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iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel

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Bioactive Materials 2022年第8期7卷 290-301页

作者： Yoshifumi Kobayashi Julie Nouet Erdenechimeg Baljinnyam zain siddiqui Daniel HFine Diego Fraidenraich Vivek A.Kumar Emi Shimizu Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Cell Biology and Molecular Medicine Rutgers New Jersey Medical SchoolNewarkNJ07103USA Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative *** study aimed to replicate the characteristics of dental pulp tissue by using cranial neural crest(CNC)-like cells(CNCLCs);these cells were generated by modifying several steps of a previously established method for deriving NC-like cells from induced pluripotent stem cells(iPSCs).CNC is the anterior region of the neural crest in vertebrate embryos,which contains the primordium of dental pulp cells or *** produced CNCLCs showed approximately 2.5-12,000-fold upregulations of major CNC marker ***,the CNCLCs exhibited remarkable odontoblastic differentiation ability,especially when treated with a combination of the fibroblast growth factors(FGFs)FGF4 and *** FGFs induced odontoblast marker genes by 1.7-5.0-fold,as compared to bone morphogenetic protein 4(BMP4)*** a mouse subcutaneous implant model,the CNCLCs briefly fated with FGF4+FGF9 replicated dental pulp tissue characteristics,such as harboring odontoblast-like cells,a dentin-like layer,and vast neovascularization,induced by the angiogenic self-assembling peptide hydrogel(SAPH),*** acts as a versatile biocompatible scaffold in the canal *** study demonstrated a successful collaboration between regenerative medicine and SAPH technology.

关键词： Regenerative endodontics iPSC Cranial neural crest Fibroblast growth factor Odontoblastic differentiation Angiogenic self-assembling peptide hydrogel

Angiogenic peptide hydrogels for treatment of traumatic brain injury

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Bioactive Materials 2020年第1期5卷 124-132页

作者： Xiaotang Ma Agnieszka Agas zain siddiqui KaKyung Kim Patricia Iglesias-Montoro Jagathi Kalluru Vivek Kumar James Haorah Department of Biomedical Engineering Center for Injury Bio-MechanicsMaterials and MedicineNew Jersey Institute of TechnologyNewarkNJ07102USA Department of Chemical and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Restorative Dentistry Rutgers School of Dental MedicineNewarkNJUSA

Traumatic brain injury(TBI)impacts over 3.17 million *** of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of *** pathologies play an important role in the underlying mechanisms of *** objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain *** utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury *** work has shown how this injectable self-assembling peptide-based hydrogel(SAPH)creates a regenerative microenvironment for neovascularization at the injury *** assembly allows for thixotropy;the injectable drug delivery system provides sustained in vivo *** this study,a moderate blunt injury model was used to cause physical vascular damage and *** angiogenic SAPH was then applied directly on the injured rat *** day 7 post-TBI,significantly more blood vessels were observed than the sham and injury control group,as well as activation of VEGF-receptor 2,demonstrating the robust angiogenic response elicited by the angiogenic *** markers von-Willebrand factor(vWF)andα-smooth muscle actin(α-SMA)showed a concomitant increase with blood vessel density in response to the angiogenic ***,blood brain barrier integrity and blood coagulation were also examined as the parameters to indicate wound recovery post *** rescue examination by NeuN and myelin basic protein staining showed that the angiogenic SAPH may provide and neuroprotective benefit in the long-term recovery.

关键词： Traumatic brain injury Cerebrovascular injury Regenerative medicine Angiogenesis Self-assembling peptide hydrogels

Cells and material-based strategies for regenerative endodontics

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Bioactive Materials 2022年第8期7卷 234-249页

作者： zain siddiqui Amanda M.Acevedo-Jake Alexandra Griffith Nurten Kadincesme Kinga Dabek Dana Hindi Ka Kyung Kim Yoshifumi Kobayashi Emi Shimizu Vivek Kumar Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Endodontics Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemicals and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Biology New Jersey Institute of TechnologyNewarkNJ07102USA

The carious process leads to inflammation of pulp *** care options include root canal treatment or *** procedures,however,result in the loss of tooth vitality,sensitivity,and *** capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue,avoiding necrosis and loss of *** studies have successfully employed stem/progenitor cell populations,revascularization approaches,scaffolds or material-based strategies for pulp *** we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative *** also summarize recent findings on efficacious peptide-based materials which target the dental niche..

关键词： Regenerative endodontics Pulp regeneration Tissue engineering Stem cells Scaffolds

Nat Med:靶向两分子或有助于彻底治愈白血病

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, zain siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam Division of Experimental Hematology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Department of Medicine University of Cincinnati Cincinnati Ohio USA Department of Anesthesia and Critical Care University of Chicago Chicago Illinois USA Division of Immunobiology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Division of Pathology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA.

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能... 详细信息

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。

关键词：白血病治愈 Nat Med 分子信号蛋白治疗效果国际学术期刊

Upper Gastrointestinal Endoscopic Outcomes in Patients with Gastrointestinal Symptoms: Retrospective Analysis at a Tertiary Care Hospital

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Open Journal of Gastroenterology 2019年第8期9卷 141-157页

作者： Iftikhar Haider Naqvi Abu Talib Muqadus Tabraze Omer Mustafa siddiqui Maheen Fatima Hussaini Neha Saleem Paryani Rida Effendi Samrah lnam siddiqui Syeda Zuhaa Hassan Maham Munawar Zaiya Waseem Ameer Ahmed Khan Zafir Zohab Hussain Khan S. zain Naeem Rizvi Sofia Fatima Farooqui Misbah Munaf Hasan Obaid Faryal Khan Dow University of Health Sciences Department of Medicine Karachi Pakistan

Background: Endoscopic procedures are frequently performed to rule out any disease process which eventuates with either a positive or negative outcome. Association of patient demographics, clinical features with endoscopic outcomes are of paramount importance for better understanding and practice of endoscopy. Objectives: This study aimed to determine the frequency of positive endoscopic findings in patients with gastrointestinal symptoms compared to those with negative findings. As a secondary objective, the association between relevant demographics, symptoms, laboratory investigations and procedural outcomes of the participants and positive endoscopic findings were also assessed. Methods: A retrospective analysis of all the patients who underwent esophagogastroduodenoscopy from January 2017 to December 2017 was conducted. A total of 1066 endoscopy records were retrieved and using a convenience sampling technique, relevant data were manually entered to the questionnaires. Records with incomplete or inconsistent data were disregarded as per the exclusion criteria, resulting in 1011 patient records ultimately utilized for the study. All data were entered and analyzed using IBM SPSS 23.0. Results: The study comprised a total of 1011 patients where 52.2% were females and 47.8% males while the mean age of patients was 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding was gastritis (49.1%). Approximately 14.5% had positive investigation findings for HBsAg and 23.1% were seropositive for anti-HCV antibody. P-values statistically significant were for age (p = 0.044), hematemesis (p = 0.002), betel quid addiction (p = 0.044), anti-HCV antibody (p = 0.043), HCV-RNA (p = 0.041) and “H. pylori” antigen (p = 0.032). Conclusion: Both genders were almost equally included where most patients presented between the 3rd and 5th decades of life. A high incidence of gastritis was noted. Positive endoscopic findings were associated with be

关键词： Esophagogastroduodenoscopy Endoscopy Gastritis Esophageal Varices