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Biomedical and Environmental Sciences 2018年第11期31卷 851-854页

作者： zachary d miller HUANG Jun Wu Heather Costigan LUO Jing dENG Hui Juan XU Xiao Qing B derrick Taff SUN Cheng YANG Xi WANG Zhong Lei LIN dan QU Shu Wen PAN Bing LI Guang Ming Peter Newman department of Recreation Parkand Tourism ManagementThe Pennsylvania State UniversityUniversity Park department of Tourism Management Shenzhen Tourism College of Jinan UniversityJinan University department of Landscape College of ArchitectureTsinghua University

Unwanted sound that is unpleasant or disruptive to hear, often interpreted as noise, is a widespread environmental pollutant. Similar to other environmental pollutants, this noise incurs a variety of costs to society. Numerous negative health impacts are linked to increases in noise exposure,such as increased cardiovascular risk;and sleep

关键词： SF NSS A Cross-cultural Examination of the Noise-sensitivity Scale-short Form:Measurement Invariance Testing between the US and Chinese Samples CFA TLI CFI US

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens zachary Fitzgerald P.Hande Ozdinler department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and drug discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury

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Neural Regeneration Research 2022年第11期17卷 2429-2430页

作者： zachary W.Castillo Michael d.Burton Neuroimmunology and Behavior Laboratory Department of NeuroscienceSchool of Behavioral and Brain SciencesCenter for Advanced Pain StudiesUniversity of Texas at Dallas

With the constant development of multiphoton microscopy,our ability to observe complex and dynamic biological processes deeper within living tissue,is steadily *** use multiphoton microscopy,because experiments can be conducted with little to no invasiveness or tissue damage over a long period of time with no photodamage(Mancuso et al.,2009).This allows for the introduction of tissue into the context of a three-dimensional 3d environment in which visualization of cellular activation and interaction is *** circumventing a distorted reconstruction with limited z-stacks,multiphoton imaging provides enhanced spatiotemporal resolution.

关键词： resolution. multiphoton distorted

Impact of hydrolysis on surface area and energy storage applications of activated carbons produced from corn fiber and soy hulls

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Carbon Resources Conversion 2020年第1期3卷 19-28页

作者： zachary d.Herde Ruchira dharmasena Gamini Sumanasekera Jaya Shankar Tumuluru Jagannadh Satyavolu Conn Center for Renewable Energy Research University of LouisvilleLouisvilleKYUSA Energy Systems Laboratory Idaho National LaboratoryIdaho FallsIDUSA School of Chemical and Biomolecular Eng Georgia Institute of TechnologyUnited States

Complete utilization of lignocellulosic biomass through the creation of value-added coproducts is one of the key strategies of the Bioenergy Technologies Office(BETO)for the cost-effective production of biofuels and biochemicals.A green approach to producing lightweight and high specific surface area(SSA)activated carbons(ACs)from sustainable biomass sources is of great interest to producers and users of energy devices such as batteries and *** direct conversion from biomass has been studied extensively,AC with relatively high surface areas can be produced more cost-effectively when leveraged as a co-product from a *** this paper,we discuss the production of high specific surface area activated carbons from residual fiber(fiber remaining after extraction of C5-sugars)generated as part of a C5 *** surface,morphological characteristics using SEM and TEM,and energy storage behavior of ACs produced using the C5 extracted residual fiber were evaluated in the present *** ACs produced from the residual fiber delivered an order of magnitude higher surface area than the one directly from corn pericarp fiber and soy *** surface area of the ACs produced from pre-hydrolysis ddG was only 10 m^(2)/g compared to 689 m^(2)/g for soy hulls whereas after hydrolysis these values increased significantly(ddG:1700 m^(2)/g and soy hulls:1300 m^(2)/g).TEM images indicated high exfoliation,explaining the change in surface area *** the same current density(500 mA/g)the cycling performance of the ACs increased as the surface area increased significantly.

