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An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings： a prospective, multicenter study in china

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Chinese Medical Journal 2014年第1期127卷 59-65页

作者： li Taisheng Guo Fuping li Yijia {2. Chengda Han yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong li Yanling Tang Xiaoping Wang Hui {2. Tong Gao Guiju lei Junkang {2. Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo ling Wang Huanlmg department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730China The infectious Disease Hospital of Henan Province ZhengzhouHenan 450061 China Shanghai Public Health Clinical Center Fudan University Shanghai201508 China Fuzhou Infectious Diseases Hospital Fujian Medical UniversityFuzhou Fujian 350002 China Guangzhou No. 8 People's Hospital Guangzhou Guangdong 510060 China Shenzhen Third People's Hospital Shenzhen Guangdong 518112China beijing You'an Hospital Capital Medical University Beijing 100054China beijing Ditan Hospital Capital Medical University Beijing 100011China Yunnan AIDS Care Center Kunming Yunnan 650000 China The First People's Hospital of Honghe State Honghe Yunnan 650000 China Tangdu Hospital Affiliated to the Fourth Military Medical {2. Xi'an Shaanxi 710038 China Kunming Third People's Hospital Kunming Yunnan 650041 China

Background An zidovudine （AZT）-substitution regimen containing 2.-week stavudine （d4.） followed by long-term AZT for HIV therapy is potential to trade off short-term AZT-related anemia and long-term risks associated with d4. in resourcelimited ***,evidence is *** study aims to assess the efficacy and safety of AZT-substitution regimen,aiming to find a regimen with better efficacy,less adverse events,and more affordability in resource-limited *** This prospective,multicenter study enrolled 4.9 （190 on d4. regimen,172.on AZT regimen,and 137 on AZT-substitution regimen） HIV-1-infected subjects who initiated combined antiretroviral therapy and attended follow-up visits over 96 weeks from 2.09 to *** （3TC） and either nevirapine （NVP） or efavirenz （EFV） were the other two drugs in the antiretroviral *** and immunologic responses and adverse events were monitored at baseline and at weeks 4.12.2.,36,4.,60,72.84.and *** In terms of hematological adverse effects,AZT-substitution group had similar safety profiles to d4. group and was superior to AZT *** comparison with AZT-substitution group,AZT group was associated with higher risk of developing anemia （adjusted hazard ratio （aHR）for anemia ≥ grade Ⅱ,8.4.,95％ CI 1.81-39.4.） and neutropenia （aHR for neutropenia ≥ grade Ⅱ,1.86,95％ CI 1.19-2.93）.The prevalence of lipodystrophy in d4. group was 19.5％,while that in AZT-substitution group was *** to antiretroviral efficacy,these three groups showed no *** AZT-substitution regimen provides a relatively safe and effective first-line antiretroviral strategy in resource-limited settings.

关键词： human immunodeficiency virus acquired immunodeficiency syndrome antiretroviral therapy zidovudine stavudine anemia lipodystrophy

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2.18 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents

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Science Bulletin 2018年第23期63卷 1558-1564页

作者： Cheng Wang Yaqi li Ying liao Hong Tian Min Huang Xiangyu Dong lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong lin Feng lijun Fu Fangqi Gong Yonghao Gui ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo li Fen li Tao li Xiaohui li Xiaoyan liu Yan li Haitao Lv Tiewei Lv Zipu li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan zhang Huili zhang li zhang Qingyou zhang Xi zhang Yanmin zhang Zhiwei zhang Cuifen Zhao Bin Zhou Hua Zhu department of Pediatric Cardiovasoloy Children's Medical CenterThe Second Xiangya HospitalCentral South UniversityChangsha 410071China department of Pediatrics Peking University First HospitalBeijing 100034China department of Pediatric Cardiology Children's Hospital of Fudan UniversityShanghai 201102China department of Pediatric Cardiology Shanghai Children's HospitalShanghai 207102China of Pediatrics the 2nd Hospital of Lanzhou UniversityLanzhou 730020China department of Pediatric Cardiology Capital Institute of PediatricsBezjing 100020China department of Pediatrics Jilin University First HospitalChangchun 130021China Chinese Pediatric Cardiology Society Chinese Pediatric Society(CPCS)Chinese Medical Association(CMA)China Committee on Pediatric Syncope Pediatricians BranchChinese Medical Doctor Association(CMDA)China Pediatric Cardiology Society Beijing Pediatric SocietyBeijing Medical Association(BMA)China Committee on Pediatric Cardiology Chinese College of Cardiovascular PhysiciansChinese Medical Doctor Association(CMDA)China

Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2. of emergency department *** syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in china, 2.18 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, beijing Pediatric Society, beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.

关键词： CPCS Children Adolescent syncope

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Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis

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Chinese Medical Journal 2019年第5期132卷 577-588页

作者： lei Yuan Yan Zeng Zhong-Qiang Chen Xin-ling {2. Shuo Mai Pan Song li-Yuan Tao department of Orthopedics Peking University Third Hospital Beijing 100191China department of Urodynamic Center and Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191China

Background: Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic acid (TXA), and epsilon-aminocaproic acid (EACA) are antifibrinolytics currently offered as prophylactic agents to reduce surgery-ass oci a ted blood loss. The aim of this study was to evaluate the efficacy and safety of aprotinin, EACA, and low/high doses of TXA in spinal surgery, and assess the use of which agent is the most optimal intervention using the network meta-analysis (NMA) method. Methods: Five electronic databases were searched, including PubMed, Cochrane library, ScienceDirect, Embase, and Web of Science, from the inception to March 1,2.18. Trials that were randomized and compared results between TXA, EACA, and placebo were identified. The NMA was conducted with software R 3.3.2.and STATA 14.0. Results: Thirty randomized controlled trial (RCT) studies were analyzed. Aprotinin (standardized mean difference [SMD]=-0.65, 95% credibility intervals [CrI;-1.2.,-0.06]), low-dose TXA (SMD=-0.58, 95% CrI [-0.92.-0.2.]), and high-dose TXA (SMD =-0.70, 95% CrI [-1.04.-0.36]) were more effective than the respective placebos in reducing intraoperative blood loss. Low-dose TXA (SMD=-1.90, 95% CrI [-3.32.-0.4.]) and high-dose TXA (SMD =-2.31, 95% CrI [-3.75,-0.87]) had less postoperative blood loss. Low-dose TXA (SMD=-1.07, 95% CrI [-1.82.-0.31]) and high-dose TXA (SMD =-1.07, 95% CrI[-1.82.-0.31]) significantly reduced total blood loss. However, only high-dose TXA (SMD =-2.07, 95% CrI [-3.2.,-0.87]) was more effective in reducing the amount of transfusion, and was significantly superior to low-dose TXA in this regard (SMD =-1.67, 95% CrI [-3.2.,-0.13]). Furthermore, aprotinin (odds ratio [OR]= 0.16, 95% CrI [0.05, 0.54.), EACA (OR = 0.4., 95% CrI [0.2., 0.97]) and high dose of TXA (OR = 0.34. 95% CrI [0.19, 0.58]) had

关键词： Antifibrinolytics Spine surgery Blood loss Transfusion Network meta-analysis

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Enhancement of radiosensitivity of lung adenocarcinoma using a decoction from the Fuzhengzengxiao formula

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Journal of Traditional Chinese Medicine 2015年第6期35卷 690-696页

