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Chinese Journal of Structural Chemistry 2006年第7期25卷 797-800页

作者： zhang gai-hong chen ru-yu huang you miao zhi-wei Institute and State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 China

The crystal structure of 2-nitrophenyl N,N-bis（2-chloroethyl）-N＇-（4-methylbenzene-sulfonamino）ethyl-phosphorodiamidate （C19H25Cl2N4O6PS） was determined by single-crystal X-ray diffraction analysis. The compound crystallizes in the triclinic system, space group PI^- with a = 9.3664（13）, b = 9.9560（14）, c = 13.1803（18） ,A, α = 87.338（2）, β= 87.632（2）, γ = 79.536（2）°, Dc = 1.484 g/cm^3, Z = 2, λ = 0.71073 A, μ（MoKα） = 0.465, Mr = 539.36, V = 1206.7（3） A^3, F（000） = 560, the final R = 0.0426 and wR = 0.1097 for 3463 observed reflections with I 〉 2σ（I）.

关键词： sulfonamide crystal structure phosphorodiamidate

Synthesis and Crystal Structure of 2-Ethoxy-spiro[2H-1, 4,2-benzoxazaphosphorine-3(4H), 1'-Cycloheptane] 2-Oxide

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Chinese Journal of Structural Chemistry 2006年第5期25卷 523-526页

作者： WANG Bin chen ru-yu huang you miao zhi-wei Institute and State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 China

The title compound 2-ethoxy-spiro[2H-1,4,2-benzoxazaphosphorine-3（4H）,1＇-cycloheptane] 2-oxide （C15H22NO3P） was synthesized by the Mannich-type reaction of ο-amino-phenol with ethyl dichlorophosphinite and cycloheptanone, and structurally characterized by single-crystal X-ray diffraction analysis. It crystallizes in orthorhombic, space group P212121 with a = 8.9840（12）, b = 9.2978（12）, c = 37.205（5） A, V= 3107.8（7） ,A^3, Z= 8, Mr = 295.31, Dc = 1.262 g/cm^3, F（000） = 1264, μ = 0.184 mm^-1, S = 1.026, the final R = 0.0502 and wR = 0.1017 for 3849 observed reflections with Ⅰ 〉 2σ（Ⅰ） and 378 variable parameters. The structure exhibits that the six-membered phosphorus heterocycle is in the envelope conformation.

关键词： crystal structure 1,4,2,-benzoxazaphosphorine 2-oxides cyclic α-aminoalkane-phosphonates organophosphorus heterocycles

Convenient and One-pot Method for Synthesis of the Aminomethylene Bisphosphonic Acid Derivatives from Aldehydes

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Chinese Chemical Letters 2006年第6期17卷 765-768页

作者： Xiang Zhu zhang Ming Shu WU you huang ru yu chen Department of Chemical Engineering Institute of Anyang Technology Anyang 455000 Institute and National Key Laboratory of Elemento-Organic Chemlstry Nankai University Tianjin 300071

Simple, efficient and convenient synthesis of aminomethylene bisphsophonic acid derivatives in one-pot reaction using aldehydes, hydroxylamine hydrochloride, phosphours trichloride and water as starting materials in t... 详细信息

关键词： Aminomethylene bisphosphonic acid derivatives aldehydes hydroxylamine hydrochloride phosphours trichloride.

Regioselective and Stereoselective Synthesis of the 3-Aryl-4- phosphoryl-1, 2, 4-triazoline-5-ones

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Chinese Chemical Letters 2006年第9期17卷 1145-1148页

作者： De Xin FENG ru yu chen you huang Institute of Elemento-Organic Chemistry National Key Laboratory of Elemento-Organic Chemistry Nankal University Tianjin 300071

A novel and efficient route of synthesizing 1, 2, 4-triazoline-5-ones is reported. The title compounds can be prepared in high yield and purity by the one-pot oxidation and cyclization of 1-acylthiosemicarbazides. The... 详细信息

关键词： Triazoline 1-acylthiosemicarbazides regioselective stereoselective cyclization.

Numerical investigation of radio-frequency negative hydrogen ion sources by a three-dimensional fluid model

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Chinese Physics B 2021年第9期30卷 335-345页

作者： Ying-Jie Wang Jia-wei huang Quan-zhi zhang yu-ru zhang Fei Gao you-Nian Wang Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China

A three-dimensional fluid model is developed to investigate the radio-frequency inductively coupled H2 plasma in a reactor with a rectangular expansion chamber and a cylindrical driver chamber,for neutral beam injection system in *** this model,the electron effective collision frequency and the ion mobility at high E-fields are employed,for accurate simulation of discharges at low pressures(0.3 Pa-2 Pa)and high powers(40 kW-100 kW).The results indicate that when the high E-field ion mobility is taken into account,the electron density is about four times higher than the value in the low E-field *** addition,the influences of the magnetic field,pressure and power on the electron density and electron temperature are *** is found that the electron density and electron temperature in the xz-plane along permanent magnet side become much more asymmetric when magnetic field ***,the plasma parameters in the yz-plane without permanent magnet side are symmetric no matter the magnetic field is applied or ***,the maximum of the electron density first increases and then decreases with magnetic field,while the electron temperature at the bottom of the expansion region first decreases and then almost keeps *** the pressure increases from 0.3 Pa to 2 Pa,the electron density becomes higher,with the maximum moving upwards to the driver region,and the symmetry of the electron temperature in the xz-plane becomes much *** power increases,the electron density rises,whereas the spatial distribution is *** can be summarized that the magnetic field and gas pressure have great influence on the symmetry of the plasma parameters,while the power only has little effect.

