Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation,balancing nutrient metabolism,and optimizing microbial community functions

作     者：Huiyue Zhong Wenjing Yu Min Wang Bo Lin Xuezhao Sun Nan Zheng Jiaqi Wang Shengguo Zhao Huiyue Zhong;Wenjing Yu;Min Wang;Bo Lin;Xuezhao Sun;Nan Zheng;Jiaqi Wang;Shengguo Zhao

作者机构：State Key Laboratory of Animal NutritionInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China Department of Animal Science and TechnologyGuangxi UniversityNanning530005China Institute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China Jilin Inter-regional Cooperation Centre for the Scientific and Technological Innovation of Ruminant Precision Nutrition and Smart and Ecological FarmingJilin Agricultural Science and Technology UniversityJilin132109China Grasslands Research CentreAgResearch LimitedPalmerston NorthNew Zealand 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第14卷第3期

页      面：88-100页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by The Agricultural Science and Technology Innovation Program and State Key Laboratory of Animal Nutrition(2004DA125184G2108) 

主　　题：Sodium butyrate Calf Gastrointestinal development Inflammation Transcriptomics Microbiome 

摘      要：Butyrate promotes the growth and gastrointestinal development of ***,the mechanisms behind its effects on signaling pathways of the gastrointestinal tract and rumen microbiome is *** study aimed to reveal transcriptomic pathways of gastrointestinal epithelium and microbial community in response to butyrate supplementation in calves fed a high fiber *** Holstein bull calves(39.9±3.7 kg,14 d of age)were assigned to 2 groups(sodium butyrate group,SB;control group,Ctrl).The SB group received 0.5%SB *** d 51,the calves were slaughtered to obtain samples for analysis of the transcriptome of the rumen and jejunum epithelium as well as ruminal microbial *** butyrate supplementation resulted in a higher performance in average daily gain and development of jejunum and rumen *** both the rumen and jejunum epithelium,SB downregulated pathways related to inflammation including NF-κB(PPKCB,CXCL8,CXCL12),interleukin-17(IL17A,IL17B,MMP9),and chemokine(CXCL12,CCL4,CCL8)and up-regulated immune pathways including the intestinal immune network for immunoglobulin A(IgA)production(CD28).Meanwhile,in the jejunum epithelium,SB regulated pathways related to nutritional metabolism including nitrogen metabolism(CA1,CA2,CA3),synthesis and degradation of ketone bodies(HMGCS2,BDH1,LOC100295719),fat digestion and absorption(PLA2G2F,APOA1,APOA4),and the PPAR signaling pathway(FABP4,FABP6,CYP4A11).The metagenome showed that SB greatly increased the relative abundance of Bacillus subtilis and Eubacterium limosum,activated ruminal microbial carbohydrate metabolism pathways and increased the abundance of carbohydrate hydrolysis *** conclusion,butyrate exhibited promoting effects on growth and gastrointestinal development by inhibiting inflammation,enhancing immunity and energy harvesting,and activating microbial carbohydrate *** findings provide new insights into the potential mechanisms behind the beneficial effects