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Neuropsychological features in post-stroke cognitive impairment with no dementia patients with different Traditional Chinese Medicine syndromes

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Journal of Traditional Chinese Medicine 2019年第1期39卷 97-102页

作者： Ma Jie Wang Yu Zhang Yunyun Guo Qihao zhen xiaomin Shi Moyi Department of Neurology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Department of Gerontology Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Internal Medicine of Traditional Chinese Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

OBJECTIVE: To investigate neuropsychological features of post-stroke cognitive impairment with no dementia(PSCIND) patients with different Traditional Chinese Medicine(TCM) ***: We recruited 50 patients with PSCIND between April 2012 and March 2013. Patients were divided into different groups according to TCM classifications. Patients were assessed using neuropsychological tests, including cognitive screening(mini-mental state examination), memory testing (auditory verbal learning test), executive/attention[shape trails test, stroop color-word test(SCWT),reading the mind in the eyes test, the digit ordering test-A(DOT-A), and symbol digit modalities test], language(action naming test, Boston naming test, famous face test, similarity test, and verbal fluency test), and visuospatial functioning [complex figure test(CFT)].RESULTS: We found no significant differences between patients with and without a diagnosis of turbid phlegm blocking the upper orifices on neuropsychological test performance. Patients diagnosed with upper hyperactivity of liver Yang syndrome scored significantly lower on the SCWT-C executive test and the CFT-delayed recall memory test. Patients with excess syndrome scored significantly lower on the SCWT-C executive test, and significantly higher on the DOT-A executive ***: Neuropsychological characteristics differ between PSCIND patients with different TCM classifications.

关键词： Cognitive dysfunction Stroke Syndromes and signs Neuropsychological tests

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CRISPR/CasΦ2-mediated gene editing in wheat and rye

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Journal of Integrative Plant Biology 2024年第4期66卷 638-641页

作者： Sanzeng Zhao Xueying Han Yachen Zhu Yuwei Han Huiyun Liu zhen Chen Huifang Li Dan Wang Chaofan Tian Yuting Yuan Yajie Guo xiaomin Si Daowen Wang Xiang Ji State Key Laboratory of Wheat and Maize Crop Science and Center for Crop Genome EngineeringCollege of AgronomyHenan Agricultural UniversityZhengzhou 450046China Collaborative Innovation Center of Henan Grain Crops College of AgronomyHenan Agricultural UniversityZhengzhou 450046China State Key Laboratory of Crop Stress Adaptation and Improvement College of AgronomyHenan UniversityKaifeng 475004China The Shennong Laboratory Zhengzhou 450002China

The recent advancements in developing the CRISPR/Cas9 system and various derivative tools(e.g.,base editors)have accelerated basic plant science research and crop improvement by creating multiple types of genetic vari... 详细信息

关键词： CRISPR/Cas9 CRISPR/Cas

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A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test

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Biosafety and Health 2024年第3期6卷 143-152页

作者： Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi zhen Zhang Ziquan Lv Qiuying Lv xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang Department of Public Health and Preventive Medicine School of MedicineJinan UniversityKangtai Biological Vaccine Industry Research Institute/Disease Prevention and Control Institute of Jinan UniversityGuangzhou 510632China Shenzhen Center for Disease Control and Prevention Shenzhen 518020China Department of Microbiology and Immunology Institute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China The Sixth Affiliated Hospital Jinan UniversityGuangzhou 510632China Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China Department of Communicable Diseases Control and Prevention Shenzhen Center for Disease Control and PreventionShenzhen 518020China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China

Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous *** the individuals who test positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated *** the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome ***,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of *** recruited 4 human leukocyte antigen A2(HLA-A2)infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2 HLA-A2 and HLA-A24 epitope-specific CD8^(+)T *** individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than *** enzyme-linked immunospot(ELISpot)results further validate this *** study forms a“method for understanding the infection history of SARS-CoV-2 subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2+and HLA-A24+donors,providing a novel method for SARS-CoV-2 infected case tracing.

