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1,25-dihydroxyvitamin D_3 regulates LPS-induced cytokine production and reduces mortality in rats

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World Journal of Gastroenterology 2008年第24期14卷 3897-3902页

作者： Xiao-Ping Qi Pei li Gang li zhen Sun jie-Shou li School of Medicine Nanjing University Department of GeneralSurgery Jinling Hospital 305 Zhongshandong Road Nanjing210002 Jiangsu Province China

AIM： To study the immunoregulatory effect of 1,25-dihydroxyvitamin-D3 Von dominant Thl response in rats. METHODS： Sixty adult Lewis rats were randomized into three groups. Rats in group 1 （n=25） were treated with 1,25-（OH）2D3 first and then challenged with LPS, rats in group 2 （n=25） were treated with vehicle first and then challenged with LPS. Ten animals in groups 1 and 2 were preserved for mortality observation. The remaining animals were injected （i.p） with endotoxin, 24 h after the last administration of 1,25-（OH）2D3 and vehicle. Rats in group 3 （n=10） were treated with 1,25-（OH）2D3 only. Serum IL-12, IFN-y, IL-2 and IL-4 levels were measured and target gene of 1,25-（OH）2D3 on Th cells was studied after 6 h. Gene abundance was verified by real-time quantitative PCR. RESULTS： No death occurred in rats pretreated with 1,25-（OH）2D3 after LPS injection. Death occurred 9 h after LPS injection in rats pretreated with the vehicle, and the number of deaths was 5 within 24 h, with a mortality rate of 50%. There was no change in the number of deaths within 96 h. Six hours after endotoxin stimulation, serum IL-12 and IFN-y levels decreased significantly in rats pretreated with 1,25-（OH）2D3 as compared with those in rats pretreated with the vehicle. The serum content of these two cytokines was very low in rats not challenged by endotoxin, and there was a significant difference as compared with the previous two groups. CONCLUSION： 1,25-（OH）2D3 attenuates injuryinduced by the lethal dose of 1PS, regulates Thl and Th2 cells at the transcription level, and dominantly responds to cytokine production in rats.

关键词： Endotoxin Cytokine 1,25-dihydroxy-vitamin-D3 Immunoregulation Mortality

The development and application of the test system for the silicon pixel modules in HEPS-BPIX

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Radiation Detection Technology and Methods 2021年第1期5卷 53-60页

作者： Ye Ding jie Zhang Wei Wei zhen-jie li Hang-xu li Xiao-lu Ji Yan Zhang Xiao-shan Jiang Ke-jun Zhu Peng liu Yuan-bo Chen Qiu-ju li Wei-fan Sheng State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China Institute of High Energy Physics Chinese Academy of Sciences19 B Yuquan RdShijingshan DistrictBeijingChina University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Background HEPS-BPIX is a prototype of photon counting pixel detector developed for the High Energy Photon *** consists of 16 silicon pixel modules which should be tested individually to ensure the function and *** Due to various factors such as the non-uniformity of the processes and voltage drop,the response of each pixel in the silicon pixel module is not identical *** response difference of pixels can be minimized by the threshold *** system is developed for the quality test and calibration of the silicon pixel *** The system consists of a mother board,a control board and a data acquisition(DAQ)*** mother board provides necessary resources including power supplies and the fanout of calibration ***,it can be used to test the connectivity by monitoring the power *** control board reads data out and provides the clock,trigger and configuration data for the silicon pixel *** DAQ system sends the control commands and receives the readout data through an Ethernet *** Compared with the previous readout system,this designed system has a lower noise level and better scanning curves making the calibration more *** it has been successfully applied to the comparison experiments of the through silicon via and wire-bonding silicon pixel *** The results show that this test system can be used to the quality test and calibration of the silicon pixel *** addition,the system can be adapted to the measurement of different pixel array detector modules.

关键词： Hybrid silicon pixel module Test and calibration Power management Through silicon via and wire-bonding HEPS

Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy

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Natural Products and Bioprospecting 2015年第1期5卷 37-45页

作者： Pei Cao zhen-jie li Wen-Wu Sun Shashwat Malhotra Yuan-liang Ma Bin Wu Virinder S.Parmar State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Bioorganic Laboratory Department of ChemistryUniversity of DelhiDelhi 110007India Institute of Chemistry and Biochemistry Freie Universita¨t BerlinTakustrasse 314195 BerlinGermany

The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.

关键词： Acortatarin alkaloids Diabetic nephropathy N-alkylation/hemiacetalization Halomethylation Chiral lactones

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li zhen Ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

^(57)Fe Mssbauer spectroscopic study on the barks of several three species grown in Lanzhou, China

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Journal of Environmental Sciences 1998年第4期10卷 40-42页

作者： Wang Hong liang Department of Biology,Lanzhou University, Lanzhou 730000,China Zhao zhen jie, li Fa shen Department of Physics,Lanzhou University,Lanzhou 730000,China

Using 57 Fe Mssbauer effect, the chemical states of iron components were investigated for the barks of Platycladus orientalis, Cedrus deodara and Platanus acerifolia sampled from Lanzhou City, China. All bark samples showed two overlapping doublets with large and small quadruple splitting. Only Platycladus orientalis's barks exhibited one sextet. Based on Mssbauer parameters, they were attributed to paramagnetic ferrous, paramagnetic ferric and magnetic iron, respectively. For the sampling site which is about 6 kilometers from Lanzhou Steel Factory, the ratio of ferrous to ferric was higher in the sample of Platanus acerifolia's barks, whereas the barks of Platycladus orientalis and Cedrus deodara gave similar values of this ratio. Platycladus orientalis was the most effective in accumulating iron complexes in barks among the three trees. Platanus acerifolia's barks sampled at Lanzhou Steel Factory's area exhibited higher absolute intensities of iron components and lower ration of ferrous to ferric, indicating that industrial air pollution is a contributing factor in accumulating iron compounds in the tree barks of this region.

关键词： Mssbauer spectroscopy iron bark air pollution.

Three new compounds from Hemsleya chinensis

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Three new compounds from Hemsleya chinensis

Cyano migration-mediated radical-polar crossover cyclopropanation

中国化学会第十届全国天然有机化学学术会议

作者： zhen-jie li Le Cai Jian-Chao Chen Ming-Hua Qiu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Science Yunnan University

The genus Hemsleya(Cucurbitaceae),containing 31 species,has its centre of distribution in Yunnan and Sichuan *** tubers of some Hemsleya species are used as folk medicine to treat bronchitis,bacillary dysentery,and *** to now,more than 50 new triterpenoids and their glycosides have been isolated from this genus,and some ones also showed interesting

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Science China Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu Chen jie li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

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liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei Zhu lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species