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Eosinophil: central mediator of allergic asthma?

中华医学杂志(英文版) 2005年第1期000卷 5-6页

作者： SHEN Huahao Department of Respiratory medicine, Second Hospital, zhejiang university college of medicine, Hangzhou 310009, China Department of Respiratory medicine Second Hospital Zhejiang University College of Medicine Hangzhou 310009 China

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CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma

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Acta Pharmacologica Sinica 2006年第12期27卷 1594-1599页

作者： Hua-hao SHEN~2 Feng XU~2 Gen-sheng ZHANG Shao-bin WANG Wei-hua XU Department of Respiratory Diseases,the Second Affiliated Hospital,zhejiang university college of medicine,Hangzhou 310009,China Department of Respiratory Diseases the Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou China

Aim:To explore the effect of a rat anti-mouse CC-chemokine receptor-3(CCR3)monoclonal antibody(CCR3 mAb)on airway eosinophilia and mucus overpro-duction in asthmatic ***:An asthma model was sensitized and chal-lenged by ovalbumin(OVA)in male C57BL/6 *** mice were givendual administration(intraperitoneal injection and aerosol inhalation)of CCR3 mAbor nonspecific rat IgG(ns-IgG).The number of total and differential inflammatorycells in the bronchial alveolar lavage fluid(BALF)was *** number,the goblet cell percentage(GCP)and airway mucus index(AMI)were measured inthe lung ***(IL)-5 levels in the BALF were *** expres-sion of MUC5AC and the epidermal growth factor receptor(EGFR)mRNA in thelung tissues was detected by semi-quantitative *** results were com-pared among the ***:CCR3 mAb significantly suppressed theincreased eosinophils in the BALF and lung tissues in OVA-challenged mice com-pared with ns-IgG-treated ***-5 levels in the BALF in CCR3 mAb and ns-IgGadministration mice exhibited no obvious changes relative to OVA-challengedasthmatic ***3 mAb reduced the increased GCP and AMI after OVA chal-lenge and decreased the enhanced expression of MUC5AC and EGFR mRNA inlung tissues in asthmatic ***:CCR3 mAb can significantlyinhibit airway eosinophilia and mucus overproduction in asthmatic ***-age of CCR3 may represent a new strategy to asthma therapy.

关键词： asthma CCR3 monoclonal antibody eosinophilic inflammation mucus overproduction MUC5AC epidermal growth factor receptor

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Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats

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Acta Pharmacologica Sinica 2007年第7期28卷 1001-1006页

作者： Wei-li LIU~2,Shu-jie CHEN~2,Yan CHEN~(2,3),Lei-min SUN~2,Wei ZHANG~2,Ya-min ZENG~2,Tian-hua ZHOU~(2,4),Jian-min SI~(2,5)~2 Department of Gastroenterology and zhejiang Key laboratory of Traditional Chinese medicine(TCM),Sir Run Run Shaw Hospital,zhejianguniversity School of medicine,Hangzhou 310012,China ~3 Department of Gastroenterology,Second Affiliated Hospital and ~4 Center forDisease Modeling,zhejiang university college of medicine,Hangzhou 310058,China Department of Gastroenterology and zhejiang Key laboratory of Traditional Chinese medicine (TCM) Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China Department of Gastroenterology Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou China Center for Disease Modeling Zhejiang University College of Medicine Hangzhou China

Aim:To investigate the effect of geranylgeranylacetone (GGA) on the progres-sion of atrophic gastritis in rats and its potential ***:Atrophicgastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution,60%ethanol,and 20 mmol/L deoxycholic acid for 24 *** by theinduction of atrophic gastritis,200 mg/kg GGA was administered by oral gavagefor 8 weeks (weeks 17-24).The histological changes in gastric mucosa werequantitated by the index of inflammation,the gastric mucosal thickness,and theamount of glands of 1 mm horizontal length in *** heat shockprotein (HSP)70 levels and distribution were determined by immunoblotting andimmunohistochemistry in gastric ***:GGA alleviated the pathologi-cal progression of atrophic gastritis with inflammation relief (inflammation index:1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandularrestoration (mucosal thickness and quantity of glands:194.3 μm and 38.7 mm inthe GGA group;123.3 μm and 32.7 mm in the atrophic gastritis group;P<0.05).GGA significantly induced HSP70 synthesis (P<0.05).Moreover,quercetin,aninhibitor of HSP70 expression,aggravated the infiltration of inflammatory cellsand glandular loss in the ***:GGA prevented the progression ofatrophic gastritis in rats via the induction of HSP70 expression.

关键词： geranylgeranylacetone heat shock protein70 atrophic gastritis quercetin

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Minimum-norm Source Estimation of Magnetoencephalography Utilizing Tikhonov Regularization Technique

Minimum-norm Source Estimation of Magnetoencephalography Uti...

