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Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min zhang yu lan zhang Kai Li LI Ping Ping Lyu yu Han LIANG Ya Xin yu yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

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基于特征提取和SVM分类的LED芯片缺陷快速检测与实现

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机械设计与制造 2024年第6期400卷 250-255页

作者：吴乾生高健张揽宇郑卓鋆省部共建精密电子制造技术与装备国家重点实验室广东工业大学广东广州510006

针对LED芯片工业化生产中人工目检缺陷检测效率低,速度慢,易疲劳,受主观影响等问题,这里研究设计了一套LED芯片缺陷的快速检测系统,提出了一种分角度多方向快速卷积、分区统计特征量、支持向量机分类的LED芯片缺陷识别算法,基于QT和Ope... 详细信息

针对LED芯片工业化生产中人工目检缺陷检测效率低,速度慢,易疲劳,受主观影响等问题,这里研究设计了一套LED芯片缺陷的快速检测系统,提出了一种分角度多方向快速卷积、分区统计特征量、支持向量机分类的LED芯片缺陷识别算法,基于QT和Opencv开发了一套LED芯片缺陷快速检测与分类系统,搭建LED芯片检测系统的硬件平台,实现LED芯片实时在线缺陷识别和自动分拣。基于研发的LED芯片缺陷快速检测与分拣系统样机,对LED芯片进行了缺陷分拣的测试。

关键词： LED 特征量提取 PCA 支持向量机多分类

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网格曲面多轴加工的刀轴矢量生成方法研究

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机械设计与制造 2024年第5期399卷 244-248页

作者：文豪徐志伟柳英杰张揽宇广东省科技干部学院机械与汽车学院广东珠海519090 广东工业大学机电工程学院广东广州510006

以网格曲面为研究对象,针对其多轴数控加工代码生成的刀具摆角控制问题,研究刀位坐标的刀轴矢量生成方法。基于网格曲面的模型数据存储特征,分析刀位坐标的求取方法与数据特点;研究面向网格曲面多轴加工的刀具摆角控制机理,提出垂直于... 详细信息

以网格曲面为研究对象,针对其多轴数控加工代码生成的刀具摆角控制问题,研究刀位坐标的刀轴矢量生成方法。基于网格曲面的模型数据存储特征,分析刀位坐标的求取方法与数据特点;研究面向网格曲面多轴加工的刀具摆角控制机理,提出垂直于部件的刀轴矢量直接生成方法;通过刀位坐标与网格顶点连线的夹角计算与判断,快速检索刀位坐标所对应的网格面片,并利用该面片法矢直接生成网格曲面多轴加工的刀轴矢量;借助计算机编程实现网格曲面多轴数控加工的刀轴矢量数据生成,使用UG的CLSF管理器仿真刀路及VERICUT的加工测试,验证所提方法的有效性。测试结果表明,所提方法生成的刀轴矢量可有效驱动多轴加工的摆角控制,实现网格曲面模型的多轴数控加工。

关键词：网格曲面多轴加工刀轴矢量摆角控制

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动态心电图和常规心电图在小儿病毒性心肌炎诊断中的比较

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中国医疗器械信息 2024年第2期30卷 143-145页

作者：潘瑶张玉兰陈快江西省儿童医院江西南昌330038

目的:分析小儿病毒性心肌炎诊断期间选用动态心电图、常规心电图所呈现出的不同效果。方法:从本院2021年1月~2022年11月收治的小儿病毒性心肌炎确诊患者中随机抽取50例作为研究对象,分别对上述患儿进行常规心电图和动态心电图检测,并将... 详细信息

目的:分析小儿病毒性心肌炎诊断期间选用动态心电图、常规心电图所呈现出的不同效果。方法:从本院2021年1月~2022年11月收治的小儿病毒性心肌炎确诊患者中随机抽取50例作为研究对象,分别对上述患儿进行常规心电图和动态心电图检测,并将两种方式检测的结果分别纳入对照组和观察组中,对两组检测结果展开对比分析。结果:观察组总检出率为98.00%,明显高于对照组的78.00%检出率,组间对比差异较大,P<0.05。结论:在对小儿病毒性心肌炎患者实施临床诊断过程中,动态心电图的检出率更高,更利于为临床治疗提供可靠参考依据。

关键词：动态心电图常规心电图小儿病毒性心肌炎诊断价值

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不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床研究

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四川生理科学杂志 2024年第7期46卷 1477-1479页

作者：陈婷张玉兰杨荣明上犹县人民医院皮肤科江西赣州341200

目的:研究不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床应用效果。方法:选取2022年1月至2023年9月我院就诊的44例慢性荨麻疹患者为研究对象。按照不同治疗方案分为对照组和观察组,各22例。对照组采用10 mg依巴斯汀片... 详细信息

目的:研究不同剂量依巴斯汀联合复方甘草酸苷递减疗法治疗慢性荨麻疹的临床应用效果。方法:选取2022年1月至2023年9月我院就诊的44例慢性荨麻疹患者为研究对象。按照不同治疗方案分为对照组和观察组,各22例。对照组采用10 mg依巴斯汀片,观察组采用20 mg依巴斯汀,两组均联合复方甘草酸苷递减疗法治疗。比较两组治疗前后临床症状积分、血液学指标[血清白介素-17(Interleukin-17,IL-17)、白介素-25(Interleukin-25,IL-25)、白介素-33(Interleukin,33,IL-33)]、T淋巴细胞计数[辅助性T细胞(Helper T cell,CD4^(+))、细胞毒性T细胞(Cytotoxic T cell,CD8^(+))]水平、临床疗效及用药不良反应发生率。结果:治疗后,观察组临床症状积分总有效率均高于对照组(P<0.05);观察组总有效率均高于对照组(P<0.05);治疗后,观察组IL-17、IL-25、IL-33及CD8^(+)均低于对照组,CD4^(+)高于对照组(P<0.05);两组不良反应发生率无显著差异。结论:20 mg依巴斯汀联合复方甘草酸苷递减疗法可以更有效缓解慢性荨麻疹患者临床症状,降低血清IL-17、IL-25、IL-33水平,改善机体免疫功能,且较为安全。

关键词：依巴斯汀不同剂量复方甘草酸苷递减疗法慢性荨麻疹临床研究

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Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： lan Yang Lai-yu Kwok Zhihong Sun Heping zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

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A Brief of Cold Spell Warning Actions of the National Meteorological Center of China Meteorological Administration

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China CDC weekly 2024年第5期6卷 88-91页

作者： Taiyuan zhang Mengxue zhang Qiutong Li yu lan Huafeng Meteorological Media Group of China Meteorological Administration(CMA) BeijingChina National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijingChina The National Meteorological Center of China Meteorological Administration(CMA) BeijingChina

The“Outline for High-Quality Development of Meteorology(2022-2035)”was published by the State Council of the People’s Republic of China in April 2022(1).This publication highlights the essential role of meteorological disaster warnings,particularly cold spell warnings,in preventing and mitigating *** outline also sets forth stricter expectations for enhancing the overall capacity of society in terms of meteorological disaster preparedness and response.

关键词： disaster meteorological warning

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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen zhang Sihui yu Qiao Peng Ping Wang lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

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Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

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Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： Chunhao Zhu Xiaobing lan Zhiqiang Wei Jianqiang yu Jian zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

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Insight into structural degradation of NCMs under extreme fast charging process

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Rare Metals 2024年第1期43卷 41-50页

作者： yu Tang Xing-yu Wang Jin-Can Ren Bo-Wen Chen Zhi-Yong Huang Wei Wang Ya-lan Huang Bing-Hao zhang Si lan zhang-Long He Qi Liu Hao He Department of Physics City University of Hong KongHong Kong 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China College of Materials Science and Engineering Changsha University of Science&TechnologyChangsha 410114China

Lithium-ion batteries(LIBs)with extreme fast charging(XFC)capability are considered an effective way to alleviate range anxiety for electric vehicle(EV)*** to the high ionic and electronic conductivity of LiNi_(x)Co_(y)Mn_zO_(2)(x+y+z=1,NCM)cathodes,the inevitable Li plating of graphite in NCM|graphite cell is usually identified as a key bottleneck for XFC ***,the capacity decay mechanism of cathode materials under XFC has not been fully *** this work,three typical NCM cathode materials with different Ni fractions were chosen and their electrochemical performances under XFC associated with structural evolution were investigated.A faster capacity decay of NCMs under XFC conditions is observed,especially for Ni-rich ***-situ X-ray diffraction(XRD)reveals that the multiple caxis parameters appear at the high-voltage regions in Nirich NCMs,which is probably triggered by the larger obstruction of Li(de)***,NCMs with moderate Ni fraction also present a similar trend under XFC *** phenomenon is more detrimental to the structural and morphological stability,resulting in a faster capacity decay than that under low current *** work provides new insight into the degradation mechanism of NCMs under XFC conditions,which can promote the development of NCM cathode materials with XFC capability.

关键词： Lithium-ion batteries Ni fraction Extreme fast charging Structural evolution

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