The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain

作     者：Zilong Wang Zhen-Zhong Xu Zilong Wang;Zhen-Zhong Xu

作者机构：Department of AnesthesiologyCenter for Translational Pain MedicineDuke University Medical CenterDurhamNC 27710USA SUSTech Center for Pain MedicineSchool of MedicineSouthern University of Science and TechnologyShenzhen 518055China Department of Neurobiology and Department of Anesthesiology of the First Affiliated HospitalNHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of MedicineHangzhou 310058ZhejiangChina 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第7期

页      面：1079-1081页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Duke University Anesthesiology Research Funds and the National Natural Science Foundation of China(31771162) 

主　　题：sensation diseases opioid 

摘      要：Neuropathic pain is a chronic pain caused by peripheral or central nervous system injury or diseases that affect the somatosensory nervous *** is usually associated with abnormal sensations called dysesthesia and exaggerated pain from normally innocuous stimuli(allodynia)or noxious stimuli(hyperalgesia),and also aversive emotional responses[1,2].Neuropathic pain can be very difficult to treat,as classical analgesics like opioids produce inadequate pain relief and may cause tolerance and hyperalgesia,and even addiction after long-term use[3].Thus,it is of critical importance to study the mechanisms of development,maintenance,and resolution of neuropathic *** study from ***’s research team at Zhejiang University reveals a critical regulatory mechanism for neuropathic pain[4].