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Drug resistance gene expression and chemotherapy sensitivity detection in Chinese women with different molecular subtypes of breast cancer

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Cancer Biology & Medicine 2020年第4期17卷 1014-1025页

作者： Jing zhao Hailian Zhang Ting Lei Juntian Liu Shichao Zhang nan Wu Bo sun Meng Wang Department of Breast Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology West China HospitalSichuan UniversityChengdu 610041China

Objective:The aim of the study was to identify specific chemosensitivity drugs for various molecular subtypes of breast tumors in Chinese women,by detecting the expression of drug resistance genes and by using the drug sensitivity test on different molecular subtypes of breast ***:The expression of drug resistance genes including Topo Ⅱ,GST-π,P-gp,LRP,and CD133 were detected with immunohistochemistry in a tissue *** sensitivity tests included those for paclitaxel,epirubicin,carboplatin,vinorelbine,and fluorouracil and were conducted on primary cancer tissue cells and cell lines,including the T47 D,BT-474,and MDA-MB-231 cells and human breast cancer xenografts in nude ***:The different drug resistant genes Topo Ⅱ,GST-π,P-gp,and LRP were differentially expressed among different molecular subtypes of breast cancers(P<0.05).Positive expression of CD133 was highest in basal-like breast cancer(P<0.05).Kaplan-Meier survival analysis showed that positive expressions of Topo Ⅱ and CD133 both correlated with shorter disease-free survival(DFS)(P<0.05)and overall survival(P<0.05),and positive expression of LRP correlated only with shorter DFS(P<0.05).BT-474 showed chemosensitivity to paclitaxel and epirubicin,while MDA-MB-231 showed chemosensitivities to paclitaxel,epirubicin,carboplatin,and fluorouracil(T/C≤50%).The basal-like and HER2+breast cancer primary cells showed chemosensitivities to paclitaxel and epirubicin with significant differences compared with luminal breast cancer primary cells(P<0.05).Conclusions:The differential expression of drug resistance genes and the differential chemosensitivities of drugs in different molecular subtype of breast cancers suggested that individual treatment should be given for each type of breast cancer.

关键词： Breast cancer molecular subtype CD133 drug resistant gene chemosensitivity

Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation,balancing nutrient metabolism,and optimizing microbial community functions

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Animal Nutrition 2023年第3期14卷 88-100页

作者： Huiyue Zhong Wenjing Yu Min Wang Bo Lin Xuezhao sun nan Zheng Jiaqi Wang Shengguo zhao State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China Department of Animal Science and Technology Guangxi UniversityNanning530005China Institute of Subtropical Agriculture Chinese Academy of SciencesChangsha410125China Jilin Inter-regional Cooperation Centre for the Scientific and Technological Innovation of Ruminant Precision Nutrition and Smart and Ecological Farming Jilin Agricultural Science and Technology UniversityJilin132109China Grasslands Research Centre AgResearch LimitedPalmerston NorthNew Zealand

Butyrate promotes the growth and gastrointestinal development of ***,the mechanisms behind its effects on signaling pathways of the gastrointestinal tract and rumen microbiome is *** study aimed to reveal transcriptomic pathways of gastrointestinal epithelium and microbial community in response to butyrate supplementation in calves fed a high fiber *** Holstein bull calves(39.9±3.7 kg,14 d of age)were assigned to 2 groups(sodium butyrate group,SB;control group,Ctrl).The SB group received 0.5%SB *** d 51,the calves were slaughtered to obtain samples for analysis of the transcriptome of the rumen and jejunum epithelium as well as ruminal microbial *** butyrate supplementation resulted in a higher performance in average daily gain and development of jejunum and rumen *** both the rumen and jejunum epithelium,SB downregulated pathways related to inflammation including NF-κB(PPKCB,CXCL8,CXCL12),interleukin-17(IL17A,IL17B,MMP9),and chemokine(CXCL12,CCL4,CCL8)and up-regulated immune pathways including the intestinal immune network for immunoglobulin A(IgA)production(CD28).Meanwhile,in the jejunum epithelium,SB regulated pathways related to nutritional metabolism including nitrogen metabolism(CA1,CA2,CA3),synthesis and degradation of ketone bodies(HMGCS2,BDH1,LOC100295719),fat digestion and absorption(PLA2G2F,APOA1,APOA4),and the PPAR signaling pathway(FABP4,FABP6,CYP4A11).The metagenome showed that SB greatly increased the relative abundance of Bacillus subtilis and Eubacterium limosum,activated ruminal microbial carbohydrate metabolism pathways and increased the abundance of carbohydrate hydrolysis *** conclusion,butyrate exhibited promoting effects on growth and gastrointestinal development by inhibiting inflammation,enhancing immunity and energy harvesting,and activating microbial carbohydrate *** findings provide new insights into the potential mechanisms behind the beneficial effects

