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Expression of matrix metallo-proteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line,JEG-3

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Chinese Science Bulletin 2002年第9期47卷 732-736页

作者： zhang, J Cao, YJ Liu, WM Zhao, BS Zeng, gq Duan, EK Chinese Acad Sci Inst Zool State Key Lab Reprod Biol Beijing 100080 Peoples R China

There are striking similiarities present between the behavior of invasive placentaL cells and that of invasive cancer cells. Matrix metalloproteinases (MMPs) are one of the most important mediators. MMP-28, the new member of MMPs, was sequenced and identified recently. Expression of MMP-28 mRNA and protein in the cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 cell, was conducted by zymography, RT-PCR and Northern blot. There is MMP-28 mRNA expression in both the cytotrophoblast cells and JEG-3 cells by RT-PCR. The activity of MMP-28 in cytotrophoblast cells was significantly weaker than that in JEG-3 (P < 0.01) by zymography. Furthermore, mRNA expression of MMP-28 was significantly stronger (P < 0.001) in JEG-3 than in human cytotrophoblast cells in a time-dependent way by Northern Blot. Our results suggest that MMP-28 may play a role in some of the tissue-remodeling events associated with normal pregnancy and tumor progression.

关键词： cytotrophoblast cell choriocarcinoma cell line JEG-3 matrix metalloproteinases MMP-28.

TWO　NEW　PHENYLPROPANOID　GLYCOSIDES　FROM　CARYOPTERIS　INCANA(THUNB.)MIQ

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Chinese Chemical Letters 1996年第5期7卷 445-448页

作者： Gao, JJ Han, gq Yang, L BEIJING MED UNIV NATL LAB NAT & BIOMIMET DRUGSBEIJING 100083PEOPLES R CHINA LANZHOU UNIV STATE KEY LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

Abstract: Two new phenylpropanoid glycosides, incanosides A and B were determined as 3-hydroxy-4-methoxy-βphenylethyl α-L-rhamnopyranosyl(1→3)-β-D-glucopyranosyl(1→2)-6-O-feruloyl-β-D-glucopyranoside and 3-hydroxy-4-methoxy-β-phenylethyl α-L-rhanmopyranosyl (1→3)-β-D-ghucopyranosyl(1→2)-β-D-glucopyranoside, respectively.

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Microbial-chemical routes to R and S-denopamine a useful drug for congestive heart failure

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Chinese Journal of Chemistry 1995年第5期13卷 475-480页

作者： Gu, JX Li, ZY Lin, gq CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Both enantiomers of denopamine were synthesized using microbial-chemical approach via bioreduction of 1-(acetoxyphenyl)ketone 4(R=CH2Cl) and 5(R=CO(2)Et) with fungus Geotrichum sp. G38.

关键词： denopamine bioreduction Geotrichum sp G38 asymmetric synthesis

A Numerical Model for Typhoon Surges

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China Ocean Engineering 1998年第2期13卷 191-202页

作者： Pan, JN Wang, HC Yao, gq Nanjing Hydraul Res Inst River Harbour Dept Nanjing 210024 Peoples R China

In this paper a simple and efficient implicit finite-difference scheme is used for depth-averaged two-dimensional storm surge model. This finite-difference scheme is simpler and more efficient than the widely-used ADI scheme. Accuracy analysis and stability analysis indicate that the scheme has two-order accuracy and is unconditionally stable when the grid size is constant. The present analysis results show that the scheme is of higher numerical accuracy than that introduced by Maa (1990). After tested by ideal models, a calculation example of a real typhoon surge is carried out, the results of the numerical simulation coincide well with the observed data and the accuracy is sufficient for engineering applications.

关键词： storm surge numerical simulation finite-difference scheme accuracy stability

Solid and liquid phase equilibria in mixtures of N, N-dimethylacetamide with chlorinated hydrocarbons

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Chinese Science Bulletin 1997年第11期42卷 918-921页

作者： Che, gq Peng, WL Che, B Department of Chemistry Zhongshan University Guangzhou China

IN refs.[1,2],we studied the solid and liquid phase equilibria in mixtures of tetra-chloromethane with oxygen and nitrogen-containing compounds,intermolecular interactionswith the formation of solid molecular addition... 详细信息

关键词： phase diagram solid and liquid equilibrium N N-dimethylacetamide.

LASER INDUCED FLUORESCENCE DETECTOR(LIF)FOR CAPILLARY ELECTROPHORESIS

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Chinese Chemical Letters 1996年第1期7卷 39-42页

作者： Ma, MS Han, HW Liu, gq ACAD SINICA INST CHEMBEIJING 100080PEOPLES R CHINA

A highly sensitive laser induced fluorescence detector for capillary electrophoresis is described. With an argon laser at 488 nm for excitation, the emitted light was collected by an optical fiber and measured by it PMT. Various elements that affected the sensitivity of the detector were discussed in detail. The detection limit for fluorescein was 5.4 amole.

关键词： LIF)FOR CAPILLARY ELECTROPHORESIS LASER INDUCED FLUORESCENCE DETECTOR

A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton: Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine

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Chinese Chemical Letters 1997年第9期8卷 773-776页

作者： Dong, HQ Shi, ZC Lin, gq CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

A new approach to the construction of pyrrolizidine and indolizidine skeleton was described. By employing this cyclization method the synthesis of (1S. 7aS)-1-hydroxypyrrolizidine (1a) and (1S. 8aS)-1-hydroxyindolizidine (1b) was achieved by treatment of the trimesylate 6a or 6b with aqueous ammonia in the presence of KaCO(3) (or Cs2CO3) in one-pot fashion.

关键词： ppm HRMS A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton hydroxyindolizidine hydroxypyrrolizidine and Enantioselective Synthesis of

Study of Iron-based Surface Composite Materials

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Journal of Materials Science & Technology 1995年第3期11卷 232-234页

作者： SHI, gq DING, PD ZHOU, SZ TANG, JX Chongqing Univ Chongqing China

A new surface infiltrating composite technique has been developed to obtain metal and ceramic composite layer on the surface of metal by traditional casting method. It has been shown that with the new method, a composite layer with a thickness of 2-5 mm can be obtained. The ceramic particulates uniformly in the matrix. The composite layer is very favorable to wear resistance and thermal resistance situations.

关键词： Composite materials

A NECESSARY AND SUFFICIENT FORMULATION FOR TORSION PROBLEMS OF ANISOTROPIC BODIES

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Acta Mechanica Solida Sinica 1995年第3期8卷 255-262页

作者： DING, HJ WANG, gq HE, WJ ZHEJIANG UNIV DEPT MECHHANGZHOU 310027PEOPLES R CHINA

Non-dimensionalized equations and boundary conditions are presented for the torsion problem of an anisotropic body. The error of the fundamental solution cited in some boundary element books Is pointed out after an examination of the fundamental solution. Furthermore,a necessary and sufficient boundary integral equation is given for the problem and compared with the conventional boundary integral equation. Numerical results show that great errors of the boundary shear stresses obtained by the conventional boundary integral equation appear with a small error of torsion stiffness. Meanwhile,the necessary and sufficient;boundary integral equation always gives accurate results.

关键词： ANISOTROPIC MEDIUM TORSION OF BODIES NECESSARY AND SUFFICIENT BOUNDARY INTEGRAL EQUATION