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Syzygium aromaticum ethanol extract reduces AlCl_3-induced neurotoxicity in mice brain through regulation of amyloid precursor protein and oxidative stress gene expression

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 123-130页

作者： Sanila Amber Syed Adnan Ali Shah Touqeer Ahmed Saadia zahid Neurobiology Research Laboratory Department of Healthcare BiotechnologyAtta-ur-Rahman School of Applied BiosciencesNational University of Sciences and Technology Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns)Universiti Teknologi MARA Puncak Alam Campus Faculty of Pharmacy Universiti Teknologi MARA Puncak Alam Campus

Objective: To investigate the neuroprotective effects of Syzygium aromaticum(***)extract(500 mg/kg) on AlCl_3(300 mg/kg)-induced mouse model of oxidative stress and ***: An ethanolic extract of *** seeds was prepared and the active compounds were identified using nuclear magnetic resonance ***/c mice were divided into five groups(negative control, AlCl_3-treated, self-recovery, AlCl_3 + ***, *** only; n=10) and treated with AlCl_3 and *** *** of oxidative markers [Superoxide dismutase 1(SOD1) and peroxiredoxin 6(Prdx6)] and amyloid precursor protein(APP) in the hippocampus and cortex was evaluated via *** assessment was performed to investigate the extent of ***: It was observed that AlCl_3 exposure increased the expression of APP770 while simultaneously down regulated the expression of ***_3 also induced a significant decrease(P<0.05) and an increase(P<0.05) in the expression level of SOD1 and Prdx6, respectively.A substantial decrease substantial(P<0.05) in the density of Nissl substance was also observed in cortex of the mice treated with AlCl_***, treatment with *** extract normalized the alterations in the expression level of SOD1, Prdx6 and APPisoforms and improved the neuronal structural ***: The results showed that *** is a promising antioxidant and a neuroprotective agent.

关键词： Amyloid precursor protein Oxidative stress Aluminum Neurodegeneration

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Bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1252-1273页

作者： Xinkai Wang Yifan Hu Xiaoyan Zhu Liyuan Cai Muhammad zahid Farooq Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Department of Animal Sciences University of Veterinary and Animal Sciences(Jhang Campus)Lahore 54000Pakistan

Background:The interaction between nutrition and immunity plays a vital role in nutrient digestion,absorption,and metabolism during poultry *** studies showed that the gut microbiota contributes to the development of intestinal mucosal ***,the mechanisms by which gut microbes regulate this process remain ***:We compared the intestinal mucosal immunity and gut microbiota of Arbor Acre broilers AA(lower mucosal immunity)and Chinese native Wuliang Mountain Black-bone chickens(WLMB)(higher mucosal immunity)using 16S rDNA sequencing,transcriptomic analysis,and immunoglobulin A(IgA)antibody repertoire *** then combined 16S rDNA sequencing with transcriptomics to identify the key microbes and found that they were positively correlated with IgA ***,we transplanted candidate microbes into 1-day-old broiler to explore their role in intestinal mucosal ***,we verified the function of candidate microbial metabolites in regulating the immune function of macrophages and the intestinal-epithelial cells(IECs)using in vitro ***:WLMB performs stronger mucosal immunity than AA,including higher IgA levels,more diverse IgA antibody repertoire,and higher bacterial *** was identified as the key microbes related to the intestinal IgA *** transplantation could increase IgA concentration in the duodenal contents by enhancing the expression of IgA,polymeric immunoglobin receptor(PIgR),B cell-activating factor of the TNF family(BAFF),and activation-induced cytidine deaminase(AID)in the ***,Bacteroides-derived isovaleric acid promoted M2 macrophage polarization of macrophage via mTOR/PPAR-γ/STAT3 signaling pathways and regulated the immunologic function of IECs to produce cytokines,including interleukin(IL)-10,IL-4,BAFF,and transforming growth factor-beta(TGF-β),thus promoting IgA production in B cells by facilitating AID ***:Our study re