关键词： Asymptomatic coronavirus disease 2019 (COVID-19) Epitopes Specific CD8^(+)T cell ELISpot

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新麦草YUCCA基因克隆及其表达特性分析

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西北农林科技大学学报（自然科学版） 2024年第7期52卷 21-28页

作者：任晓敏云岚艾芊李珍赵乔石凤翎内蒙古农业大学草原与资源环境学院内蒙古呼和浩特010018 草地资源教育部重点实验室内蒙古呼和浩特010011 中国科学院深圳先进技术研究院广东深圳518055

【目的】克隆新麦草分蘖关键基因YUCCA并明确其表达特性,为该基因功能验证和育种利用奠定基础。【方法】以不同分蘖类型的新麦草分蘖节为材料,采用PCR法克隆新麦草YUCCA基因并进行同源序列比对,构建1300-cYFP-YUCCA过表达载体,利用烟草... 详细信息

【目的】克隆新麦草分蘖关键基因YUCCA并明确其表达特性,为该基因功能验证和育种利用奠定基础。【方法】以不同分蘖类型的新麦草分蘖节为材料,采用PCR法克隆新麦草YUCCA基因并进行同源序列比对,构建1300-cYFP-YUCCA过表达载体,利用烟草瞬时转染及蛋白质印迹法分析新麦草YUCCA蛋白的表达位置及表达情况,通过RNA-Seq数据及qRT-PCR分析验证YUCCA基因的相对表达量。【结果】成功克隆了新麦草YUCCA基因全长,大小为1336 bp,最大阅读框为1236 bp,并成功构建了1300-cYFP-YUCCA过表达载体。多序列比对结果显示,新麦草YUCCA主要与麦类作物的亲缘关系较近。表达特性分析发现,YUCCA基因在多分蘖型新麦草中的相对表达量远低于少分蘖型新麦草;与叶、根等组织相比,YUCCA基因在分蘖节中的相对表达量最高。烟草瞬时转化和蛋白质印迹法分析均显示,YUCCA蛋白可以正常表达,其亚细胞定位于细胞质中。【结论】YUCCA基因在调控新麦草分蘖中起下调作用,可用于后续YUCCA基因功能的研究。

关键词：新麦草 YUCCA 过表达载体亚细胞定位基因克隆

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致密油藏注伴生气驱油可行性分析及效果评价

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油气井测试 2024年第3期33卷 72-78页

作者：刘昕李震袁雪花郑小敏段朝伟王绍祥中国石油集团测井有限公司地质研究院陕西西安710075 中国石油集团测井有限公司西南分公司重庆401120 中国石油大港油田公司勘探开发研究院天津300280 中国石油集团测井有限公司市场生产部陕西西安710075

致密油藏在开发过程中注水困难,亟需探索补充地层能量的新方式,同时油藏伴生气难以规模性开发。为研究油藏注气可行性,在室内开展原油相态特征、注气驱混相机理及注气驱长岩心实验研究,分析了M区块原油的相态特征、注入气与原油的互溶... 详细信息

致密油藏在开发过程中注水困难,亟需探索补充地层能量的新方式,同时油藏伴生气难以规模性开发。为研究油藏注气可行性,在室内开展原油相态特征、注气驱混相机理及注气驱长岩心实验研究,分析了M区块原油的相态特征、注入气与原油的互溶特征、注气混相机理以及长岩心注气驱油动态关键指标变化规律,结合现场应用情况,对其应用效果进行分析。结果表明,地层压力16 MPa下,原油溶解伴生气体积膨胀了1.161倍,黏度降低了20.5%;地层温度65℃下,注伴生气驱替长岩心原油采收率比衰竭开采提高23.15%;油藏开发中后期注入伴生气可有效促进油水界面下移,射孔段剩余油增多,目的层段由高含水变为低含水。经X井现场应用,剩余油饱和度由注气前的28.62%升高至42.17%。注伴生气可有效提高油藏采收率,可为同类油藏制定开发方案提供重要实验数据支撑和理论指导。

