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Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min zhang yu lan zhang Kai Li LI Ping Ping Lyu yu Han LIANG Ya Xin yu yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

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基于特征提取和SVM分类的LED芯片缺陷快速检测与实现

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机械设计与制造 2024年第6期400卷 250-255页

作者：吴乾生高健张揽宇郑卓鋆省部共建精密电子制造技术与装备国家重点实验室广东工业大学广东广州510006

针对LED芯片工业化生产中人工目检缺陷检测效率低,速度慢,易疲劳,受主观影响等问题,这里研究设计了一套LED芯片缺陷的快速检测系统,提出了一种分角度多方向快速卷积、分区统计特征量、支持向量机分类的LED芯片缺陷识别算法,基于QT和Ope... 详细信息

针对LED芯片工业化生产中人工目检缺陷检测效率低,速度慢,易疲劳,受主观影响等问题,这里研究设计了一套LED芯片缺陷的快速检测系统,提出了一种分角度多方向快速卷积、分区统计特征量、支持向量机分类的LED芯片缺陷识别算法,基于QT和Opencv开发了一套LED芯片缺陷快速检测与分类系统,搭建LED芯片检测系统的硬件平台,实现LED芯片实时在线缺陷识别和自动分拣。基于研发的LED芯片缺陷快速检测与分拣系统样机,对LED芯片进行了缺陷分拣的测试。

关键词： LED 特征量提取 PCA 支持向量机多分类

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网格曲面多轴加工的刀轴矢量生成方法研究

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机械设计与制造 2024年第5期399卷 244-248页

作者：文豪徐志伟柳英杰张揽宇广东省科技干部学院机械与汽车学院广东珠海519090 广东工业大学机电工程学院广东广州510006

以网格曲面为研究对象,针对其多轴数控加工代码生成的刀具摆角控制问题,研究刀位坐标的刀轴矢量生成方法。基于网格曲面的模型数据存储特征,分析刀位坐标的求取方法与数据特点;研究面向网格曲面多轴加工的刀具摆角控制机理,提出垂直于... 详细信息

以网格曲面为研究对象,针对其多轴数控加工代码生成的刀具摆角控制问题,研究刀位坐标的刀轴矢量生成方法。基于网格曲面的模型数据存储特征,分析刀位坐标的求取方法与数据特点;研究面向网格曲面多轴加工的刀具摆角控制机理,提出垂直于部件的刀轴矢量直接生成方法;通过刀位坐标与网格顶点连线的夹角计算与判断,快速检索刀位坐标所对应的网格面片,并利用该面片法矢直接生成网格曲面多轴加工的刀轴矢量;借助计算机编程实现网格曲面多轴数控加工的刀轴矢量数据生成,使用UG的CLSF管理器仿真刀路及VERICUT的加工测试,验证所提方法的有效性。测试结果表明,所提方法生成的刀轴矢量可有效驱动多轴加工的摆角控制,实现网格曲面模型的多轴数控加工。

关键词：网格曲面多轴加工刀轴矢量摆角控制

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动态心电图和常规心电图在小儿病毒性心肌炎诊断中的比较

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中国医疗器械信息 2024年第2期30卷 143-145页

作者：潘瑶张玉兰陈快江西省儿童医院江西南昌330038

目的:分析小儿病毒性心肌炎诊断期间选用动态心电图、常规心电图所呈现出的不同效果。方法:从本院2021年1月~2022年11月收治的小儿病毒性心肌炎确诊患者中随机抽取50例作为研究对象,分别对上述患儿进行常规心电图和动态心电图检测,并将... 详细信息

目的:分析小儿病毒性心肌炎诊断期间选用动态心电图、常规心电图所呈现出的不同效果。方法:从本院2021年1月~2022年11月收治的小儿病毒性心肌炎确诊患者中随机抽取50例作为研究对象,分别对上述患儿进行常规心电图和动态心电图检测,并将两种方式检测的结果分别纳入对照组和观察组中,对两组检测结果展开对比分析。结果:观察组总检出率为98.00%,明显高于对照组的78.00%检出率,组间对比差异较大,P<0.05。结论:在对小儿病毒性心肌炎患者实施临床诊断过程中,动态心电图的检出率更高,更利于为临床治疗提供可靠参考依据。

关键词：动态心电图常规心电图小儿病毒性心肌炎诊断价值

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不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床研究

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四川生理科学杂志 2024年第7期46卷 1477-1479页

作者：陈婷张玉兰杨荣明上犹县人民医院皮肤科江西赣州341200

目的:研究不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床应用效果。方法:选取2022年1月至2023年9月我院就诊的44例慢性荨麻疹患者为研究对象。按照不同治疗方案分为对照组和观察组,各22例。对照组采用10 mg依巴斯汀片... 详细信息

目的:研究不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床应用效果。方法:选取2022年1月至2023年9月我院就诊的44例慢性荨麻疹患者为研究对象。按照不同治疗方案分为对照组和观察组,各22例。对照组采用10 mg依巴斯汀片,观察组采用20 mg依巴斯汀,两组均联合复方甘草酸苷递减疗法治疗。比较两组治疗前后临床症状积分、血液学指标[血清白介素-17(Interleukin-17,IL-17)、白介素-25(Interleukin-25,IL-25)、白介素-33(Interleukin,33,IL-33)]、T淋巴细胞计数[辅助性T细胞(Helper T cell,CD4^(+))、细胞毒性T细胞(Cytotoxic T cell,CD8^(+))]水平、临床疗效及用药不良反应发生率。结果:治疗后,观察组临床症状积分总有效率均高于对照组(P<0.05);观察组总有效率均高于对照组(P<0.05);治疗后,观察组IL-17、IL-25、IL-33及CD8^(+)均低于对照组,CD4^(+)高于对照组(P<0.05);两组不良反应发生率无显著差异。结论:20 mg依巴斯汀联合复方甘草酸苷递减疗法可以更有效缓解慢性荨麻疹患者临床症状,降低血清IL-17、IL-25、IL-33水平,改善机体免疫功能,且较为安全。