关键词： Sodium butyrate Calf Gastrointestinal development Inflammation Transcriptomics Microbiome

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li zhaohan Xu Shiyao Zhang Huiling sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child

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World Journal of Pediatrics 2014年第1期10卷 86-88页

作者： Dong-Lai Hu Xiao-Dong Guo Zhi-nan sun Yan-Min zhao Department of Pediatric Surgery Jinhua Hospital of Zhejiang UniversityJinhua Municipal Central HospitalJinhua 321000China

Background:XELOX(oxaliplatin 130mg/m^(2)iv,capecitabine 1000mg/m^(2)bid oral d1–14,q3w)chemotherapy has never been used in *** this report,we present a case of a 12-year-old girl with colon adenocarcinoma,treated with surgery and XELOX ***:On admission,the girl complained of abdominal pain and intestinal *** examination revealed a distended abdomen with tenderness on the left upper *** enema revealed a stenotic lesion at the distal end of the transverse colon,and abdominal computed tomography showed acute obstruction and a colonic *** was performed after the failure of conservative ***:The mass was originated from the transverse *** sections of the specimens revealed an *** colectomy was performed and regional lymph nodes were *** examination confirmed that the mass was a poorly differentiated adenocarcinoma,and XELOX chemotherapy was *** evidence of recurrent or metastatic tumor was found after 18 ***:Although complete resection is the most effective treatment,XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma.

关键词： chemotherapy colon adenocarcinoma XELOX regimen

Extended damage range of(Al0.3Cr0.2Fe0.2Ni0.3)3O4 high entropy oxide films induced by surface irradiation

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Chinese Physics B 2020年第6期29卷 374-378页

作者： Jian-Cong Zhang Sen sun zhao-Ming Yang nan Qiu Yuan Wang Key Laboratory of Radiation Physics and Technology Ministry of EducationInstitute of Nuclear Science and TechnologyCollege of PhysicsSichuan UniversityChengdu 610064China

Irradiation makes structural materials of nuclear reactors degraded and ***,the damage process of materials induced by irradiation is not fully elucidated,mostly because the charged particles only bombarded the surface of the materials(within a few microns).In this work,we investigated the effects of surface irradiation on the indirect irradiation region of the(Al0.3Cr0.2Fe0.2Ni0.3)3O4 high entropy oxide(HEO)films in detail by plasma surface *** results show that the damage induced by surface irradiation significantly extends to the indirect irradiation region of HEO film where the helium bubbles,dislocations,phase transformation,and the nickel oxide segregation were observed.