关键词： Bacteroides Chicken IgA Intestinal health Isovaleric acid Macrophage

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First Principle Study of the Electronic Properties of 3C-SiC Doped with Different Amounts of Ni

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Chinese Physics Letters 2012年第7期29卷 250-253页

作者： DOU Yan-Kun QI Xin JIN Hai-Bo CAO Mao-Sheng Usman zahid HOU Zhi-Ling School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081 State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081 School of Science Beijing University of Chemical TechnologyBeijing 100029

The electronic properties of 3C-SiC doped with different contents of Ni are investigated by using first-principles *** is observed that the non-filled impurity energy levels in the band-gap region increase with increasing Ni content,which subsequently results in an enhancement of electrical conductivity of *** enhancement in conductivity is verified by the conductivity spectrum in which new peaks appear in the middleinfrared region,visible region,and middle-ultraviolet *** is further observed that the width and intensity of these newly appeared peaks increase with the increase of Ni *** electronic density of states exhibits the peaks crossing the Fermi level,which favors the electronic transitions and proves Ni-doped 3C-SiC to be a half-metallic *** the analysis of electron density difference and Mulliken overlap population,it is found that the covalent bonds are formed between Ni and near-by C *** features confirm that the Ni-doped 3C-SiC semiconductor is a promising material for device applications in modern day electronics.

关键词： conductivity ultraviolet filled

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Impact of dogs with deltamethrin-impregnated collars on prevalence of visceral leishmaniasis

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Infectious Disease Modelling 2020年第1期5卷 235-247页

作者： Mondal Hasan zahid Christopher M.Kribs University of Texas at Arlington Department of MathematicsArlington76019USA

Leishmaniasis is a vector borne zoonosis which is classified as a neglected tropical *** the three most common forms of the disease,Visceral Leishmaniasis(VL)is the most threatening to human health,causing 20,000 to 30,000 deaths worldwide each *** where VL is mostly endemic have unprotected dogs in community and ***"presence of dogs usually increases VL risk for humans since dogs are the principal reservoir host for the parasite of the *** on this fact,most earlier studies consider culling dogs as a control measure for the spread of VL.A more recent control measure has been the use of deltamethrin-impregnated dog collars(DIDCs)to protect both humans and dogs by putting DIDCs on dogs *** presence of dogs helps to grow the sandfly population faster by offering a more suitable blood-meal *** the other hand,the presence of DIDCs on dogs helps to reduce sandfly population by the lethality of deltamethrin *** study brings an ecological perspective to this public health concern,aiming to understand the impact of an additional host(here,protected dogs)on disease risk to a primary host(here,humans).To answer this question,we compare two different settings:a community without dogs,and a community with dogs protected with *** analysis shows the presence of protected dogs can reduce VL infection risk in ***,this disease risk reduction depends on dogs’tolerance for sandfly bites.

关键词： dogs delta protected

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Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 89-97页

作者： Hnin Ei Thu zahid Hussain Isa Naina Mohamed Ahmad Nazrun Shuid Department of Pharmacology Faculty of MedicineUniversity Kebangsaan Malaysia(The National University of Malaysia) Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam Campus

Eurycoma longifolia Jack(***) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, antiinflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer *** review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of *** and its bioactive *** of pharmacokinetic profile revealed that *** exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 *** has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts(i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and *** various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical(isolated or extracted from root extracts) against various types of animals and human *** on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that *** can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments.

关键词： Eurycoma longifolia Jack Pharmacokinetic profile Pharmacodynamic algorithm Eurycomanone Quassinoids

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Prevalence of viral HBV and HCV among different group patients in Gujrat Pakistan

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Advances in Bioscience and Biotechnology 2012年第4期3卷 423-436页

作者： Muhammad Irshad Muhammad Naem Raza zahid Anwar Nadia Ikram Amber Afroz Hafiz Muhammad Nasir iqbal Department of Biochemistry and Molecular Biology University of Gujrat Pakistan Department of Biochemistry NSMC University of Gujrat Pakistan Department of Chemistry and Biochemistry University of Agriculture Faisalabad Pakistan

In this study we analyzed blood samples collected from 400 high risk patients for the prevalence of an inflammatory viral disease hepatitis B virus (HBV) and hepatitis C virus (HCV) with the help of standard kit assay and Enzyme-linked immunosorbent assay (ELISA). All the samples were selected randomly from the various places of District Gujrat, Pakistan. All the selected cases were first divided into four groups according to the age and sex (Group 1, Male below age 35 years;Group 2, Male above age 35 years;Group 3, Female below age 35 years;Group 4, Female above age 35 years), each group was comprised of 100 individual patients and analyzed for different parameters for the presence of HBV and HCV in comparison with positive and negative controls. The prevalence of HBV and HCV was higher in groups 2 (22%) and 4 (39%) respectively. Assay profile revealed that the incidence of HCV was higher in female patients as compare to the male patients. The present study indicates that more than 60% of the cirrhosis and hepatocellular carcinoma in the Region is attributable to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

关键词： HBV HCV Liver Inflammation LFTs ELISA ALP Bilirubin

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Behavioral interventions to eliminate fear responses

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Science China(Life Sciences) 2018年第6期61卷 625-632页

作者： Jingli Yue Le Shi Xiao Lin Muhammad zahid Khan Jie Shi Lin Lu Peking University Sixth Hospital Peking University Institute of Mental Health Key of Mental Health Ministry of Health (Peking University)National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) National Institute on Drug Dependence Peking University Peking-Tsinghua Center for Life Sciences and PKU-IDG/Mc Govern Institute for Brain Research Peking University

Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder(PTSD). PTSD is a fear-based disorder,characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However,the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory. This review discusses research that targeted extinction and reconsolidation to manipulate fear memory. Recent studies indicate that sleep is an active state that can regulate memory processes. We also discuss the influence of sleep on fear memory. For each manipulation, we briefly summarize the neural mechanisms that have been identified in human studies. Finally, we highlight potential limitations and future directions in the field to better translate existing interventions to clinical settings.

关键词： fear memory extinction sleep manipulation reconsolidation human

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Multi-Modality and Feature Fusion-Based COVID-19 Detection Through Long Short-Term Memory

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Computers, Materials & Continua 2022年第9期72卷 4357-4374页

作者： Noureen Fatima Rashid Jahangir Ghulam Mujtaba Adnan Akhunzada zahid Hussain Shaikh Faiza Qureshi Center of Excellence for Robotics Artificial Intelligenceand BlockchainDepartment of Computer ScienceSukkur IBA UniversitySukkurPakistan Department of Computer Science COMSATS University Islamabad–Vehari CampusPakistan Faculty of Computing and Informatics University Malaysia SabahKota Kinabalu88400Malaysia Department of Mathematics Sukkur IBA UniversitySukkurPakistan

The Coronavirus Disease 2019(COVID-19)pandemic poses the worldwide challenges surpassing the boundaries of country,religion,race,and *** current benchmark method for the detection of COVID-19 is the reverse transcription polymerase chain reaction(RT-PCR)***,this testing method is accurate enough for the diagnosis of ***,it is time-consuming,expensive,expert-dependent,and violates social *** this paper,this research proposed an effective multimodality-based and feature fusion-based(MMFF)COVID-19 detection technique through deep neural *** multi-modality,we have utilized the cough samples,breathe samples and sound samples of healthy as well as COVID-19 patients from publicly available COSWARA *** set of experimental analyses were performed to evaluate the performance of our proposed *** useful features were extracted from the aforementioned modalities that were then fed as an input to long short-term memory recurrent neural network algorithms for the classification *** set of experimental analyses were performed to evaluate the performance of our proposed *** experimental results showed that our proposed approach outperformed compared to four baseline approaches published *** believe that our proposed technique will assists potential users to diagnose the COVID-19 without the intervention of any expert in minimum amount of time.

关键词： Covid-19 detection long short-term memory feature fusion deep learning audio classification

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Colorectal surgeon consensus with diverticulitis clinical practice guidelines

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World Journal of Gastrointestinal Surgery 2017年第11期9卷 224-232页

作者： Javariah Siddiqui Assad zahid Jonathan Hong Christopher John Young Discipline of Surgery University of Sydney Department of Colorectal Surgery Royal Prince Alfred Hospital

AIM To determine the application of clinical practice guidelines for the current management of diverticulitis and colorectal surgeon specialist consensus in Australia and New *** A survey was distributed to 205 colorectal surgeons in Australia and New Zealand, using 22 hypothetical clinical *** The response rate was 102(50%). For 19 guidelinebased scenarios, only 11(58%) reached consensus(defined as > 70% majority opinion) and agreed with guidelines; while 3(16%) reached consensus and did not agree with guidelines. The remaining 5(26%) scenarios showed community equipoise(defined as less than/equal to 70% majority opinion). These included diagnostic imaging where CT scan was contraindicated, management options in the failureof conservative therapy for complicated diverticulitis, surgical management of Hinchey grade 3, proximal extent of resection in sigmoid diverticulitis and use of oral mechanical bowel preparation and antibiotics for an elective colectomy. The consensus areas not agreeing with guidelines were management of simple diverticulitis, management following the failure of conservative therapy in uncomplicated diverticulitis and follow-up after an episode of complicated diverticulitis. Fifty-percent of rural/regional based surgeons would perform an urgent sigmoid colectomy in failed conservative therapy of diverticulitis compared to only 8% of surgeons city-based(Fisher's exact test P = 0.016). In right-sided complicated diverticulitis, a greater number of those in practice for more than ten years would perform an ileocecal resection and ileocolic anastomosis(79% vs 41%, P < 0.0001).CONCLUSION While there are areas of consensus in diverticulitis management, there are areas of community equipoise for future research, potentially in the form of RCTs.

关键词： Diverticulitis Clinical practice guidelines Consensus

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Hypothesized summative anal physiology score correlates but poorly predicts incontinence severity

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World Journal of Gastroenterology 2017年第31期23卷 5732-5738页

作者： Christopher J Young Assad zahid Cherry E Koh Jane M Young Department of Colorectal Surgery University of Sydney RPAH Medical Centre Discipline of Surgery University of Sydney Surgical Outcome Research Centre(SOu RCe) Royal Prince Alfred HospitalUniversity of Sydney School of Public health University of Sydney

To explore the relationship between such a construct and an existing continence score. METHODSA retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (MRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed. Multiple regression analyses were performed. RESULTSOf 508 (419 women) patients, 311 had both APS and CCCS measured. Average MRP was 51 mmHg (SD 23.2 mmHg) for men and 39 mmHg (19.2 mmHg) for women. Functional ACL was 1.7 cm for men and 0.7 cm for women. Univariate analyses demonstrated significant associations between CCCS and MRP (P = 0.0002), ACL (P = 0.0006) and pudendal neuropathy (P < 0.0001). The association between APS and CCCS was significant (P < 0.0001) but accounted for only 9.2% of the variability in CCCS. Multiple regression showed that the variables most useful in predicting CCCS were external sphincter defect, pudendal neuropathy and previous pelvic surgery, but only improving the scores predictive ability to 12.5%. CONCLUSIONThis study shows that the ability of AP tests to predict continence scores improves when considered collectively, but that a constructed summation model before and after multiple regression is poor at predicting the variability in continence scores.

关键词： Incontinence Anal physiology Anal canal Anal ultrasound Manometry Electromyography

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