong Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Adult neural stem cells are neurogenesis progenitor cells that play an important role in ***,neural regeneration may be a promising target for treatment of many neurological *** regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and *** adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell *** adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural *** review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein ***,we discuss the physiological significance and underlying advantages of these diffe *** to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms.

关键词： adult neurogenesis cell metabolic pathway cellular proliferation neural stem cell niches neural stem cells neuronal differentiation nutrient sensing pathway proteostasis

A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019

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Virologica Sinica 2022年第4期37卷 513-520页

作者： Yingliang Duan zhenxing yang Pei Zhu Lei Xiao Zhanhong Li Zhuoran Li Le Li Jianbo Zhu Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory Yunnan Animal Science and Veterinary InstituteKunming650000China

Epizootic hemorrhagic disease virus(EHDV)is a member of the genus Orbivirus,family *** was firstly recognized in 1955 to cause a highly fatal disease of wild white-tailed deer in *** far,EHDV was detected and isolated in many wild or domestic ruminants,and widely distributed all over the *** the domestic cattle and sheep infected by EHDV were usually asymptomatic or subclinical,several outbreaks of epizootic hemorrhagic disease(EHD)in deer and cattle had been *** EHDV strains were isolated and sequenced in last two decades in China,which promoted a general serologic investigation of EHDV in *** this study,18,122 sera were collected from asymptomatic or subclinical domestic ruminants(cattle,cow,yaks,sheep,goats,and deer)in 116 regions belonging to 15 provinces in *** the sera were tested by EHDV CELISA,and the results were obtained by big data *** infections were detected in the 14 of 15provinces,and only Tibet(average altitude≥4000 m)which was the highest province in China was free of *** numbers of seropositive collections in both bovine and goat/sheep were in an inverse proportion to the ***,the seropositive rates in bovine were ranged from 0%to 100%,while the seropositive rates in goat/sheep were no more than 50%.The results suggested that bovine was obviously more susceptive for EHDV infection than goat and sheep,therefore might be a major reservoir of EHDV in *** prevalence of EHDV was consistent with the distribution of Culicoides which were known as the sole insect vectors of *** particular,the seropositive rates of EHDV were very high in the southern provinces,which required the enhanced surveillance in the future.

关键词： Epizootic hemorrhagic disease virus(EHDV) Prevalence Ruminant China

Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population

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Neuroscience Bulletin 2014年第1期30卷 33-42页

作者： Bo Xiang zhenxing yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu State Key Laboratory of Biotherapy Laboratory of Psychiatry Research West China Hospital Sichuan University Mental Health Center West China Hospital Sichuan University Guangzhou Brain Hospital Biobank West China Hospital Sichuan University

Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder. （BP-I）, a mood disorder, is not clear. We selected 21 single- nucleotide polymorphisms （SNPs） within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs （rs1475196 and rs9567747） in the HTR2A gene and 1/23 SNPs （rs17110566） in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I.

关键词： bipolar affective disorder serotonin pathway TPH2 HTR2A SLC6A4

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带有预应力的连续体组合结构拓扑优化

应用力学学报 2005年第2期22卷 231-236,i008页

作者：傅建林荣见华杨振兴长沙理工大学长沙410076

考虑梁结构的预应力,导出了结构的应力及其灵敏度公式。同时,结合结构单元应力水平和相对差商,对于带有尺寸和拓扑变量的连续体组合结构优化问题,建立了一套优化准则,在双方向渐进结构优化方法思想的基础上,形成了一种新的拓扑优化算法... 详细信息

考虑梁结构的预应力,导出了结构的应力及其灵敏度公式。同时,结合结构单元应力水平和相对差商,对于带有尺寸和拓扑变量的连续体组合结构优化问题,建立了一套优化准则,在双方向渐进结构优化方法思想的基础上,形成了一种新的拓扑优化算法。最后,算例表明了该方法的正确性和有效性。

关键词：预应力组合结构渐进结构优化拓扑优化

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三维结构的频率拓扑优化设计

振动与冲击 2006年第3期25卷 44-47页

作者：杨振兴荣见华傅建林长沙理工大学汽车与机械工程学院长沙410076

根据工程实际要求,利用频率灵敏度公式,提出了结构特性参数计算模型与三维结构优化模型的处理方案,研究了三维结构的频率拓扑优化设计方法和算法。提供的算例表明了本方法的实用性和有效性。

关键词：三维结构渐进结构优化频率优化

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窄带随机激励下的结构动力学拓扑优化设计

振动与冲击 2005年第6期24卷 85-87,94页

作者：杨振兴荣见华傅建林长沙理工大学汽车与机械工程学院长沙410076

基于模态截断法和一些近似处理,导出了一套窄带随机均方动响应及其灵敏度公式,再根据工程实际要求,研究了静载荷和窄带随机载荷作用下结构的动力学拓扑优化设计方法和算法,提供的算例显示了本方法的合理性和有效性。

关键词：结构优化渐进结构优化动力学窄带随机

云边协同下基于博弈论的云机器人部分任务卸载策略

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系统仿真学报 2023年第5期35卷 987-997页

作者：姜春茂杨振兴福建工程学院计算机科学与数学学院福建福州350118 哈尔滨师范大学计算机科学与信息工程学院黑龙江哈尔滨150500

如何合理地利用中心云、边缘云的资源,既降低系统设备能耗,又能缩短任务平均完成时间,是云机器人计算任务卸载面临的重大挑战。将云机器人的计算任务完成时间与能耗作为代价衡量指标,根据自身需求设置不同的代价权重,将多个云机器人的... 详细信息

如何合理地利用中心云、边缘云的资源,既降低系统设备能耗,又能缩短任务平均完成时间,是云机器人计算任务卸载面临的重大挑战。将云机器人的计算任务完成时间与能耗作为代价衡量指标,根据自身需求设置不同的代价权重,将多个云机器人的计算任务卸载问题转换成了一种多个玩家参与的博弈模型,设计了一种基于博弈论的部分任务卸载算法(game theory-partial task offloading,GT-PTO)。通过算法下的纳什平衡状态,找到参与者的最佳卸载阈值,从而达到系统总代价的优化。仿真结果表明,采用所提算法进行任务卸载,能够减少云机器人计算任务的能耗,缩短平均任务完成时间,大大提高云边协同服务质量。

关键词：博弈论云机器人任务卸载云边协同能耗优化