关键词： negative hydrogen ion source inductively coupled plasma three-dimensional fluid model magnetic field effect

Association of the retinol to all-trans retinoic acid pathway with autism spectrum disorder

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World Journal of Pediatrics 2024年第10期20卷 1043-1058页

作者： yu-ru Feng Qian zhang Jing-Kun miao Ting Yang Jie chen hong-yu chen Qiu-hong Mou Xue-Li Xiang Dan Long Qiu-hong wei yuan Wu Ting-yu Li Children Nutrition Research Center Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive DisordersMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChildren’s Hospital of Chongqing Medical UniversityNo 1362nd Zhongshan RdYuzhong DistrictChongqingChina Department of Pediatrics Women and Children’Hospital of Chongqing Medical UniversityChongqing Health Center for Women and ChildrenChongqingChina

Background Autism spectrum disorder(ASD)is a complex group of neurodevelopmental *** has highlighted a close association between the retinoic acid(RA)signaling pathway and *** study investigates alterations in the vitamin A(VA,retinol)to RA metabolic pathway in children with ASD and speculates on the underlying reasons for these *** propose a subtype characterized by downregulated RA signaling in ASD,laying the groundwork for precise diagnosis and treatment *** We included 489 children with ASD and 280 typically developing(TD)*** with ASD underwent evaluations of core symptoms and neuro-developmental levels,which were conducted by professional developmental behavior physicians using assessment *** VA and all-trans RA(atRA)levels were determined by high-performance liquid chromatography and ultra-high-performance liquid chromatography–tandem mass *** expression levels and concentrations of enzyme molecules such as retinol dehydrogenase 10 were assessed using quantitative polymerase chain reaction and enzyme-linked immunosorbent *** Children with ASD exhibited reduced serum atRA,accompanied by a downregulation of atRA synthesis *** reduction in serum atRA levels was linked not only to VA levels but also to the aberrant expression of metabolic enzymes responsible for ***,the serum atRA levels in children with ASD were more strongly correlated with core symptoms and neurodevelopmental levels than VA *** Children with ASD exhibited a dual regulation of reduced serum atRA levels,influenced by both VA levels and abnormal expression of atRA metabolic enzymes.

关键词： All-trans retinoic acid Autism spectrum disorder Retinoic acid signaling pathway Vitamin A Vitamin A metabolism

The transcription factor NAC102 confers cadmium tolerance by regulating WAKL11 expression and cell wall pectin metabolism in Arabidopsis

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Journal of Integrative Plant Biology 2023年第10期65卷 2262-2278页

作者： Guang Hao Han ru Nan huang Li hong hong Jia Xi Xu Yi Guo hong yu Huan Wu wei wei chen Research Center for Plant RNA Signaling College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 310036China Warwick‐Hangzhou RNA Signaling Joint Laboratory School of Life SciencesUniversity of WarwickWarwick CV47ALUnited Kingdom State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China

Cadmium(Cd) toxicity severely limits plant growth and development. Moreover, Cd accumulation in vegetables, fruits, and food crops poses health risks to animals and humans. Although the root cell wall has been implicated in Cd stress in plants, whether Cd binding by cell wall polysaccharides contributes to tolerance remains controversial, and the mechanism underlying transcriptional regulation of cell wall polysaccharide biosynthesis in response to Cd stress is unknown. Here, we functionally characterized an Arabidopsis thaliana NAC-type transcription factor, NAC102, revealing its role in Cd stress responses. Cd stress rapidly induced accumulation of NAC102.1, the major transcript encoding functional NAC102, especially in the root apex. Compared to wild type(WT) plants, a nac102 mutant exhibited enhanced Cd sensitivity, whereas NAC102.1-overexpressing plants displayed the opposite phenotype. Furthermore, NAC102 localizes to the nucleus, binds directly to the promoter of WALL-ASSOCIATED KINASE-LIKE PROTEIN11(WAKL11), and induces transcription, thereby facilitating pectin degradation and decreasing Cd binding by pectin. Moreover, WAKL11 overexpression restored Cd tolerance in nac102mutants to the WT levels, which was correlated with a lower pectin content and lower levels of pectin-bound Cd. Taken together, our work shows that the NAC102-WAKL11 module regulates cell wall pectin metabolism and Cd binding, thus conferring Cd tolerance in Arabidopsis.

关键词： cadmium stress cell wall NAC102 transcriptional regulation WAKL

Automated Identification of Ordered Phases for Simulation Studies of Block Copolymers

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Chinese Journal of Polymer Science 2024年第5期42卷 683-692,I0011页

作者： yu-chen zhang wei-Ling huang Yi-Xin Liu State Key Laboratory of Molecule Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

In unit cell simulations,identification of ordered phases in block copolymers(BCPs)is a tedious and time-consuming task,impeding the advancement of more streamlined and potentially automated research *** this study,we propose a scattering-based automated identification strategy(SAIS)for characterization and identification of ordered phases of BCPs based on their computed scattering *** approach leverages the scattering theory of perfect crystals to efficiently compute the scattering patterns of periodic morphologies in a unit *** the first stage of the SAIS,phases are identified by comparing reflection conditions at a sequence of Miller *** confirm or refine the identification results of the first stage,the second stage of the SAIS introduces a tailored residual between the test phase and each of the known candidate ***,our strategy incorporates a variance-like criterion to distinguish background species,enabling its extension to multi-species BCP *** has been demonstrated that our strategy achieves exceptional accuracy and robustness while requiring minimal computational ***,the approach allows for real-time expansion and improvement to the candidate phase library,facilitating the development of automated research workflows for designing specific ordered structures and discovering new ordered phases in BCPs.

关键词： Block copolymer Phase identification Scattering function

丹酚酸B调控脂质代谢改善非酒精性脂肪肝实验研究

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中国药理学通报 2025年第1期41卷 107-115页

作者：张佳健郭梦茹梅金玉陈明安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第二附属医院耳鼻喉科安徽合肥230601

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低... 详细信息

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低剂量为15 mg·kg^(-1)·d^(-1),高剂量为30 mg·kg^(-1)·d^(-1),对照组和模型组用等剂量生理盐水灌胃。肝脏转录组测序结果揭示模型组和SalB组的差异表达基因,HE染色、油红O染色观察肝组织的病理变化,试剂盒检测血清和肝组织的脂质、氧化应激和炎症指标,RT-qPCR检测Lcn2、SREBP-1C以及脂质合成相关酶的mRNA水平。体外实验,用棕榈酸(PA)诱导L02和LX-2细胞24 h建立NAFLD模型,用SalB(30μmol·L^(-1))和PA(0.2 mmol·L^(-1))共孵育检测SalB体外改善NAFLD的情况。试剂盒检测L02细胞TC、TG的含量,细胞油红O染色试剂盒检测L02细胞的脂质积累,RT-qPCR检测LX-2细胞Lcn2、SREBP-1C以及脂质合成相关酶基因的mRNA水平。结果模型组血清、肝脏的生化指标异常,肝组织脂质、炎症和氧化应激水平升高,出现大面积脂肪空泡和大量的脂质沉积,PA诱导的L02细胞也出现大量的脂质积累,在SalB干预后均有明显改善。转录组测序结果表明SalB可以调控肝脏脂质代谢和炎症。肝脏和LX-2细胞mRNA水平显示模型组Lcn2、SREBP-1C以及脂质合成相关酶基因表达明显上调,SalB干预后均能降低这些基因的表达。结论丹酚酸B可以明显改善非酒精性脂肪肝,其机制可能是通过下调Lcn2、SREBP-1C和脂质合成酶的表达。

关键词： SalB 非酒精性脂肪肝脂质代谢 Lcn2 SREBP-1C 脂质合成相关酶

Prevalence and Genotypes of Rotavirus A and Human Adenovirus among Hospitalized Children with Acute Gastroenteritis in Fujian, China, 2009-2017

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Biomedical and Environmental Sciences 2019年第3期32卷 210-214页

作者： WU Bing Shan huang zhi miao WENG yu wei chen Feng Qin zhang yun Lin LIN wei Dong yu Ting Ting Fujian Provincial Key Laboratory of Zoonosis Research Fujian Center for Disease Control and Prevention Fuzhou children's hospital Pingtan Center for Disease Control and Prevention

Gastroenteritis is an infectious diarrhea that has been considered as an important cause of hospitalizations and death in children aged < 5 years, particularly in developing countries. Unsanitary water, contaminated f... 详细信息

Gastroenteritis is an infectious diarrhea that has been considered as an important cause of hospitalizations and death in children aged rus (RV) infections have been reported to be the most common, especially among young children aged ruses associated with acute gastroenteritis include human Adenovirus (HAdV), Norovirus, Sapovirus (SaV), human Astrovirus (HAstV), and Aichi virus. Recent research has reported that adenovirus types 40 and 41, belonging to species F, cause gastroenteritis and were therefore termed as enteric adenoviruses. In addition, non-enteric HAdV species such as A, B, C, and D have been associated with diarrheal.

关键词： Prevalence and Genotypes Rotavirus A Acute Gastroenteritis