Studies on biomechanics of skeletal muscle based on the working mechanism of myosin motors:An overview

作     者：YIN YueHong GUO Zhao CHEN Xing FAN YuanJie 

作者机构：State Key Laboratory of Mechanism System and VibrationInstitute of RoboticsShanghai Jiao Tong UniversityShanghai 200240China 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2012年第57卷第30期

页      面：4533-4544页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the National Natural Science Foundation of China(61075101,60643002) the National Basic Research Program of China(2011CB013203) the Science and Technology Intercrossing and the Medical and Technology Intercrossing Research Foundation of Shanghai Jiao Tong University(LG2011ZD106,YG2010ZD101) 

主　　题：工作机制 生物力学 分子马达 骨骼肌 肌球蛋白 诺贝尔文学奖 收缩原理 生物电化学 

摘      要：Skeletal muscle is the source of human body *** scholars have been studying in this field to reveal its contraction mechanism,and relevant achievements have been awarded the Nobel *** paper reviewed the current researches on biomechanics of skeletal muscle,and concluded two strategies(top-down and bottom-up methods) for the biomechanical research of skeletal ***,this paper generalized two major aspects of muscle research:(1) the multi-force coupling mechanism and the collective operation mechanism of molecular motors;(2) the bioelectrochemical driving and control principium of muscle *** discussed the solution for experimental verification and induced a novel idea to study the biomechanics of skeletal muscle based on the microscopic working mechanism of molecular motor,which is the origin of muscle *** we analyzed the disadvantages in existent researches and explored future directions that need further studies.