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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Temperature influence of ceramic form on the structure of cobalt alloy MAR-M509 castings

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Acta Metallurgica Sinica(English Letters) 2011年第1期24卷 23-33页

作者： zenon OPIEKUN Department of Casting and Welding The Faculty of Mechanical Engineering and AeronauticsRzeszów University of Technology

The manuscript presents changes of macrostructure and microstructure of plate and shaft castings made of cobalt alloy MAR-M509. They have different values of geometric module M within the range of 0.91 -5.56 mm that have been created with multilayer ceramic shell moulds （MSC） of different initial temperatures of 200-1000 ℃ at the moment of pouring. It has been stated that decrease of initial temperature of MSC and value M causes increase in casting fine-granularity, distance reduction between dendrite branches λ2 and refinement of initial carbides in irregular ternary eutectic γ＋M23C6 ＋MC.

关键词： Multilayer ceramic shell mould (MSC) Cobalt alloyMAR-M509 Casting

Evaluation of Human Impacts on Bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. Bhatt Amede Rubio Ganesh B. Malla Cristobal Lopez Virginia Morales Erick Vazquez cano David Marquez Orlando Berumen Alvarez Alfred Addo-Mensah Department of Biology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within Bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

Long-term changes and periodicity of ice phenomena in the high mountain Lake Morskie Oko(Tatra Mountains,Western Carpathians)

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Journal of Mountain Science 2022年第11期19卷 3063-3075页

作者： POCIASK-KARTECZKA Joanna NIECKARZ zenon CHOIŃSKI Adam Institute of Geography and Spatial Management Jagiellonian UniversityKraków 30387Poland Marian Smoluchowski Institute of Physics Jagiellonian UniversityKraków 30348Poland Institute of Physical Geography and Environmental Planning Adam Mickiewicz University in PoznańPoznań61680Poland

High montain lakes are regarded as sensitive indicators of environmental changes in local and global *** recent years,climate change has considerablely influenced the timing of ice phenomena in these *** objective of the paper is an investigation of long-term changes and periodicity of ice phenomena in high mountain Lake Morskie Oko(1392.8 m a.s.l.)located in the Tatra *** the period *** study employed the Lomb-Scargle periodogram,linear regression modelling for temporal trends,correlation analysis,parameters of variability,and flashiness *** of the duration of ice phenomena(~5.4 y)and ice cover on the lake(~13.5 y)was observed,although both are statistically *** cover duration has been interrupted several times by winter thaws after 1996 whereas no such events had been reported *** trend towards a delayed appearance of ice phenomena reaches 4.0 d·decade^(-1)(p<0.001).The observed trend towards an earlier ice phenomena disappearance reaches 5.1 d·decade^(-1)(p<0.001).It results in a decline of the number of days with ice phenomena on Lake Morskie Oko at a rate of 9.0 d·decade^(-1)(p<0.001).The duration of ice cover on Lake Morskie Oko has been decreasing at a rate of 10.4 d·decade^(-1).It is attributed to later freezeup(3.9 d·decade^(-1),p<0.001)and earlier ice break-up(5.6 d·decade^(-1),p<0.001).An increasing trend of average annual air temperature(0.4°C·decade^(-1),p<0.001)in the period 1971-2020 is observed.A statistically significant correlation is recorded between ice phenomena and ice cover(beginning,end,duration),average annual air temperature,average air temperature of three summer months(June,July,August),and average air temperature of the six months period from June to *** air temperature induces growing heat resources accumulated in the lake water in the summer and autumn seasons,potentially causing later initiation of ice phenomena in the *** is no statistically significant r

关键词： Ice phenomena Lakes High mountains Climate warming East-Central Europe

Potential distribution of a montane rodent (Cricetidae, Handleyomys chapmani) through time in Mexico: the importance of occurrence data

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Journal of Mountain Science 2021年第8期18卷 2024-2033页

作者： cano Ivonne GUEVARA Lazaro Department of Zoology Institute of BiologyNational Autonomous University of Mexico04510Mexico CityMexico