关键词： Agricultural residues Hydrolysis Activated carbon Surface area characterization Surface morphology

Facile synthesis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian T.Scarpitti Zhewen Luo Abigail E.Smith Jian Ye zachary d.Schultz department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering intra-gap nanoparticles 4-nitrobenzenethiol

Bipolar depression:a review of treatment options

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General Psychiatry 2022年第4期35卷 230-239页

作者： Kate Levenberg zachary A Cordner Psychiatry and Behavioral Sciences Johns Hopkins School of MedicineBaltimoreMarylandUSA

Bipolar depression(Bd-d)is both common and incredibly challenging to *** treated individuals with Bd-d experience depression approximately 19%of the time,and subsyndromal depression an additional 18%.This stands in clear contrast to the approximately 10%of time spent in hypomania and 1%of time spent in *** this high illness burden,there remain relatively few treatment options approved by the US Food and drug Administration for *** the approved medications,four are second-generation antipsychotics(SGAs)and one is an SGA combined with an ***,particularly when used long-term,antipsychotics can pose a significant risk of adverse effects,raising the clinical conundrum of weighing the risks associated with longterm antipsychotic use versus the risk of relapse when patients are off ***,we review commonly used treatments for Bd-d,including antipsychotics,classic mood stabilisers,electroconvulsive therapy and *** then address the somewhat controversial topic of antidepressant use in ***,we summarise emerging treatment options and highlight ongoing clinical *** hope this review will help compare the risks and benefits of several common and novel options for the treatment of patients with *** doing so,we also hope this review will aid the individualised selection of treatments based on each patient’s history and treatment goals.

关键词： treatment spite approved

The pervasive effects of lighting environments on sensory drive in bluefin killifish： an investigation into male/male competition, female choice, and predation

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Current Zoology 2018年第4期64卷 499-512页

作者： Lisa d. MITCHEM Shannon STANIS Nicholas M. SUTTON zachary TURNER Rebecca C. FULLER School of Integrative Biology University of Illinois Urbana IL 61801 USA department of Biology University of Virginia Charlottesville VA 22904 USA department of Mathematics University of Illinois Urbana IL 61801 USA

Sensory drive predicts that the conditions under which signaling takes place have large effects on signals, sensory systems, and behavior. The coupling of an ecological genetics approach with sen sory drive has been fruitful. An ecological genetics approach compares populations that experi ence different environments and asks whether population differences are adaptive and are the result of genetic and/or environmental variation. The multifaceted effects of signaling environ ments are wellexemplified by the bluefin killifish. In this system, males with blue anal fins are abundant in tanninstained swamps that lack UV/blue light but are absent in clear springs where UV/blue light is abundant. Past work indicates that lighting environments shape genetic and envir onmental variation in color patterns, visual systems, and behavior. Less is known about the select ive forces creating the across population correlations between UV/blue light and the abundance of blue males. Here, we present three new experiments that investigate the roles of lighting environ ments on male competition, female mate choice, and predation. We found strong effects of lighting environments on male competition where blue males were more likely to emerge as dominant in teastained water than in clear water. Our preliminary study on predation indicated that blue males may be less susceptible to predation in teastained water than in clear water. However, there was little evidence for female preferences favoring blue males. The resulting pattern is one where the effects of lighting environments on genetic variation and phenotypic plasticity match the direction of selection and favor the expression of blue males in swamps.

关键词： Lucania goodei adaptive plasticity intrasexual selection male competition private communication predation

Multi-component liquid-infused systems:a new approach to functional coatings

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Industrial Chemistry & Materials 2024年第3期2卷 378-392页

作者： zachary Applebee Caitlin Howell department of Chemical and Biomedical Engineering Maine College of Engineering and ComputingUniversity of MaineME 04469USA Graduate School of Biomedical Science and Engineering University of MaineME 04469USA

Antifouling liquid-infused surfaces have generated interest in multiple fields due to their diverse applications in industry and *** nearly all reports to date,the liquid component consists of only one chemical ***,unlike traditional solid surfaces,the unique nature of liquid surfaces holds the potential for synergistic and even adaptive functionality simply by including additional elements in the liquid *** this work,we explore the concept of multi-component liquid-infused systems,in which the coating liquid consists of a primary liquid and a secondary component or components that provide additional *** ease of understanding,we categorize recently reported multi-component liquid-infused surfaces according to the size of the secondary components:molecular scale,in which the secondary components are molecules;nanoscale,in which they are nanoparticles or their equivalent;and microscale,in which the additional components are micrometer size or *** present examples at each scale,showing how introducing a secondary element into the liquid can result in synergistic effects,such as maintaining a pristine surface while actively modifying the surrounding environment,which are difficult to achieve in other surface *** review highlights the diversity of fabrication methods and provides perspectives on future research *** secondary components into the liquid matrix of liquid-infused surfaces is a promising strategy with significant potential to create a new class of multifunctional materials.

关键词： Active surfaces Antimicrobial Antifouling Interfaces Sensing surfaces

Old vs new: Risk factors predicting early onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1011-1020页

作者： Aslam R Syed Payal Thakkar zachary d Horne Heitham Abdul-Baki Gursimran Kochhar Katie Farah Shyam Thakkar division of Gastroenterology Allegheny Health NetworkPittsburghPA 15212United States Allegheny Singer Research Institute Allegheny Health NetworkPittsburghPA 15212United States division of Radiation Oncology Allegheny Health Network Cancer InstitutePittsburghPA 15212United States

BACKGROUNd Colorectal cancer(CRC)is the second leading cause of all cancer related deaths in the United States and *** the incidence has been decreasing for individuals’≥50,it has been on the rise for individualsdentify potential risk factors for early-onset *** A population-based cohort analysis using a national database,Explorys,screened all patients with an active electronic medical record from January 2012 to december 2016 with a diagnosis of *** were stratified based on age(25–49 years vs≥50 years).demographics,comorbidities,and symptom profiles were recorded and compared between both age ***,the younger group was also compared with a control group consisting of individuals aged 25-49 years within the same timeframe without a diagnosis of *** points for CRC related factors were analyzed to identify potential risk factors specific to early-onset *** A total of 68860 patients were identified with CRC,of which 5710(8.3%)were younger than 50 years old,with 4140(73%)between 40-49 years of *** analysis was reported using odds ratio(OR)with 95%CI and demonstrated that several factors were associated with an increased risk of CRC in the early-onset group versus the later-onset *** factors included:African-American race(OR 1.18,95%CI:1.09-1.27,Pdominal pain(OR 1.82,95%CI:1.72-1.92,Pd bowel function(OR 1.12,95%CI:1.05-1.19,P=0.0005),having a family history of any cancer(OR 1.78,95%CI:1.67-1.90,Pd obesity(OR 1.14,95%CI:1.08-1.20,Pd with an increased risk of CRC were:male gender(OR 1.34,95%CI:1.27-1.41),Pd African-American race(OR 1

关键词： Colorectal cancer Early-onset colorectal cancer Colorectal cancer screening Epidemiology analysis Colorectal neoplasm Average-risk screening

Methodologies for preparation of prokaryotic extracts for cell-free expression systems

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Synthetic and Systems Biotechnology 2020年第4期5卷 252-267页

作者： Stephanie d.Cole Aleksandr E.Miklos Abel C.Chiao zachary Z.Sun Matthew W.Lux US Army Combat Capabilities development Command Chemical Biological Center 8567 Ricketts Point RoadAberdeen Proving GroundMD21010USA division of Biology and Biological Engineering California Institute of TechnologyPasadenaCAUSA Synvitrobio Inc. San FranciscoCAUSA 8567 Ricketts Point Road Bldg E3549 Room B140APGMD21010USA

Cell-free systems that mimic essential cell functions,such as gene expression,have dramatically expanded in recent years,both in terms of applications and widespread *** we provide a review of cell-extract methods,with a specific focus on prokaryotic ***,we describe the diversity of Escherichia coli genetic strains available and their corresponding *** then trace the history of cell-extract methodology over the past 20 years,showing key improvements that lower the entry level for new ***,we survey the rise of new prokaryotic cell-free systems,with associated methods,and the opportunities ***,we use this historical perspective to comment on the role of methodology improvements and highlight where further improvements may be possible.

关键词： Cell-free systems Cell-free expression Cell-free extract Synthetic biology Methods