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CCAST“北京第二次医学影像物理和工程”国际研讨会

作者： Hu Jie Hu JingFirst Affiliated Hospital zhejiang university college of medicine Hangzhou China 310006 college of Information Engineering zhejiang university of Technology Hangzhou China

＜正＞ In neuromagnetic source reconstruction, according to the dipole source model and distributed source model, there have two main classes of reconstruction techniques—parametric current dipole localization and nonparametric source reconstruction. MEG inverse problem base on distributed source model becomes an ill-posed undetermined linear problem. In this paper, In order to yield a unique and stable solution, we propose the minimum-norm estimation with Tikhonov regularization technique in order to yield an robust and plausible neural current distribution. We propose a modified regularization method, comparing its performance with the conventional method, computer simulation analysis show how the solution is improved.

关键词： MEG distributed source minimum-norm estimation Tikhonov regularization

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Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development

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Acta Pharmacologica Sinica 2006年第5期27卷 629-634页

作者： Yu-hong L1~(2,5) Fu-sheng WU~3 Jian-guo XU~4 ~2Department of Anesthesiology,~3Department of Surgical Oncology,First Affiliated Hospital,zhejiang university college of medicine,Hangzhou 310003,China ~4Department of Anesthesiology,Nanjing Jinling Hospital,Nanjing 210002,China Department of Anesthesiology First Affiliated Hospital Zhejiang University College of Medicine Hangzhou China Department of Surgical Oncology First Affiliated Hospital Zhejiang University College of Medicine Hangzhou China Department of Anesthesiology Nanjing Jinling Hospital Nanjing China

Aim:To determine propofol concentration in the cerebral spinal fluid （CSF） ofneurosurgical patients and carry out a preliminary population ***:Twenty-seven elective neurosurgical patients （12 men and 15women） aged 17-74 years received propofol in a bolus dose of 2 mg/kg for 5 minand an infusion of 10 mg/kg per h for 5 *** CSF samples were drawn andassayed for propofol *** bispectral index （BIS） was used to mea-sure the drug *** data were analyzed first with the Excel software package,then pharmacodynamics modeling was performed using the NONMEM ***:The CSF concentration was related to the drug effect withlinear and sigmoid *** parameters for the linear addictive modelwere a= 1.11 and b=*** parameters for the linear exponential model were a=1.05 and b=*** parameters for the sigmoid Emaxmodel were Emax=119,EC50=53.6ng/mL,and N=*** the covariates of age,weight and sex wereconsidered,the parameters of models,objective function,the standard error of themean and the prediction error were not ***:Linear additive,linear exponential and sigmoid Emaxmodels can be used to describe the pharmaco-dynamics of propofol with respect to the concentration in *** this smallpopulation,age （17-74 years）,weight （47-98kg） and sex did not influence any ofthe pharmacodynamic parameters of *** verify these preliminary results,a larger study population is required.

关键词： propofol cerebrospinal fluid age factors sex factors pharmcodynamics

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Symposium on the early detection and intervention of Alzheimer's disease: national continuing education program

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上海精神医学 2015年第2期27卷 129-129页

作者： Run Run Shaw Hospital, zhejiang university college of medicine Run Run Shaw Hospital Zhejiang University College of Medicine

The national continuing education program‘Symposium on the early detection and intervention of Alzheimer’s disease’will be held at Sir Run Run Shaw Hospital,college of medicine,zhejiang university on May 7-10,2015(program ID,2015-03-09-126/127[Guo]).Keynote speakers include *** Song(Scholar of the Canadian Academy of Health Sciences),*** Gong(Neuroscience Institute of New York university School of medicine),

关键词：阿尔茨海默氏病继续教育早期检测浙江大学科学研究院科学研究所医学院博士

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TRAF3 Interacts with Smac/DIABLO and Enhances the Proapoptotic Effect of Smac/DIABLO in Cytoplasm

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Acta Biochimica et Biophysica Sinica 2007年第2期39卷 108-116页

作者： Cuili ZHANG~(1,2) Lei XIE~4 Hai'en CHENG~3 and Yingxiong WANG~2 ~1Clinical Laboratory,Sichuan Corps Hospital of The people's Armed Police Forces,Leshan 614000,China ~2Department of Procreation medicine,Chongqing Medical Universtity,Chongqing 400016,China ~3Clinical Laboratory,Second Affiliated Hospital zhejiang university college of medicine,Hangzhou 310009,China ~4Sitchuan Corps Hospital The People's Armed Police Forces,Leshan 614000,China Clinical Laboratory Sichuan Corps Hospital of The People's Armed Police ForcesLeshan 614000 China Department of Procreation medicine Chongqing Medical UniversityChongqing 400016 China Sichuan Corps Hospital of The People's Armed Police ForcesLeshan 614000 China Clinical Laboratory Second Affiliated Hospital Zhejiang University College of MedicineHangzhou 310009 China