作者： zhang Qiaoli Wu Tong {2. Yong li Bo liu Weiyi Tian Yehong Zhao Weipeng Huang Jingchang department of Traditional Chinese Medicine Beijing Hepingli Hospital department of Traditional Chinese Medicine Beijing Ditan HospitalCapital Medical University Graduate School of beijing university of Traditional Chinese Medicine Health Science Center Peking University department of Acupuncture and Minimally Invasive Oncology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To study the effects of a decoction of Fuzhengzengxiao formula on lung adenocarcinoma regarding the inflammatory protein S100A9 known to enhance cancer cell ***: A nude mouse model of human lung adenocarcinoma was established. The mice were randomly divided into four groups using the random number table method: Group Ⅰ, control;Group Ⅱ, treatment with a decoction of the Fuzhengzengxiao formula alone; Group Ⅲ, treatment with radiotherapy alone; and Group Ⅳ, treatment with radiotherapy plus a decoction of Fuzhengzengxiao formula. When the tumor body was 1 cm^3 in diameter, the tumor bearing mice in GroupsⅢ and Ⅳ were irradiated at a single dose of 10 Gy and the tumor inhibition rate was *** expression of S100A9 was determined using Western blotting and q-PCR(Real-time Quantitative PCR Detecting System). The sensitivity of cells containing RNAi S100A9 to radiotherapy was evaluated using the Click multiple target model,and the cell cycle was analyzed using flow ***: Relative to the control group,the expression of S100A9 in the tumors in each treatment group was decreased,especially in Group Ⅳ. The sensitizing enhancement ratio(SER) Dq was >1 after RNAi S100A9; it decreased the surviving fraction after a 2.Gy dose exposure,and also the D_0 and Dq of the tumor cells; in addition, the radiosensitivity of G_2.M cells was significantly ***: The decoction of the Fuzhengzengxiao formula downregulated the expression of S100A9 in lung adenocarcinoma cells.

关键词： Calgranulin B RNA interference Radia-tion tolerance Adenocarcinoma of lung Fuzhengz-engxiao formula

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No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in china

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Chinese Journal of Cancer Research 2020年第4期32卷 516-529页

作者： Haike lei lin lei Jufang Shi Yongzhong Wu ling liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng liu Jia Du Hong Wang Yan zhang Mengdi Cao Ji Peng Ni li Chunfeng Qu Min Dai Wanqing Chen Jie He Office of Chongqing Cancer Prevention and Treatment Chongqing University Cancer HospitalChongqing 400030China department of Cancer Control Shenzhen Center for Chronic Disease ControlShenzhen 518020China Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Lab of Molecular Oncology/Immunology department National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The number of liver cancer patients in china accounts for more than half of the ***,china currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer ***,the aim of the study was to measure the economic burden of liver cancer by various ***:A hospital-based,multicenter and cross-sectional survey was conducted during 2.12.2.14.covering 39 hospitals and 2. project sites in 13 provinces across *** questionnaire covers clinical information,sociology,expenditure,and related *** expenditure data were reported in Chinese Yuan(CNY)using 2.14.***:A total of 2.2.3 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular *** average total expenditure per liver cancer patient was estimated as 53,2.0 CNY,including 4.,612.CNY of medical expenditures(91.3%)and 4.608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52.817 CNY,50,877 CNY,50,678 CNY and 54.089 CNY(P>0.05),***-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,4.3 CNY,839 CNY,94. CNY,679 CNY and 2.0 CNY,*** one-year out-of-pocket expenditure of a newly diagnosed patient was 2.,953 CNY,and 77.2.of the patients suffered an unmanageable financial *** analysis showed that overall expenditure differed in almost all subgroups(Plinical stage,and pathologic ***:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not *** fiirtherly reduce the overall economic burden from liver cancer,more effort should be

关键词： liver cancer medical expenditure non-medical expenditure economic burden

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Minimally Invasive Cochlear Implantation Assisted by Bi-planar Device： An Exploratory Feasibility Study in vitro

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Chinese Medical Journal 2016年第20期129卷 2476-2483页

作者： Jia Ke Shao-Xing zhang lei Hu Chang-Sheng {2. Yun-Feng Zhu Shi-Long Sun {2.-Feng Wang Fu-Rong Ma department of Otorhinolarygology-Head and Neck Surgery Peking University Third HospitalBeijing 100191China Robotics Institute School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China

Background：A single drilled tunnel from the lateral mastoid cortex to the cochlea via the facial recess is essential for minimally invasive cochlear implant *** study aimed to explore the safety profile of this kind of new image-guided and bi-planar device-assisted surgery procedure in ***：Image-guided minimally invasive cochlear implantations were performed on eight cadaveric temporal bone *** main procedures were：（1） temporal bone specimens were prepared for surgery and fiducial markers were registered.（2. computed tomography （CT） scans were performed for future reference.（3） CT scan images were processed and drill path was planned to minimize cochlear damage.（4. bi-planar device-assisted drilling was performed on the specimens using the registration.（5） surgical safety was evaluated by calculating the deviation between the drill and the planned paths,and by measuring the closest distance between the drilled path and critical anatomic ***：Eight cases were operated successfully to the basal turn of the cochlear with intact facial nerves （FNs）.The deviations from target points and entrance points were 0.86 mm （0.68-1.00 mm） and 0.4. mm （0.30-0.96 mm）,*** angular error between the planned and the drilled trajectory was 1.74. （1.2.-2.4.°）.The mean distance from the edge of the drilled path to the FN and to the external canal was 0.60 mm （0.35-0.83 mm） and 1.60 mm （1.30-2.05 mm）,*** five specimens,the chorda tympani nerves were well *** all cases,no injury happened to auditory ***：This exploratory study demonstrated the safety of the newly developed image-guided minimally invasive cochlear implantation assisted by the bi-planar device and established the operational ***,more in vitro experiments are needed to improve the system operation and its safety.

关键词： Cochlear Implantation Minimally Invasive Surgical Procedures Navigation

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Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802.:An International Multicenter Study

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 818-827页

作者： Yanna liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo li Zhiwei li Weimin An Dengxiang liu Chunqing {4. Changchun liu Jinqiang liu Chuan liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller lei li Haijun {4. Ning Kang Dan Xu Ruiling He Yan Wang {14. Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina CHESS Center The Sixth People’s Hospital of ShenyangShenyangLiaoningChina department of Infectious Disease Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina department of Microbiology and Infec-tious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Depart-ment of Radiology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsuChina Istanbul Health and Technology university Zytinburnu/İstanbulTurkey CHESS Working Party Xingtai People’s HospitalXingtaiHebeiChina department of Hepatobiliary Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina department of Radiology Fifth Medical Center of PLA General HospitalBeijingChina department of Gastroenterol-ogy Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaUniversity of BolognaItaly department of Radiology Ankara University School of MedicineAnkaraTurkey department of Gastroenterology Ankara University School of MedicineAnkaraTurkey department of Hepatobiliary Surgery People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxiaChina

Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in ***:In this international multicenter,diagnostic study(***,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in china(n=4.and Turkey(n=1)between December 2.18 and April 2.19.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2.15 and November *** segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface ***:A total of 14. patients were included,of which 12. were from four Chinese hospitals(training cohort)and 2. were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(plidation cohorts,*** area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,*** intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.84. and 0.84.,***:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive ***,this score could be used to detect CSPH in patients with cirrhosis.

关键词： liver cirrhosis Advanced chronic liver disease Hepatic venous pressure gradient liver surface nodularity Imaging

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Pyoderma Gangrenosum as the Initial Manifestation of Small Cell Lung Cancer with Dermatomyositis

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Chinese Medical Journal 2017年第17期130卷 2132-2133页

作者： Man li Tian Guan zhang-{2. Mu Qian-Xi Xu lin Cai Xue Chen department of Dermatology Peking University People&#39 s Hospital Beijing 100044 China department of Thoracic Surgery Peking University People&#39 s Hospital Beijing 100044 China

To the Editor：A 54.year-old man developed painful ulcers on the neck one month ago,followed by periorbital *** ulcers then spread to his trunk,back,and upper *** had muscle weakness,mild muscle soreness with activity,and dysphagia for foods for the past three *** was diagnosed as drug eruption in a local hospital and received irregular corticosteroids therapy for two ***,the ulcers started to *** had a 4. years＆#39; history of *** patient was emaciation,and physical examination revealed heliotrope sign,poikiloderma involving the face,＆quot;V＆quot; sign of the chest,and the upper arm,nail fold telangiectasia,and large well-defined ulcers on the abdomen,back,and upper arms,there was no Gottron sign [Figure 1].It was hard for him to raise his arms and *** triceps and quadriceps were tender to *** revealed elevated levels of antinuclear antibodies （1：4.;normal range,〈1：4.）,creatin kinase （382.U/L;normal range,56-2.4.U/L）,lactic dehydrogenase （2.4.U/L;normal range,109-2.5 U/L）,white blood cell （19.71 x 109/L,normal range,3.5-9.5 ＆#2.5; 109/L）,erythrocyte sedimentation rate （78 mm/h;normal range,0-15 mm/h）,C-reactive protein （117.52.mg/L;normal range,〈8 mg/L）,neurospecific enolase （2..03 ng/ml;normal range,0-16.30 ng/ml）,and electromyography showed muscle *** computed tomography plain and enhanced scan suggested possible malignant tumor in left upper lobe [Figure 1].The biopsy of axillary lymph node showed ＆quot;small cell lung cancer＆quot;.Histopathology of ulcer edge revealed ulceration of the epidermis with a dense neutrophils *** was no organisms or vasculitis [Figure 1].

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Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy

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Chinese Medical Journal 2022年第14期135卷 1639-1641页

作者： Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua li Aibin liang Qifa liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu linhua yang Renchi yang lei zhang liansheng zhang Xi zhang Xiaohui zhang Weili Zhao Weidong Han Yu Hu department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Hematology Xiangya Third HospitalCentral South UniversityChangshaHunan 410013China Jiangsu Institute of Hematology National Clinical Research Center for Hematologic DiseasesThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250063China Institute of Hematology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China peking university People’s Hospital Peking University Institute of HematologyBeijing 100044China department of Hematology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510282China department of Hematology Tongji Hospital of Tongji UniversityShanghai 200092China department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China department of Hematology West China HospitalSichuan UniversityChengduSichuan 610041China department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310009China Affiliated Cancer Hospital of Zhengzhou university ZhengzhouHenan 450008China State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Disease Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China department of Hematology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China department of Hematology Lanzhou University Second HospitalLanzhouGansu 730030China Medical Center of Hematology Xinqiao HospitalThe Third Military Medical UniversityChongqing 400037China Shanghai Institute of Hematology State Key Laboratory of Medical

Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been *** should be paid to the safety of CAR-T *** main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4.

关键词： clinical cytokine release

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Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit

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CCS Chemistry 2019年第5期1卷 476-489页

作者： Man Pan Qingyun Zheng Shuai Gao Qian Qu Yuanyuan Yu Ming Wu Huan Lan Yulei li Sanling liu Jiabin li Demeng Sun lining Lu Tian Wang Wenhao zhang Jiawei Wang Yiming li Hong-Gang Hu Changlin Tian lei liu Tsinghua-peking Center for life Sciences Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyState Key Laboratory of Chemical OncogenomicsDepartment of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical BiologyGraduate School at ShenzhenTsinghua UniversityShenzhenGuangdong 518055China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Hefei National Laboratory for Physical Sciences at Microscale and School of life Sciences University of Science and Technology of ChinaHefei 230027China School of Biological and Medical Engineering Hefei University of TechnologyHefeiAnhui 230009China

Mutations in genes encoding PINK1(PTEN-induced kinase 1)and Parkin(E3 ubiquitin ligase)are identified in familial Parkinson’s ***,it remains unclear whether the phosphorylated Ub chains activate wild-type Parkin(w-Pa... 详细信息

关键词： chemical protein synthesis ubiquitin phosphorylation Parkin mitochondrial autophagy

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