Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

作     者：Jiawen Zhang Sihui Yu Qiao Peng Ping Wang Lan Fang Jiawen Zhang;Sihui Yu;Qiao Peng;Ping Wang;Lan Fang

作者机构：Tongji University Cancer CenterShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine CenterDepartment of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and GynecologyZhongshan HospitalFudan UniversityShanghai 200032China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2024年第21卷第1期

页      面：45-64页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Key Research and Development Program of China(Grant Nos.2022YFC3401500 and 2020YFA0803201 to P.W.,and 2021YFA1302200 to L.F.) the National Natural Science Foundation of China(Grant Nos.31830053,31920103007,and 82341028 to P.W 82122056,82073153,and 31871398 to L.F.and 31900568 to P.W.) the Natural Science Foundation of Shanghai(Grant No.22ZR1450700 to Z.J.W.) 

主　　题：cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy 

摘      要：The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway s involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.