Smac/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding proteinwith low PI) is a 29 kDa mitochondrial precursor protein,which is proteolytically processed in mitochondriainto a 23 kDa mature *** is released from the mitochondrial intermembrane space to cytosol after anapoptotic ***/DIABLO acts as a dimer and it contributes to caspase activation by sequestering theinhibitor of apoptosis proteins (IAPs).In order to further investigate the mechanism of Smac/DIABLOaction,we used the mature form of Smac/DIABLO as a bait and screened proteins that interact with matureSmac/DIABLO in human liver cDNA library using the yeast two-hybrid ***-two colonies wereobtained after 5.8x 10～6 colonies were screened by nutrition limitation and X-galactosidase *** DNAsequence analysis and homology retrieval,one of the candidate proteins was identified as TRAF domain ofthe TNF receptor associated factor 3 (TRAF3).The interaction site between TRAF3 and Smac/DIABLOwas identified by β-galactosidase test. The interaction between TRAF3 and Smac/DIABLO via TRAF domainwas identified in vivo by co-immunoprecipitation in HepG2 cells,and the direct interaction between TRAF3and Smac/DIABLO in vitro was identified by GST-pull down ***-expression of TRAF3 and matureSmac/DIABLO in 293 cells could enhance the Smac/DIABLO-mediated *** results suggestedthat TRAF3 interacted with Smac/DIABLO via TRAF domain,leading to an increased proapoptotic effectof Smac/DIABLO in cytoplasm.

关键词： Smac/DIABLO TRAF3 apoptosis yeast two-hybrid system GST-pull down assay

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The Distribution of Cytochrome P450 2C19 Expression in Normal Tissues and ItsExpression Difference with Tumor Tissues in Chinese Han Populations

The Distribution of Cytochrome P450 2C19 Expression in Norma...

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华东六省一市生物化学与分子生物学会2003年学术交流会

作者： Wu Min-liang, Chen Shu-qing (Second affiliated hospital of zhejiang university college of medicine, Hangzhou 310009)

Background and Objective Cytochrome P450 2C19 (CYP2C19) is a clinically important metabolic enzymeresponsible for the metabolism of a number of therapeutie drugs and other xenobiotics, such as S-mephenytoin,opeprazole, diazepam, proguanil, propranolol and certain antidepressants, it exists genetic ***2C19 is the main cause for large differences in the pharmacokinetics of a number of clinically important *** the basis of their ablity to metabolise (S)-mephenytoin or other CYP2C19 substrates, individuals can be classi-fied as extensive metabolisers(EMs) or poor metabolisers(PMs). In healthy individuals, CYP2C19 genotype nor-mally predicts CYP2C19 phenotype. Fiftten variant alleles(CYP2C19 * 2 to CYP2C19 * 15)that predict PMs havebeen identified. It has heen shown that changes in metabolic activity of CYP2C19 may occur due to dietary factors,environmental faetors, drug interactions and disease status. The distributin of EM and PM phenotypes shows wideinterethnic differences. The incidences of PMs is much higher in Oriental populations (18%～23%)than in Cau-casian populations (3%～5%).CYP2C19 EMs and PMs can both influence cancer susceptibility, PMs can rapidly metabolise precarcinogen to

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Effect of propofol on inflammatory cytokines in rats following cerebral ischemia-reperfusion

Effect of propofol on inflammatory cytokines in rats followi...

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2006年浙江省麻醉学学术年会

作者： Xiu-zhen Lei Department of Anaesthesiology, First Affiliated Hospital, zhejiang university college of medicine, Hangzhou 310003,china

Objective To explore changes of tumor necrosis factor-alpha (TNF-α). interleukin-1β (IL-1β), interleukin-6 (IL-6 ),interleukin-8 (IL-8), malondialdehyde (MDA), and superoxide dismutase (SOD) in plasma and the effect of propofol on these cytokines in rats following cerebral ischemia-reperfusion injury. Methods Focal cerebral ischemia model was induced with occluding the middle cerebral artery

关键词： ischemia/reperfusion injury tumor necrosis factor-alpha (TNF-α) interleukin-1β (IL-1β) interleukin-6 (IL-6) interleukin-8 (IL-8) propofol rat

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慢性阻塞性肺疾病激素抵抗机制

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中国新药与临床杂志 2011年第11期30卷 824-829页

作者：陈志华沈华浩浙江大学医学院附属第二医院呼吸与重症医学科浙江大学呼吸疾病研究所浙江杭州310009

慢性阻塞性肺疾病(COPD)病理学基础是气道对不同有害颗粒和气体刺激引发的异常炎症反应。吸烟是COPD最主要的诱发因素,但其发病机制目前仍不明确,且缺乏有效的防治手段。糖皮质激素作为最常用的临床抗炎药物,对COPD炎症的治疗却没有理... 详细信息

慢性阻塞性肺疾病(COPD)病理学基础是气道对不同有害颗粒和气体刺激引发的异常炎症反应。吸烟是COPD最主要的诱发因素,但其发病机制目前仍不明确,且缺乏有效的防治手段。糖皮质激素作为最常用的临床抗炎药物,对COPD炎症的治疗却没有理想的效果。最近的研究表明由新型的辅助性T细胞17(Th17)介导的中性粒细胞性气道炎症可能是COPD激素抵抗的重要原因。在COPD发病过程中,Th17与中性粒细胞的产生可能由氧化应激、组蛋白去乙酰化酶和炎症小体等共同调控。针对这些信号通路的新型靶向治疗药物和方案有望给COPD的治疗带来新希望。

关键词：糖皮质激素类肺疾病慢性阻塞性抗药性

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