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人工智能在慢加急性肝衰竭预后预测模型中的研究现状

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临床肝胆病杂志 2024年第9期40卷 1891-1896页

作者：姜伟常秀君曾帆兰蕴平成都中医药大学医学与生命科学学院成都610075 电子科技大学附属医院/四川省人民医院重症医学中心成都610072

慢加急性肝衰竭(ACLF)是在慢性肝病基础上出现的急性肝功能恶化,且以肝脏和/或肝外器官衰竭和短期高病死率为主要特征的复杂临床综合征。目前缺乏有效的治疗手段,内科综合治疗下病死率高达50%~90%。开发简单快捷、准确性高的ACLF预后预... 详细信息

慢加急性肝衰竭(ACLF)是在慢性肝病基础上出现的急性肝功能恶化,且以肝脏和/或肝外器官衰竭和短期高病死率为主要特征的复杂临床综合征。目前缺乏有效的治疗手段,内科综合治疗下病死率高达50%~90%。开发简单快捷、准确性高的ACLF预后预测模型,能帮助临床医师早期准确判断ACLF患者预后,识别预后不良患者,从而实施早期干预,可在一定程度上改善预后,有助于降低病死率。随着计算机科学的不断发展,数据处理能力愈发强大,人工智能越来越受到重视,在肝脏疾病的诊断、治疗、预后预测等多方面均有应用。本文结合国内外研究现状,对常见的ACLF预后模型和机器学习预后预测模型进行综述,总结最新研究进展,为ACLF预后预测模型未来发展提供新思路。

关键词：慢加急性肝功能衰竭人工智能机器学习预后

Polyethersulfone-polyvinylpyrrolidone composite membranes: Effects of polyvinylpyrrolidone content and polydopamine coating on membrane morphology, structure and performances

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Chinese Journal of Chemical Engineering 2021年第10期34卷 84-97页

作者： Yanna Wu Jianxian zeng Yajie zeng Hu Zhou Guoqing Liu Jian Jian Jie Ding School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyHunan Provincial Engineering Research Center for Functional MembranesXiangtan 411201China School of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China

Hydrophilic modification is a promising method to inhibit fouling formation on ultrafiltration *** this work,different mass concentrations(1%–16%)of hydrophilic polyvinylpyrrolidone were incorporated into polyethersulfone(PES)membranes fabricated by none-solvent induced phase ***,polydopamine(PDA)coating on the surface of prepared membrane was carried out at pH *** morphology and structure,surface hydrophilicity,permeation flux,BSA rejection,antifouling and stability performances of PES and PDA/PES modified membranes were investigated in *** results indicated that PDA was successfully attached onto the *** hydrophilicity was evaluated by water contact angle *** contact angles of modified membranes reduced remarkably,suggesting that the membrane hydrophilicities were significantly *** results of filtration tests,which were done by dead-end filtration of bovine serum albumin solution,showed that the properties of permeability and fouling resistance were obviously improved by PDA *** polyvinylpyrrolidone mass content reached 10%,flux recovery ratio of modified membrane was up to91.23%,and its BSA rejection were over 70%.The results of stability tests showed that the modified membranes had good mechanical stability and chemical *** facile fabrication procedure and outstanding performances suggested that the modified membranes had a potential in treating fouling.

关键词： Polyethersulfone membrane Polydopamine coating Hydrophilicity Permeability Antifouling

Evaluation of a resoruf in-based fluorescent probe for tyrosinase detection in skin pigmentation disorders

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Bio-Design and Manufacturing 2021年第4期4卷 806-817页

作者： Yibo Hu Hongliang zeng Jiaxing Jiang Sheng Yang Jinhua Huang Jing Chen Qinghai zeng Department of Dermatology The Third Xiangya Hospital of Central South UniversityTongzipo Road No.138Yuelu DistrictChangsha 410013China Institute of Chinese Materia Medica Hunan Academy of Chinese MedicineChangsha 410006China School of Chemistry and Food Engineering Changsha University of Science and Technology(CSUST)Changsha 410114China

Purpose Skin pigmentation disorders,such as vitiligo and melasma,are difficult to diagnose in the early stages,but abnor-mal tyrosinase levels and tyrosinase activity are potential *** resorufin-based fluorescence probes(RBFPs)have been designed to detect tyrosinase in tumors,but they have not been used in skin pigmentation *** this study,one of these RBFPs(synthesized by resorufin salt coupled with 3-(bromomethyl)phenol)was evaluated *** The RBFP was tested in different kinds of mouse and human skin cells,as well as in in vivo models,including zebrafish,guinea pigs,and Sprague-Dawley *** addition,small interfering RNAs(siRNAs),kojic acid,and 1-phenyl-2-thiourea(PTU)were used to inhibit tyrosinase levels or tyrosinase *** This probe successfully detected tyrosinase and emitted red fluorescence in melanoma cells and *** was also observable in zebrafish and on the skin of guinea pigs when using the *** mouse and human cells,the RBFP showed good selectivity to ***,in the case of decreased tyrosinase levels or activity caused by siRNAs,kojic acid,or PTU,the probe was sensitive to these ***,the RBFP showed no toxic effects at concentrations of<20μmol/L,both in vitro and in *** Our findings indicate the value and limitations of the RBFP in tyrosinase detection,but suggest the need for further improvement of fluorescent probes in the diagnosis of skin pigmentation disorders.

