X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

作     者：Hanrun Zheng Lin Liu Yi’ang Li Rui Rong Liang Song Junpeng Shi Jing Teng Xia Sun Yun Zhang Hanrun Zheng;Lin Liu;Yi'ang Li;Rui Rong;Liang Song;Junpeng Shi;Jing Teng;Xia Sun;Yun Zhang

作者机构：State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of SciencesBeijing100049China Xiamen Hospital of Traditional Chinese MedicineXiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou350108China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2024年第42卷第1期

页      面：28-35,I0001页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Project supported by the National Natural Science Foundation of China(62105333) the Key Research Program of the Chinese Academy of Sciences(ZDRW-CN-2021-3) Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(2020ZZ114) the Xiamen Medical and Health Guidance Project,China(3502Z20209124) 

主　　题：Persistent luminescence X-ray Biological window In vivo imaging Rare earths 

摘      要：In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity *** metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window ***,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence *** excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 *** *** can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence *** addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in *** LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be *** the persistent luminescence decays,LYGM can be re-excited for repeated ***,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.