Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy

作     者：Pei Cao Zhen-Jie Li Wen-Wu Sun Shashwat Malhotra Yuan-Liang Ma Bin Wu Virinder S.Parmar 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Bioorganic LaboratoryDepartment of ChemistryUniversity of DelhiDelhi 110007India Institute of Chemistry and BiochemistryFreie Universita¨t BerlinTakustrasse 314195 BerlinGermany 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2015年第5卷第1期

页      面：37-45页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the“Hundred Talents Project”of Chinese Academy of Science and“High-end Science and Technology Talents Program”’of Yunnan Province(2011HA008) 

主　　题：Acortatarin alkaloids Diabetic nephropathy N-alkylation/hemiacetalization Halomethylation Chiral lactones 

摘      要：The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.