Ecological Niche Modeling uses the geographic coordinates of species presence records as the primary input to estimate potential geographic *** is little known whether carrying out rigorous data pre-processing is necessary before building niche models to be transferred to different time *** we compared the current,past,and future potential distributions projected by niche models built from two different databases,an open-access database and a database compiled ad hoc,for Handleyomys chapmani,a rodent closely associated with montane cloud forests in *** models predicted different spatial patterns of climatic suitability for the three periods *** on our current knowledge of cloud forest species in Mexico,the distributions predicted by the model built from the ad hoc database are more ecologically realistic than those obtained from the open-access *** models built using the open-access database were particularly inaccurate at the limits of the geographic range,predicting larger,more diffuse distributions for the three *** conclude that pre-processing occurrence data is crucial for mountain species,as the number of localities and even minor inaccuracies in the geographic coordinates can translate into very different climatic conditions due to abrupt altitudinal ***,the predicted shifts in the potential distribution of *** over time indicate that this species is highly susceptible to climate change.

关键词： Cloud forests Ecological Niche Modeling Handleyomys chapmani Maxent Rodentia

Effect of Soybean Cultivars on the Nutrients and Consumer Acceptance of Soymilk

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Food and Nutrition Sciences 2024年第8期15卷 807-826页

作者： Ilana Felberg Mercedes Concórdia Carrão-Panizzi Rosires Deliza Sidinéa Cordeiro de Freitas Manuela Cristina Pessanha de Araujo Santiago Marilia Penteado Stephan Monalisa santana Coelho de Jesus Elisabeth Borges Gonçalves Rosemar Antoniassi Embrapa Food Technology Rio de Janeiro Brazil Embrapa Wheat Passo Fundo Brazil

Soymilk is one of the most available beverages, an alternative to dairy milk and is recognized for its nutritional value. The nutritional quality, the presence of anti-nutritional factors, isoflavones and sensory acceptability of soymilk depended on the soybean variety as well as the processing conditions. The soymilks from conventional and specialty Brazilian soybean cultivars were compared regarding the composition and consumer acceptance. There were significant differences on the protein, oil, sugars, isoflavones, presence of anti-nutritional factors (phytate and trypsin inhibitor activity) and NSI (nitrogen solubility index) among cultivars and soymilks and for sensory acceptance of soymilks. The preference mapping and cluster analysis identified three different segments of consumers. The soymilk from the conventional cultivar BRS284 achieved higher and similar acceptance score for the three consumer’s segments while the lipoxygenase free cultivars (BRS213 and BRS257) and specialty cultivar BRS216 showed higher score for two segments of consumers. The sensory evaluation of soymilk from different soybean cultivars could improve consumer uptake.

关键词： Preference Mapping Cluster Analysis Protein Phytate

PLANE WAVES NUMERICAL STABILITY OF SOME EXPLICIT EXPONENTIAL METHODS FOR CUBIC SCHRODINGER EQUATION

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Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona cano Adolfo Gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and Lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting Lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

An interfacial mechanical model for the analysis of earthquake

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Acta Seismologica Sinica(English Edition) 2000年第5期13卷 591-596页

作者：张之立沈新普 zenon Mroz Department of Mechanics Northeast University Shenyang China Institute of Fundamental Technological Research Polish Academy of Sciences Warsaw Poland

In this paper, the shear beam model for analysis of interface failure under joint action of anti-plane shearing and lateral compression and its principal behavior were briefly introduced. The calculation of energy release that is related to the strength of earthquake was presented by using the shear beam model. The sudden increase of load resulted from the 'stress locking' at the interface layer in the reloading process was investigated. At the end of the paper, discussions on the mechanism of earthquake were given out.

关键词： interface failure shear beam model stress locking sudden variation of load instability earthquake

Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of Mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas HALLER Domenico BRANCA Deyvis cano Institute for Interdisciplinary Mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： Mountain cities Mountain agriculture Land use change Land cover change Rural-urban linkages Montology