Angiogenic peptide hydrogels for treatment of traumatic brain injury

作     者：Xiaotang Ma Agnieszka Agas Zain Siddiqui KaKyung Kim Patricia Iglesias-Montoro Jagathi Kalluru Vivek Kumar James Haorah 

作者机构：Department of Biomedical EngineeringCenter for Injury Bio-MechanicsMaterials and MedicineNew Jersey Institute of TechnologyNewarkNJ07102USA Department of Chemical and Materials EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA Department of Restorative DentistryRutgers School of Dental MedicineNewarkNJUSA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第1期

页      面：124-132页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This work was supported by grant 1R21AA022734-01A1(to JH)from National Institutes of Health and NIH R15 EY029504 NSF IIP 1903617 the NJIT Undergraduate Research and Innovation(URI)Program and NJIT Startup funds(to V.A.K.) 

主　　题：Traumatic brain injury Cerebrovascular injury Regenerative medicine Angiogenesis Self-assembling peptide hydrogels 

摘      要：Traumatic brain injury(TBI)impacts over 3.17 million *** of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of *** pathologies play an important role in the underlying mechanisms of *** objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain *** utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury *** work has shown how this injectable self-assembling peptide-based hydrogel(SAPH)creates a regenerative microenvironment for neovascularization at the injury *** assembly allows for thixotropy;the injectable drug delivery system provides sustained in vivo *** this study,a moderate blunt injury model was used to cause physical vascular damage and *** angiogenic SAPH was then applied directly on the injured rat *** day 7 post-TBI,significantly more blood vessels were observed than the sham and injury control group,as well as activation of VEGF-receptor 2,demonstrating the robust angiogenic response elicited by the angiogenic *** markers von-Willebrand factor(vWF)andα-smooth muscle actin(α-SMA)showed a concomitant increase with blood vessel density in response to the angiogenic ***,blood brain barrier integrity and blood coagulation were also examined as the parameters to indicate wound recovery post *** rescue examination by NeuN and myelin basic protein staining showed that the angiogenic SAPH may provide and neuroprotective benefit in the long-term recovery.