关键词：致密油藏气驱采油伴生气物理模拟提高采收率动态监测混相驱现场应用

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浅议火电企业成本控制

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江西能源 2005年第3期21卷 21-23,48页

作者：曾晓敏江西新余发电有限责任公司江西新余338001

国家电力改革已按“厂网分开”将国家电力公司管理的电力资产按照发电和电网两类业务进行划分。并在发电环节引入竞争机制,本文在分析电力企业的成本构成的基础上,分析了影响成本的因素,提出了降低成本的建议和对策。

关键词：成本构成成本控制对策建议

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恶性肺小结节371例的临床和分子病理学特征

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中国临床研究 2024年第1期37卷 24-28页

作者：陆晓旻王晓镇海文孙怡朱际平南京中医药大学附属医院江苏省中医院呼吸与危重症医学科江苏南京210029 南京中医药大学附属医院江苏省中医院心胸外科江苏南京210029 南京中医药大学附属医院江苏省中医院病理科江苏南京210029

目的总结恶性肺小结节的临床和分子病理学特征,提高对该疾病的认识。方法以2018年3月至2021年12月于江苏省中医院心胸外科行肺小结节手术切除治疗且病理证实为恶性的患者为研究对象。回顾性分析其临床资料和手术标本分子病理学特征。... 详细信息

目的总结恶性肺小结节的临床和分子病理学特征,提高对该疾病的认识。方法以2018年3月至2021年12月于江苏省中医院心胸外科行肺小结节手术切除治疗且病理证实为恶性的患者为研究对象。回顾性分析其临床资料和手术标本分子病理学特征。结果共纳入患者371例,原位癌39例,微浸润腺癌164例,浸润腺癌168例;女性69.8%,男性30.2%,女性占多数;87.6%患者不吸烟;右肺上叶的恶性结节最多(37.5%),其次为左肺下叶(18.6%)。不同病理类型比较,原位癌、微浸润腺癌和浸润腺癌患者的年龄分别为(54.1±10.9)、(52.2±12.6)和(59.1±9.9)岁(F=16.05,P<0.01),吸烟率分别为10.3%、3.7%和21.4%(χ^(2)=24.31,P<0.01),瘤体直径中位值分别为0.55、0.60、0.80 cm(H=76.13,P<0.01),均以浸润腺癌最高,差异均有统计学意义。浸润腺癌表皮生长因子受体(EGFR)的21外显子、肿瘤抑制蛋白p53(TP53)的突变频率高于原位癌和微浸润腺癌(P<0.05),而人类表皮生长因子受体2(HER2)的外显子20ins、丝裂原活化蛋白激酶(MAP2K1)和丝氨酸/苏氨酸蛋白激酶(BRAF)的突变频率低于原位癌和微浸润腺癌,差异有统计学意义(P<0.05)。结论具有恶性肺结节的患者,可能有下列特性:女性、不吸烟、位于右肺上叶多见。三种病理类型的恶性结节中,年龄、吸烟率、瘤体直径和驱动基因突变频率存在差异。

关键词：肺小结节,恶性原位癌微浸润腺癌浸润腺癌分子病理学特征

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一种基于多模态变分自编码器的联合认知表征学习方法

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军事医学 2024年第7期48卷 516-523页

作者：宋秋月陈圆贾淑钰应晓敏何振南京农业大学人工智能学院南京210031 军事科学院军事医学研究院北京100850

目的学习大脑视觉认知活动的多模态联合认知表征,提高认知表征的视觉信息分类性能,并从视觉图像特征中预测大脑脑电图(EEG)响应以及从EEG信号中解码出视觉图像。方法基于多模态变分自编码器网络结构,结合混合专家乘积(MoPoE)方法学习联... 详细信息

