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Chinese Geographical Science 2002年第3期12卷 212-217页

作者： zhu xi-gang,zhang jing-xiang,chen hu (Department of Urban and Resources Sciences,Nanjing University,Nanjin g 210093,P.R.China,) Department of Urban and Resources Sciences Nanjing University Nanjing P. R. China

In rapid socio-economic developme nt,the process of concentration and dispersal of various elements tends to be more dramatic,tremendously in fluencing the shaping and transform ation of the space in metropolitan *** of spatial concentration and decent ralization has thus become a basic me thod in examining metropolitan spatial *** this research,three elements were selected as the essential indicato rs of the process:demographic density distribu-tion,employment density distribut ion and business office *** of these elements in Nanji ng City was exam-ined *** Nanjing City c ould be regarded as a representative of metropolitan areas in China,its s ituation large-ly suggestes the general characteristics in similar areas of *** based on the investigation of Nanji ng City,four general implications were highligh ***,metropolitan areas inChina are in a violentprocess and shift of spatialconcentra-tion and ***,from now to at least the near future,c oncentration will continue to be the central ***,the landscape of metrop olitan areas basically exhibits a dual structure *** gap in en vironmental and ecological qualities among different districts will continue for a l ong ***,Central Business District(CBD)is playing an important role in helpi ng to convert the traditionally single-centered city structure into a polycentric one.

关键词： concentration decentralization dynamic mechanism nanjing metropolis

Neuro- and immuno-modulation mediated by the cardiac sympathetic nerve: a novel insight into the anti-ischemic efficacy of acupuncture

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1058-1066页

作者： xi Hanqing LI xia zhang Ziyi CUI xiang jing xianghong zhu Bing GAO xinyan Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences

Communication between sympathetic nerves and the immune system is a crucial and active process during myocardial ischemia(MI), as myocardial damage and inflammatory stimuli concurrently occur. Sympathetic nerves undergo structural and functional changes after MI,leading to adverse left ventricular(LV) remodeling and heart failure(HF). The complex inflammatory response to MI, including local myocardial anti-inflammatory repair and systemic immune reactions, plays a key role in adverse LV remodeling. Here, we review the progressive structural and electrophysiological remodeling of the LV and the involvement of sympathetic tone in complex and dynamic processes that are susceptible to MI pathological conditions. Acupuncture has been reported to effectively improve cardiac function, eliminate arrhythmia, and mitigate adverse LV remodeling via somatosensory regulation after MI. Moreover,acupuncture has an anti-inflammatory effect on the pathological process of myocardial ischemia. In this Review, we aim to summarize the involvement of sympathetic nerve activation in the neuro-immune modulation of structural and functional cardiac changes after MI. As a noninvasive method for sympathetic regulation, acupuncture is an ideal option because of its anti-ischemic efficacy. A better understanding of the neural circuitry that regulates cardiac function and immune responses following MI could reveal novel targets for acupuncture treatment.

关键词： acupuncture myocardial ischemia neuroinflammatory diseases review sympathetic nerves

Restraining growth of Zn dendrites by poly dimethyl diallyl ammonium cations in aqueous electrolytes

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Rare Metals 2024年第8期43卷 3735-3747页

作者： xiang-xin zhang Yuan-Qiang chen Chang-xin Lin Yuan-Sheng Lin Guo-Lin hu Yong-Chuan Liu xi-Lai Xue Su-jing chen Zhan-Lin Yang Bai-Sheng Sa Yi-Ning zhang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Helmholtz Institute Ulm(HIU) 89081 UlmGermany Karlsruhe Institute of Technology(KIT) 76021 KarlsruheGermany College of Materials Science and Engineering Fuzhou UniversityFuzhou350108China

Metallic zinc is an excellent anode material for Zn-ion batteries,but the growth of Zn dendrite severely hinders its practical ***,an efficient and economical cationic additive,poly dimethyl diallyl ammonium(PDDA) was reported,used in aqueous Zn-ion batteries electrolyte for stabilizing Zn *** growth of zinc dendrites can be significantly restrained by benefiting from the pronounced electrostatic shielding effect from PDDA on the Zn metal ***,the PDDA is preferentially absorbed on Zn(002) plane,thus preventing unwanted side reactions on Zn *** to the introduction of a certain amount of PDDA additive into the common ZnSO_(4)-based electrolyte,the cycle life of assembled Zn‖Zn cells(1 mA·cm^(-2) and 1 mAh·cm^(-2)) is prolonged to more than 1100 *** response to the perforation issue of Zn electrodes caused by PDDA additives,the problem can be solved by combining foamy copper with zinc *** real application,Zn-ion hybrid supercapacitors and MnO_(2)‖Zn cells were assembled,which exhibited excellent cycling stability with PDDA *** work provides a new solution and perspective to cope with the dendrite growth problem of Zn anode.

关键词： PDDA Electrostatic shielding effect Zn anode Zn dendrites

Early systemic anticoagulation reduces hospital readmission in acute necrotizing pancreatitis patients:A retrospective cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 77-82页

作者： Wen-Jian Mao jing Zhou Guo-Fu zhang Fa-xi chen jing-zhu zhang Bai-Qiang Li Lu Ke Wei-Qin Li Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China National Institute of Healthcare Data Science Nanjing UniversityNanjing 210010China

Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been ***,whether it affects long-term outcomes is *** study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP ***:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were *** primary outcome was 90-day readmission after *** proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day ***:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did *** who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,P<0.01]and lower 90-day readmission with an RR of 0.61(95%CI:0.41-0.91,P=0.02)than those who did *** the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two *** Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission ***:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.

关键词： Anticoagulation Splanchnic venous thrombosis Acute necrotizing pancreatitis Readmission Long-term outcomes

Learning background restoration and local sparse dictionary for infrared small target detection

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Optoelectronics Letters 2024年第7期20卷 437-448页

作者： HE Yue zhang Rui xi Chunmei zhu hu School of Communications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China12

This paper proposes a method for learning background restoration for infrared small target detection,employing a local sparse dictionary alongside an equalized structural texture *** method is specifically designed for the detection of small infrared targets,accommodating various levels of brightness,spatial size,and *** proposed model intelligently combines global low-rankness and local sparsity to estimate the rank of the background tensor,leveraging spatial and structural information to overcome the limitations posed by insufficient detailed texture ***,a structural texture representation,combining local gradient maps and local intensity maps,is applied to emphasize small *** comparing our method with nine advanced and representative approaches and quantifying the comparison using various metrics,the experimental results indicate that our proposed method has achieved favorable outcomes in both quantitative assessments and visual results.

关键词： local structural overcome

Precisely Control Relationship between Sulfur Vacancy and H Absorption for Boosting Hydrogen Evolution Reaction

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Nano-Micro Letters 2024年第4期16卷 14-24页

作者： jing Jin xinyao Wang Yang hu zhuang zhang Hongbo Liu Jie Yin Pinxian xi College of Chemistry and Chemical Engineering Frontiers Science Center for Rare IsotopesState Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000People’s Republic of China

Ef fective and robust catalyst is the core of water splitting to produce ***, we report an anionic etching method to tailor the sulfur vacancy(VS) of NiS_(2) to further enhance the electrocatalytic performance for hydrogen evolution reaction(HER). With the VS concentration change from 2.4% to 8.5%, the H* adsorption strength on S sites changed and NiS_(2)-VS 5.9% shows the most optimized H* adsorption for HER with an ultralow onset potential(68 m V) and has long-term stability for 100 h in 1 M KOH media. In situ attenuated-total-reflection Fourier transform infrared spectroscopy(ATR-FTIRS) measurements are usually used to monitor the adsorption of intermediates. The S-H* peak of the Ni S_(2)-VS 5.9% appears at a very low voltage, which is favorable for the HER in alkaline media. Density functional theory calculations also demonstrate the Ni S_(2)-VS 5.9% has the optimal |ΔG^(H*)| of 0.17 e V. This work offers a simple and promising pathway to enhance catalytic activity via precise vacancies strategy.

关键词： Hydrogen evolution reaction S vacancies Nanosheet H Adsorption

Sex Disparities in the Association of Blood Pressure Parameters and Arterial Sclerosis Risk

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Biomedical and Environmental Sciences 2024年第7期37卷 795-799页

作者： Dongdong zhang Weiling chen Minqi Gu xi Li Yuying Wu Xueru Fu Ping Tang Fulan hu jing Li xizhuo Sun Dongsheng hu Ming zhang Department of General Practice The Affiliated Luohu Hospital of Shenzhen University Medical SchoolShenzhen 518060GuangdongChina Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120GuangdongChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Medical SchoolShenzhen 518060GuangdongChina

Cardiovascular disease(CVD)is the leading cause of death worldwide[1].Arterial sclerosis(AS)and hypertension are the main risk factors and pathological bases of *** pulse wave velocity(PWV)measurements could reflect early progression of *** on the structure-function properties of the vascular wall and hemodynamics,strong evidence suggests that any increase in blood pressure levels can mechanically impair the ability of the endothelium to maintain vascular homeostasis[2].High levels of blood pressure parameters,such as systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),and mean arterial pressure(MAP)have been identified as essential risk biomarkers for atherosclerosis.

关键词： Blood Arterial atherosclerosis

Precision medicine in inflammatory bowel disease

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Precision Clinical Medicine 2024年第1期7卷 54-80页

作者： Zhen Zeng Mingshan Jiang xi Li jing Yuan hu zhang Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041China Centrefor Inflammatory Bowel Disease West China HospitalSichuan UniversityChengdu 610041China Lab of Inflammatory Bowel Disease Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China General Practice Ward/International Medical Center Ward General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041China

Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its *** Crohn's disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency to develop complications and substantial heterogeneity in terms of frequency and severity of relapse,thus posing great challenges to the clinical management for *** treatment strategies are effective in different ways in induction and maintenance therapies for *** advances in studies of genetics,pharmacogenetics,proteomics and microbiome provide a strong driving force for identifying molecular markers of prognosis and treatment response,which should help clinicians manage IBD patients more effectively,and then,improve clinical outcomes and reduce treatment costs of *** this review,we summarize and discuss precision medicine in IBD,focusing on predictive markers of disease course and treatment response,and monitoring indices during therapeutic drug monitoring.

关键词： disease course inflammatory bowel disease precision treatment precision monitoring treatment response

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

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Regenerative Biomaterials 2024年第1期3卷 82-93页

作者： jing zhang Jie Wang Jiayi You Xuan Qin huimin chen xiantong hu Yantao Zhao Yang xia Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029PR China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjingJiangsu 210029PR China Department of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongHong Kong SARPR China Senior Department of Orthopedics The Fourth Medical Center of PLA General HospitalBeijing100048PR China Beijing Engineering Research Center of Orthopedics Implants Beijing 100048PR China State Key Laboratory of Military Stomatology Xi'an 710032PR China

The removal of a failed implant with high torque causes significant damage to the surrounding tissue,compromising bone regeneration and subsequent osseointegration in the defect ***,we report a case of carrier screw fracture followed by immediate implant removal,bone grafting and delayed reimplantation.A dental implant with a fractured central carrier screw was removed using the bur-forceps *** resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft(SD-FDBA).Cone-beam computerized tomography was performed at 1week,6months and 15months postoperatively and standardized for quantitative *** alveolar bone width and height at 15months post-surgery were about 91%of the original values,with a slightly lower bone density,calculated using the gray value *** graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone *** followed by restoration was performed 8months *** quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and longterm implant *** excellent osteogenic properties of SD-FDBA are attributed to its human origin,cortical bone-like structure,partly demineralized surfaces and bone morphogenetic protein-2-containing *** investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： dental implant implant failure allogeneic bone bone regeneration reimplantation

A machine learning-based calibration method for strength simulation of self-piercing riveted joints

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Advances in Manufacturing 2024年第3期12卷 465-483页

作者： Yu-xiang Ji Li huang Qiu-Ren chen Charles K.S.Moy jing-Yi zhang xiao-Ya hu Jian Wang Guo-Bi Tan Qing Liu Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Design School Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuPeople’s Republic of China Materials Bigdata and Applications Division Materials Academy JitriSuzhou215131JiangsuPeople’s Republic of China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

This paper presents a new machine learning-based calibration framework for strength simulation models of self-piercing riveted(SPR)*** simulations were conducted through the integrated modeling of SPR joints from process to performance,while physical quasi-static tensile tests were performed on combinations of DP600 high-strength steel and 5754 aluminum alloy sheets under lap-shear loading conditions.A sensitivity study of the critical simulation parameters(e.g.,friction coefficient and scaling factor)was conducted using the controlled variables method and Sobol sensitivity analysis for feature ***,machine-learning-based surrogate models were used to train and accurately represent the mapping between the detailed joint profile and its load-displacement *** of the simulation model is defined as a dual-objective optimization task to minimize errors in key load displacement features between simulations and experiments.A multi-objective genetic algorithm(MOGA)was chosen for *** three combinations of SPR joints illustrated the effectiveness of the proposed framework,and good agreement was achieved between the calibrated models and experiments.

关键词： Machine learning Self-piercing riveting(SPR) Sensitivity analysis Multi-objective optimization