Female Fertility： Is it Safe to Freeze.

作     者：Lu Zhang Li-Ying Yan Xu Zhi Jie Yah Jie Qiao Zhang Lu;Yan Li-Ying;Zhi Xu;Yan Jie;Qiao Jie

作者机构：Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Key Laboratory of Assisted Reproduction Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 100191 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第3期

页      面：390-397页

核心收录：

学科分类：0907[农学-林学] 1002[医学-临床医学] 090705[农学-野生动植物保护与利用] 08[工学] 09[农学] 0836[工学-生物工程] 

基　　金：This work was supported by grants from National Natural Science Foundation of China （No. 31230047 and No. 81200470） and National Basic Research Program of China （No. 2011 CB944503 and No. 2011 CB944504）. 

主　　题：Embryo Cryopreservation Oocyte Cryopreservation： Ovarian Tissue Cryopreservation 

摘      要：Objective： To evaluate the safety and risk of cryopreservation in female fertility preservation. Data sources： The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as tbllowing： （ 1 ） human; embryo; cryopreservation/freezing/vitrification, （2） human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, （3） human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, （4） human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and （5） human; fertility preservation; maternal age. Study selection： The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate. pregnancy rate. and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of tile primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years （from 2006 to 2013. since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques）. The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the at, thors. Results： Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively. Conclusions： Both embryo and oocyte vitrifications are safe applications in female fertility preservation.