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Synthesis and Characterization of TS-1 with Aid of Supercritical CO2

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Chemical Research in Chinese Universities 2013年第6期29卷 1036-1039页

作者： zhu guo-wei CHEN Xiao-bo JIANG Hong HUANG Jian WANG Run-wei QIU Shi-lun State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P.R.China School of Chemical and Biological Beihua University Jinlin 132013 P.R.China

A new route to synthesize TS-1 has been developed using the supercritical carbon dioxide（SCCO2） as a crystallization-assistant agent. SCCO2 plays a dual role： as a reagent changing the alkalinity during the crystallization process and as a medium eliminating mass-transfer limitations（both within the bulk fluid and through liquid/gas, solid/gas or solid/liquid phase boundaries）. In this route, it was shown that the Ti content in TS-I increase compared with that in the TS-1 prepared without SCCO2, but decrease while the SCCO2 pressure increase. The prepared crystal morphology also underwent significant change. The crystallization time of TS-1 can be shorten a lot.

关键词： Aided crystallization regulator Supercritical carbon dioxide Crystal morphology

人工智能在成人脊柱畸形诊疗中的应用研究进展

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中国骨与关节杂志 2024年第7期13卷 507-511页

作者：汪启钧朱卫国孔超鲁世保首都医科大学宣武医院骨科北京100053

人工智能(artificial intelligence,AI)作为一门新兴学科,在过去10年中取得了巨大的进步。AI涵盖多个领域,包括计算机视觉(computer vision)、机器人(robotics)和机器学习(machine learning,ML)^([1])。其中,ML领域主要指开发一系列计算机算法来学习大型复杂数据集并生成研究者感兴趣的预测输出,实现自动化、流程化、快速并准确的事件预测。

关键词：人工智能机器学习脊柱弯曲综述

Breeding for Male-Sterility Line with G. barbadense Nuclear Background and Cytological Observation of Its Microsporogenesis

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Agricultural Sciences in China 2007年第5期6卷 529-535页

作者： ZHANG Xiao-quan WANG Xue-de zhu Yun-guo zhu wei JIANG Pei-dong Department of Agronomy College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 P.R.China

To study the feasibility of utilizing the heterosis of interspecific （Gossypium barbadense x G. hirsutum） hybrid cotton based on cytoplasmic male-sterility system, a G. barbadense male-sterility line HaiA with G. harknessii cytoplasm and its maintainer HaiB were developed by replacing nuclear genome from G. hirsuturn to G. barbadense in a backcross breeding program. Its male cell abortion was observed using a light microscope through a paraffin slice for H.E staining technique. The results showed that the abortion characteristics in HaiA were not significantly changed at the cytological level, although G. hirsuturn nuclear genome of sterile line was replaced by G. barbadense nuclear genome, and its abortion mainly took place at the stage of the microspore mother cell meiosis. HaiA sterility was very stable because of its early abortion and no-pollens in anthers. Hybrids between HaiA and G. hirsuturn restorers were high in pollen viability, boll setting rate, boll weight and lint percentage which contributed to high yield heterosis. It is suggested that HaiA is of great value in the application of cotton interspecific hybrid seed production.

关键词： Gossypium barbadense cytoplasmic male sterility interspecific heterosis

退行性腰椎侧凸冠状面失衡新分型及优先-匹配矫正方法

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中国骨与关节杂志 2024年第7期13卷 491-497页

作者：朱卫国鲁世保王宇陈小龙孔超王玮李翔宇北京首都医科大学宣武医院骨科北京100032

目的介绍退行性腰椎侧凸(degenerative lumbar scoliosis,DLS)患者脊柱整体冠状面形态异常(global coronal malalignment,GCM)的新分型并分析基于此分型的优先-匹配矫正技术减少术后冠状面失衡发生的有效性。方法回顾分析2020年1月至202... 详细信息

目的介绍退行性腰椎侧凸(degenerative lumbar scoliosis,DLS)患者脊柱整体冠状面形态异常(global coronal malalignment,GCM)的新分型并分析基于此分型的优先-匹配矫正技术减少术后冠状面失衡发生的有效性。方法回顾分析2020年1月至2023年10月在我科接受手术治疗和非手术治疗的382例DLS患者的GCM,其中男52例,女330例;平均年龄(65.3±2.4)岁。将GCM分为1型和2型,以腰弯为核心弯的GCM为1型,以腰骶弯为核心弯的GCM为2型。其中对冠状面躯干偏移贡献更大的弯被定义为核心弯,优先-匹配矫形理念的基本原则即优先并充分矫正核心弯。手术患者接受优先-匹配矫正手术或传统矫正手术。分析新分型的可靠性,比较不同分型和分组间患者的临床和影像学参数。结果可信度分析结果显示新分型具有较好的组内和组间可重复性[组内相关系数(intradass correlation coefficient,ICC)>0.75]。1型患者占42.4%,2型患者占57.6%。相比于1型患者,2型患者具有较大的腰骶弯Cobb’s角[(17.9±3.4)°vs.(7.5±3.0)°,P<0.001]和L_(4)tilt[(18.7±4.2)°vs.(11.6±4.4)°,P<0.001]。118例患者接受矫形手术治疗,其中55例接受优先-匹配矫正技术,63例接受传统矫正技术。30例患者在平均随访(15.0±2.1)个月后出现冠状面失衡,16.7%为1型GCM,83.3%为2型GCM。接受优先-匹配矫正和传统矫正患者术后冠状面失衡的发生率分别为7.3%和41.3%(P<0.001)。结论DLS患者GCM新分型基于侧弯对G_(7)铅垂线(G_(7)plumb,C7PL)偏移的贡献距离。以腰弯为核心弯的GCM为1型,以腰骶弯为核心弯的GCM为2型。基于新分型的优先-匹配矫正技术被证实能够显著减少DLS矫形术后冠状面失代偿的发生。

关键词：脊柱疾病腰椎脊柱侧凸优先-匹配矫正

Cystadenoma in a seminal vesicle is cured by laparoscopic ablation

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Asian Journal of Andrology 2013年第5期15卷 697-698页

作者： Jian-guo zhu wei-Hong Chen Shu-Xiong Xu Rong-Ping Wang Zhao-Lin Sun Department of Urology The People's Hospital of Guizhou Province Guiyang 550001 China

Dear Editor, We present here a case report of a benign seminal vesicle cystadenoma treated with laparoscopic ablation in a 31-year-old man. The clinical presentation, gross appearance, microscopic characteristics, im... 详细信息

关键词： Cystadenoma seminal vesicle laparoscopic ablation

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li Wenchao Xu Feng Chen Jun Zhang wei-guo zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu zhu Min guo Jianxin Zhao Hao Zhang Gang Wang wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun zhu wei-wei Peng Jie Wang Hong-wei Zhao Ai-guo Li Min Chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

PbrARF4 contributes to calyx shedding of fruitlets in ‘Dangshan Suli’ pear by partly regulating the expression of abscission genes

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Horticultural Plant Journal 2024年第2期10卷 341-354页

作者： guoling guo Pengfei wei Tao Yu Haiyan Zhang wei Heng Lun Liu Liwu zhu Bing Jia School of Horticulture Anhui Agricultural UniversityHefeiAnhui 230036China Huayuan Foreign Language School Zhejiang Normal UniversityJinhuaZhejiang 322100China Agricultural Experimental Center of Guiyang Guiyang Agriculture and Rural BureauGuiyangGuizhou 550018China

Fruitlet calyx shedding in pear plants is apparently regulated via numerous pathways that involve both environmental triggers and phytohormones cues such as auxin. In this study, we found at 10 days after full bloom (DAFB) higher levels of indoleacetic acid (IAA) and tryptophan (Trp) in calyx persistence fruitlet (CPF) than calyx shedding fruitlet (CSF) ofDanshan Suli’ pear (Pyrus bretschneideri Rhed.). Consisting with this, the activity of indolealdehyde oxidase (IAAIdO), which promotes IAA synthesis, was remarkably increased, and that of peroxidase(POD), which degrades IAA, dropped markedly in CPF but not in CSF. Further, qRT-PCR results revealed that most of 31 PbrARFs (encoding auxin response factors) in Pyrus bretschneideri were highly expressed in CPF, whereas PbrARF4, PbrARF24 and PbrARF26 were significantly downregulated in CPF vis-a-vis CSF. Phylogenetic analysis revealed that 6 PbrARFs clustered in the group III, where PbrARF4 showed the closest affinity with AtARF1 that promotes organ abscission, indicating a putative role of PbrARF4 in mediating the process of calyx shedding in pear. In fact, the ectopic overexpression of PbrARF4 in Solanum lycopersicum resulted in an earlier-formed and deeper abscission layer (AL) in the transgenic plants, whose calyxes were more prone to wilt at the mature red stage (MR) compared with the control plants (wild-type). More importantly, expression levels of the abscission genes SILS and Sl Cel2 in transgenic plants overexpressing PbrARF4 were significantly upregulated in comparation with the WT, whereas those of Sl BI and Sl TAPG2 were considerably inhibited. Further, PbrJOINTLESS and PbrIDA,the two genes related to calyx shedding in pear, were up-regulated more in CSF than CPF. The findings contribute to a better understanding of PbrARFs involved in fruitlet calyx shedding of pear, which could prove beneficial to improving the quality of pear fruit.

关键词： Pear Pyrus bretschneideri Rehd Calyx shedding IAA PbrARF4 Abscission genes