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Studies on biomechanics of skeletal muscle based on the working mechanism of myosin motors:An overview

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Chinese Science Bulletin 2012年第30期57卷 4533-4544页

作者： YIN YueHong GUO zhao CHEN xing fan YuanJie State Key Laboratory of Mechanism System and Vibration Institute of RoboticsShanghai Jiao Tong UniversityShanghai 200240China

Skeletal muscle is the source of human body *** scholars have been studying in this field to reveal its contraction mechanism,and relevant achievements have been awarded the Nobel *** paper reviewed the current researches on biomechanics of skeletal muscle,and concluded two strategies(top-down and bottom-up methods) for the biomechanical research of skeletal ***,this paper generalized two major aspects of muscle research:(1) the multi-force coupling mechanism and the collective operation mechanism of molecular motors;(2) the bioelectrochemical driving and control principium of muscle *** discussed the solution for experimental verification and induced a novel idea to study the biomechanics of skeletal muscle based on the microscopic working mechanism of molecular motor,which is the origin of muscle *** we analyzed the disadvantages in existent researches and explored future directions that need further studies.

关键词：工作机制生物力学分子马达骨骼肌肌球蛋白诺贝尔文学奖收缩原理生物电化学

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Miniature EMP Generator Based on Marx Circuit

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高电压技术 2013年第10期39卷 2403-2408页

作者： ZHOU xing zhao Min fan Lisi WANG Qingguo YANG Qingxi Institute of Electrostatic and Electromagnetic Protection Mechanical Engineering College Shijiazhuang 050003 China

A monopole and a dual-polar ten-stage miniature Marx generators with avalanche transistors are designed and developed for experiments of electromagnetic *** avalanche transistors,which exceed traditional gas-gap switches in stability,size and repetition rate,are used as the high-speed switches in the Marx *** influences of charging resistors,capacitances and load impedances on pulse width,repetition rate of output pulses are *** monopole Marx circuit has a size of 74 mm×32 mm,and its output voltage is1.8 kV when the charging voltage is 280 *** dual-polar Marx circuit,which is 98 mm×32 mm,can generate either positive or negative polarity pulses synchronously with an output voltage of±1.6 kV,and a repetition rate of 10 *** feasibility of the presented dual-polar Marx generator is proved by further tests.

关键词：电磁脉冲发生器微型发电机马克思电路雪崩晶体管输出电压充电电压双极性

Chromosomal polymorphisms due to the addition of heterochromatin and pericentric inversions in white-bellied rat, Niviventer confucianus, from China

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Chromosomal polymorphisms due to the addition of heterochrom...

Single-cell omics: experimental workflow, data analyses and applications

中国动物学会兽类学分会第六届会员代表大会暨学术讨论会

作者： Wang Jin-xing zhao Xiao-fan Deng Yi Qi Hong-Ying (School of Life Sciences, Shandong University, Jinan 250100, China)

Niviventer confucianus (Milne-Edwards, 1871) as one of the harmful rodents in the woods, is widely distributed in China. Wang and Zheng (1981) divided it into 6 subspecies. Different cytogenetic techniques were used to analyze the chromosomes of white-bellied rat, Niviventer confucianus from Mt. Tai and Jinan, Shandong Province and Ningshan,

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao fangqing zhao Jing-Dong J.Han Qi Liu Xiaohui fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin Li Xin Zhang Wanyu zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

胸腰椎爆裂性骨折椎体后上缘骨折块与椎基静脉孔的相关性

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中华骨科杂志 2017年第19期37卷 1223-1230页

作者：张旭阳李生鋆虞天明赵兴范顺武赵凤东浙江大学医学院附属邵逸夫医院骨科杭州310016

目的探讨胸腰椎爆裂性骨折椎体后上缘骨折块形成与椎基静脉孔的关系及椎体后上缘骨折块的形成机制。方法2013年6月至2016年6月收治带有椎体后上缘骨折块的胸腰椎爆裂性骨折患者62例，术前行胸腰椎CT扫描及矢状面重建。在横断面图像上测... 详细信息