关键词： Tyrosinase Pigmentation disorder Diagnosis Fluorescence probe

Quantitative Biostratigraphic Analysis upon the Upper Cretaceous in Tethyan Himalaya

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Acta Geologica Sinica(English Edition) 2013年第4期87卷 926-935页

作者： LI Guangwei zeng Jun State Key Laboratory of Continental Tectonics and Dynamics Institute of Geology Chinese Academy of Geological Sciences School of the Geosciences and Resources China University of Geosciences

Biostratigraphic analysis is an essential element for understanding global tectonics and the evolution of life on Earth. Quantitative analysis of sedimentary sequences provides the precise age constraints on timing of significant events in Earth＇s history. This paper presents results from quantitative stratigraphic analysis of Upper Cretaceous Tethyan Himalayan sequences. This analysis resulted in a new composite stratigraphic section for the Cretaceous strata of Tibet （TIBETKCS）. The eight Upper Cretaceous sections were analyzed in this study and 12 planktonic foraminifera zones were recognized based on available data. Quantitative measurements were made using a Graphic Correlation with Graphcor 3.0 software and correlated to the world standard Cretaceous Composite Section （MIDKCS）. The sections were also examined using Constrained Optimization software by CONOP9. Level Penalty was applied as the rule to measure misfit among automatically correlated sections. The new TIBETKCS correlates well with planktonic foraminifera ages from previous work in southern Tibet. A fitting equation of y=？0.19x＋305 with a correlation coefficient of 0.94 was obtained from this work. The ages of the first and last appearances of 64 planktonic foraminifera can be calculated with this equation with ± 0.3 Ma precision. This level of precision is approximately 10 times higher than age determinations with traditional methods. Two extinction events were resolved within this analysis at ~93.5 Ma and ~85.5 Ma corresponding to the Ocean Anoxic Events at Cenomanian-Turonian and Coniacian-Santonian boundaries respectively.

关键词： quantitative biostratigraphy graphic correlation constrained optimization TethyanHimalayan sequences Upper Cretaceous

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基于体验记忆模型的服务触点优化策略研究

包装工程 2024年第12期45卷 129-136页

作者：贺雪梅田安洁宋宁曾佳屿陕西科技大学西安710021

目的将体验记忆模型应用于服务触点的优化研究,结合体验与记忆两个因素筛选需优化服务触点(即威胁触点),建立基于体验记忆模型的服务触点优化策略。方法首先,基于特定服务系统梳理并确定用户群,建立用户画像。基于行为追踪获取服务触点... 详细信息

目的将体验记忆模型应用于服务触点的优化研究,结合体验与记忆两个因素筛选需优化服务触点(即威胁触点),建立基于体验记忆模型的服务触点优化策略。方法首先,基于特定服务系统梳理并确定用户群,建立用户画像。基于行为追踪获取服务触点,并采取量表法对服务触点进行体验评价。其次,根据艾宾浩斯遗忘曲线确定记忆评分的3个时间点,选取定量用户并分别对服务触点进行记忆评分,结合服务触点体验评价构建体验记忆分区图,明确服务系统中的威胁触点。最后,结合用户需求,提出威胁触点的优化建议,并最终完成服务触点原型输出。结果以公园骑行服务触点优化为例证,验证了该策略的可靠性。结论体验记忆模型可有效筛选服务触点,提高设计效率,降低服务优化成本。

关键词：服务触点体验记忆模型优化策略记忆评分

左氧氟沙星在水环境中的赋存、风险及降解技术研究进展

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环境污染与防治 2024年第3期46卷 392-399页

作者：卢洪斌卢少勇曾泽泉黄张根中国科学院山西煤炭化学研究所煤转化国家重点实验室山西太原030001 中国环境科学研究院湖泊水污染治理与生态修复技术国家工程实验室环境基准与风险评估国家重点实验室北京100012 北京师范大学水科学研究院北京100875

水环境中的抗生素不仅诱导微生物产生抗性基因(ARGs)及耐药细菌,而且危害生物安全,对人类生命健康产生严重威胁。氟喹诺酮类抗生素(FQs)及其引发的ARGs问题已引起国内外学者广泛关注。左氧氟沙星(LVFX)是使用最广泛的FQs之一,因生物体... 详细信息

水环境中的抗生素不仅诱导微生物产生抗性基因(ARGs)及耐药细菌,而且危害生物安全,对人类生命健康产生严重威胁。氟喹诺酮类抗生素(FQs)及其引发的ARGs问题已引起国内外学者广泛关注。左氧氟沙星(LVFX)是使用最广泛的FQs之一,因生物体代谢率低且化学结构稳定,在环境中被广泛检出。因此亟需掌握LVFX在水环境中的赋存特征,厘清其对生态环境的危害,并比较分析现有技术对其去除效果。在现有研究基础上综述了LVFX在水环境中的赋存特征,从诱导微生物产生ARGs和耐药细菌及威胁水生态安全两个方面阐述了LVFX的生态风险,系统阐述了物理法、化学法和生物法去除LVFX的效果及研究进展,分析了这些技术的优缺点,以期为高效低耗降解LVFX并抑制ARGs的传播提供一定的参考。

关键词：左氧氟沙星抗性基因环境风险处理技术

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我国成人高血压的流行病学现状及趋势

中国胸心血管外科临床杂志 2024年第6期31卷 922-928页

作者：罗云梅曾智何文博张伟四川大学华西医院医院管理研究所成都610041

高血压及其所导致的脑卒中、缺血性心脏病等心血管疾病,导致较高的疾病负担和健康损失,是全球负担最重的疾病,也是我国面临的重要公共卫生问题之一。目前我国学者开展了大量的高血压患病率研究,包括地域性的和全国性的患病率研究,但长... 详细信息

高血压及其所导致的脑卒中、缺血性心脏病等心血管疾病,导致较高的疾病负担和健康损失,是全球负担最重的疾病,也是我国面临的重要公共卫生问题之一。目前我国学者开展了大量的高血压患病率研究,包括地域性的和全国性的患病率研究,但长期随访的发病率研究相对较少且多限于特定年龄和地域。本文对我国成人高血压的患病率和发病率现状及趋势进行总结:高血压患病率从1959年的5.1%上升至2018年的27.5%,患病率上升较快且总体呈现北高南低的趋势;高血压发病率处于较高水平(22年高血压累积发病率为33.4%),但大地域范围高血压发病率趋势研究较少。

关键词：高血压患病率发病率综述

Comprehensive Study on the Influence of Evapotranspiration and Albedo on Surface Temperature Related to Changes in the Leaf Area Index

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Advances in Atmospheric Sciences 2015年第7期32卷 935-942页

作者： ZHU Jiawen zeng Xiaodong International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology

Many studies have investigated the influence of evapotranspiration and albedo and emphasize their separate effects but ignore their interactive influences by changing vegetation status in large amplitudes. This paper focuses on the comprehensive influence of evapotranspiration and albedo on surface temperature by changing the leaf area index （LAD between 30^-90~N. Two LAI datasets with seasonally different amplitudes of vegetation change between 30^-90~N were used in the simulations. Seasonal differences between the results of the simulations are compared, and the major findings are as follows. （1） The interactive effects of evapotranspiration and albedo on surface temperature were different over different regions during three seasons [March-April-May （MAM）, June-July-August （JJA）, and September-October-November （SON）], i.e., they were always the same over the southeastern United States during these three seasons but were opposite over most regions between 30°-90°N during JJA. （2） Either evapotranspiration or albedo tended to be dominant over different areas and during different seasons. For example, evapotranspiration dominated almost all regions between 30^-90~N during JJA, whereas albedo played a dominant role over northwestern Eurasia during MAM and over central Eurasia during SON. （3） The response of evapotranspiration and albedo to an increase in LAI with different ranges showed different paces and signals. With relatively small amplitudes of increased LAI, the rate of the relative increase in evapotranspiration was quick, and positive changes happened in albedo. But both relative changes in evapotranspiration and albedo tended to be gentle, and the ratio of negative changes of albedo increased with relatively large increased amplitudes of LAI.

关键词： surface temperature evapotranspiration albedo leaf area index comprehensive influence

Single-photon detection and its applications

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Science China(Physics,Mechanics & Astronomy) 2014年第7期57卷 1218-1232页

作者： LIANG Yan zeng HePing Shanghai Key Laboratory of Modern Optical System Engineering Research Center of Optical Instrument and System Ministry of Education School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology State Key Laboratory of Precision Spectroscopy East China Normal University

A single-photon detector is an extremely sensitive device capable of registering photons,offering essential technical support for optics quantum information *** review herein our recent experimental progress in the development and application of single-photon detection *** based on advanced self-differencing,low-pass filtering,frequency up-conversion and photon-number-resolving are introduced for attaining high-speed,high-efficiency,low-noise single-photon detection at infrared *** advantages of high-speed single-photon detection are discussed in some applications,such as the laser ranging and quantum key *** photon-number-resolving detection is shown to support efficient quantum random number generation.

关键词： quantum optics photodetection avalanche photodiode frequency up-conversion