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Chinese Journal of Catalysis 2021年第1期42卷 97-106页

作者： wenliang Wang wenli zhao Haochun Zhang Xincheng Dou Haifeng Shi School of Science Jiangnan UniversityWuxi 214122 JiangsuChina Jiangsu Provincial Research Center of Light Industrial Optoelectronic Engineering and Technology Jiangnan UniversityWuxi 214122JiangsuChina

Although the traditional Fenton reaction is considered an effective strategy for solving problems caused by environmental pollution,construction of an efficient photocatalytic system by coordinating the Fenton reaction is *** this study,2D/2D step-schemeα-Fe2O3/Bi2WO6(FO/BWO)heterostructure photo-Fenton catalysts were successfully fabricated by a facile hydrothermal *** as-prepared materials were characterized by XRD,FT-IR,TEM,XPS,UV-vis DRS,PL,I-t,EIS,and BET *** visible light irradiation,FO/BWO exhibited remarkably high and stable photo-Fenton catalytic activity for the degradation of methyl blue(MB)at low concentrations of *** was noted that FO/BWO(0.5)displayed a significantly enhanced photo-Fenton catalytic activity,which was 11.06 and 3.29 times those of FO nanosheets and BWO nanosheets,*** notably improved photo-Fenton catalytic activity of FO/BWO was mainly due to the combination of H2O2 and FO under light illumination and the presence of the 2D/2D S-scheme heterostructure,with the large contact surface,abundant active sites,and efficient separation rate of photogenerated carriers playing contributory ***,a possible catalytic mechanism for the FO/BWO composite was preliminarily proposed via active species trapping *** summary,this study provided new insights into the synthesis of an effectively heterogeneous 2D/2D S-scheme photo-Fenton catalyst for degradation of organic pollutants in wastewater.

关键词： Bi2WO6 α-Fe2O3 S-scheme Photo-Fenton 2D photocatalyst

A canine model of aortic arch aneurysm created with autologous pericardium

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Journal of Interventional Medicine 2022年第3期5卷 133-137页

作者： Weixiao Li Jun Li Qiang li Mingzhe Cui Rutao Xu Shuiting Zhai Cheshire Nick Tianxiao Li Jiangbo Chen wenli zhao Department of Vascular and Endovascular Surgery Zhengzhou University People's HospitalHenan Provincial Peoples HospitalZhenghouChina Operation Department Zhengzhou University People's HospitalHenan Provincial People's HospitalZhenghouChina Department of Medical Imaging Zhengzhou University People's HospitalHenan Provincial People's HospitalZhenghouChina Department of Vascular Surgery Royal Brompton and Harefield HospitalLondonUK Department of Cerebrovascular Disease Zhengzhou University People's HospitalHenan Provincial People's HospitalZhenghouChina

Background:To establish a canine model of aortic arch aneurysm that is suitable for research on new devices and techniques applied to the aortic *** and methods:Fifteen mongrel dogs underwent *** autologous pericardial patch was sewn on the aortotomy site in the anterior wall of the aortic *** animals were followed up for 3 months *** tomography angiography was used to visualize and measure the aneurysm *** and eosin staining was used to observe the histological characteristics of the aneurysm *** in aneurysm diameter over time were analyzed using analysis of ***:One dog died of hemorrhage during *** dogs survived the surgical *** of them died on the first postoperative day because of ruptures at the suturing *** diameter of the aneurysm model was twice as large as that of the aortic *** was no significant change in the maximum diameter of the aneurysm model during the follow-up ***:We established a controllable and stable aortic arch aneurysm model created with an autologous pericardium *** aneurysm model can be used to research endoleaks after thoracic endovascular aortic repair and new endovascular techniques can be applied to the aortic arch.

关键词： Aortic aneurysm Pericardium patch Ascending aorta Aortic arch Animal model

急性颈动脉血栓性闭塞形成后巨噬细胞浸润行为的动态演变研究

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中国脑血管病杂志 2024年第7期21卷 433-443页

作者：李世凯梁佳何艳艳丁乾昊李晨卿刘阳冯英璞赵文利黄宇梦索莉娜李天晓贺迎坤新乡医学院医学工程学院 453003 河南省脑血管病国际联合实验室、河南省脑血管介入创新工程技术研究中心河南省人民医院(郑州大学人民医院)脑血管病科

目的探索急性颈动脉血栓性闭塞(ACTO)形成后,血栓动态演变过程中巨噬细胞的浸润行为变化。方法选用健康雄性新西兰大白兔15只,通过使用氯化铁处理后的外科缝合线对兔颈动脉造成损伤来建立ACTO模型。采用随机数字表法将所有兔按照实验终... 详细信息

目的探索急性颈动脉血栓性闭塞(ACTO)形成后,血栓动态演变过程中巨噬细胞的浸润行为变化。方法选用健康雄性新西兰大白兔15只,通过使用氯化铁处理后的外科缝合线对兔颈动脉造成损伤来建立ACTO模型。采用随机数字表法将所有兔按照实验终点时间分为5组;术后24 h组及术后1、4、8、12周组,每组3只。术后24 h,使用DSA检查ACTO模型建立情况。到达实验时间终点时对该组3只兔进行血栓栓塞段动脉取材并用石蜡包埋。采用苏木素-伊红(HE)染色和马休黄猩红蓝(MSB)对血栓样本进行染色,分析血栓形态和血栓组成(包括红细胞、纤维蛋白和胶原纤维)的变化,使用Orbit Imaging Analysis软件对血栓组成成分进行半定量分析。使用免疫组织化学对血栓中M0和M2型巨噬细胞的分布进行检测,依据检测结果总结ACTO发生后不同时期血栓的形态、组成及血栓中巨噬细胞浸润行为的动态演变规律。结果术后24 h DSA结果显示,所有的实验兔均成功建立了ACTO模型。(1)HE染色结果显示,在术后24 h至1周的时间段内,血栓呈持续增大趋势;术后4周时,血栓开始出现溶解现象;术后8周时,血栓内部观察到了新生血管的形成;而术后12周时,血栓开始呈现出纤维化的迹象。(2)MSB染色结果显示,在血栓形成的急性期(术后24 h内),红细胞为主要成分;在此之后,以纤维蛋白和胶原纤维为主要成分。(3)M0型巨噬细胞(细胞表面标志物为CD206)检测结果显示,术后24 h,血栓中M0型巨噬细胞并未均匀分布于整个血栓中,而主要聚集于血栓边缘;术后1周时,血栓内M0型巨噬细胞阳性面积百分比相较于术后24 h增加[血栓边缘:(41.7±27.0)%比(24.6±16.7)%,血栓核心:(35.7±19.6)%比(11.1±10.4)%,均P0.05)。此外,术后12周血栓边缘M0型巨噬细胞的阳性面积百分比少于血栓核心处[(8.9±5.3)%比(15.7±11.0)%,P0.05;血栓核心:(17.9±8.8)%比(14.4±10.0)%,P>0.05]。此外,术后8、12周时血栓核心M2型巨噬细胞阳性面积百分比均多于血栓边缘处[术后8周:(17.9±8.8)%比(9.4±6.3)%,P<0.001;术后12周:(14.4±10.0)%比(8.5±5.3)%,P<0.001]。结论本研究成功构建了ACTO动物模型,首次展示了血栓形成后12周内巨噬细胞的动态演变规律。巨噬细胞在血栓形成和血栓纤维化过程中发挥着重要作用,并可能促进了血栓溶解和血栓内新生血管形成,进而促进闭塞血管自发再灌注的发生。本研究结果有待进一步验证。

关键词：急性颈动脉血栓血栓栓塞巨噬细胞动物模型

FOXC1蛋白在弥漫大B细胞淋巴瘤中的表达及与患者预后的关系

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黑龙江医药科学 2024年第5期47卷 29-33页

作者：詹雪冰舒准刘英霞刘泽标陈明铨黄海杰钟鸣赵文丽惠州市第一人民医院病理科广东惠州516001

目的:探讨弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)中叉头框蛋白C1(forkhead box C1,FOXC1)蛋白的表达情况及临床病理意义,并评估其在患者预后判断方面的潜在价值。方法:对2018年4月至2022年3月惠州市第一人民医院经... 详细信息

目的:探讨弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)中叉头框蛋白C1(forkhead box C1,FOXC1)蛋白的表达情况及临床病理意义,并评估其在患者预后判断方面的潜在价值。方法:对2018年4月至2022年3月惠州市第一人民医院经病理学诊断的33例DLBCL患者进行回顾性分析,利用免疫组织化学技术对FOXC1蛋白表达水平进行检测,收集患者的随访信息,并分析其表达水平与临床病理参数以及患者预后的相关性。利用GEPIA2数据库分析FOXC1在DLBCL中表达情况及其与BCL-2的相关性;利用UCSC数据库进行FOXC1在泛癌中的生存分析;利用HPA数据库和STRING数据库分析与FOXC1直接相互作用的蛋白。结果:33例DLBCL组织中FOXC1阳性表达17例(51.5%),12例淋巴组织反应性增生(reactive lymphoid hyperplasia, RH)中FOXC1阳性表达0例(0.0%),两者差异有统计学意义(P<0.01)。统计分析结果表明,在DLBCL中,FOXC1蛋白的表达水平与患者的Ann Arbor临床分期和BCL-2的表达情况有关(P<0.01)。同时,FOXC1蛋白表达水平与DLBCL患者的预后密切相关,高表达患者的生存时间明显短于低表达患者(P<0.01)。GEPIA数据库分析结果显示,FOXC1在DLBCL中的表达高于正常组织,FOXC1与BCL-2表达正相关(P<0.01,R=0.36)。UCSC数据库分析显示,FOXC1在包括DLBCL的4种肿瘤中与患者预后相关(P<0.05)。结论:本研究发现DLBCL中FOXC1蛋白表达水平升高,其高表达与患者的不良预后相关,提示FOXC1有可能成为DLBCL预后评估的潜在分子标志。

关键词：弥漫大B细胞淋巴瘤免疫组织化学叉头框蛋白C1 预后标志物

2005—2023年广东省南澳县肺结核流行特征分析

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结核与肺部疾病杂志 2024年第4期5卷 317-324页

作者：赵文丽方梓昊徐雁南刘苏洋林健雄陈壮濠符慧陈蕊明常巧呈汕头大学公共卫生学院汕头515063 广东省汕头市结核病防治所汕头515031

目的:分析南澳县2005—2023年监测数据中结核病报告发病流行特征和变化规律,为结核病防控措施的制定提供参考依据。方法:通过“中国疾病预防控制信息系统”的子系统“结核病管理信息系统”筛选2005—2023年广东省汕头市南澳县登记管理... 详细信息

目的:分析南澳县2005—2023年监测数据中结核病报告发病流行特征和变化规律,为结核病防控措施的制定提供参考依据。方法:通过“中国疾病预防控制信息系统”的子系统“结核病管理信息系统”筛选2005—2023年广东省汕头市南澳县登记管理的肺结核患者病案数据。南澳县各年度人口学资料来源于《南澳统计年鉴》。采用描述性流行病学方法分析2005—2023年南澳县肺结核监测报告数据,描述其发病的主要特征,并采用Joinpoint回归模型分析结核病的发病变化趋势。结果:2005—2023年南澳县共报告结核病患者1636例,年均报告发病率为134.79/10万,其中病原学阳性肺结核患者占34.72%(568/1636),发病率曲线呈波动分布[平均年度变化百分比(AAPC)=-5.478%,P<0.001]。无明显季节性高峰。在报告的1636例患者中,男性1211例,女性425例;利福平耐药患者9例,且均为男性;发病年龄以60~69岁人群为主(415例,占25.37%);职业以家务及待业为主(628例,占38.39%)。结论:南澳县结核病发病率总体呈现下降趋势,应进一步加强对男性、老年人、家务及待业人群的防控。

关键词：结核,肺发病率流行病学研究小地区分析

维普期刊数据库博看期刊

医工交叉融合促进高端医疗设备产业创新能力提升

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实用医技杂志 2024年第2期31卷 77-80页

作者：崔艳华任晓强王小健赵文莉严继萍尉志红原雪军周静怡山西省人民医院超声科太原030012 山西省人民医院信息处太原030012 山西省人民医院骨科太原030012 太原钢铁(集团)有限公司总医院超声科太原030003 山西省人民医院科教处太原030012

高端医疗设备产业在疾病的预防、诊断、治疗、康复等领域起着至关重要的作用。当前,高端医疗设备产业发展所需要的医学专业理论和工程技术知识要求不断提高,国产高端医疗设备在国内市场份额比重相对较小,医疗设备产业“卡脖子”难题仍... 详细信息

高端医疗设备产业在疾病的预防、诊断、治疗、康复等领域起着至关重要的作用。当前,高端医疗设备产业发展所需要的医学专业理论和工程技术知识要求不断提高,国产高端医疗设备在国内市场份额比重相对较小,医疗设备产业“卡脖子”难题仍然存在。高端医疗设备产业自主创新能力的提升对促进国产高端医疗设备替代进口产品、降低医疗成本、保障医疗卫生事业高质量发展起着重要作用。医工结合可以将专业医疗知识与当前工程学科的新技术综合运用,为解决当今高端医疗设备的关键技术提供新思路、新方法,为高端医疗设备产业创新能力的提高提供潜在的可行性。本文通过对医工结合的人才培养及成果转化影响因素进行分析,以期为实现高端医疗设备产业创新能力提高提供信息支持。

关键词：交叉学科医疗器械高端创新医工结合

A simplified ZOOM FFT algorithm in digital sonar

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Chinese Journal of Acoustics 1999年第2期18卷 97-104页

作者： LI Qihu LI Weichang zhao wenli(Institute of Acoustics, Academia Sinica Beijing 100080)

DEMON and LOFAR have been proved the powerful means in underwater acoustic signal processing, especially in weak signal detection and target noise classification. Sometimes one need to know the fine structure of frequency spectrum of received signal. It is necessary to take a very long data to get high frequency resolution. This is not always possible due to the hardware and software limitation. Zoom FFT is one of the trade-off consideration for solving high frequency resolution problem, if we are only focus on some special frequency bins. Previous discussions mainly bifurcate into two different representations, the Complex Modulation and Cascade FFT. The former one traditionally needs some kind of special treatments, such as the complex modulation, Lowpass filtering, down-sampling. While the latter achieves the same result by two cascade FFT, with necessary modifications in phase and amplitude, thus is feasible for real-time implementation. Based on some theoretical analysis, a relationship between the complex moduIation and cascade FFT has been described in this paper. In addition, the selection of parameters such as windows function, sample rate, overlap factor have been discussed. Finally, the algorithm is presented and some simulation results are illustrated

关键词： FFT A simplified ZOOM FFT algorithm in digital sonar

Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue Xu Shurui Song Huiying Wang Xilong Cao Xinran zhao wenli Wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan Shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and ***,the industrial development of pear fruit is significantly limited by its short shelf *** acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf ***,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly *** this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide *** COL genes were divided into three subgroups according to the structural domains of the COL *** COL8,with two B-box motifs and one CCT domain,belonged to the first *** contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third *** four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit ***,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp ***,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its *** the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit *** contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit *** co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit *** re

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS

基于随机共振原理的中低频信号检测方法与电路设计

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仪器仪表学报 2011年第4期32卷 721-728页

作者：赵文礼刘进殷园平杭州电子科技大学机械工程学院

大量研究表明,对于满足绝热近似理论的所谓小参数信号,利用随机共振特性可以实现被测信号中噪声能量向周期性有用信号能量的跃迁,从而增强信号输出的信噪比。针对在机械故障中常见的难以实现随机共振的中低频周期信号,利用信号调制特性... 详细信息

大量研究表明,对于满足绝热近似理论的所谓小参数信号,利用随机共振特性可以实现被测信号中噪声能量向周期性有用信号能量的跃迁,从而增强信号输出的信噪比。针对在机械故障中常见的难以实现随机共振的中低频周期信号,利用信号调制特性,将其变换为可满足绝热近似理论的小参数信号,从而实现了基于随机共振原理的微弱信号检测。在此基础上,设计出了混频随机共振电路系统,利用混频器将待测信号与扫描信号发生器产生的信号作选频处理,然后输入非线性双稳态系统实现基于随机共振的检测。模拟实验结果表明,该电路系统能够实现随机共振并从噪声背景中检测出微弱的中低频周期信号。

关键词：中低频周期信号随机共振微弱信号电路设计

Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity

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Engineering 2024年第7期38卷 113-123页

作者： Xiangyang Liu Fei-Peng zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang wenli Guo Shuangjun Lin Yasuhiro Igarashi Gong-Li Tang State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Microbial Metabolism&Joint International Research Laboratory on Metabolic and Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Biotechnology Research Center Toyama Prefectural UniversityImizu 939-0398Japan

A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea *** TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which generated a trace of the target products but accumulated a large amount of shunt *** on rational analysis of the relevant secondary metabolism,directed engineering of the biosynthetic pathways resulted in the high production of HBM B,as well as new HBM derivates with improved antitumor *** results not only establish a biosynthetic system to effectively synthesize HBMs-a class of the largest and most complex Type-Ⅱpolyketides,with a unique pseudo-dimeric structure-but also set the stage for further engineering and deep investigation of this complex biosynthetic pathway toward potent anticancer drugs.

关键词： Hibarimicin Biosynthesis Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide