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Journal of Integrative Plant Biology 2021年第4期63卷 613-627页

作者： Dawei Dai zeyang ma Rentao Song State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterBeijing Key Laboratory of Crop Genetic ImprovementJoint International Research Laboratory of Crop Molecular BreedingCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Shanghai Key Laboratory of Bio-Energy Crops Plant Science CenterSchool of Life SciencesShanghai UniversityShanghai 200444China

Recent breakthroughs in transcriptome analysis and gene characterization have provided valuable resources and information about the maize endosperm developmental *** high temporal-resolution transcriptome analysis has yielded unprecedented access to information about the genetic control of seed *** spatial transcriptome analysis using laser-capture microdissection has revealed the expression patterns of specific populations of genes in the four major endosperm compartments:the basal endosperm transfer layer(BETL),aleurone layer(AL),starchy endosperm(SE),and embryo-surrounding region(ESR).Although the overall picture of the transcriptional regulatory network of endosperm development remains fragmentary,there have been some exciting advances,such as the identification of OPAQUE11(O11)as a central hub of the maize endosperm regulatory network connecting endosperm development,nutrient metabolism,and stress responses,and the discovery that the endosperm adjacent to scutellum(EAS)serves as a dynamic interface for endosperm-embryo *** addition,several genes that function in BETL development,AL differentiation,and the endosperm cell cycle have been identified,such as ZmSWEET4c,Thk1,and Dek15,***,we focus on current advances in understanding the molecular factors involved in BETL,AL,SE,ESR,and EAS development,including the specific transcriptional regulatory networks that function in each compartment during endosperm development.

关键词： endosperm development maize transcriptional regulatory network

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Expansion and improvement of ChinaMu by MuT-seq and chromosome-level assembly of the Mu-starter genome

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Journal of Integrative Plant Biology 2024年第4期66卷 645-659页

作者： Lei Liang Yuancong Wang Yanbin Han Yicong Chen Mengfei Li Yibo Wu zeyang ma Han Zhao Rentao Song State Key Laboratory of maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100091China Institute of Crop Germplasm and Biotechnology Jiangsu Provincial Key Laboratory of AgrobiologyJiangsu Academy of Agricultural SciencesNanjing 210014China Sanya Institute of China Agricultural University Sanya 572025China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

ChinaMu is the largest sequence-indexed Mutator(Mu)transposon insertional library in maize(Zea mays).In this study,we made significant improvements to the size and quality of the ChinaMu *** developed a new Mu-tag isolation method Mu-Tn5-seq(MuT-seq).Compared to the previous method used by ChinaMu,MuT-seq recovered 1/3 more germinal insertions,while requiring only about 1/14 of the sequencing volume and 1/5 of the experimental *** MuT-seq,we identified 113,879 germinal insertions from 3,168 Mu-active F1 *** also assembled a high-quality genome for the Mu-active line Mu-starter,which harbors the initial active MuDR element and was used as the pollen donor for the mutation *** the Mu-starter genome,we recovered 33,662(15.6%)additional germinal insertions in 3,244(7.4%)genes in the Mu-starter *** Mu-starter genome also improved the assignment of 117,689(54.5%)germinal *** newly upgraded ChinaMu dataset currently contains 215,889 high-quality germinal *** insertions cover 32,224 pan-genes in the Mu-starter and B73Ref5 genomes,including 23,006(80.4%)core genes shared by the two *** a test model,we investigated Mu insertions in the pentatricopeptide repeat(PPR)superfamily,discovering insertions for 92%(449/487)of PPR genes in ChinaMu,demonstrating the usefulness of ChinaMu as a functional genomics resource for maize.

关键词： ChinaMu Mutator MuT-seq PPR gene Zea mays

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Folate polyglutamylation is involved in DNA methylation and chromatin silencing of Arabidopsis

Folate polyglutamylation is involved in DNA methylation and ...

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第十四届全国植物基因组学大会

作者： Haoran Zhou Fangfang Zhang zeyang ma Huanwei Huang Xinjian He National Institute of Biological Sciences

DNA methylation is dynamically regulated and correlated with chromatin silencing in plants and *** identified a folylpolyglutamate synthetase FPGS1 by screening for suppressors of the repressor of silencing 1(ros1) mu... 详细信息

关键词： folate polyglutamylation FPGS1 chromatin silencing DNA methylation

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A pre-mRNA-splicing factor is required for RNA-directed DNA methylation in Arabidopsis

A pre-mRNA-splicing factor is required for RNA-directed DNA ...

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2013全国植物生物学大会

作者： HUANG Chaofeng MIKI Daisuke TANG Kai ZHOU Haoran ZHENG Zhimin CHEN Wei ma zeyang YANG Lan ZHANG Heng LIU Renyi HE Xinjian ZHU Jiankang Shanghai Center for Plant Stress Biology and Institute of Plant Physiology and Ecology Chinese Academy of Sciences State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental ScienceNanjing Agricultural University Department of Horticulture and Landscape Architecture Purdue UniversityIN 47907USA National Institute of Biological Sciences Department of Botany&Plant Sciences University of California RiversideCA 92521USA

Cytosine DNA methylation is a stable epigenetic mark that is frequently associated with the silencing of genes and transposable elements(TEs).In Arabidopsis,the establishment of DNA methylation is through the RNA-directed DNA methylation(RdDM) *** identify components of the RdDM machinery,we carried out a forward genetic screen on a T-DNA-mutagenized population in the rosl background,based on reactivation of the RD29A promoter-driven luciferase reporter ***,we report the identification and characterization of RDM16,a new factor in the RdDM *** of RDM16 reduced the DNA methylation levels and partially released the silencing of a reporter gene as well as some endogenous genomic loci in the DNA demethylase rosl-1 mutant *** rdm16 mutant had morphological defects and was hypersensitive to salt stress and abscisic acid (ABA).map-based cloning and complementation test led to the identification of RDM16, which encodes a pre-mRNA-splicing factor 3,a component of the U4/U6 ***-seq analysis showed that 308 intron retention events occurred in rdm16,confirming that RDM16 is involved in pre-mRNA splicing in ***-seq and mRNA expression analysis also revealed that the RDM16 mutation did not affect the pre-mRNA splicing of known RdDM genes, suggesting that RDM16 might be directly involved in *** RNA expression analysis on loci showing RDM16-dependent DNA methylation suggested that unlike the previously reported putative splicing factor mutants,rdm16 did not affect small RNA levels;instead,the rdm16 mutation caused a decrease in the levels of Pol V *** assays revealed that RDM16 was enriched at some Pol V target *** results suggest that RDM16 regulates DNA methylation through influencing Pol V transcript ***,our genome-wide DNA methylation analysis indicated that RDM16 regulates the overall methylation of TEs and gene-surrounding regions,and preferentially targets PolⅣ-dependent DNA methylation loc

关键词： DNA methylation DNA demethylation ROS1 RNA splicing small RNA

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基于S型效用函数的区间直觉模糊多属性决策方法

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统计与决策 2019年第23期35卷 42-46页

作者：高建伟马泽洋郭奉佳华北电力大学经济与管理学院北京102206 华北电力大学新能源电力与低碳发展研究北京市重点实验室北京102206

针对属性值为区间直觉模糊数的多属性决策问题,文章提出一种基于S型效用函数的决策方法。该决策方法定义新的记分函数,方案属性值可据此转化为实数值。基于有限理性假设,引入双曲绝对风险规避函数,得到S型效用函数的一般形式,构建效用... 详细信息

针对属性值为区间直觉模糊数的多属性决策问题,文章提出一种基于S型效用函数的决策方法。该决策方法定义新的记分函数,方案属性值可据此转化为实数值。基于有限理性假设,引入双曲绝对风险规避函数,得到S型效用函数的一般形式,构建效用矩阵。关于定权问题,建立综合考虑主客观因素的优化模型。最后结合效用矩阵及属性权重计算方案效用值并选择最优方案。

关键词：效用函数记分函数多属性决策区间直觉模糊数

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计及风光出力时变相关特性的输电可靠性裕度评估

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电力建设 2021年第9期42卷 85-95页

作者：高建伟郭贵雨郎宇彤高芳杰马泽洋华北电力大学经济与管理学院北京市102206

风光并网背景下,为准确评估风光相关性出力及系统输电可靠性裕度(transmission reliability margin,TRM),提出了一种计及风光出力时变相关特性的TRM评估方法.首先,计及风光出力存在的时变相关特性和季节特性,提出了基于时变Copula函数... 详细信息

风光并网背景下,为准确评估风光相关性出力及系统输电可靠性裕度(transmission reliability margin,TRM),提出了一种计及风光出力时变相关特性的TRM评估方法.首先,计及风光出力存在的时变相关特性和季节特性,提出了基于时变Copula函数的风光24 h联合出力场景生成方法,所生成的场景为准确评估TRM提供基础.然后,在考虑TRM时间尺度特性的同时,引入GlueVaR度量系统存在的传输能力缺额风险,进而构建了区分决策者不同风险偏好的TRM期望净收益模型.最后,以风光场景集为基础,利用序贯蒙特卡洛模拟方法生成系统时序运行场景集,结合IEEE-RTS系统利用优化算法求解模型.与以往方法相比,所提评估方法不仅提高了风光出力场景生成的精度,而且保障了系统的可靠经济运行,实现了TRM的差异化评估.

关键词：输电可靠性裕度时变相关特性时变Copula 风光24h联合出力场景 GlueVaR

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基于NIR的模式识别技术在地理标志产品响水大米鉴别中的应用

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河北大学学报（自然科学版） 2013年第5期33卷 484-488页

作者：谌蓓夏立娅窦玉蕾马泽洋熊娜东方汇理银行(中国)有限公司北京分行北京100020 河北大学化学与环境科学学院河北保定071002 河北大学质量技术监督学院河北保定071002

分别利用多元线性回归判别分析和BP人工神经网络分析建立了近红外光谱（NIR）快速鉴别地理标志产品响水大米的新方法．大米的近红外光谱数据经过一阶导数和平滑处理后，利用主成分分析对数据进行了降维处理，并确定了相关性最大的特征... 详细信息

分别利用多元线性回归判别分析和BP人工神经网络分析建立了近红外光谱（NIR）快速鉴别地理标志产品响水大米的新方法．大米的近红外光谱数据经过一阶导数和平滑处理后，利用主成分分析对数据进行了降维处理，并确定了相关性最大的特征波段（7700～6700cm-1与5700～4300cm-1）．利用特征波段的主成分数据建立了多元线性回归判别分析和BP人工神经网络鉴别模型．2种模型对于地理标志产品响水大米的鉴别正确率均为100％，适用于地理标志产品的快速无损鉴别．

关键词：多元线性回归分析 BP人工神经网络地理标志产品响水大米近红外

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Towards Text-to-SQL over Aggregate Tables

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Data Intelligence 2023年第2期5卷 457-474页

作者： Shuqin Li Kaibin Zhou zeyang Zhuang Haofen Wang Jun ma College of Design and Innovation Tongji UniversityShanghai200092 School of Software Tongji UniversityShanghai201804 School of Automotive Studies Tongji UniversityShanghai201804

Text-to-SQL aims at translating textual questions into the corresponding SQL *** tables are widely created for high-frequent *** text-to-SQL has emerged as an important task,recent studies paid little attention to the task over aggregate *** increased aggregate tables bring two challenges:(1)mapping of natural language questions and relational databases will suffer from more ambiguity,(2)modern models usually adopt self-attention mechanism to encode database schema and *** mechanism is of quadratic time complexity,which will make inferring more time-consuming as input sequence length *** this paper,we introduce a novel approach named WAGG for text-to-SQL over aggregate *** effectively select among ambiguous items,we propose a relation selection mechanism for relation *** deal with high computation costs,we introduce a dynamical pruning strategy to discard unrelated items that are common for aggregate *** also construct a new large-scale dataset SpiderwAGG extended from Spider dataset for validation,where extensive experiments show the effectiveness and efficiency of our proposed method with 4%increase of accuracy and 15%decrease of inference time w.r.t a strong baseline RAT-SQL.

关键词： Text-to-SQL Question Answering Business Intelligence Deep Learning

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Studying the current properties of buffer solution through micro-fluidic channels driven with the pulse bias

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Science China(Technological Sciences) 2014年第2期57卷 249-253页

作者： GAO zeyang WANG KaiGe ZHANG Chen ma HongWei WANG GuiRen BAI JinTao Institute of Photonics & Photo-Technology International Scientific and Technological Cooperation Base of Photoelectric Technology & Functional Materials and Application Northwest University Mechanical Engineering Department & Biomedical Engineering Program University of South CarolinaColumbia 29208 USA

In the research of bio-molecular chips and sensors, extra electric biases are most often employed to control and manipulate the DNA and protein molecules moving through micro/nano-fluidic channels. In order to accurately and flexibly control the bio-molecules as they move within the channels, a clear understanding of how the current changes within the buffer solution caused by an applied bias is fundamental. In this report, the current changed value of different buffer solutions, e.g., KC1, TE, and TBE was systematically studied with real-time monitoring and quantitative analysis in the situation of the buffers moving through a fluidic channel with a 5 μm inner diameter, driven by biases of 50 or 100 mV. The results revealed that the relation- ship between the current changed value and the pause interval of the applied electric field is highly consistent with the Hill Equation, which is helpful for accurately detecting and manipulating single biomolecules in microfluidic sensors and biochips.

关键词： micro-fluidic channel transporting mechanics current changed value interval time

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Design and validation of a navigation system of multimodal medical images for neurosurgery based on mixed reality

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Visual Informatics 2023年第2期7卷 64-71页

作者： zeyang Zhou Zhiyong Yang Shan Jiang Tao Zhu Shixing ma Yuhua Li Jie Zhuo School of Mechanical Engineering Tianjin UniversityTianjin300350China Department of Neurosurgery Tianjin Huanhu HospitalTianjin300200China

Purpose: This paper aims to develop a navigation system based on mixed reality, which can displaymultimodal medical images in an immersive environment and help surgeons locate the target areaand surrounding important tissues ***: To be displayed properly in mixed reality, medical images are processed in this ***-quality cerebral vessels and nerve fibers with proper colors are reconstructed and exported tomixed reality environment. Multimodal images and models are registered and fused, extracting theirkey information. The multiple processed images are fused with the real patient in the same coordinatesystem to guide the ***: The multimodal image system is designed and validated properly. In phantom experiments,the average error of preoperative registration is 1.003 mm and the standard deviation is 0.096 *** average proportion of well-registered areas is 94.9%. In patient experiments, the surgeons whoparticipated in the experiments generally indicated that the system had excellent performance andgreat application prospect for ***: This article proposes a navigation system of multimodal images for neurosurgery basedon mixed reality. Compared with other navigation methods, this system can help surgeons locate thetarget area and surrounding important tissues more precisely and rapidly.

关键词： Augmented reality Neurosurgery Image-guided intervention Multimodal images

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