目的学习大脑视觉认知活动的多模态联合认知表征,提高认知表征的视觉信息分类性能,并从视觉图像特征中预测大脑脑电图(EEG)响应以及从EEG信号中解码出视觉图像。方法基于多模态变分自编码器网络结构,结合混合专家乘积(MoPoE)方法学习联合认知表征,并添加基于自适应鉴别器增强的样式生成对抗网络(StyleGAN2⁃ADA)实现对EEG信号的编码和解码任务,包括分类任务以及图像和EEG的跨模态生成。结果实现了不同模态的特征融合,提高了认知表征视觉信息的分类性能,并将不同模态的特征空间对齐到一个联合隐空间,为跨模态生成任务奠定了基础。基于联合隐空间进行的EEG和图像的相互跨模态生成结果优于以往工作中从一个模态到另一个模态的单向映射方法。结论能够融合并对齐多个模态的信息,使联合认知表征的分类性能优于使用任何单一模态,并且在跨模态生成任务中取得优于模态单向映射的结果,为大脑视觉认知信息有效统一的编码和解码建模研究提供了新思路。

关键词：多模态变分自编码器认知表征脑电图跨模态生成

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Nonlinear Dynamic Analysis and Fatigue Study of Steep Wave Risers Under Irregular Loads

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Journal of Ocean University of China 2022年第3期21卷 669-680页

作者： GU Honglu GUO Haiyan LI xiaomin LI Fuheng LIU zhen College of Engineering Ocean University of ChinaQingdao266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao266100China

As a reliable alternative option for traditional steel catenary risers(SCRs),steep wave risers(SWRs)have been widely applied to deepwater oil and gas ***,the nonlinear dynamic analysis of SWRs is more complicated than that of traditional SCRs due to their special configuration and significant geometric ***,SWRs are highly susceptible to fatigue failure under the combined excitation of irregular waves and top floater motions(TFMs).In this study,considering irregular waves and TFMs,a numerical SWR model with an internal flow is constructed based on the slender rod model and finite element *** Newmark-βmethod is adopted to solve the dynamic behavior of ***,the Palmgren-Miner rule,a specified S-N curve,and rainflow counting method are applied to estimate the fatigue *** efficient numerical computation procedure,i.e.,DRSWR,is programmed with MATLAB in this *** results are compared with those of OrcaFlex to verify the accuracy of the *** nonlinear dynamic response and fatigue damage of an SWR under the combined excitation of irregular waves and TFMs are obtained,and a comprehensive parametric analysis is then *** analysis results show that the buoyancy section undergoes the highest level of stress and fatigue damage under the combined excitation of irregular waves and *** internal flow with high velocity and high density produces a high level of fatigue *** buoyancy factor and length of the buoyancy section should be set moderately to reconcile the reduction of the top tension with increased fatigue *** results are expected to provide some reference significance for the engineering design of SWR.

关键词： steep wave riser slender rod model nonlinear dynamic analysis fatigue damage sensitivity analysis

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Deformation and Stress Analysis of the Deepwater Steel Lazy Wave Riser Subjected to Internal Solitary Waves

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Journal of Ocean University of China 2023年第2期22卷 377-392页

作者： LI Fuheng GUO Haiyan GU Honglu LIU zhen LI xiaomin College of Engineering Ocean University of ChinaQingdao 266100China

The dynamic response of the steel lazy wave riser(SLWR)subjected to the internal solitary wave is a key to assessing its application *** innovation of this paper is to study the dynamic response properties of the SLWR with large deformation characteristics under internal wave excitation.A numerical scheme of the SLWR is constructed using the slender-rod theory,and the internal solitary wave(ISW)with a two-layer seawater model is simulated by the extended Korteweg-deVries *** finite element method combined with the Newmark-βmethod is applied to discretize the equations and update the time *** ISW excitation combined with vessel motion on the dynamic deformation and stress of the SLWR is investigated,and extensive simulations of the ISW parameters,including the interface depth ratio and density difference,are carried *** calculation reveals that the displacement of the riser in the lower interface layer increases significantly under the ISW excitation,and the stresses at a part of both ends grow ***,the mean value of riser responses under a combination of vessel motion and ISW coincides with the ISW-induced ***,the dynamic responses along the whole riser,including the displacement amplitudes,bending moment amplitudes,and stress amplitudes,almost increase with the increase in interface depth ratios and density differences.

关键词： steel lazy wave riser(SLWR) internal solitary wave(ISW) slender-rod theory deformation stress

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