Neuro-and immuno-modulation mediated by the cardiac sympathetic nerve:a novel insight into the anti-ischemic efficacy of acupuncture

作     者：XI Hanqing LI Xia ZHANG Ziyi CUI Xiang JING Xianghong ZHU Bing GAO Xinyan XI Hanqing;LI Xia;ZHANG Ziyi;CUI Xiang;JING Xianghong;ZHU Bing;GAO Xinyan

作者机构：Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2024年第44卷第5期

页      面：1058-1066页

核心收录：

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Key R&D Program of China:Research on the Specificity and Systemic Effects of Acupoints on Target Organs(No.2022YFC3500702) National Natural Science Foundation of China:Autonomic Neural Modulation underlying“One Acupoint for Multi-Organ Comorbidity”via Propriospinal Interaction(No.82330127) 

主　　题：neuroinflammatory diseases sympathetic nerves myocardial ischemia acupuncture review 

摘      要：Communication between sympathetic nerves and the immune system is a crucial and active process during myocardial ischemia(MI),as myocardial damage and inflammatory stimuli concurrently *** nerves undergo structural and functional changes after MI,leading to adverse left ventricular(LV)remodeling and heart failure(HF).The complex inflammatory response to MI,including local myocardial anti-inflammatory repair and systemic immune reactions,plays a key role in adverse LV ***,we review the progressive structural and electrophysiological remodeling of the LV and the involvement of sympathetic tone in complex and dynamic processes that are susceptible to MI pathological *** has been reported to effectively improve cardiac function,eliminate arrhythmia,and mitigate adverse LV remodeling via somatosensory regulation after ***,acupuncture has an anti-inflammatory effect on the pathological process of myocardial *** this Review,we aim to summarize the involvement of sympathetic nerve activation in the neuro-immune modulation of structural and functional cardiac changes after *** a noninvasive method for sympathetic regulation,acupuncture is an ideal option because of its anti-ischemic efficacy.A better understanding of the neural circuitry that regulates cardiac function and immune responses following MI could reveal novel targets for acupuncture treatment.