目的探讨胸腰椎爆裂性骨折椎体后上缘骨折块形成与椎基静脉孔的关系及椎体后上缘骨折块的形成机制。方法2013年6月至2016年6月收治带有椎体后上缘骨折块的胸腰椎爆裂性骨折患者62例，术前行胸腰椎CT扫描及矢状面重建。在横断面图像上测量后上缘骨折块长度（RL）和椎体长度（VL），并计算RUVL值。在矢状面图像上测量后上缘骨折块宽度（RW）和椎体宽度（vw），并计算Rw，vw值；测量后上缘骨折块高度（RH）和椎体高度（VH），并计算RH／VH值，进而确定后上缘骨折块与椎基静脉孔的位置关系。选取8个新鲜冰冻腰椎标本行Micro-CT扫描，将图像分为三层、每层九个区域进行分析（上层SR1-SR9，中层MR1-MR9，下层IR1MR9），比较各个区域骨微结构——骨体积分数、骨密度、连接密度、结构模型指数、骨小梁数量、骨小梁厚度的差异，观察椎基静脉孔能否影响其周围的骨小梁分布。将腰椎标本制作为体外爆裂性骨折模型，观察椎体后上缘骨折块的形态及影像学表现，进一步分析椎体后上缘骨折块与椎基静脉孔的解剖位置关系。结果RL／VL、RH／VH值接近1／2（分别为0．497±0．059、0．485±0．036），RW，VW值接近1／3（0．319±0．025），提示骨折块位于椎基静脉孔所在区域上方。Micro-CT结果显示椎基静脉孔所在区域MR2、MR5骨微结构参数（骨体积分数、结构模型指数、骨小梁数量）明显较同层其他区域薄弱，上层SR5相应参数较同层其他区域薄弱，提示椎基静脉孔可能改变其上方区域的骨小梁分布而使强度降低。体外模拟爆裂骨折模型显示骨折线经过椎基静脉孔的顶角或上缘，椎基静脉孔的上缘为骨折块的底面，后纵韧带损伤的位置主要邻近椎基静脉孔边缘。结论作为骨质缺损区，椎基静脉孔是正常椎体最薄弱的区域，且影响其周边区域的骨小梁分布。当遭受垂直暴力时，上层SR5区域和中层MR2、MR5区域最先发生骨折，进而形成后上缘骨折块；骨折块位于椎基静脉孔上方，包括全部或部分椎基静脉孔的上缘。

关键词：胸椎腰椎骨折体层摄影术螺旋计算机

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金属硅酸浸除杂试验研究

中国有色冶金 2016年第3期45卷 71-75页

作者：张忠益赵兴凡王国卫云南永昌硅业股份有限公司云南保山678300

本文就金属硅产品酸浸脱杂技术进行了系统性试验研究,重点对各种试剂浓度、浸出时间、浸出温度、压力对脱杂效果的影响进行了研究和分析,获得了最佳的除杂工艺。采用常压的酸浸工艺,Fe、Al、Ca的脱除率分别达到40%~45%、34%~36%、48%~51... 详细信息

本文就金属硅产品酸浸脱杂技术进行了系统性试验研究,重点对各种试剂浓度、浸出时间、浸出温度、压力对脱杂效果的影响进行了研究和分析,获得了最佳的除杂工艺。采用常压的酸浸工艺,Fe、Al、Ca的脱除率分别达到40%~45%、34%~36%、48%~51%。采用加压酸浸工艺对杂质的脱除效果较常规酸浸工艺理想,Fe的脱除率接近60%、而Al、Ca的脱除率达到了50%以上,金属硅产品质量得到大幅度提高。

关键词：金属硅常压酸浸加压酸浸除杂

2014—2016年深圳市空气污染时空分布特征

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卫生研究 2018年第2期47卷 270-276页

作者：牟敬锋赵星樊静洁严宙宁严燕曾丹罗文亮范志伟深圳市南山区疾病预防控制中心深圳518054 四川大学华西公共卫生学院深圳市妇幼保健院

目的分析深圳市空气质量指数(AQI)的时间变化和空间分布特征,为空气污染治理提供科学依据。方法收集覆盖深圳市10个行政区的19个空气质量监测点2014—2016年AQI和首要污染物的日报监测数据,汇总得到监测点小时均值、日均值、季度均值和... 详细信息

目的分析深圳市空气质量指数(AQI)的时间变化和空间分布特征,为空气污染治理提供科学依据。方法收集覆盖深圳市10个行政区的19个空气质量监测点2014—2016年AQI和首要污染物的日报监测数据,汇总得到监测点小时均值、日均值、季度均值和年均值,采用空间自相关分析研究AQI空间自相关性的强弱与集聚模式。结果研究期间深圳市AQI中位数为50.0,空气质量级别为二级。2014年深圳空气首要污染物以PM_(2.5)为主,2015年和2016年空气首要污染物以O_3为主;从时间分布看,深圳空气质量呈现"冬劣夏优"的特点,但夜间空气污染程度与白天无差异;空间自相关分析表明,研究期间AQI存在正空间自相关性,AQI全局moran's I指数为0.167(Z=2.000,P<0.05),greary系数为0.801(Z=1.711,P<0.05),光明新区AQI局部moran's I指数为1.027(P<0.05)。光明新区AQI moran散点图处于第一象限,属于高值-高值分布特点,而盐田区moran散点图处于第三象限,属于低值-低值分布特点。结论深圳市空气质量总体状况较好,PM_(2.5)和O_3是深圳主要的空气污染物,冬季应重视与加强防控空气污染,尤其在深圳的西北部几个行政区。

关键词：空气质量指数空气污染时空分析空间自相关

Immune function and heavy physical exercise

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Acta Pharmacologica Sinica 1999年第5期 92-92页

作者： SHAO Li, DAI Wei, zhao Yan-xing, fan Shao-Guang (Department of Physiology, Beijing Medical University, Beijing 100083, China)

To investigate the relationship between heavy physical exercise and immune function, T-lymphocyte proliferation was determined by Descriptor Differential Scale (DDS).Serum from human beings after 7-d heavy physical ex... 详细信息

关键词： DDS Immune function and heavy physical exercise