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Theoretical investigation of the stereoselectivity of some Diels-Alder reactions involving cyclopentadiene

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Chinese Chemical Letters 2008年第9期19卷 1135-1138页

作者： Dong Xia Zhao zhen zhen xu zhong Zhi Yang College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China

The stereoselectivity of some Diels-Alder reactions was investigated by means of ABEEM-oTr model. Combined with local hard-soft and acid-base （HSAB） principle, we made reasonable explanation by calculating local sof... 详细信息

关键词： ABEEM-σπ model Diels--Alder reaction Stereoselectivity Local softness

Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

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Neuroscience Bulletin 2023年第1期39卷 173-175页

作者： Jing Yang Shulan Xie Shengmei Zhu zhen-zhong xu Department of Anesthesiology and Department of Neurobiology of the First Affiliated Hospital Zhejiang University School of MedicineHangzhou310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain–Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310058China

Neuropathic pain is a major health problem affecting up to 10%of the general population,resulting from a lesion or dysfunction of the somatosensory nervous system,including peripheral nerve injury(PNI)^([1]).However,neuropathic pain is difficult to treat because of its obscure *** types of neuropathic pain have been modelled in rodents to study its underlying mechanisms and identify novel therapeutic targets.

关键词： pain mechanisms Spinal

Resolution of Inflammatory Pain by Endogenous Chemerin and G Protein-Coupled Receptor ChemR23

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Neuroscience Bulletin 2021年第9期37卷 1351-1356页

作者： Ya-Kai Xie Hao Luo Xiao-Yun Qiu zhen-zhong xu Department of Neurobiology and Department of Anesthesiology of the First Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain–Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China

Dear Editor,Inflammatory pain,such as arthritic pain,is a common health problem *** pain is generally treated by opioids and non-steroidal anti-inflammatory drugs including cyclooxygenase-2(COX-2)***,side-effects limit the analgesic efficiency of current treatments and there is an urgent need to develop novel strategies for treatment.

关键词： Inflammatory drugs pain

A new tumor necrosis factor（TNF）-α regulator,lipopolysaccharides-induced TNF-α factor,is associated with obesity and insulin resistance

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Chinese Medical Journal 2011年第2期124卷 177-182页

作者： JI zhen-zhong DAI Zhe xu Yan-cheng Department of Endocrinology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China

Background Tumor necrosis factor （TNF）-α plays an important role in mediating inflammatory state in obesity and related *** （LPS）-induced TNF-α factor （LITAF） is recently verified as a regulator of TNF-α and other inflammatory cytokines,and maybe act as a transcriptional *** aim of this study was to confirm the association between LITAF and obesity and insulin *** Forty-seven subjects with a wide range of body mass index （BMI） were *** were divided intothree groups according to the criteria of normal weight,overweight and *** and metabolic profile were tested for all the *** monocytes were isolated and *** transcription was detected by real time PCR,and the protein expression in whole cell and nucleus extracts was detected by Western blotting analysis;transcriptional activity of LITAF was detected by ELISA like assay using a probe containing the DNA binding sequence of *** TNF-α and interleukin （IL）-6 concentrations were determined with ELISA *** The LITAF mRNA and protein expression in whole cell were higher in overweight （P 〈0.05） and obese group （P 〈0.05） compared with that in normal weight *** LITAF protein expression in the nucleus and transcriptional activity could not be *** protein expression was positively correlated with BMI （r=0.541,P 〈0.001）,waist circumference （r=0.391,P=0.007）,the homeostasis model assessment for insulin resistance （r=0.372,P=0.011） and fasting insulin levels （r=0.359,P=0.013）.As a regulator of inflammatory cytokines,LITAF protein expression was positively correlated with plasma TNF-α （r=0.621,P=0.002） and IL-6 （r=0.407,P=0.039） *** variant regression analysis indicated that BMI （P=0.002） and waist circumference （P=0.017） were independent predictors of LITAF protein *** LITAF is associated with obesity and insulin resistance,as well as inflammatory cytokine se

关键词： obesity insulin resistance lipopolysaccharides-induced TNF-α factor TNF-α

Modulation of chronic pain by novel pro-resolution lipid mediators

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Modulation of chronic pain by novel pro-resolution lipid med...

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

中国神经科学学会第十二届全国学术会议

作者： zhen-zhong xu Rougang Xie Ya-Kai Xie Ru-Rong Ji Center of Neuroscience Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang University School of Medicine Departments of Anesthesiology Duke University Medical Center

Chemotherapy-induced peripheral neuropathy（CIPN）, including chronic pain, is the dose-limiting toxicity for many commonly used classes of anti-cancer agents. CIPN results in morphological and functional insults to the nervous system, including axonal degeneration and neuronal hyperactivity in the DRG and spinal cord. Chemotherapyinduced chronic pain is difficult to treat and its mechanisms are still unclear, so it is a major challenge of pain medicine and there is an urgent need to develop novel strategies for treatment. Neuroinflammation, a local inflammation in the peripheral or central nervous system, plays an important role in the initiation and maintenance of chronic pain. Our previously studies have shown that the pro-resolution lipid mediators（PRLMs） were involved in the resolution of acute and chronic pain. Neuroprotectin D1（NPD1） is a newly identified endogenous PRLM and demonstrates potent neuroprotective actions. NPD1 potently inhibits inflammatory pain and nerve trauma-induced neuropathic pain. We also investigated whether NPD1 could prevent and reverse chemotherapy-induced chronic pain and further address the underlying mechanisms. Treatment with NPD1 not only prevented mechanical allodynia but also abrogated chemotherapy-induced ongoing pain. Mechanistically, NPD1 treatment protected chemotherapy-induced axonal degeneration in vivo and reversed chemotherapy-induced hyperexcitability in large DRG neurons. Spinal NPD1 treatment dose-dependently attenuated chronic pain and spinal cord synaptic plasticity induced by chemotherapy. Thus, NPD1 could effectively attenuate chronic pain by resolving axonal degeneration, neuroinflammation, and neuronal hyperactivity in the DRG and spinal cord. NPD1 and its mimetics might be novel therapeutics for preventing and treating chronic pain.

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang Yin Fan‑zhen Jiao zhong‑zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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基于ANSYS永磁无刷电动机的温度场分析

微特电机 2017年第10期45卷 31-33,42页

作者：史忠震许贞俊张宇贵州交通职业技术学院贵阳550008 贵州省机械工业学校贵阳550001 贵州凯敏博机电科技有限公司贵阳520100

通过有限元软件对永磁无刷电动机进行温度场分布研究,根据电机实际结构特点建立仿真模型,特别是定子绕组等效成层层叠压,即每两个绕组层之间为绝缘层建立绕组热模型,以电机热交换边界条件建立了温度场边界,通过分析得出永磁无刷电动机... 详细信息

通过有限元软件对永磁无刷电动机进行温度场分布研究,根据电机实际结构特点建立仿真模型,特别是定子绕组等效成层层叠压,即每两个绕组层之间为绝缘层建立绕组热模型,以电机热交换边界条件建立了温度场边界,通过分析得出永磁无刷电动机各部件温度场分布,实验研究结果与仿真结果对比得出模型等效方法的正确性和温度场分析方法的正确性,对永磁无刷电动机优化设计提供参考数据,对电机热场研究精确度提高有十分重要意义。

关键词：永磁电机等效模型温度场研究有限元

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao Yue Yiman Zhang Lulu Li zhong-zhen Yu Peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability