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Chinese Chemical Letters 2009年第9期20卷 1131-1135页

作者： Hai yan zhang Xing ying zhang Key Laboratory on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical Technology Beijing 100029 China

A new kind of multifunctional macromolecular initiator with Sn-C bonds and polydiene arms was synthesized by living anionic polymerization. At first, polydiene-stannum chloride （PD-SnCl3） was prepared by the reaction of n-butyl-Li （n-BuLi）, stannic chloride （SnCl4） and diene. Then PD-SnCl3 was used to react with the dilithium initiator to prepare the multifunctional organic macromolecular initiators. The result suggested that the initiators had a remarkable yield by GPC, nearly 90%. By using these multifunctional macromolecular initiators, styrene and butadiene were effectively polymefized via anionic polymerization, which gave birth to novel miktoarm star copolymers. The relative molecular weight and polydispersity index, microstructure contents, copolymerization components, glass transition temperature （Tg） and morphology of the miktoarm star copolymers were investigated by GPC-UV, ~H NMR, DSC and TEM, respectively. 2009 Xing ying zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Mnitifunctional macromolecular initiator Miktoarm star copolymer Styrene Butadiene Isoprene Anionic polymerization

NORMAL APPEARANCE OF LARGE FIELD DIFFUSION WEIGHTED IMAGING ON 3.0T MRI

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Chinese Medical Sciences Journal 2008年第3期23卷 158-161页

作者： Rong Rong Chun-yan zhang Xiao-ying Wang Department of Radiology Peking University First Hospital Functional Imaging Center Advanced Academy of Interdisciplinary Sciences Peking University Beijing 100034

Objective To evaluate the normal appearance of large field diffusion weighted imaging (DWI) on 3.0T magnetic resonance imaging (MRI). Methods Twenty healthy volunteers and thirty patients with benign prostate hyperplasia were included in this study. All patients were examined with large field DWI on 3.0T MRI. Normal tissue appearance was analyzed and apparent diffusion coefficient (ADC) of normal tissue with high signal intensity was measured. The ADC values of bilateral symmetrical tissue were also compared. The ADC values of intervertebral disks of healthy people younger than 50 years and exceeding 50 years were compared. Results Salivary gland, spleen, kidney, gallbladder, bladder, prostate, seminal vesicle, testis, intervertebral disk, liquid in articular cavity and lymph node showed high signal intensity on large field DWI, while lung, liver and bone showed hypo-signal intensity. The mean ADC values of partial hyperintensity tissue were as followed: parotid gland (1.088 ± 0.114) ×10-3 mm2/s, submaxillary gland (1.309 ± 0.189) ×10-3 mm2/s, kidney (1.909 ± 0.143) ×10-3 mm2/s, seminal vesicle (1.669 ± 0.168) ×10-3 mm2/s, testis (1.028 ± 0.075) ×10-3 mm2/s, spleen (0.963 ± 0.108) ×10-3 mm2/s, bladder (2.898 ± 0.267) ×10-3 mm2/s, prostate (1.448 ± 0.132) ×10-3 mm2/s, intervertebral disks (1.360 ± 0.140) ×10-3 mm2/s. No statistical significance was found between the ADC values of bilateral symmetrical tissues. The difference of ADC values of intervertebral disks of healthy people younger than 50 years [(1.372 ± 0.142) ×10-3 mm2/s] and exceeding 50 years [(1.344 ± 0.134) ×10-3 mm2/s] showed statistical significance (P = 0.040). Conclusion Understanding the high signal intensity of normal tissue on large field DWI may help to differentiate the normal tissues and abnormal ones.

关键词： diffusion weighted imaging magnetic resonance imaging normal appearance

Morphologies of solid-liquid interface and surface steps during rapid growth of BaB_2O_4 single crystals

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Science China(Physics,Mechanics & Astronomy) 2007年第4期50卷 539-545页

作者： PAN XiuHong, AI Fei, JIN WeiQing, LIU yan & zhang ying Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China 1. Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

The evolution of solid-liquid interface during BBO single crystal growth was stud- ied by the differential interference microscopy. And the step morphology on (0001) surface of the as-grown crystal was observed by the atomic force microscopy as well. It was found that the transition from a flat solid-liquid interface to a skeletal shape will occur in case of rapid growth. However, AFM images of surface steps revealed morphology differences correlated with crystallographic directions. The steps advancing along direction form the step flow, whereas those steps propagating along direction shape into step segments. Measurements of step heights by AFM indicated that it is the high anisotropy of the dimension of growth unit and step bunching due to the enlargement of concentration difference along the surface that results in the anisotropy of step morphologies.

关键词： crystal growth morphological instability growth step AFM observation

Effect and mechanism of β-L-D4A on DNA polymerase α

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World Journal of Gastroenterology 2007年第46期13卷 6243-6248页

作者： yan Li Ju-Sheng Lin ying-Hui zhang Xiao-yan Wang ying Chang Xing-Xing He Institute of Liver Diseases Tongji MedicalCollege Huazhong University of Science and Technology 1095Jiefang Street Wuhan 430030 Hubei Province China

AIM： To investigate the safety of β-L-D4A on DNA polymerase α.METHODS： Ion exchange chromatography was used to separate DNA polymerase cc from crude extract of human Hela cells. Detailed kinetic parameters were determined for β-L-D4A against DNA polymeraseα . RESULTS： DNA polymerase was purified with 4% yield and 31000 units/mg specific activity. The Michaelis constant （Km = 3.22 i^mol/L）, 50% inhibition concentration （IC50 = 178.49 μmol/L） and inhibition constant （Ki = 126 mol/L） of β-L-D4A were determined by kinetic analysis. CONCLUSION： β-L-D4A is a more safe nucleoside for hepatitis B virus （HBV） infection with a lower host toxicity.

关键词： Nucleoside β-L-D4A DNA polymeraseα Kinetic study Side effect Hepatitis B virus

Female Fertility： Is it Safe to Freeze.

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Chinese Medical Journal 2015年第3期128卷 390-397页

作者： Lu zhang Li-ying yan Xu Zhi Jie Yah Jie Qiao Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Key Laboratory of Assisted Reproduction Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 100191 China

Objective： To evaluate the safety and risk of cryopreservation in female fertility preservation. Data sources： The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as tbllowing：（ 1 ） human; embryo; cryopreservation/freezing/vitrification, （2） human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, （3） human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, （4） human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and （5） human; fertility preservation; maternal age. Study selection： The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate. pregnancy rate. and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of tile primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years （from 2006 to 2013. since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques）. The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the at, thors. Results： Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively. Conclusions： Both embryo and oocyte vitrifications are safe applications in female fertility preservation.

关键词： Embryo Cryopreservation Oocyte Cryopreservation: Ovarian Tissue Cryopreservation

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右端为函数的线性方程组解的精确表示

哈尔滨工业大学学报 2007年第12期39卷 1912-1915页

作者：张艳英哈尔滨师范大学信息科学系哈尔滨150025

为讨论方程组(有限或无限)右端为函数时的求解问题.利用再生核的技巧,用解析式精确地表示方程组的解,这种解是用级数形式表示的.值得提出的是,级数一截断就可以得出近似解,其误差随截断项数的增加而单调下降.

关键词：线性方程组再生核近似解

Liquid Chromatography-mass Spectrometry Analysis on Effect of Roughage Types on Liver Metabolic in Dairy Cows

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Journal of Northeast Agricultural University(English Edition) 2020年第2期27卷 59-66页

作者： Wang Wei-hua zhang yan-ying Huang Guan zhang Na College of Life Sciences Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Dairy Science of Education Ministry Northeast Agricultural UniversityHarbin 150030China

The major objective of this study was to determine the effect of corn straw or mixed diet on the small molecule metabolites of liver and milk production of healthy Chinese Holstein cows during *** this study,metabolomic methods based on ultra performance liquid chromatography-mass spectrometry(LC-MS)were used to study the liver metabolites of dairy cows fed on corn straw diet or mixed *** healthy Chinese Holstein cows were randomly assigned to two groups,under the same management condition,fed different diets respectively,corn straw group(CS)or a mixture of alfalfa hay and Chinese wild rye hay mixed forage group(MF).All the cows were fed for 8 weeks and recorded body weight,dry matter intake,body condition score,fat,protein,lactose,milk yield and the total *** were sampled from each cow through a liver puncture needle for analysis of a significant difference in small molecule metabolites in cow liver samples from the two different *** results suggested that different diet types had significant effects on liver metabolism and milk components in dairy *** contents of milk fat,the total solids,milk protein,lactose,dry matter intake(DMI),milk yield,milk protein(%),lactose(%)and milk fat(%)of the corn straw group were significantly lower than those of the mixed forage group(p<0.05);the contents of phosphatidylcholine(PC),histidine,hypoxanthine and mridine in liver tissues of the corn straw group were significantly lower than those in the mixed forage group(p<0.05);acetylcarnitine,uric acid,triacylglycerol(TG),acetal phosphatidylcholine(plasmenyl-PC),acetalphosphatidylethanolamine(plasmenyl-PE)and sphingomyelin(SM)of the corn straw group were significantly higher than those in the mixed forage group(p<0.05).In summary,cows fed on mixed forage diet significantly improved milk yield and lactation performance clearly.

关键词： dairy cow liver liquid chromatography-mass spectrometry(LC-MS) lactation metabolomics

Clinical improvement in the therapy of aural keloids

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Chinese Medical Journal 2009年第23期122卷 2865-2868页

作者： zhang yan-ge CEN ying LIU Xiao-xue YU Rong XU Xue-wen Department of Burns and Plastic Surgery West China HospitalSichuan University Chengdu Sichuan 610041 China

Background Keloids have a predilection for the aural region because of the special shape of the pinna. It is difficult to resect keloids entirely and maintain a satisfactory pinnal shape. Surgical excision in combination with radiotherapy is considered to be the most efficacious treatment available for severe keloids. This study was conducted to evaluate the treatment of aural keloids with intralesional excision and immediate postoperative adjuvant radiotherapy. Methods Forty-six patients with a combined total of 74 aural keloids were treated by intralesional excision and immediate postoperative adjuvant radiotherapy. All patients received a total dose of 20 Gy in 10 consecutive days. The time interval between keloid excision and delivery of the first radiotherapy fraction was 〈24 hours in all cases. The median follow-up was 2.2 years. Results Twenty-nine patients with 48 keloids （64.9%） were highly satisfied with their outcome, and were rated as good by the surgeon. Six patients with 12 keloids （16.2%） showed general satisfaction but wanted aesthetic refinement, and these patients were rated as fair by the surgeon. Three patients with four keloids （5.4%） showed no evidence of recurrence after surgery, but disliked the result because of the discoloration and irregularity of the scar surface. These patients were rated as poor by the surgeon. Partial recurrence occurred in 8 patients with 10 keloids （13.5%）. No major complications were observed. Conclusion Intralesional excision and immediate postoperative adjuvant radiotherapy is well tolerated and very effective in Dreventing recurrence of aural region keloids.

关键词： keloid surgery radiotherapy, adjuvant ear

涉法涉诉信访之案件成因、制度困局与破解之道

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法学论坛 2011年第1期26卷 55-61页

作者：章彦英山东经济学院法学院山东济南250014

外在的制度性诱因和内在的观念性诱因促成了当下持续攀升的涉法涉诉信访案件。此类信访不仅打破了司法救济的最终性,人治色彩浓厚,而且因处访机构众多、效率低下、处访程序失范、救济成本高昂等屡遭诟病。但在司法公信力低下、权利救济... 详细信息

外在的制度性诱因和内在的观念性诱因促成了当下持续攀升的涉法涉诉信访案件。此类信访不仅打破了司法救济的最终性,人治色彩浓厚,而且因处访机构众多、效率低下、处访程序失范、救济成本高昂等屡遭诟病。但在司法公信力低下、权利救济机制尚不健全的今天,相比终止信访的救济功能而言,结合我国实际情况,有针对性地改善现有信访制度,使其适应我国转型期的特殊需要,似乎来得更为妥当。

关键词：涉法涉诉信访案件成因制度困局破解之道

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冯家慧教授的民族声乐艺术实践及其理论

黄钟（武汉音乐学院学报） 2012年第1期 165-173页

作者：张莺燕星海音乐学院声乐系

冯家慧教授是武汉音乐学院的声乐系教授,是我国当代艺术院校民族声乐教育家的代表性人物之一。半个世纪以来,她民族唱法立足戏曲、说唱、民歌,重视从各种丰富多彩的民间音乐中吸取营养,追求民族特点、歌曲风格和个性特征,追求演唱风格... 详细信息

冯家慧教授是武汉音乐学院的声乐系教授,是我国当代艺术院校民族声乐教育家的代表性人物之一。半个世纪以来,她民族唱法立足戏曲、说唱、民歌,重视从各种丰富多彩的民间音乐中吸取营养,追求民族特点、歌曲风格和个性特征,追求演唱风格色彩的多样性,并借鉴西洋传统唱法,在不断努力探索中,身体力行地追求民族声乐审美范式。文章探索她在民族声乐教学与演唱中与时俱进地发展中国民族声乐道路的追求。

关键词：冯家慧民族声乐教育家民族唱法审美范式教学