A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton: Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine

作     者：Dong, HQ Shi, ZC Lin, GQ 

作者机构：CHINESE ACAD SCISHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1997年第8卷第9期

页      面：773-776页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：ppm HRMS A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton hydroxyindolizidine hydroxypyrrolizidine and Enantioselective Synthesis of 

摘      要：A new approach to the construction of pyrrolizidine and indolizidine skeleton was described. By employing this cyclization method the synthesis of (1S. 7aS)-1-hydroxypyrrolizidine (1a) and (1S. 8aS)-1-hydroxyindolizidine (1b) was achieved by treatment of the trimesylate 6a or 6b with aqueous ammonia in the presence of KaCO(3) (or Cs2CO3) in one-pot fashion.