关键词：依巴斯汀不同剂量复方甘草酸苷递减疗法慢性荨麻疹临床研究

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Review of pre-processing technologies for ice cores

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Journal of Mountain Science 2018年第9期15卷 1950-1960页

作者： DU Wen-tao KANG Shi-chang QIN Xiang SUN Wei-jun zhang yu-lan LIU yu-shuo CHEN Ji-zu Qilian Shan Station of Glaciology and Ecologic Environment State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Population Resources and EnvironmentShandong Normal UniversityJinan 250014China

High-resolution ice core records covering long time spans enable reconstruction of the past climatic and environmental conditions allowing the investigation of the earth system's evolution. Preprocessing of ice cores has direct impacts on the data quality control for further analysis since the conventional ice core processing is time-consuming, produces qualitative data, leads to ice mass loss, and leads to risks of potential secondary pollution. However, over the past several decades, preprocessing of ice cores has received less attention than the improvement of ice drilling, the analytical methodology of various indices, and the researches on the climatic and environmental significance of ice core records. Therefore, this papers reviews the development of the processing for ice cores including framework, design as well as materials, analyzes the technical advantages and disadvantages of the different systems. In the past, continuous flowanalysis(CFA) has been successfully applied to process the polar ice cores. However, it is not suitable for ice cores outside polar region because of high level of particles, the memory effect between samples, and the filtration before injection. Ice core processing is a subtle and professional operation due to the fragility of the nonmetallic materials and the random distribution of particles and air bubbles in ice cores, which aggravates uncertainty in the measurements. The future developments of CFA are discussed in preprocessing, memory effect, challenge for brittle ice, coupling with real-time analysis and optimization of CFA in the field. Furthermore, non-polluting cutters with many different configurations could be designed to cut and scrape in multiple directions and to separate inner and outer portions of the core. This system also needs to be coupled with streamlined operation of packaging, coding, and stacking that can be implemented at high resolution and rate, avoiding manual intervention. At the same time, information

关键词： Ice core Alpine region Polar region Pre-processing Innovation

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Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： lan Yang Lai-yu Kwok Zhihong Sun Heping zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

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A Brief of Cold Spell Warning Actions of the National Meteorological Center of China Meteorological Administration

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China CDC weekly 2024年第5期6卷 88-91页

作者： Taiyuan zhang Mengxue zhang Qiutong Li yu lan Huafeng Meteorological Media Group of China Meteorological Administration(CMA) BeijingChina National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijingChina The National Meteorological Center of China Meteorological Administration(CMA) BeijingChina

The“Outline for High-Quality Development of Meteorology(2022-2035)”was published by the State Council of the People’s Republic of China in April 2022(1).This publication highlights the essential role of meteorological disaster warnings,particularly cold spell warnings,in preventing and mitigating *** outline also sets forth stricter expectations for enhancing the overall capacity of society in terms of meteorological disaster preparedness and response.

关键词： disaster meteorological warning

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Effect of N and K Fertilizers on Yield and Quality of Greenhouse Vegetable Crops

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Pedosphere 2008年第4期18卷 496-502页

作者： LIU Zhao-Hui JIANG Li-Hua LI Xiao-Lin R. HARDTER zhang Wen-Jun zhang yu-lan ZHENG Dong-Feng Soil and Fertilizer Institute Shandong Academy of Agricultural Sciences Jinan 250100 （China） China Agricultural University College of Agricultural Resources and Environmental-Sciences Beijing 100094 K＋S Folska sp. z o.o. Pl. Wiosny Ludów 2 61-831 Poznan （Poland）

The application of large amounts of fertilizers, a conventional practice in northern China for the production of vegetable crops, generally leads to substantial accumulation of soil nutrients within a relatively short period of time. A fixed field experiment was designed to study the effects of nitrogen （N） and potassium （K） fertilizers applied to optimize the yield and quality of typical vegetable crops. Application of N and K fertilizers significantly increased the yields of kidney bean. The largest yields were obtained in the first and second years after application of 1 500 kg N and 300 kg K20 ha^-1. In the third year, however, there was a general decline in yields. Maximum yields occurred when intermediate rates of N and K （750 kg N and 300 kg K20 ha 1） were applied. However, no significant differences were observed in the concentrations of vitamin C （VC） in kidney bean among different years and various rates of fertilizer treatments. Yields of tomato grown in rotation after kidney bean showed significant responses to the application of N and K in the first year. In the second year, the yields of tomato were much lower. This suggested that the application of N fertilizer did not have any effect upon tomato yield, whereas application of K fertilizer did increase the yield. Application of K fertilizer was often associated with increased sugar concentrations.

关键词： K fertilizer N fertilizer protected cultivation vegetable quality vegetable yield

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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen zhang Sihui yu Qiao Peng Ping Wang lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

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