关键词： high entropy oxide films surface irradiation radiation-induced segregation vacancies extended irradiation damage region

Grain selection and growth orientation of prior-β phase for Ti-6-4 during additive manufacturing:insights from a modeling perspective

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China Foundry 2021年第2期18卷 83-93页

作者： Wei-zhao sun Fei-hu Shan nan-fu Zong Hong-biao Dong Tao Jing Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Science and Technology on Power Beam Processes Laboratory AVIC Beijing Aeronautical Manufacturing Technology Research InstituteBeijing 100024China School of Engineering University of LeicesterLEI 7RHUK

The microstructure of Ti-6-4 components produced by additive manufacturing suffers from the coarse and elongated prior-β grain,which leads to a decrease of the tensile behavior and the occurrence of *** understand and control the grain evolution,a multiscale simulation is applied to investigate the relationship between the grain selection,growth orientation,and the molten pool morphology with the different deposition layer numbers and processing *** accuracy of the simulation is validated by experiments in both qualitative and quantitative *** show that when the grain with unfavorable orientation loses the competitive growth with its neighbors,there will be a great chance that the blocked grain is eliminated in the following layer-and-layer deposition,which leads to the increase of the grain *** size of the molten pool increases remarkably as the layer number increases,which lays a heavy burden on the stability of the molten *** analytical relationship between the molten pool morphology and the grain growth orientation is also *** flat molten pool causes the grains with the direction close to the building direction to have greater survival ***,decreasing the line power energy shows little effect on the stability of the molten pool and the grain growth orientation,especially when the deposited layer number is *** revealing mechanisms will help in understanding and further controlling the grain evolution.

关键词： additive manufacturing Ti-6-4 simulation grain selection grain growth

An improved adaptive Sage filter with applications in GEO orbit determination and GPS kinematic positioning

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Science China(Physics,Mechanics & Astronomy) 2012年第5期55卷 892-898页

作者： XU TianHe JIANG nan sun ZhangZhen Xi'an Research Institute of Surveying and Mapping Xi'an 710054China GFZ German Research Centre for Geosciences Potsdam 14473Germany College of Geology Engineering and Geomatic Chang'an UniversityXi'an 710054China

The shortcomings of an adaptive Sage filter are analyzed in this *** improved adaptive Sage filter is developed by using a weighted average quadratic form of the historical residuals of observations and predicted states to evaluate the covariance matrices of observations and dynamic model errors at the present *** weight function is constructed based on the variances of observational residuals or predicted state residuals and the space distance between the previous and the present *** order to balance the contributions of the measurements and the dynamic model information,an adaptive factor is applied by using a two-segment function and predicted state discrepancy *** applications,orbit determination of a maneuvered GEO satellite and GPS kinematic positioning,are conducted to verify the performance of the proposed method.

关键词： Kalman filter adaptive Sage filter orbit determination kinematic positioning two-segment function

Nitrogen-doped carbon dots-modified Prussian blue with sandwichlike structure as a high-performance electrochromic material

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nano Research 2024年第10期17卷 9174-9180页

作者： Yaqi Zhang Lide Li Siming zhao Yilin Ding nan Shen Yujie sun Hao Wang Jingfa Li Rufan Zhang School of Chemistry and Materials Science School of Physics and Optoelectronic EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Prussian blue(PB),as a promising inorganic electrochromic material(ECM),has been widely used in smart windows,displays,sensors,***,there are still many challenges for PB to achieve high electrochromic ***,we synthesized nitrogen-doped carbon dots-modified PB film(defined as PB@N-CDs)with a sandwich-like structure by a simple stepwise electrodeposition *** carbon dots show an obvious advantage in ultrafast electron transfer ability,which can reduce charge loss during the transfer process,improve the electrochemical activity on both sides of PB,and thus facilitate a rapid electrochromic ***,the surface of nitrogen-doped carbon dots contains multiple organic functional groups,which widen the movement path of K+ions under electrostatic ***,the PB@N-CDs film exhibits a short bleaching/coloring time(0.5/0.9 s)and a superior optical modulation range(78.6%).Particularly,the coloring efficiency has been significantly improved to 137.71 cm^(2)/C(at 700 nm).All of these results open up new avenues for developing highperformance PB-based ECMs and promoting their applications in corresponding electrochromic devices(ECDs)and smart windows.

关键词： electrochromic Prussian blue carbon dots nanostructure

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect