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World Journal of Gastrointestinal Oncology 2017年第4期9卷 153-159页

作者： zheng-yun liang Xing Kang Hong Chen Meng Wang Wen-Xian Guan Department of General Surgery Qianxinan People’s Hospital Department of General Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical School

AIM To investigate the effects of Clostridium perfringens enterotoxin(CPE) on gastric cancer cells which highly expressed claudin-4(CL4) *** In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on sub-cutaneous tumor in nude mice *** CL4 are highly expressed in SGC7901 cells. CPE expressedsignificant cytotoxicity in SGC7901 cells. Suppression of CL4 expression significantly decreased CPE-mediated cytotoxicity. CPE also inhibited tumor growth in subcutaneous tumor xenograft *** CPE showed CL4 mediated cytotoxicity on gastric cancer cells SGC7901 and inhib-ited tumor growth in nude mice models.

关键词： Gastric cancer Clostridium perfringens enterotoxin Claudin-4 protein Cytotoxicity Tight junction

Application and prospect of adipose stem cell transplantation in treating lymphedema

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World Journal of Stem Cells 2020年第7期12卷 676-687页

作者： Zhu-Jun Li Elan Yang yun-Zhu Li zheng-yun liang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane Library,and OVID-using the following search string:(“lymphedema”or“lymphoedema”or“lymphangiogenesis”)and(“adipose-derived stem cells”or“adipose-derived stromal cells”or“adipose-derived regenerative cells”).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.

关键词： Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis

Diagnostic workup of lymphedema

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Plastic and Aesthetic Research 2019年第10期6卷 15-23页

作者： zheng-yun liang Xiao Long Nan-Ze Yu Jiu-Zuo Huang Department of Plastic Surgery and Reconstructive Surgery Peking Union Medical College HospitalBeijing 100005China

Lymphedema is a chronic and progressive pathological state of tissue swelling caused by congenital or acquired lymphatic ***,physical and laboratory examinations could help to diagnosis>90%lymphedema *** stage lymphedema could be challenging to *** aim of this review is to provide an objective appraisal of current diagnostic methods,such as lymphoscintigraphy,lympho-fluoroscopies,lymphangiography and *** on their respective advantages and weaknesses,and hopefully shed some lights on developing a practical diagnosis modality beneficial to early detection and clinical decision making of lymphedema.

关键词： Lymphedema diagnosis lymphoscintigraphy magnetic resonance lymphangiography indocyanine green tissue dielectric constant bioelectrical impedance spectroscopy

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基于PHAST的苯海上运输船泄漏模拟分析

舰船科学技术 2024年第6期46卷 150-156页

作者：金浩王吉武郑云亮吉洪文栾虹锐孙海滨王伟章中国船舶集团有限公司第七一四研究所北京100101 交通运输部救助打捞局北京100736 北京伯尔明建筑工程设计有限公司北京101399 中国船舶集团有限公司第七〇四研究所上海200031 大连船舶重工集团有限公司辽宁大连116021

为预防苯海上运输中的泄漏安全事故,利用PHAST软件,以苯海上运输船为研究对象,探究不同泄漏孔径、风速对苯泄漏后的扩散距离及泄漏导致的池火、闪火、喷射火与超压爆炸范围的影响规律。结果表明,事故发生后,云团泄漏扩散距离、喷射火辐... 详细信息

为预防苯海上运输中的泄漏安全事故,利用PHAST软件,以苯海上运输船为研究对象,探究不同泄漏孔径、风速对苯泄漏后的扩散距离及泄漏导致的池火、闪火、喷射火与超压爆炸范围的影响规律。结果表明,事故发生后,云团泄漏扩散距离、喷射火辐射影响半径及爆炸超压影响半径与泄漏孔径尺寸成正比,泄漏扩散距离、爆炸超压影响半径与风速成反比。浓度100×106以及风速3 m/s下,泄漏孔径由25 mm增加到时75 mm,顺风扩散最大距离扩大了近4倍,云团最大单侧宽度增加了3倍。风速越小,越不利于苯的扩散,使得安全距离较远,且超压半径较大,风险较高。

关键词：海上运输苯泄漏扩散距离爆炸范围

Optical Extinctions of Inter-Arm Molecular Clouds in M31:A Pilot Study for the Upcoming CSST Observations

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Research in Astronomy and Astrophysics 2024年第6期24卷 323-333页

作者： Cailing Chen zheng zheng Chao-Wei Tsai Sihan Jiao Jing Tang Jingwen Wu Di Li yun zheng Linjing Feng Yujiao Yang Yuan liang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Zhejiang Lab Hangzhou 311121China

Recent submillimeter dust thermal emission observations have unveiled a significant number of inter-arm massive molecular clouds in ***,the effectiveness of this technique is limited to its sensitivity,making it challenging to study more distant *** study introduces an alternative approach,utilizing optical extinctions derived from space-based telescopes,with a focus on the forthcoming China Space Station Telescope(CSST).We first demonstrate the capability of this method by constructing dust extinction maps for 17 inter-arm massive molecular clouds in M31 using the Panchromatic Hubble Andromeda Treasury *** analysis reveals that inter-arm massive molecular clouds with an optical extinction(A_(V)) greater than 1.6 mag exhibit a notable A_(V) excess,facilitating their *** majority of these inter-arm massive molecular clouds show an A_(V) around 1 mag,aligning with measurements from our JCMT *** validation using a mock CSST RGB star catalog confirms the method's *** show that the derived A_(V)values using CSST z and y photometries align more closely with the input *** clouds with A_(V)> 1.6 mag can also be identified using the CSST mock *** thus claim that future CSST observation clouds provide an effective way for the detection of inter-arm massive molecular clouds with significant optical extinction in nearby galaxies.

关键词： infrared:stars ISM:clouds Galaxy:structure

X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun zheng Lin Liu Yi’ang Li Rui Rong liang Song Junpeng Shi Jing Teng Xia Sun yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China Xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity *** metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window ***,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence *** excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 *** *** can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence *** addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in *** LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be *** the persistent luminescence decays,LYGM can be re-excited for repeated ***,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths

Development of a Front End Array for Broadband Phased Array Receiver

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Research in Astronomy and Astrophysics 2024年第4期24卷 60-70页

作者： Kai Wang liang Cao Jun Ma Xue-Feng Duan Hao Yan Mao-zheng Chen yun-Wei Ning Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 8300lChina University of the Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China

The receiver is a signal receiving device placed at the focus of the *** order to improve the observation efficiency,the concept of phased array receiver has been proposed in recent years,which places a small phased array at the focal plane of the reflector,and flexible pattern and beam scanning functions can be achieved through a beamforming *** combined with the element multiplexing,all beams within the entire field of view can be observed simultaneously to achieve continuous sky *** article focuses on the front-end array of phased array receiver at 0.7-1.8 GHz for QiTai Telescope,and designs a Vivaldi antenna array of PCB structure with dual line *** polarization antenna is designed to arrange in a rectangle manner by 11×*** on the simulation results of the focal field,32,18,and eight elements were selected to form one beam at 0.7,1.25,and1.8 *** analog beamforming network was constructed,and the measured gains of axial beam under uniform weighting were 19.32,13.72,and 15.22 *** the beam scanning method of reflector antenna,the pattern test of different position element sets required for PAF beam scanning was carried out under independent *** pattern optimization at 1.25 GHz was carried out by weighting method of conjugate field *** with uniform weighting,the gain,sidelobe level,and main beam direction under conjugate field matching have been *** the above test and simulation results are slightly different,which is related to the passive array and laboratory testing condition,the relevant work has accumulated experience in the development of the front-end array for the phased array receiver,and has good guiding significance for future performance verification after the array is installed on the telescope.

关键词： telescopes instrumentation:detectors techniques:radar astronomy

Mechanical Performance of Bio-inspired Bidirectional Corrugated Sandwich Pressure Shell Under External Hydrostatic Pressure

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China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG Yi CHEN Yue yun Lai liang Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of *** cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress *** suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical *** static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical *** is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 *** simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich ***,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried *** to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich *** has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell ***,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

Proposing a machine learning approach to analyze and predict basic high-temperature properties of iron ore fines and its factors

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Journal of Iron and Steel Research International 2024年第5期31卷 1082-1094页

作者： Qing-ke Sun Yao-zu Wang Jian-liang Zhang zheng-jian Liu Le-le Niu Chang-dong Shan yun-fei Ma Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The basic high-temperature properties of iron ore play a crucial role in optimizing sintering and ore blending,but the testing process for these properties is complex and has significant lag time,which cannot meet the actual needs of ore blending.A prediction model for the basic high-temperature properties of iron ore fines was thus proposed based on a combination of machine learning algorithms and genetic ***,the prediction accuracy of different machine learning models for the basic high-temperature properties of iron ore fines was ***,a random forest model optimized by genetic algorithms was built,further improving the prediction accuracy of the *** test results show that the random forest model optimized by genetic algorithms has the highest prediction accuracy for the lowest assimilation temperature and liquid phase fluidity of iron ore,with a determination coefficient of 0.903 for the lowest assimilation temperature and 0.927 for the liquid phase fluidity after *** trained model meets the fluctuation requirements of on-site testing and has been successfully applied to actual production on site.

关键词： Iron ore Basic high-temperature property Machine learning Random forest Genetic algorithm

Hybrid stacking ensemble algorithm and simulated annealing optimization for stability evaluation of underground entry-type excavations

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Underground Space 2024年第4期17卷 25-44页

作者： Leilei Liu Guoyan Zhao Weizhang liang zheng Jian School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The stability of underground entry-type excavations(UETEs)is of paramount importance for ensuring the safety of mining *** more engineering cases are accumulated,machine learning(ML)has demonstrated great potential for the stability evaluation of *** this study,a hybrid stacking ensemble method aggregating support vector machine(SVM),k-nearest neighbor(KNN),decision tree(DT),random forest(RF),multilayer perceptron neural network(MLPNN)and extreme gradient boosting(XGBoost)algorithms was proposed to assess the stability of ***,a total of 399 historical cases with two indicators were collected from seven ***,to pursue better evaluation performance,the hyperparameters of base learners(SVM,KNN,DT,RF,MLPNN and XGBoost)and meta learner(MLPNN)were tuned by combining a five-fold cross validation(CV)and simulated annealing(SA)*** on the optimal hyperparameters configuration,the stacking ensemble models were constructed using the training set(75%of the data).Finally,the performance of the proposed approach was evaluated by two global metrics(accuracy and Cohen’s Kappa)and three within-class metrics(macro average of the precision,recall and F1-score)on the test set(25%of the data).In addition,the evaluation results were compared with six base learners optimized by *** hybrid stacking ensemble algorithm achieved better comprehensive performance with the accuracy,Kappa coefficient,macro average of the precision,recall and F1-score were 0.92,0.851,0.885,0.88 and 0.883,*** rock mass rating(RMR)had the most important influence on evaluation ***,the critical span graph(CSG)was updated based on the proposed model,representing a significant improvement compared with the previous *** study can provide valuable guidance for stability analysis and risk management of ***,it is necessary to consider more indicators and collect more extensive and balanced dataset to validate the model in futur

关键词： Underground entry-type excavations(UETEs) Hybrid stacking ensemble Machine learning Simulated annealing Critical span graph Base and meta learners